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1
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82955247909
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IDF diabetes atlas: global estimates of the prevalence of diabetes for 2011 and 2030
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PID: 22079683
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Whiting DR, Guariguata L, Weil C, Shaw J. IDF diabetes atlas: global estimates of the prevalence of diabetes for 2011 and 2030. Diabetes Res Clin Pract. 2011;94:311–21.
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(2011)
Diabetes Res Clin Pract
, vol.94
, pp. 311-321
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Whiting, D.R.1
Guariguata, L.2
Weil, C.3
Shaw, J.4
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2
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84877854022
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Non-alcoholic fatty liver disease (NAFLD) and its connection with insulin resistance, dyslipidemia, atherosclerosis and coronary heart disease
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COI: 1:CAS:528:DC%2BC3sXosVSmtbg%3D, PID: 23666091, This review analyzes the mechanisms relating NAFLD to CVD, including the role of ectopic fat accumulation, dyslipidemia, and lipotoxicity
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Gaggini M, Morelli M, Buzzigoli E, et al. Non-alcoholic fatty liver disease (NAFLD) and its connection with insulin resistance, dyslipidemia, atherosclerosis and coronary heart disease. Nutrients. 2013;5:1544–60. This review analyzes the mechanisms relating NAFLD to CVD, including the role of ectopic fat accumulation, dyslipidemia, and lipotoxicity.
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(2013)
Nutrients
, vol.5
, pp. 1544-1560
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Gaggini, M.1
Morelli, M.2
Buzzigoli, E.3
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3
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84861197159
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Hepatocellular carcinoma in non-alcoholic fatty liver disease: an emerging menace
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PID: 22326465
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Baffy G, Brunt EM, Caldwell SH. Hepatocellular carcinoma in non-alcoholic fatty liver disease: an emerging menace. J Hepatol. 2012;56:1384–91.
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(2012)
J Hepatol
, vol.56
, pp. 1384-1391
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Baffy, G.1
Brunt, E.M.2
Caldwell, S.H.3
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4
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39549118158
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Noninvasive markers of fibrosis in nonalcoholic fatty liver disease: validating the European Liver Fibrosis Panel and exploring simple markers
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PID: 18038452
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Guha IN, Parkes J, Roderick P, Chattopadhyay D, Cross R, Harris S, et al. Noninvasive markers of fibrosis in nonalcoholic fatty liver disease: validating the European Liver Fibrosis Panel and exploring simple markers. Hepatology. 2008;47:455–60.
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(2008)
Hepatology
, vol.47
, pp. 455-460
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Guha, I.N.1
Parkes, J.2
Roderick, P.3
Chattopadhyay, D.4
Cross, R.5
Harris, S.6
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5
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33750606061
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Long-term follow-up of patients with NAFLD and elevated liver enzymes
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COI: 1:CAS:528:DC%2BD28XhtFyqsrzN, PID: 17006923
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Ekstedt M, Franzen LE, Mathiesen UL, Thorelius L, Holmqvist M, Bodemar G, et al. Long-term follow-up of patients with NAFLD and elevated liver enzymes. Hepatology. 2006;44:865–73.
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(2006)
Hepatology
, vol.44
, pp. 865-873
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Ekstedt, M.1
Franzen, L.E.2
Mathiesen, U.L.3
Thorelius, L.4
Holmqvist, M.5
Bodemar, G.6
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6
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33645963121
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Similarities and differences in outcomes of cirrhosis due to nonalcoholic steatohepatitis and hepatitis C
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PID: 16502396
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Sanyal AJ, Banas C, Sargeant C, Luketic VA, Sterling RK, Stravitz RT, et al. Similarities and differences in outcomes of cirrhosis due to nonalcoholic steatohepatitis and hepatitis C. Hepatology. 2006;43:682–9.
