Inhibition of JAK1/STAT3 signaling mediates compound K-induced apoptosis in human multiple myeloma U266 cells

Food and Chemical Toxicology

Volumn 49, Issue 6, 2011, Pages 1367-1372

  Park, Sora ^a   Lee, Hyo Jung ^a   Jeong, Soo Jin ^a   Song, Hyo Sook ^a   Kim, Minseok ^b   Lee, Hyo Jeong ^a   Lee, Eun Ok ^a   Kim, Dong Hyun ^a   Ahn, Kyoo Seok ^a   Kim, Sung Hoon ^a  

^a Kyung Hee University   (South Korea)

^b TUFTS UNIVERSITY SCHOOL OF DENTAL MEDICINE   (United States)

Author keywords

Apoptosis; Compound K; JAK1; Multiple myeloma; STAT3

Indexed keywords

20 O BETA DEXTRO GLUCOPYRANOSYL 20 PROTOPANAXADIOL; ANTINEOPLASTIC AGENT; CASPASE 3; CYCLIN D1; CYCLIN E; GINSENG SAPONIN; JANUS KINASE 1; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PROTEIN BCL 2; PROTEIN BCL XL; PROTEIN TYROSINE PHOSPHATASE SHP 1; STAT3 PROTEIN; SURVIVIN; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DNA CLEAVAGE; DOWN REGULATION; DRUG CYTOTOXICITY; DRUG MECHANISM; DRUG SCREENING; DRUG STRUCTURE; DRUG TARGETING; ENZYME PHOSPHORYLATION; HUMAN; HUMAN CELL; INTRACELLULAR SIGNALING; MULTIPLE MYELOMA; MYELOMA CELL; PROTEIN EXPRESSION; WESTERN BLOTTING;

ANTINEOPLASTIC AGENTS; APOPTOSIS; BLOTTING, WESTERN; CASPASE 3; CELL CYCLE; CELL LINE, TUMOR; CELL SURVIVAL; DOWN-REGULATION; DRUG SCREENING ASSAYS, ANTITUMOR; ENZYME INHIBITORS; GINSENOSIDES; HUMANS; JANUS KINASE 1; MULTIPLE MYELOMA; PANAX; POLY(ADP-RIBOSE) POLYMERASES; PROTEIN TYROSINE PHOSPHATASES; SIGNAL TRANSDUCTION; STAT3 TRANSCRIPTION FACTOR; VANADATES;

PANAX GINSENG;

EID: 79955672688     PISSN: 02786915     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.fct.2011.03.021     Document Type: Article

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