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Volumn 59, Issue 2, 2010, Pages 267-273

Genetic variants regulating insulin receptor signalling are associated with the severity of liver damage in patients with non-alcoholic fatty liver disease

Author keywords

[No Author keywords available]

Indexed keywords

ECTOENZYME NUCLEOTIDE PYROPHOSPHATE PHOSPHODIESTERASE 1; GLYCINE; GLYCOPROTEIN; INSULIN RECEPTOR; INSULIN RECEPTOR SUBSTRATE 1; LYSINE; PLASMA CELL ANTIGEN 1; PROTEIN KINASE B; UNCLASSIFIED DRUG;

EID: 77149168465     PISSN: 00175749     EISSN: 14683288     Source Type: Journal    
DOI: 10.1136/gut.2009.190801     Document Type: Article
Times cited : (147)

References (34)
  • 1
    • 10644220306 scopus 로고    scopus 로고
    • Prevalence of hepatic steatosis in an urban population in the United States: Impact of ethnicity
    • Browning JD, Szczepaniak LS, Dobbins R, et al. Prevalence of hepatic steatosis in an urban population in the United States: impact of ethnicity. Hepatology 2004;40:1387-95.
    • (2004) Hepatology , vol.40 , pp. 1387-1395
    • Browning, J.D.1    Szczepaniak, L.S.2    Dobbins, R.3
  • 2
    • 0033982172 scopus 로고    scopus 로고
    • Prevalence of and risk factors for hepatic steatosis in Northern Italy
    • Bellentani S, Saccoccio G, Masutti F, et al. Prevalence of and risk factors for hepatic steatosis in Northern Italy. Ann Intern Med 2000;132:112-17.
    • (2000) Ann Intern Med , vol.132 , pp. 112-117
    • Bellentani, S.1    Saccoccio, G.2    Masutti, F.3
  • 3
    • 0035431018 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease: A feature of the metabolic syndrome
    • Marchesini G, Brizi M, Bianchi G, et al. Nonalcoholic fatty liver disease: a feature of the metabolic syndrome. Diabetes 2001;50:1844-50.
    • (2001) Diabetes , vol.50 , pp. 1844-1850
    • Marchesini, G.1    Brizi, M.2    Bianchi, G.3
  • 4
    • 33750606061 scopus 로고    scopus 로고
    • Long-term follow-up of patients with NAFLD and elevated liver enzymes
    • Ekstedt M, Franzen LE, Mathiesen UL, et al. Long-term follow-up of patients with NAFLD and elevated liver enzymes. Hepatology 2006;44:865-73.
    • (2006) Hepatology , vol.44 , pp. 865-873
    • Ekstedt, M.1    Franzen, L.E.2    Mathiesen, U.L.3
  • 5
    • 0036302288 scopus 로고    scopus 로고
    • Expanding the natural history of nonalcoholic steatohepatitis: From cryptogenic cirrhosis to hepatocellular carcinoma
    • Bugianesi E, Leone N, Vanni E, et al. Expanding the natural history of nonalcoholic steatohepatitis: from cryptogenic cirrhosis to hepatocellular carcinoma. Gastroenterology 2002;123:134-40.
    • (2002) Gastroenterology , vol.123 , pp. 134-140
    • Bugianesi, E.1    Leone, N.2    Vanni, E.3
  • 6
    • 30044431801 scopus 로고    scopus 로고
    • From fat to inflammation
    • Day CP. From fat to inflammation. Gastroenterology 2006;130:207-10.
    • (2006) Gastroenterology , vol.130 , pp. 207-210
    • Day, C.P.1
  • 7
    • 0037382786 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver, steatohepatitis, and the metabolic syndrome
    • Marchesini G, Bugianesi E, Forlani G, et al. Nonalcoholic fatty liver, steatohepatitis, and the metabolic syndrome. Hepatology 2003;37:917-23.
    • (2003) Hepatology , vol.37 , pp. 917-923
    • Marchesini, G.1    Bugianesi, E.2    Forlani, G.3
  • 8
    • 51349083814 scopus 로고    scopus 로고
    • The risk of severe liver disease in NAFLD with normal aminotransferase levels: A role for insulin resistance and diabetes
    • Fracanzani AL, Valenti L, Bugianesi E, et al. The risk of severe liver disease in NAFLD with normal aminotransferase levels: a role for insulin resistance and diabetes. Hepatology 2008;48:792-8.
    • (2008) Hepatology , vol.48 , pp. 792-798
    • Fracanzani, A.L.1    Valenti, L.2    Bugianesi, E.3
  • 9
    • 33847008303 scopus 로고    scopus 로고
