메뉴 건너뛰기




Volumn 35, Issue 4, 2012, Pages 573-581

Metabolism of ginsenoside Rb1 by human intestinal microflora and cloning of its metabolizing β-D-glucosidase from Bifidobacterium longum H-1

Author keywords

D glucosidase; D glucosidase coding gene; Bifidobacterium longum H 1; Ginsenoside Rb1; Intestinal microflora; Metabolism

Indexed keywords

ARBUTIN; ARCTIIN; BETA GLUCOSIDASE; GINSENOSIDE RB 1; LOGANIN;

EID: 84859476056     PISSN: 09186158     EISSN: 13475215     Source Type: Journal    
DOI: 10.1248/bpb.35.573     Document Type: Article
Times cited : (52)

References (38)
  • 1
    • 0036345691 scopus 로고    scopus 로고
    • Intestinal microflora activate the pharmacological effects of herbal medicines
    • Kim DH. Intestinal microflora activate the pharmacological effects of herbal medicines. Nat. Prod. Sci., 8, 35-43 (2002).
    • (2002) Nat. Prod. Sci. , vol.8 , pp. 35-43
    • Kim, D.H.1
  • 2
    • 0001833433 scopus 로고    scopus 로고
    • Relation of intestinal bacteria to pharmacological effect of glycosides
    • Kobashi K, Akao T. Relation of intestinal bacteria to pharmacological effect of glycosides. Biosci. Microflora, 16, 1-7 (1997).
    • (1997) Biosci. Microflora , vol.16 , pp. 1-7
    • Kobashi, K.1    Akao, T.2
  • 3
    • 11244305292 scopus 로고
    • Relation of intestinal bacteria to pharmacological effect of glycosides
    • Kobashi K, Nakata H, Takebe H, Terasawa K. Relation of intestinal bacteria to pharmacological effect of glycosides. Wakan-yakukaishi, 1, 166-167 (1984).
    • (1984) Wakan-yakukaishi , vol.1 , pp. 166-167
    • Kobashi, K.1    Nakata, H.2    Takebe, H.3    Terasawa, K.4
  • 4
    • 6944253961 scopus 로고    scopus 로고
    • Transformation of ginseng saponins to ginsenoside Rh2 by acids and human intestinal bacteria and biological activities of their transformants
    • Bae EA, Han MJ, Kim EJ, Kim DH. Transformation of ginseng saponins to ginsenoside Rh2 by acids and human intestinal bacteria and biological activities of their transformants. Arch. Pharm. Res., 27, 61-67 (2004).
    • (2004) Arch. Pharm. Res. , vol.27 , pp. 61-67
    • Bae, E.A.1    Han, M.J.2    Kim, E.J.3    Kim, D.H.4
  • 5
    • 53149089114 scopus 로고    scopus 로고
    • Biotransformation of ginsenoside Rb1, crocin, amygdalin, geniposide, puerarin, ginsenoside Re, hesperidin, poncirin, glycyrrhizin, and baicalin by human fecal microflora and its relation to cytotoxicity against tumor cells
    • Kim YS, Kim JJ, Cho KH, Jung WS, Moon SK, Park EK, Kim DH. Biotransformation of ginsenoside Rb1, crocin, amygdalin, geniposide, puerarin, ginsenoside Re, hesperidin, poncirin, glycyrrhizin, and baicalin by human fecal microflora and its relation to cytotoxicity against tumor cells. J. Microbiol. Biotechnol., 18, 1109-1114 (2008).
    • (2008) J. Microbiol. Biotechnol. , vol.18 , pp. 1109-1114
    • Kim, Y.S.1    Kim, J.J.2    Cho, K.H.3    Jung, W.S.4    Moon, S.K.5    Park, E.K.6    Kim, D.H.7
  • 7
    • 21644454094 scopus 로고    scopus 로고
    • Metabolic activities of ginsenoside Rb1, baicalin, glycyrrhizin and geniposide to their bioactive compounds by human intestinal microflora
    • Yim JS, Kim YS, Moon SK, Cho KH, Bae HS, Kim JJ, Park EK, Kim DH. Metabolic activities of ginsenoside Rb1, baicalin, glycyrrhizin and geniposide to their bioactive compounds by human intestinal microflora. Biol. Pharm. Bull., 27, 1580-1583 (2004).
    • (2004) Biol. Pharm. Bull. , vol.27 , pp. 1580-1583
    • Yim, J.S.1    Kim, Y.S.2    Moon, S.K.3    Cho, K.H.4    Bae, H.S.5    Kim, J.J.6    Park, E.K.7    Kim, D.H.8
  • 8
    • 85008118525 scopus 로고
    • Chemical studies on the oriental plant drugs: XXVIII. Saponins and sapogenins of ginseng; stereochemistry of sapogenin of ginsenoside Rb1, Rb2 and Rc
    • Nagai M, Ando T, Tanaka N, Tanaka O, Shibata S. Chemical studies on the oriental plant drugs: XXVIII. Saponins and sapogenins of ginseng; stereochemistry of sapogenin of ginsenoside Rb1, Rb2 and Rc. Chem. Pharm. Bull., 20, 1212-1216 (1972).
    • (1972) Chem. Pharm. Bull. , vol.20 , pp. 1212-1216
    • Nagai, M.1    Ando, T.2    Tanaka, N.3    Tanaka, O.4    Shibata, S.5
  • 9
    • 78651125802 scopus 로고
    • Studies on the constituents of Japanese and Chinese crude drugs. XI. Panaxadiol, a sapogenin of ginseng roots
    • Shibata S, Fujita M, Itokawa H, Tanaka O, Ishii T. Studies on the constituents of Japanese and Chinese crude drugs. XI. Panaxadiol, a sapogenin of ginseng roots. Chem. Pharm. Bull., 11, 759-761 (1963).
    • (1963) Chem. Pharm. Bull. , vol.11 , pp. 759-761
    • Shibata, S.1    Fujita, M.2    Itokawa, H.3    Tanaka, O.4    Ishii, T.5
  • 10
    • 79959563146 scopus 로고    scopus 로고
    • Ginsenoside Rb1 and its metabolite compound K inhibit IRAK-1 activation - The key step of inflammation
    • Joh EH, Lee IA, Jung IH, Kim DH. Ginsenoside Rb1 and its metabolite compound K inhibit IRAK-1 activation - the key step of inflammation. Biochem. Pharmacol., 82, 278-286 (2011).
    • (2011) Biochem. Pharmacol. , vol.82 , pp. 278-286
    • Joh, E.H.1    Lee, I.A.2    Jung, I.H.3    Kim, D.H.4
  • 11
    • 51349086818 scopus 로고    scopus 로고
    • Comparison of the pharmacological effects of Panax ginseng and Panax quinquefolium
    • Chen CF, Chiou WF, Zhang JT. Comparison of the pharmacological effects of Panax ginseng and Panax quinquefolium. Acta Pharmacol. Sin., 29, 1103-1108 (2008).
    • (2008) Acta Pharmacol. Sin. , vol.29 , pp. 1103-1108
    • Chen, C.F.1    Chiou, W.F.2    Zhang, J.T.3
  • 12
    • 0031303557 scopus 로고
    • An intestinal bacterial metabolite of ginseng protopanaxadiol saponins has the ability to induce apoptosis in tumor cells
    • Wakabayashi C, Hasegawa H, Murata J, Saiki I. An intestinal bacterial metabolite of ginseng protopanaxadiol saponins has the ability to induce apoptosis in tumor cells. Oncol. Res., 9, 411-417 (1989).
    • (1989) Oncol. Res. , vol.9 , pp. 411-417
    • Wakabayashi, C.1    Hasegawa, H.2    Murata, J.3    Saiki, I.4
  • 13
    • 25444483090 scopus 로고    scopus 로고
    • Antipruritic effect of ginsenoside rb1 and compound k in scratching behavior mouse models
    • Shin YW, Kim DH. Antipruritic effect of ginsenoside rb1 and compound k in scratching behavior mouse models. J. Pharmacol. Sci., 99, 83-88 (2005).
    • (2005) J. Pharmacol. Sci. , vol.99 , pp. 83-88
    • Shin, Y.W.1    Kim, D.H.2
  • 14
    • 85009708837 scopus 로고
    • Appearance of compound K, a major metabolite of ginsenoside Rb1 by intestinal bacteria, in rat plasma after oral administration - Measurement of compound K by enzyme immunoassay
    • Akao T, Kanaoka M, Kobashi K. Appearance of compound K, a major metabolite of ginsenoside Rb1 by intestinal bacteria, in rat plasma after oral administration - measurement of compound K by enzyme immunoassay - . Biol. Pharm. Bull., 21, 245-249 (1988).
