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Volumn 17, Issue 6, 2015, Pages 1-10

Potential contributions of intimal and plaque hypoxia to atherosclerosis

Author keywords

Angiogenesis; Atherosclerosis; Hypoxia; Inflammation; Intima; Vasa vasorum

Indexed keywords

ANGIOGENESIS INHIBITOR; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; HYPOXIA INDUCIBLE FACTOR 1ALPHA; INTERLEUKIN 1BETA; MONOCYTE CHEMOTACTIC PROTEIN 1; OXIDIZED LOW DENSITY LIPOPROTEIN; SAPONIN; THALIDOMIDE; TNF 470; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; VASCULOTROPIN A; LOW DENSITY LIPOPROTEIN;

EID: 84928346704     PISSN: 15233804     EISSN: 15346242     Source Type: Journal    
DOI: 10.1007/s11883-015-0510-0     Document Type: Review
Times cited : (39)

References (86)
  • 1
    • 0033552883 scopus 로고    scopus 로고
    • Atherosclerosis—an inflammatory disease
    • COI: 1:STN:280:DyaK1M%2FptFSqtQ%3D%3D, PID: 9887164
    • Ross R. Atherosclerosis—an inflammatory disease. N Engl J Med. 1999;340(2):115–26. doi:10.1056/NEJM199901143400207.
    • (1999) N Engl J Med , vol.340 , Issue.2 , pp. 115-126
    • Ross, R.1
  • 2
    • 0034648768 scopus 로고    scopus 로고
    • COI: 1:CAS:528:DC%2BD3cXmvVSlsrk%3D
    • Lusis AJ. Atheroscler Nat. 2000;407(6801):233–41. doi:10.1038/35025203.
    • (2000) Atheroscler Nat , vol.407 , Issue.6801 , pp. 233-241
    • Lusis, A.J.1
  • 3
    • 84908178749 scopus 로고    scopus 로고
    • Infection with Porphyromonas gingivalis exacerbates endothelial injury in obese mice
    • PID: 25334003
    • Ao M, Miyauchi M, Inubushi T, et al. Infection with Porphyromonas gingivalis exacerbates endothelial injury in obese mice. PLoS One. 2014;9(10):e110519. doi:10.1371/journal.pone.0110519.
    • (2014) PLoS One , vol.9 , Issue.10 , pp. e110519
    • Ao, M.1    Miyauchi, M.2    Inubushi, T.3
  • 4
    • 0033188294 scopus 로고    scopus 로고
    • The role of infection in atherosclerosis and coronary artery disease: a new therapeutic target
    • COI: 1:STN:280:DC%2BD3MnnsVSgsA%3D%3D, PID: 11720630
    • Ismail A, Khosravi H, Olson H. The role of infection in atherosclerosis and coronary artery disease: a new therapeutic target. Heart Dis. 1999;1(4):233–40.
    • (1999) Heart Dis , vol.1 , Issue.4 , pp. 233-240
    • Ismail, A.1    Khosravi, H.2    Olson, H.3
  • 5
    • 38349174911 scopus 로고    scopus 로고
    • Leukocyte influx in atherosclerosis
    • COI: 1:CAS:528:DC%2BD1cXhsFSju7k%3D, PID: 18220701
    • Galkina E, Ley K. Leukocyte influx in atherosclerosis. Curr Drug Targets. 2007;8(12):1239–48.
    • (2007) Curr Drug Targets , vol.8 , Issue.12 , pp. 1239-1248
    • Galkina, E.1    Ley, K.2
  • 6
    • 56849103111 scopus 로고    scopus 로고
    • Inflammatory angiogenesis in atherogenesis—a double-edged sword
    • COI: 1:CAS:528:DC%2BD1cXhsVegtrjP, PID: 18608127
    • Ribatti D, Levi-Schaffer F, Kovanen PT. Inflammatory angiogenesis in atherogenesis—a double-edged sword. Ann Med. 2008;40(8):606–21. doi:10.1080/07853890802186913.
    • (2008) Ann Med , vol.40 , Issue.8 , pp. 606-621
    • Ribatti, D.1    Levi-Schaffer, F.2    Kovanen, P.T.3
  • 7
    • 84896461224 scopus 로고    scopus 로고
    • Matrix metalloproteinase 7 is associated with symptomatic lesions and adverse events in patients with carotid atherosclerosis
    • PID: 24400123