    • Genetics of alcoholic liver disease and nonalcoholic fatty liver disease
    • Wilfred de Alwis NM, Day CP. Genetics of alcoholic liver disease and nonalcoholic fatty liver disease. Semin Liver Dis 2007;27:44-54.
    • (2007) Semin Liver Dis , vol.27 , pp. 44-54
    • Wilfred de Alwis, N.M.1    Day, C.P.2
  • 10
    • 0036165809 scopus 로고    scopus 로고
    • Tumor necrosis factor alpha promoter polymorphisms and insulin resistance in nonalcoholic fatty liver disease
    • Valenti L, Fracanzani AL, Dongiovanni P, et al. Tumor necrosis factor alpha promoter polymorphisms and insulin resistance in nonalcoholic fatty liver disease. Gastroenterology 2002;122:274- 80.
    • (2002) Gastroenterology , vol.122 , pp. 274-280
    • Valenti, L.1    Fracanzani, A.L.2    Dongiovanni, P.3
  • 11
    • 46049097550 scopus 로고    scopus 로고
    • The Kruppel-like factor 6 genotype is associated with fibrosis in nonalcoholic fatty liver disease
    • Miele L, Beale G, Patman G, et al. The Kruppel-like factor 6 genotype is associated with fibrosis in nonalcoholic fatty liver disease. Gastroenterology 2008;135:282-91.
    • (2008) Gastroenterology , vol.135 , pp. 282-291
    • Miele, L.1    Beale, G.2    Patman, G.3
  • 12
    • 33750622941 scopus 로고    scopus 로고
    • alpha1-Antitrypsin mutations in NAFLD: High prevalence and association with altered iron metabolism but not with liver damage
    • Valenti L, Dongiovanni P, Piperno A, et al. alpha1-Antitrypsin mutations in NAFLD: high prevalence and association with altered iron metabolism but not with liver damage. Hepatology 2006;44:857-64.
    • (2006) Hepatology , vol.44 , pp. 857-864
    • Valenti, L.1    Dongiovanni, P.2    Piperno, A.3
  • 13
    • 56749096610 scopus 로고    scopus 로고
    • Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease
    • Romeo S, Kozlitina J, Xing C, et al. Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease. Nat Genet 2008;40:1461-5.
    • (2008) Nat Genet , vol.40 , pp. 1461-1465
    • Romeo, S.1    Kozlitina, J.2    Xing, C.3
  • 14
    • 2342496712 scopus 로고    scopus 로고
    • FoxOs at the crossroads of cellular metabolism, differentiation, and transformation
    • Accili D, Arden KC. FoxOs at the crossroads of cellular metabolism, differentiation, and transformation. Cell 2004;117:421-6.
    • (2004) Cell , vol.117 , pp. 421-426
    • Accili, D.1    Arden, K.C.2
  • 15
    • 10644268512 scopus 로고    scopus 로고
    • IRS-2 mediates the antiapoptotic effect of insulin in neonatal hepatocytes
    • Valverde AM, Fabregat I, Burks DJ, et al. IRS-2 mediates the antiapoptotic effect of insulin in neonatal hepatocytes. Hepatology 2004;40:1285-94.
    • (2004) Hepatology , vol.40 , pp. 1285-1294
    • Valverde, A.M.1    Fabregat, I.2    Burks, D.J.3
  • 16
    • 45749114635 scopus 로고    scopus 로고
    • Increased expression and activity of the transcription factor FOXO1 in nonalcoholic steatohepatitis
    • Valenti L, Rametta R, Dongiovanni P, et al. Increased expression and activity of the transcription factor FOXO1 in nonalcoholic steatohepatitis. Diabetes 2008;57:1355-62.
    • (2008) Diabetes , vol.57 , pp. 1355-1362
    • Valenti, L.1    Rametta, R.2    Dongiovanni, P.3
  • 17
    • 0033636523 scopus 로고    scopus 로고
    • Loss of insulin signaling in hepatocytes leads to severe insulin resistance and progressive hepatic dysfunction
    • Michael MD, Kulkarni RN, Postic C, et al. Loss of insulin signaling in hepatocytes leads to severe insulin resistance and progressive hepatic dysfunction. Mol Cell 2000;6:87-97.
    • (2000) Mol Cell , vol.6 , pp. 87-97
    • Michael, M.D.1    Kulkarni, R.N.2    Postic, C.3
  • 18
    • 33745904468 scopus 로고    scopus 로고
    • In vivo assessment of liver cell apoptosis as a novel biomarker of disease severity in nonalcoholic fatty liver disease
