The ginsenoside 20-O-β-D-glucopyranosyl-20(S)-protopanaxadiol induces autophagy and apoptosis in human melanoma via AMPK/JNK phosphorylation

PLoS ONE

Volumn 9, Issue 8, 2014, Pages

  Kang, Soouk ^a,b   Kim, Jong Eun ^a,b   Song, Nu Ry ^a,c   Jung, Sung Keun ^a,b,d   Lee, Mee Hyun ^b   Park, Jun Seong ^e   Yeom, Myeong Hun ^e   Bode, Ann M ^b   Dong, Zigang ^b   Lee, Ki Won ^a,c,f  

^a Seoul National University   (South Korea)

^b UNIVERSITY OF MINNESOTA   (United States)

^c Seoul National University   (South Korea)

^d Korea Food Research Institute   (South Korea)

^e AmorePacific Corporation   (South Korea)

^f Seoul National University   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

20 O BETA DEXTRO GLUCOPYRANOSYL 20 PROTOPANAXADIOL; ANTINEOPLASTIC AGENT; CASPASE 3; CASPASE 7; CASPASE 9; GINSENOSIDE; GINSENOSIDE RB 1; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; MAMMALIAN TARGET OF RAPAMYCIN; PROTEIN C JUN; STRESS ACTIVATED PROTEIN KINASE; UNCLASSIFIED DRUG; GINSENOSIDE M1; MTOR PROTEIN, HUMAN; TARGET OF RAPAMYCIN KINASE;

ANTINEOPLASTIC ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; ARTICLE; AUTOPHAGY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFICACY; DRUG MECHANISM; DRUG STRUCTURE; ENZYME INDUCTION; ENZYME PHOSPHORYLATION; HUMAN; HUMAN CELL; MELANOMA; MELANOMA CELL LINE; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; SK MEL 28 CELL LINE; ANTAGONISTS AND INHIBITORS; CHEMISTRY; DOSE RESPONSE; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETICS; ISOLATION AND PURIFICATION; MELANOCYTE; METABOLISM; PANAX; PATHOLOGY; PHOSPHORYLATION; TUMOR CELL LINE;

AMP-ACTIVATED PROTEIN KINASES; ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; AUTOPHAGY; CELL LINE, TUMOR; DOSE-RESPONSE RELATIONSHIP, DRUG; GENE EXPRESSION REGULATION, NEOPLASTIC; GINSENOSIDES; HUMANS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MELANOCYTES; PANAX; PHOSPHORYLATION; SIGNAL TRANSDUCTION; TOR SERINE-THREONINE KINASES;

EID: 84928383920     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0104305     Document Type: Article

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