    • Abbas A, Aukrust P, Russell D, et al. Matrix metalloproteinase 7 is associated with symptomatic lesions and adverse events in patients with carotid atherosclerosis. PLoS One. 2014;9(1):e84935. doi:10.1371/journal.pone.0084935.
    • (2014) PLoS One , vol.9 , Issue.1 , pp. e84935
    • Abbas, A.1    Aukrust, P.2    Russell, D.3
  • 8
    • 84866940088 scopus 로고    scopus 로고
    • The role of hypoxia-inducible factor 1 in atherosclerosis
    • COI: 1:CAS:528:DC%2BC38Xhslygu7vN, PID: 22569539
    • Gao L, Chen Q, Zhou X, Fan L. The role of hypoxia-inducible factor 1 in atherosclerosis. J Clin Pathol. 2012;65(10):872–6. doi:10.1136/jclinpath-2012-200828.
    • (2012) J Clin Pathol , vol.65 , Issue.10 , pp. 872-876
    • Gao, L.1    Chen, Q.2    Zhou, X.3    Fan, L.4
  • 9
    • 84860481730 scopus 로고    scopus 로고
    • Plaque neovascularization: defense mechanisms, betrayal, or a war in progress
    • COI: 1:CAS:528:DC%2BC38XpvFCht7k%3D, PID: 22548565
    • Moreno PR, Purushothaman M, Purushothaman KR. Plaque neovascularization: defense mechanisms, betrayal, or a war in progress. Ann N Y Acad Sci. 2012;1254:7–17. doi:10.1111/j.1749-6632.2012.06497.x.
    • (2012) Ann N Y Acad Sci , vol.1254 , pp. 7-17
    • Moreno, P.R.1    Purushothaman, M.2    Purushothaman, K.R.3
  • 10
    • 84859499566 scopus 로고    scopus 로고
    • Neovascularization of coronary tunica intima (DIT) is the cause of coronary atherosclerosis. Lipoproteins invade coronary intima via neovascularization from adventitial vasa vasorum, but not from the arterial lumen: a hypothesis
    • COI: 1:CAS:528:DC%2BC38XhvVShs73J, PID: 22490844, This article prevents a novel hypothesis, accompanied with data and illustration, which argue that angiogenesis in the outer intimal tissues, is a critical requirement which allows the entry of oxLDL particles into arterial vascular wall tissues. This hypothesis contrasts the traditional concept that oxLDL enter the vascular wall through injured arterial vascular endothelium. The concept that angiogenesis controls the initiation of atherosclerotic development may lead to the identification of new therapeutic targets for the prevention and treatment of atherosclerosis
    • Subbotin VM. Neovascularization of coronary tunica intima (DIT) is the cause of coronary atherosclerosis. Lipoproteins invade coronary intima via neovascularization from adventitial vasa vasorum, but not from the arterial lumen: a hypothesis. Theor Biol Med Model. 2012;9:11. doi:10.1186/1742-4682-9-11. This article prevents a novel hypothesis, accompanied with data and illustration, which argue that angiogenesis in the outer intimal tissues, is a critical requirement which allows the entry of oxLDL particles into arterial vascular wall tissues. This hypothesis contrasts the traditional concept that oxLDL enter the vascular wall through injured arterial vascular endothelium. The concept that angiogenesis controls the initiation of atherosclerotic development may lead to the identification of new therapeutic targets for the prevention and treatment of atherosclerosis.
    • (2012) Theor Biol Med Model , vol.9 , pp. 11
    • Subbotin, V.M.1
  • 11
    • 84891818196 scopus 로고    scopus 로고
    • The role of monocytes in angiogenesis and atherosclerosis
    • COI: 1:CAS:528:DC%2BC2cXltVGjsw%3D%3D, PID: 24140662
    • Jaipersad AS, Lip GY, Silverman S, Shantsila E. The role of monocytes in angiogenesis and atherosclerosis. J Am Coll Cardiol. 2014;63(1):1–11. doi:10.1016/j.jacc.2013.09.019.