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(2006)
Hepatology
, vol.43
, pp. 682-689
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Sanyal, A.J.1
Banas, C.2
Sargeant, C.3
Luketic, V.A.4
Sterling, R.K.5
Stravitz, R.T.6
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7
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84878930738
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Progression of NAFLD to diabetes mellitus, cardiovascular disease or cirrhosis
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COI: 1:CAS:528:DC%2BC3sXptVOlsrs%3D, PID: 23507799, This article highlights the evidence that NAFLD is a multisystem disease and T2DM and CVD are factors that might determine interindividual variation in the development and progression of hepatic damage
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Anstee QM, Targher G, Day CP. Progression of NAFLD to diabetes mellitus, cardiovascular disease or cirrhosis. Nat Rev Gastroenterol Hepatol. 2013;10:330–44. This article highlights the evidence that NAFLD is a multisystem disease and T2DM and CVD are factors that might determine interindividual variation in the development and progression of hepatic damage.
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(2013)
Nat Rev Gastroenterol Hepatol
, vol.10
, pp. 330-344
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Anstee, Q.M.1
Targher, G.2
Day, C.P.3
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8
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84912080070
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Liver transplantation and non-alcoholic fatty liver disease
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PID: 25400437
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Zezos P, Renner EL. Liver transplantation and non-alcoholic fatty liver disease. World J Gastroenterol: WJG. 2014;20:15532–8.
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(2014)
World J Gastroenterol: WJG
, vol.20
, pp. 15532-15538
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Zezos, P.1
Renner, E.L.2
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9
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84901616858
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Nonalcoholic steatohepatitis is the most rapidly growing indication for liver transplantation in patients with hepatocellular carcinoma in the U.S
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PID: 24375711, By analyzing the United Network for Organ Sharing/Organ Procurement and Transplantation Network database (more than 61,000 patients, 16% of whom received liver transplants), the authors found that NAFLD is the second leading cause of liver transplantation, but more importantly, it is the most rapidly growing indication for transplantation
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Wong RJ, Cheung R, Ahmed A. Nonalcoholic steatohepatitis is the most rapidly growing indication for liver transplantation in patients with hepatocellular carcinoma in the U.S. Hepatology. 2014;59:2188–95. By analyzing the United Network for Organ Sharing/Organ Procurement and Transplantation Network database (more than 61,000 patients, 16% of whom received liver transplants), the authors found that NAFLD is the second leading cause of liver transplantation, but more importantly, it is the most rapidly growing indication for transplantation.
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(2014)
Hepatology
, vol.59
, pp. 2188-2195
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Wong, R.J.1
Cheung, R.2
Ahmed, A.3
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10
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84861543083
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The diagnosis and management of non-alcoholic fatty liver disease: practice guideline by the American Association for the Study of Liver Diseases, American College of Gastroenterology, and the American Gastroenterological Association
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PID: 22488764, These are the most recently published guidelines for the diagnosis and management of NAFLD
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Chalasani N, Younossi Z, Lavine JE, et al. The diagnosis and management of non-alcoholic fatty liver disease: practice guideline by the American Association for the Study of Liver Diseases, American College of Gastroenterology, and the American Gastroenterological Association. Hepatology. 2012;55:2005–23. These are the most recently published guidelines for the diagnosis and management of NAFLD.
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(2012)
Hepatology
, vol.55
, pp. 2005-2023
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Chalasani, N.1
Younossi, Z.2
Lavine, J.E.3
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11
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84902672359
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Non-alcoholic fatty liver disease as a cause and a consequence of metabolic syndrome
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COI: 1:CAS:528:DC%2BC2MXhtlWgur0%3D, PID: 24731669
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Yki-Jarvinen H. Non-alcoholic fatty liver disease as a cause and a consequence of metabolic syndrome. Lancet Diabetes Endocrinol. 2014;2(11):901–10.
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(2014)
Lancet Diabetes Endocrinol
, vol.2
, Issue.11
, pp. 901-910
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Yki-Jarvinen, H.1
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12
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77956631214
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Liver enzymes, nonalcoholic fatty liver disease, and incident cardiovascular disease: a narrative review and clinical perspective of prospective data
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PID: 20658466
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Ghouri N, Preiss D, Sattar N. Liver enzymes, nonalcoholic fatty liver disease, and incident cardiovascular disease: a narrative review and clinical perspective of prospective data. Hepatology. 2010;52:1156–61.
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(2010)
Hepatology
, vol.52
, pp. 1156-1161
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Ghouri, N.1
Preiss, D.2
Sattar, N.3
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13
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79955925904
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Why does NAFLD predict type 2 diabetes?
