β-Lactam formation by a non-ribosomal peptide synthetase during antibiotic biosynthesis

Nature

Volumn 520, Issue 7547, 2015, Pages 383-387

  Gaudelli, Nicole M ^a,b   Long, Darcie H ^a   Townsend, Craig A ^a  

^a JOHNS HOPKINS UNIVERSITY   (United States)

^b HARVARD UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; CARBAPENEM; CEPHALOSPORIN; CLAVULANIC ACID; COENZYME A; NOCARDICIN A; NOCARDICIN B; NOCARDICIN G; NONRIBOSOMAL PEPTIDE SYNTHETASE; NUCLEOPHILE; PENICILLIN DERIVATIVE; PENTAPEPTIDE; TETRAPEPTIDE; TRIPEPTIDE; UNCLASSIFIED DRUG; ANTIINFECTIVE AGENT; BETA LACTAM; HISTIDINE; LACTAM; NOCARDICIN; PEPTIDE SYNTHASE; SERINE;

AMINO ACID; ANTIBIOTICS; BIOACTIVITY; ENZYME ACTIVITY; PEPTIDE;

AFFINITY CHROMATOGRAPHY; AMINO TERMINAL SEQUENCE; ANTIBIOTIC BIOSYNTHESIS; ARTICLE; CARBOXY TERMINAL SEQUENCE; CATALYSIS; CHEMICAL BOND; CONTROLLED STUDY; CYCLIZATION; ELECTROSPRAY MASS SPECTROMETRY; EPIMERIZATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYDROLYSIS; NOCARDIA; NOCARDIA UNIFORMIS; NONHUMAN; PEPTIDE BOND FORMATION; PRIORITY JOURNAL; STEREOCHEMISTRY; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY; WILD TYPE; BIOCATALYSIS; BIOSYNTHESIS; CHEMISTRY; METABOLISM;

ANTI-BACTERIAL AGENTS; BETA-LACTAMS; BIOCATALYSIS; BIOSYNTHETIC PATHWAYS; CYCLIZATION; HISTIDINE; LACTAMS; PEPTIDE SYNTHASES; SERINE;

EID: 84928388575     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature14100     Document Type: Article

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