    • (1988) Biol. Pharm. Bull. , vol.21 , pp. 245-249
    • Akao, T.1    Kanaoka, M.2    Kobashi, K.3
  • 15
    • 0031736410 scopus 로고    scopus 로고
    • Intestinal bacterial hydrolysis is required for the appearance of compound K in rat plasma after oral administration of ginsenoside Rb1 from Panax ginseng
    • Akao T, Kida H, Kanaoka M, Hattori M, Kobashi K. Intestinal bacterial hydrolysis is required for the appearance of compound K in rat plasma after oral administration of ginsenoside Rb1 from Panax ginseng. J. Pharm. Pharmacol., 50, 1155-1160 (1998).
    • (1998) J. Pharm. Pharmacol. , vol.50 , pp. 1155-1160
    • Akao, T.1    Kida, H.2    Kanaoka, M.3    Hattori, M.4    Kobashi, K.5
  • 16
    • 0034536269 scopus 로고    scopus 로고
    • Constitutive beta-glucosidases hydrolyzing ginsenoside Rb1 and Rb2 from human intestinal bacteria
    • Bae EA, Park SY, Kim DH. Constitutive beta-glucosidases hydrolyzing ginsenoside Rb1 and Rb2 from human intestinal bacteria. Biol. Pharm. Bull., 23, 1481-1485 (2000).
    • (2000) Biol. Pharm. Bull. , vol.23 , pp. 1481-1485
    • Bae, E.A.1    Park, S.Y.2    Kim, D.H.3
  • 17
    • 59849098283 scopus 로고    scopus 로고
    • Studies on absorption, distribution and metabolism of ginseng in humans after oral administration
    • Lee J, Lee E, Kim DH, Lee J, Yoo J, Koh B. Studies on absorption, distribution and metabolism of ginseng in humans after oral administration. J. Ethnopharmacol., 122, 143-148 (2009).
    • (2009) J. Ethnopharmacol. , vol.122 , pp. 143-148
    • Lee, J.1    Lee, E.2    Kim, D.H.3    Lee, J.4    Yoo, J.5    Koh, B.6
  • 19
    • 0038163804 scopus 로고    scopus 로고
    • Ginsenoside Rh1 possesses antiallergic and anti-inflammatory activities
    • Choo MK, Park EK, Han MJ, Kim DH. Ginsenoside Rh1 possesses antiallergic and anti-inflammatory activities. Planta Med., 69, 518-522 (2003).
    • (2003) Planta Med. , vol.69 , pp. 518-522
    • Choo, M.K.1    Park, E.K.2    Han, M.J.3    Kim, D.H.4
  • 20
    • 0036594246 scopus 로고    scopus 로고
    • Metabolism of ginsenoside R(c) by human intestinal bacteria and its related antiallergic activity
    • Bae EA, Choo MK, Park EK, Park SY, Shin HY, Kim DH. Metabolism of ginsenoside R(c) by human intestinal bacteria and its related antiallergic activity. Biol. Pharm. Bull., 25, 743-747 (2002).
    • (2002) Biol. Pharm. Bull. , vol.25 , pp. 743-747
    • Bae, E.A.1    Choo, M.K.2    Park, E.K.3    Park, S.Y.4    Shin, H.Y.5    Kim, D.H.6
  • 21
    • 0037300761 scopus 로고    scopus 로고
    • Transformation of ginsenosides to compound K (IH-901) by lactic acid bacteria of human intestine
    • Bae EA, Kim NY, Han MJ, Choo MK, Kim DH. Transformation of ginsenosides to compound K (IH-901) by lactic acid bacteria of human intestine. J. Microbiol. Biotechnol., 13, 9-14 (2003).