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COI: 1:CAS:528:DC%2BC3MXlsFagsLc%3D
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Lattuada G, Ragogna F, Perseghin G. Why does NAFLD predict type 2 diabetes? Curr Diabetes Rep. 2011;11:167–72.
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(2011)
Curr Diabetes Rep
, vol.11
, pp. 167-172
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Lattuada, G.1
Ragogna, F.2
Perseghin, G.3
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14
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84873637593
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Clinical review: nonalcoholic fatty liver disease: a novel cardiometabolic risk factor for type 2 diabetes and its complications
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COI: 1:CAS:528:DC%2BC3sXjtlOlu7g%3D, PID: 23293330
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Targher G, Byrne CD. Clinical review: nonalcoholic fatty liver disease: a novel cardiometabolic risk factor for type 2 diabetes and its complications. J Clin Endocrinol Metab. 2013;98:483–95.
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(2013)
J Clin Endocrinol Metab
, vol.98
, pp. 483-495
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Targher, G.1
Byrne, C.D.2
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15
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80052840577
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The metabolically benign and malignant fatty liver
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COI: 1:CAS:528:DC%2BC3MXhtValurvL, PID: 21788578
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Stefan N, Haring HU. The metabolically benign and malignant fatty liver. Diabetes. 2011;60:2011–7.
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(2011)
Diabetes
, vol.60
, pp. 2011-2017
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Stefan, N.1
Haring, H.U.2
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16
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84859404868
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Role of obesity and lipotoxicity in the development of nonalcoholic steatohepatitis: pathophysiology and clinical implications
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COI: 1:CAS:528:DC%2BC38XltVyrsLs%3D, PID: 22326434
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Cusi K. Role of obesity and lipotoxicity in the development of nonalcoholic steatohepatitis: pathophysiology and clinical implications. Gastroenterology. 2012;142:711–25.
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(2012)
Gastroenterology
, vol.142
, pp. 711-725
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Cusi, K.1
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17
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79960029926
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Systematic review: the epidemiology and natural history of non-alcoholic fatty liver disease and non-alcoholic steatohepatitis in adults
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COI: 1:STN:280:DC%2BC3MnlsVamsg%3D%3D, PID: 21623852
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Vernon G, Baranova A, Younossi ZM. Systematic review: the epidemiology and natural history of non-alcoholic fatty liver disease and non-alcoholic steatohepatitis in adults. Aliment Pharmacol Ther. 2011;34:274–85.
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(2011)
Aliment Pharmacol Ther
, vol.34
, pp. 274-285
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Vernon, G.1
Baranova, A.2
Younossi, Z.M.3
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18
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34547514221
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Relationship between hepatic/visceral fat and hepatic insulin resistance in nondiabetic and type 2 diabetic subjects
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COI: 1:CAS:528:DC%2BD2sXhtVWqsr%2FO, PID: 17681171
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Gastaldelli A, Cusi K, Pettiti M, Hardies J, Miyazaki Y, Berria R, et al. Relationship between hepatic/visceral fat and hepatic insulin resistance in nondiabetic and type 2 diabetic subjects. Gastroenterology. 2007;133:496–506.
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(2007)
Gastroenterology
, vol.133
, pp. 496-506
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Gastaldelli, A.1
Cusi, K.2
Pettiti, M.3
Hardies, J.4
Miyazaki, Y.5
Berria, R.6
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19
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38149030206
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Liver fat is increased in type 2 diabetic patients and underestimated by serum alanine aminotransferase compared with equally obese nondiabetic subjects
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COI: 1:CAS:528:DC%2BD1cXhs1ejtL4%3D, PID: 17934148
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Kotronen A, Juurinen L, Hakkarainen A, Westerbacka J, Corner A, Bergholm R, et al. Liver fat is increased in type 2 diabetic patients and underestimated by serum alanine aminotransferase compared with equally obese nondiabetic subjects. Diabetes Care. 2008;31:165–9.