    • (2014) J Am Coll Cardiol , vol.63 , Issue.1 , pp. 1-11
    • Jaipersad, A.S.1    Lip, G.Y.2    Silverman, S.3    Shantsila, E.4
  • 12
    • 84875237109 scopus 로고    scopus 로고
    • Hypoxia in murine atherosclerotic plaques and its adverse effects on macrophages
    • COI: 1:CAS:528:DC%2BC3sXhvFWlt78%3D, PID: 23375596
    • Parathath S, Yang Y, Mick S, Fisher EA. Hypoxia in murine atherosclerotic plaques and its adverse effects on macrophages. Trends Cardiovasc Med. 2013;23(3):80–4. doi:10.1016/j.tcm.2012.09.004.
    • (2013) Trends Cardiovasc Med , vol.23 , Issue.3 , pp. 80-84
    • Parathath, S.1    Yang, Y.2    Mick, S.3    Fisher, E.A.4
  • 13
    • 73349141136 scopus 로고    scopus 로고
    • The role of hypoxia in atherosclerosis
    • COI: 1:CAS:528:DC%2BD1MXhtV2qsbvM, PID: 19644366
    • Hulten LM, Levin M. The role of hypoxia in atherosclerosis. Curr Opin Lipidol. 2009;20(5):409–14. doi:10.1097/MOL.0b013e3283307be8.
    • (2009) Curr Opin Lipidol , vol.20 , Issue.5 , pp. 409-414
    • Hulten, L.M.1    Levin, M.2
  • 14
    • 84880512414 scopus 로고    scopus 로고
    • Macrophages transmit potent proangiogenic effects of oxLDL in vitro and in vivo involving HIF-1alpha activation: a novel aspect of angiogenesis in atherosclerosis
    • PID: 23661177
    • Hutter R, Speidl WS, Valdiviezo C, et al. Macrophages transmit potent proangiogenic effects of oxLDL in vitro and in vivo involving HIF-1alpha activation: a novel aspect of angiogenesis in atherosclerosis. J Cardiovasc Transl Res. 2013;6(4):558–69. doi:10.1007/s12265-013-9469-9.
    • (2013) J Cardiovasc Transl Res , vol.6 , Issue.4 , pp. 558-569
    • Hutter, R.1    Speidl, W.S.2    Valdiviezo, C.3
  • 15
    • 84902131678 scopus 로고    scopus 로고
    • Mechanisms of plaque formation and rupture
    • COI: 1:CAS:528:DC%2BC2cXpt1KktL8%3D, PID: 24902970
    • Bentzon JF, Otsuka F, Virmani R, Falk E. Mechanisms of plaque formation and rupture. Circ Res. 2014;114(12):1852–66. doi:10.1161/CIRCRESAHA.114.302721.
    • (2014) Circ Res , vol.114 , Issue.12 , pp. 1852-1866
    • Bentzon, J.F.1    Otsuka, F.2    Virmani, R.3    Falk, E.4
  • 16
    • 0033855615 scopus 로고    scopus 로고
    • The initiation of intimal thickening in human arteries
    • COI: 1:STN:280:DC%2BD3M%2FmsFWgtg%3D%3D, PID: 10968389
    • Sims FH. The initiation of intimal thickening in human arteries. Pathology. 2000;32(3):171–5.
    • (2000) Pathology , vol.32 , Issue.3 , pp. 171-175
    • Sims, F.H.1
  • 17
    • 0032788539 scopus 로고    scopus 로고
    • Neovascularization in early atherosclerotic lesions of human carotid arteries: its potential contribution to plaque development
    • COI: 1:STN:280:DyaK1MznvFGksQ%3D%3D, PID: 10452504
    • Jeziorska M, Woolley DE. Neovascularization in early atherosclerotic lesions of human carotid arteries: its potential contribution to plaque development. Hum Pathol. 1999;30(8):919–25.
    • (1999) Hum Pathol , vol.30 , Issue.8 , pp. 919-925
    • Jeziorska, M.1    Woolley, D.E.2
  • 18
    • 80055022338 scopus 로고    scopus 로고
    • Early atheroma-derived agonists of peroxisome proliferator-activated receptor-gamma trigger intramedial angiogenesis in a smooth muscle cell-dependent manner
    • COI: 1:CAS:528:DC%2BC3MXhtlSlu7bL, PID: 21885829
    • Ho-Tin-Noe B, