Protease-triggered siRNA delivery vehicles

Journal of Controlled Release

Volumn 209, Issue , 2015, Pages 57-66

  Rozema, David B ^a   Blokhin, Andrei V ^a   Wakefield, Darren H ^a   Benson, Jonathan D ^a   Carlson, Jeffrey C ^a   Klein, Jason J ^a   Almeida, Lauren J ^a   Nicholas, Anthony L ^a   Hamilton, Holly L ^a   Chu, Qili ^a   Hegge, Julia O ^a   Wong, So C ^a   Trubetskoy, Vladimir S ^a   Hagen, Collin M ^a   Kitas, Eric ^b   Wolff, Jon A ^a   Lewis, David L ^a  

^a Arrowhead Research Corporation   (United States)

^b F HOFFMANN LA ROCHE LTD   (Switzerland)

Author keywords

siRNA polymer conjugate; Subcutaneous; Targeted delivery

Indexed keywords

CELL MEMBRANES; CELL PROLIFERATION; MOLECULAR BIOLOGY; RNA; VEHICLES;

ASIALOGLYCOPROTEIN RECEPTORS; CYTOPLASMIC MEMBRANE; MEMBRANE INTERACTIONS; POLYMER CONJUGATE; REVERSIBLE INHIBITIONS; SMALL INTERFERING RNA (SIRNA); SUBCUTANEOUS; TARGETED DELIVERY;

POLYMERS;

ASIALOGLYCOPROTEIN RECEPTOR; MACROGOL; N ACETYLGALACTOSAMINE; PROTEINASE; SMALL INTERFERING RNA; BLOOD CLOTTING FACTOR 7; PEPTIDE HYDROLASE; POLYMER;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; CYTOPLASM; ENDOCYTOSIS; FEMALE; GENE DELIVERY SYSTEM; GENE TARGETING; LIVER CELL; MACACA FASCICULARIS; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN HYDROLYSIS; PROTEIN TARGETING; RAT; ANIMAL; CHEMISTRY; DRUG EFFECTS; ERYTHROCYTE; GENE TRANSFER; GENETICS; HEMOLYSIS; INSTITUTE FOR CANCER RESEARCH MOUSE; METABOLISM;

ANIMALS; ERYTHROCYTES; FACTOR VII; FEMALE; GENE TRANSFER TECHNIQUES; HEMOLYSIS; MACACA FASCICULARIS; MALE; MICE, INBRED ICR; PEPTIDE HYDROLASES; POLYMERS; RATS; RNA, SMALL INTERFERING;

EID: 84928379371     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2015.04.012     Document Type: Article

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