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(2008)
Diabetes Care
, vol.31
, pp. 165-169
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Kotronen, A.1
Juurinen, L.2
Hakkarainen, A.3
Westerbacka, J.4
Corner, A.5
Bergholm, R.6
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20
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84930791899
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High prevalence of nonalcoholic fatty liver disease in patients with type 2 diabetes mellitus and normal plasma aminotransferase levels
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Portillo Sanchez P, Bril F, Maximos M, Lomonaco R, Biernacki D, Orsak B, Subbarayan S, Webb A, Hecht J, Cusi K (2014) High prevalence of nonalcoholic fatty liver disease in patients with type 2 diabetes mellitus and normal plasma aminotransferase levels. The Journal of Clinical Endocrinology and Metabolism 2014:jc20142739
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(2014)
The Journal of Clinical Endocrinology and Metabolism 2014:jc20142739
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Portillo Sanchez, P.1
Bril, F.2
Maximos, M.3
Lomonaco, R.4
Biernacki, D.5
Orsak, B.6
Subbarayan, S.7
Webb, A.8
Hecht, J.9
Cusi, K.10
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21
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51349083814
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Risk of severe liver disease in nonalcoholic fatty liver disease with normal aminotransferase levels: a role for insulin resistance and diabetes
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COI: 1:CAS:528:DC%2BD1cXhtFKrsLbK, PID: 18752331
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Fracanzani AL, Valenti L, Bugianesi E, Andreoletti M, Colli A, Vanni E, et al. Risk of severe liver disease in nonalcoholic fatty liver disease with normal aminotransferase levels: a role for insulin resistance and diabetes. Hepatology. 2008;48:792–8.
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(2008)
Hepatology
, vol.48
, pp. 792-798
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Fracanzani, A.L.1
Valenti, L.2
Bugianesi, E.3
Andreoletti, M.4
Colli, A.5
Vanni, E.6
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22
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84865545850
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Association between diabetes, family history of diabetes, and risk of nonalcoholic steatohepatitis and fibrosis
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PID: 22505194, This analysis of 1069 NAFLD patients participating in the PIVENS trial and NAFLD Database Study showed that both a personal and a family history of diabetes are associated with the presence of NASH and fibrosis
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Loomba R, Abraham M, Unalp A, et al. Association between diabetes, family history of diabetes, and risk of nonalcoholic steatohepatitis and fibrosis. Hepatology. 2012;56:943–51. This analysis of 1069 NAFLD patients participating in the PIVENS trial and NAFLD Database Study showed that both a personal and a family history of diabetes are associated with the presence of NASH and fibrosis.
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(2012)
Hepatology
, vol.56
, pp. 943-951
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Loomba, R.1
Abraham, M.2
Unalp, A.3
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23
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84883763886
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Non-alcoholic fatty liver disease independently predicts prediabetes during a 7-year prospective follow-up
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COI: 1:CAS:528:DC%2BC3sXhs1GkurnM
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Zelber-Sagi S, Lotan R, Shibolet O, Webb M, Buch A, Nitzan-Kaluski D, et al. Non-alcoholic fatty liver disease independently predicts prediabetes during a 7-year prospective follow-up. Liver Int: Off J Int Assoc Study Liver. 2013;33:1406–12.
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(2013)
Liver Int : Off J Int Assoc Study Liver
, vol.33
, pp. 1406-1412
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Zelber-Sagi, S.1
Lotan, R.2
Shibolet, O.3
Webb, M.4
Buch, A.5
Nitzan-Kaluski, D.6
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24
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10644220306
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Prevalence of hepatic steatosis in an urban population in the United States: impact of ethnicity
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PID: 15565570
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Browning JD, Szczepaniak LS, Dobbins R, Nuremberg P, Horton JD, Cohen JC, et al. Prevalence of hepatic steatosis in an urban population in the United States: impact of ethnicity. Hepatology. 2004;40:1387–95.
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(2004)
Hepatology
, vol.40
, pp. 1387-1395
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Browning, J.D.1
Szczepaniak, L.S.2
Dobbins, R.3
Nuremberg, P.4
Horton, J.D.5
Cohen, J.C.6
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25
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84915749084
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Fatty liver indices in the multiethnic United States National Health and Nutrition Examination Survey
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COI: 1:STN:280:DC%2BC2M3mt1KntA%3D%3D, PID: 25376360
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Ruhl CE, Everhart JE. Fatty liver indices in the multiethnic United States National Health and Nutrition Examination Survey. Aliment Pharmacol Ther. 2015;41:65–76.