    • (2003) J. Microbiol. Biotechnol. , vol.13 , pp. 9-14
    • Bae, E.A.1    Kim, N.Y.2    Han, M.J.3    Choo, M.K.4    Kim, D.H.5
  • 22
    • 80052422949 scopus 로고    scopus 로고
    • Arctigenin isolated from the seeds of Arctium lappa ameliorates memory deficits in mice
    • Lee IA, Joh EH, Kim DH. Arctigenin isolated from the seeds of Arctium lappa ameliorates memory deficits in mice. Planta Med., 77, 1525-1527 (2011).
    • (2011) Planta Med. , vol.77 , pp. 1525-1527
    • Lee, I.A.1    Joh, E.H.2    Kim, D.H.3
  • 23
    • 60749131389 scopus 로고    scopus 로고
    • Mangiferin ameliorates scopolamine-induced learning deficits in mice
    • Jung K, Lee B, Han SJ, Ryu JH, Kim DH. Mangiferin ameliorates scopolamine-induced learning deficits in mice. Biol. Pharm. Bull., 32, 242-246 (2009).
    • (2009) Biol. Pharm. Bull. , vol.32 , pp. 242-246
    • Jung, K.1    Lee, B.2    Han, S.J.3    Ryu, J.H.4    Kim, D.H.5
  • 24
    • 0346245127 scopus 로고    scopus 로고
    • Protective effects of kakkalide from Flos puerariae on ethanol-induced lethality and hepatic injury are dependent on its biotransformation by human intestinal microflora
    • Han YO, Han MJ, Park SH, Kim DH. Protective effects of kakkalide from Flos puerariae on ethanol-induced lethality and hepatic injury are dependent on its biotransformation by human intestinal microflora. J. Pharmacol. Sci., 93, 331-336 (2003).
    • (2003) J. Pharmacol. Sci. , vol.93 , pp. 331-336
    • Han, Y.O.1    Han, M.J.2    Park, S.H.3    Kim, D.H.4
  • 25
    • 0017184389 scopus 로고
    • A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of proteindye binding
    • Bradford MM. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of proteindye binding. Anal. Biochem., 72, 248-254 (1976).
    • (1976) Anal. Biochem. , vol.72 , pp. 248-254
    • Bradford, M.M.1
  • 27
    • 0026451450 scopus 로고
    • In vivo and in vitro models of the human colonic flora
    • Rumney CJ, Rowland IR. In vivo and in vitro models of the human colonic flora. Crit. Rev. Food Sci. Nutr., 31, 299-331 (1992).
    • (1992) Crit. Rev. Food Sci. Nutr. , vol.31 , pp. 299-331
    • Rumney, C.J.1    Rowland, I.R.2
  • 29
    • 0020203634 scopus 로고
    • Simultaneous saccharification and fermentation of cellulose: Effect of beta-D-glucosidase activity and ethanol inhibition of cellulases
    • Ghosh P, Pamment NB, Martin WRB. Simultaneous saccharification and fermentation of cellulose: Effect of beta-D-glucosidase activity and ethanol inhibition of cellulases. Enzyme Microb. Technol., 4, 425-430 (1982).
    • (1982) Enzyme Microb. Technol. , vol.4 , pp. 425-430
    • Ghosh, P.1    Pamment, N.B.2    Martin, W.R.B.3
  • 30
    • 0032719738 scopus 로고    scopus 로고
    • Degradation of cyanogenic glycosides by Lactobacillus plantarum strains from spontaneous cassava fermentation and other microorganisms
    • Lei V, Amoa-Awua WK, Brimer L. Degradation of cyanogenic glycosides by Lactobacillus plantarum strains from spontaneous cassava fermentation and other microorganisms. Int. J. Food Microbiol., 53, 169-184 (1999).
    • (1999) Int. J. Food Microbiol. , vol.53 , pp. 169-184
    • Lei, V.1    Amoa-Awua, W.K.2    Brimer, L.3
  • 31
    • 42549167529 scopus 로고    scopus 로고
    • Microbial metabolism of loganin by intestinal bacteria and identification of new metabolites in rat
    • Li X, Huo C, Wang Q, Zhang X, Sheng X, Zhang L. Microbial metabolism of loganin by intestinal bacteria and identification of new metabolites in rat. Biomed. Chromatogr., 22, 367-373 (2008).
