Non-ribosomal propeptide precursor in nocardicin A biosynthesis predicted from adenylation domain specificity dependent on the MbtH family protein NocI

Journal of the American Chemical Society

Volumn 135, Issue 5, 2013, Pages 1749-1759

  Davidsen, Jeanne M ^a   Bartley, David M ^a,b   Townsend, Craig A ^a  

^a JOHNS HOPKINS UNIVERSITY   (United States)

^b ADRIAN COLLEGE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENYLATION; ANTIBIOTIC ACTIVITY; BIOINFORMATIC ANALYSIS; BROAD SPECTRUM; C TERMINUS; DOMAIN SPECIFICITY; GENE CLUSTERS; GRAM-NEGATIVE BACTERIA; GRAM-NEGATIVE STRAINS; L-SERINE; MULTI DOMAINS; NATURAL PRODUCTS; NOCARDIA; NONLINEAR REACTION; PROPEPTIDES; SUBSTRATE SPECIFICITY; SYNTHETASES; TRIPEPTIDE;

AMINO ACIDS; ANTIBIOTICS; BACTERIA; BIOINFORMATICS; BIOSYNTHESIS; ENCODING (SYMBOLS); ESCHERICHIA COLI; GENES; PROTEINS; SEWAGE TREATMENT PLANTS;

BIOCHEMISTRY;

ADENOSINE TRIPHOSPHATE; ANTIBIOTIC AGENT; ARGININE; BACTERIAL PROTEIN; ISOPENICILLIN N; MBTH PROTEIN; NOCARDICIN A; NOCARDICIN B; NOCL PROTEIN; NONRIBOSOMAL PEPTIDE SYNTHETASE; OXFENICINE; PENTAPEPTIDE; PHENYLGLYCINE; PYROPHOSPHATE; SERINE; TRYPSIN; UNCLASSIFIED DRUG;

ADENYLATION; AMINO ACID SEQUENCE; ANTIMICROBIAL ACTIVITY; ARTICLE; BIOINFORMATICS; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; DRUG SYNTHESIS; ENZYME SPECIFICITY; ESCHERICHIA COLI; EXPRESSION VECTOR; GENE CLUSTER; GENE EXPRESSION; GENE IDENTIFICATION; GENE SEQUENCE; GRAM NEGATIVE BACTERIUM; HETEROLOGOUS EXPRESSION; NONRIBOSOMAL PEPTIDE SYNTHESIS; NUCLEOTIDE SEQUENCE; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN FAMILY; RADIOCHEMISTRY; STOICHIOMETRY;

LACTAMS; MOLECULAR STRUCTURE; NOCARDIA; OLIGOPEPTIDES; PEPTIDE SYNTHASES; POLYADENYLATION; PROTEIN PRECURSORS;

EID: 84873336552     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja307710d     Document Type: Article

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