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(2015)
Aliment Pharmacol Ther
, vol.41
, pp. 65-76
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Ruhl, C.E.1
Everhart, J.E.2
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26
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84856945930
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Margariti E, Deutsch M, Manolakopoulos S, et al. Non-alcoholic fatty liver disease may develop in individuals with normal body mass index. Ann Gastroenterol. 2012;25:45–51. This study showed that about one in eight NAFLD patients referred to a tertiary liver center has a normal BMI (<25 kg/m2). These patients have higher levels of ALT/AST than overweight or obese NAFLD patients.
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Margariti E, Deutsch M, Manolakopoulos S, et al. Non-alcoholic fatty liver disease may develop in individuals with normal body mass index. Ann Gastroenterol. 2012;25:45–51. This study showed that about one in eight NAFLD patients referred to a tertiary liver center has a normal BMI (<25 kg/m2). These patients have higher levels of ALT/AST than overweight or obese NAFLD patients.
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27
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84869498671
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Nonalcoholic fatty liver disease in lean individuals in the United States
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PID: 23117851, In this analysis of NHANES III, the authors show that the prevalence of diabetes is higher in people with NAFLD, independent of obesity, although there is a higher prevalence among overweight/obese than lean subjects
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Younossi ZM, Stepanova M, Negro F, Hallaji S, Younossi Y, Lam B, et al. Nonalcoholic fatty liver disease in lean individuals in the United States. Medicine. 2012;91:319–27. In this analysis of NHANES III, the authors show that the prevalence of diabetes is higher in people with NAFLD, independent of obesity, although there is a higher prevalence among overweight/obese than lean subjects.
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(2012)
Medicine
, vol.91
, pp. 319-327
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Younossi, Z.M.1
Stepanova, M.2
Negro, F.3
Hallaji, S.4
Younossi, Y.5
Lam, B.6
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28
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84889658153
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Cohort study of non-alcoholic fatty liver disease, NAFLD fibrosis score, and the risk of incident diabetes in a Korean population
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COI: 1:CAS:528:DC%2BC3sXhvFCqtL3J, PID: 24100261
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Chang Y, Jung HS, Yun KE, Cho J, Cho YK, Ryu S. Cohort study of non-alcoholic fatty liver disease, NAFLD fibrosis score, and the risk of incident diabetes in a Korean population. Am J Gastroenterol. 2013;108:1861–8.
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(2013)
Am J Gastroenterol
, vol.108
, pp. 1861-1868
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Chang, Y.1
Jung, H.S.2
Yun, K.E.3
Cho, J.4
Cho, Y.K.5
Ryu, S.6
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29
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84866395319
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Dysfunctional adiposity and the risk of prediabetes and type 2 diabetes in obese adults
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COI: 1:CAS:528:DC%2BC38XhsFemurfJ, PID: 22990274
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Neeland IJ, Turer AT, Ayers CR, Powell-Wiley TM, Vega GL, Farzaneh-Far R, et al. Dysfunctional adiposity and the risk of prediabetes and type 2 diabetes in obese adults. JAMA. 2012;308:1150–9.
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(2012)
JAMA
, vol.308
, pp. 1150-1159
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Neeland, I.J.1
Turer, A.T.2
Ayers, C.R.3
Powell-Wiley, T.M.4
Vega, G.L.5
Farzaneh-Far, R.6
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30
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77955657267
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Insulin resistance, lipotoxicity, type 2 diabetes and atherosclerosis: the missing links. The Claude Bernard Lecture 2009
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COI: 1:CAS:528:DC%2BC3cXmsFyrs7w%3D, PID: 20361178
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DeFronzo RA. Insulin resistance, lipotoxicity, type 2 diabetes and atherosclerosis: the missing links. The Claude Bernard Lecture 2009. Diabetologia. 2010;53:1270–87.