    • (2008) Biomed. Chromatogr. , vol.22 , pp. 367-373
    • Li, X.1    Huo, C.2    Wang, Q.3    Zhang, X.4    Sheng, X.5    Zhang, L.6
  • 32
    • 80052859722 scopus 로고    scopus 로고
    • Cloning of β-Glucosidase gene from Streptomyces coelicolor A3(2) and characterization of the recombinant β-glucosidase expressed in Escherichia coli
    • Kim JY, Kim BK, Lee YS, Kang CS, Ahn JH, Lim YH. Cloning of β-Glucosidase gene from Streptomyces coelicolor A3(2) and characterization of the recombinant β-glucosidase expressed in Escherichia coli. Kor. J. Microbiol. Biotechnol., 37, 99-104 (2009).
    • (2009) Kor. J. Microbiol. Biotechnol. , vol.37 , pp. 99-104
    • Kim, J.Y.1    Kim, B.K.2    Lee, Y.S.3    Kang, C.S.4    Ahn, J.H.5    Lim, Y.H.6
  • 33
    • 0030426625 scopus 로고    scopus 로고
    • Cloning and nucleotide sequence of the beta-D-glucosidase gene from Bifidobacterium breve clb, and expression of beta-D-glucosidase activity in Escherichia coli
    • Nunoura N, Ohdan K, Tanaka K, Tamaki H, Yano T, Inui M, Yukawa H, Yamamoto K, Kumagai H. Cloning and nucleotide sequence of the beta-D-glucosidase gene from Bifidobacterium breve clb, and expression of beta-D-glucosidase activity in Escherichia coli. Biosci. Biotechnol. Biochem., 60, 2011-2018 (1996).
    • (1996) Biosci. Biotechnol. Biochem. , vol.60 , pp. 2011-2018
    • Nunoura, N.1    Ohdan, K.2    Tanaka, K.3    Tamaki, H.4    Yano, T.5    Inui, M.6    Yukawa, H.7    Yamamoto, K.8    Kumagai, H.9
  • 34
    • 38549170356 scopus 로고    scopus 로고
    • Cloning, expression, and characterization of two beta-glucosidases from isoflavone glycoside-hydrolyzing Bacillus subtilis natto
    • Kuo LC, Lee KT. Cloning, expression, and characterization of two beta-glucosidases from isoflavone glycoside-hydrolyzing Bacillus subtilis natto. J. Agric. Food Chem., 56, 119-125 (2008).
    • (2008) J. Agric. Food Chem. , vol.56 , pp. 119-125
    • Kuo, L.C.1    Lee, K.T.2
  • 35
    • 0029951880 scopus 로고    scopus 로고
    • Purification and characterization of a novel sennoside-hydrolyzing beta-glucosidase from Bifidobacterium sp. strain SEN, a human intestinal anaerobe
    • Yang L, Akao T, Kobashi K, Hattori M. Purification and characterization of a novel sennoside-hydrolyzing beta-glucosidase from Bifidobacterium sp. strain SEN, a human intestinal anaerobe. Biol. Pharm. Bull., 19, 705-709 (1996).
    • (1996) Biol. Pharm. Bull. , vol.19 , pp. 705-709
    • Yang, L.1    Akao, T.2    Kobashi, K.3    Hattori, M.4
  • 36
    • 0029804130 scopus 로고    scopus 로고
    • Purification and characterization of beta-glucosidase from Bacteroides JY-6, a human intestinal bacterium
    • Kim DH, Sohng IS, Kobashi K, Han MJ. Purification and characterization of beta-glucosidase from Bacteroides JY-6, a human intestinal bacterium. Biol. Pharm. Bull., 19, 1121-1125 (1996).
    • (1996) Biol. Pharm. Bull. , vol.19 , pp. 1121-1125
    • Kim, D.H.1    Sohng, I.S.2    Kobashi, K.3    Han, M.J.4
  • 37
    • 79960181692 scopus 로고    scopus 로고
    • Novel PI3K/Akt inhibitors screened by the cytoprotective function of human immunodeficiency virus type 1 Tat
    • Kim Y, Hollenbaugh JA, Kim DH, Kim B. Novel PI3K/Akt inhibitors screened by the cytoprotective function of human immunodeficiency virus type 1 Tat. PLoS ONE, 6, e21781 (2011).
    • (2011) PLoS ONE , vol.6
    • Kim, Y.1    Hollenbaugh, J.A.2    Kim, D.H.3    Kim, B.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.