    • Wieckowska A, Zein NN, Yerian LM, et al. In vivo assessment of liver cell apoptosis as a novel biomarker of disease severity in nonalcoholic fatty liver disease. Hepatology 2006;44:27-33.
    • (2006) Hepatology , vol.44 , pp. 27-33
    • Wieckowska, A.1    Zein, N.N.2    Yerian, L.M.3
  • 19
    • 33746726490 scopus 로고    scopus 로고
    • Studies of the relationship between the ENPP1 K121Q polymorphism and type 2 diabetes, insulin resistance and obesity in 7,333 Danish white subjects
    • Grarup N, Urhammer SA, Ek J, et al. Studies of the relationship between the ENPP1 K121Q polymorphism and type 2 diabetes, insulin resistance and obesity in 7,333 Danish white subjects. Diabetologia 2006;49:2097-104.
    • (2006) Diabetologia , vol.49 , pp. 2097-2104
    • Grarup, N.1    Urhammer, S.A.2    Ek, J.3
  • 20
    • 14844336893 scopus 로고    scopus 로고
    • Human insulin receptor substrate-1 (IRS-1) polymorphism G972R causes IRS-1 to associate with the insulin receptor and inhibit receptor autophosphorylation
    • McGettrick AJ, Feener EP, Kahn CR. Human insulin receptor substrate-1 (IRS-1) polymorphism G972R causes IRS-1 to associate with the insulin receptor and inhibit receptor autophosphorylation. J Biol Chem 2005;280:6441-6.
    • (2005) J Biol Chem , vol.280 , pp. 6441-6446
    • McGettrick, A.J.1    Feener, E.P.2    Kahn, C.R.3
  • 21
    • 0042572474 scopus 로고    scopus 로고
    • Gly972Arg variant in the insulin receptor substrate-1 gene and association with type 2 diabetes: A meta-analysis of 27 studies
    • Jellema A, Zeegers MP, Feskens EJ, et al. Gly972Arg variant in the insulin receptor substrate-1 gene and association with type 2 diabetes: a meta-analysis of 27 studies. Diabetologia 2003;46:990-5.
    • (2003) Diabetologia , vol.46 , pp. 990-995
    • Jellema, A.1    Zeegers, M.P.2    Feskens, E.J.3
  • 22
    • 33751246499 scopus 로고    scopus 로고
    • The Fatty Liver Index: A simple and accurate predictor of hepatic steatosis in the general population
    • Bedogni G, Bellentani S, Miglioli L, et al. The Fatty Liver Index: a simple and accurate predictor of hepatic steatosis in the general population. BMC Gastroenterol 2006;6:33.
    • (2006) BMC Gastroenterol , vol.6 , pp. 33
    • Bedogni, G.1    Bellentani, S.2    Miglioli, L.3
  • 23
    • 20044374023 scopus 로고    scopus 로고
    • Design and validation of a histological scoring system for nonalcoholic fatty liver disease
    • Kleiner DE, Brunt EM, Van Natta M, et al. Design and validation of a histological scoring system for nonalcoholic fatty liver disease. Hepatology 2005;41:1313-21.
    • (2005) Hepatology , vol.41 , pp. 1313-1321
    • Kleiner, D.E.1    Brunt, E.M.2    Van Natta, M.3
  • 24
    • 2542460652 scopus 로고    scopus 로고
    • The Arg972 variant in insulin receptor substrate-1 is associated with an increased risk of secondary failure to sulfonylurea in patients with type 2 diabetes
    • Sesti G, Marini MA, Cardellini M, et al. The Arg972 variant in insulin receptor substrate-1 is associated with an increased risk of secondary failure to sulfonylurea in patients with type 2 diabetes. Diabetes Care 2004;27:1394-8.
    • (2004) Diabetes Care , vol.27 , pp. 1394-1398
    • Sesti, G.1    Marini, M.A.2    Cardellini, M.3
  • 25
    • 0032857338 scopus 로고    scopus 로고
    • A polymorphism (K121Q) of the human glycoprotein PC-1 gene coding region is strongly associated with insulin resistance
    • Pizzuti A, Frittitta L, Argiolas A, et al. A polymorphism (K121Q) of the human glycoprotein PC-1 gene coding region is strongly associated with insulin resistance. Diabetes 1999;48:1881-4.
    • (1999) Diabetes , vol.48 , pp. 1881-1884
    • Pizzuti, A.1    Frittitta, L.2    Argiolas, A.3
  • 26
    • 36849065071 scopus 로고    scopus 로고
    • The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: Guidelines for reporting observational studies