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(2010)
Diabetologia
, vol.53
, pp. 1270-1287
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DeFronzo, R.A.1
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31
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84859942552
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Effect of adipose tissue insulin resistance on metabolic parameters and liver histology in obese patients with nonalcoholic fatty liver disease
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COI: 1:CAS:528:DC%2BC38XlslyjtL8%3D, PID: 22183689, These authors found that in patients with NAFLD, adipose tissue insulin resistance was associated with liver fibrosis, increased liver enzymes and TGs, and reduced HDL and adiponectin but found no association with NAFLD activity score
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Lomonaco R, Ortiz-Lopez C, Orsak B, et al. Effect of adipose tissue insulin resistance on metabolic parameters and liver histology in obese patients with nonalcoholic fatty liver disease. Hepatology. 2012;55:1389–97. These authors found that in patients with NAFLD, adipose tissue insulin resistance was associated with liver fibrosis, increased liver enzymes and TGs, and reduced HDL and adiponectin but found no association with NAFLD activity score.
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(2012)
Hepatology
, vol.55
, pp. 1389-1397
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Lomonaco, R.1
Ortiz-Lopez, C.2
Orsak, B.3
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32
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84903144240
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Abdominal subcutaneous adipose tissue insulin resistance and lipolysis in patients with non-alcoholic steatohepatitis
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COI: 1:CAS:528:DC%2BC2cXhtVKnsb7K, PID: 24962805
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Armstrong MJ, Hazlehurst JM, Hull D, Guo K, Borrows S, Yu J, et al. Abdominal subcutaneous adipose tissue insulin resistance and lipolysis in patients with non-alcoholic steatohepatitis. Diabetes Obes Metab. 2014;16:651–60.
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(2014)
Diabetes Obes Metab
, vol.16
, pp. 651-660
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Armstrong, M.J.1
Hazlehurst, J.M.2
Hull, D.3
Guo, K.4
Borrows, S.5
Yu, J.6
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33
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84908043988
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Adipose tissue insulin resistance in adolescents with and without type 2 diabetes
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COI: 1:STN:280:DC%2BC3sfhslShtA%3D%3D, PID: 23861170
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Kelsey MM, Forster JE, Van Pelt RE, Reusch JE, Nadeau KJ. Adipose tissue insulin resistance in adolescents with and without type 2 diabetes. Pediatr Obes. 2014;9:373–80.
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(2014)
Pediatr Obes
, vol.9
, pp. 373-380
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Kelsey, M.M.1
Forster, J.E.2
Van Pelt, R.E.3
Reusch, J.E.4
Nadeau, K.J.5
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34
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20944450486
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Insulin resistance in non-diabetic patients with non-alcoholic fatty liver disease: sites and mechanisms
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COI: 1:CAS:528:DC%2BD2MXjtlGhs7w%3D, PID: 15747110
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Bugianesi E, Gastaldelli A, Vanni E, Gambino R, Cassader M, Baldi S, et al. Insulin resistance in non-diabetic patients with non-alcoholic fatty liver disease: sites and mechanisms. Diabetologia. 2005;48:634–42.
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(2005)
Diabetologia
, vol.48
, pp. 634-642
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Bugianesi, E.1
Gastaldelli, A.2
Vanni, E.3
Gambino, R.4
Cassader, M.5
Baldi, S.6
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35
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79953795047
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Dissociation between fatty liver and insulin resistance: the role of adipose triacylglycerol lipase
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COI: 1:CAS:528:DC%2BC3cXhsFWqtLbO, PID: 20953581
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Stefan N, Staiger H, Haring HU. Dissociation between fatty liver and insulin resistance: the role of adipose triacylglycerol lipase. Diabetologia. 2011;54:7–9.
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(2011)
Diabetologia
, vol.54
, pp. 7-9
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Stefan, N.1
Staiger, H.2
Haring, H.U.3
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36
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84894327806
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Increased de novo lipogenesis is a distinct characteristic of individuals with nonalcoholic fatty liver disease
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COI: 1:CAS:528:DC%2BC2cXislKmsbs%3D, PID: 24316260, This study measured DNL in vivo in subjects with NAFLD by using deuterated water and found that DNL increased up to three times compared with controls
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Lambert JE, Ramos-Roman MA, Browning JD, et al. Increased de novo lipogenesis is a distinct characteristic of individuals with nonalcoholic fatty liver disease. Gastroenterology. 2014;146:726–35. This study measured DNL in vivo in subjects with NAFLD by using deuterated water and found that DNL increased up to three times compared with controls.
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(2014)
Gastroenterology
, vol.146
, pp. 726-735
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Lambert, J.E.1
Ramos-Roman, M.A.2
Browning, J.D.3
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37
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63249121641
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