Aminoacyl-SNACs as small-molecule substrates for the condensation domains of nonribosomal peptide synthetases

Chemistry and Biology

Volumn 7, Issue 10, 2000, Pages 765-772

  Ehmann, David E ^a   Trauger, John W ^a   Stachelhaus, Torsten ^a   Walsh, Christopher T ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

Author keywords

Condensation domain; Nonribosomal peptide synthetase; Substrate specificity

Indexed keywords

DRUG DERIVATIVE; ENTEROBACTIN SYNTHETASE; ENTEROCHELIN; ESTER; LIGASE; MERCAPTAMINE; MULTIENZYME COMPLEX; NON RIBOSOMAL PEPTIDE SYNTHASE; NON-RIBOSOMAL PEPTIDE SYNTHASE; PEPTIDE SYNTHASE; PROTEIN SUBUNIT; TYROCIDINE SYNTHETASE;

ARTICLE; CATALYSIS; CHEMISTRY; ENZYME ACTIVE SITE; ENZYME SPECIFICITY; ENZYMOLOGY; ESCHERICHIA COLI; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; KINETICS; METABOLISM; PROTEIN TERTIARY STRUCTURE; STEREOISOMERISM; SYNTHESIS;

CATALYSIS; CATALYTIC DOMAIN; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CYSTEAMINE; ENTEROBACTIN; ESCHERICHIA COLI; ESTERS; KINETICS; LIGASES; MULTIENZYME COMPLEXES; PEPTIDE SYNTHASES; PROTEIN STRUCTURE, TERTIARY; PROTEIN SUBUNITS; STEREOISOMERISM; SUBSTRATE SPECIFICITY;

EID: 0033782162     PISSN: 10745521     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1074-5521(00)00022-3     Document Type: Article

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