    • von Elm E, Altman DG, Egger M, et al. The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: guidelines for reporting observational studies. Lancet 2007;370:1453-7.
    • (2007) Lancet , vol.370 , pp. 1453-1457
    • von Elm, E.1    Altman, D.G.2    Egger, M.3
  • 27
    • 55549115654 scopus 로고    scopus 로고
    • Genes mirror geography within Europe
    • Novembre J, Johnson T, Bryc K, et al. Genes mirror geography within Europe. Nature 2008;456:98-101.
    • (2008) Nature , vol.456 , pp. 98-101
    • Novembre, J.1    Johnson, T.2    Bryc, K.3
  • 28
    • 33845434199 scopus 로고    scopus 로고
    • No evidence of association of ENPP1 variants with type 2 diabetes or obesity in a study of 8,089 U.K. Caucasians
    • Weedon MN, Shields B, Hitman G, et al. No evidence of association of ENPP1 variants with type 2 diabetes or obesity in a study of 8,089 U.K. Caucasians. Diabetes 2006;55:3175-9.
    • (2006) Diabetes , vol.55 , pp. 3175-3179
    • Weedon, M.N.1    Shields, B.2    Hitman, G.3
  • 29
    • 9444276572 scopus 로고    scopus 로고
    • Association studies of insulin receptor substrate 1 gene (IRS1) variants in type 2 diabetes samples enriched for family history and early age of onset
    • Zeggini E, Parkinson J, Halford S, et al. Association studies of insulin receptor substrate 1 gene (IRS1) variants in type 2 diabetes samples enriched for family history and early age of onset. Diabetes 2004;53:3319-22.
    • (2004) Diabetes , vol.53 , pp. 3319-3322
    • Zeggini, E.1    Parkinson, J.2    Halford, S.3
  • 30
    • 33845478157 scopus 로고    scopus 로고
    • The pleiotropic effect of the ENPP1 (PC-1) gene on insulin resistance, obesity, and type 2 diabetes
    • Prudente S, Trischitta V. The pleiotropic effect of the ENPP1 (PC-1) gene on insulin resistance, obesity, and type 2 diabetes. J Clin Endocrinol Metab 2006;91:4767-8.
    • (2006) J Clin Endocrinol Metab , vol.91 , pp. 4767-4768
    • Prudente, S.1    Trischitta, V.2
  • 31
    • 55149110908 scopus 로고    scopus 로고
    • Transgenic mice overexpressing human G972R IRS-1 show impaired insulin action and insulin secretion
    • Hribal ML, Tornei F, Pujol A, et al. Transgenic mice overexpressing human G972R IRS-1 show impaired insulin action and insulin secretion. J Cell Mol Med 2008;12:2096-106.
    • (2008) J Cell Mol Med , vol.12 , pp. 2096-2106
    • Hribal, M.L.1    Tornei, F.2    Pujol, A.3
  • 32
    • 11244308124 scopus 로고    scopus 로고
    • Chronological development of elevated aminotransferases in a nonalcoholic population
    • Suzuki A, Angulo P, Lymp J, et al. Chronological development of elevated aminotransferases in a nonalcoholic population. Hepatology 2005;41:64-71.
    • (2005) Hepatology , vol.41 , pp. 64-71
    • Suzuki, A.1    Angulo, P.2    Lymp, J.3
  • 33
    • 33845426384 scopus 로고    scopus 로고
    • The association of PC-1 (ENPP1) K121Q polymorphism with metabolic syndrome in patients with coronary heart disease
    • Tasic I, Milojkovic M, Sunder-Plassmann R, et al. The association of PC-1 (ENPP1) K121Q polymorphism with metabolic syndrome in patients with coronary heart disease. Clin Chim Acta 2007;377:237- 42.
    • (2007) Clin Chim Acta , vol.377 , pp. 237-242
    • Tasic, I.1    Milojkovic, M.2    Sunder-Plassmann, R.3
  • 34
    • 39149099952 scopus 로고    scopus 로고
    • The role of membrane glycoprotein plasma cell antigen 1/ectonucleotide pyrophosphatase phosphodiesterase 1 in the pathogenesis of insulin resistance and related abnormalities
    • Goldfine ID, Maddux BA, Youngren JF, et al. The role of membrane glycoprotein plasma cell antigen 1/ectonucleotide pyrophosphatase phosphodiesterase 1 in the pathogenesis of insulin resistance and related abnormalities. Endocr Rev 2008;29:62-75.
    • (2008) Endocr Rev , vol.29 , pp. 62-75
    • Goldfine, I.D.1    Maddux, B.A.2    Youngren, J.F.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.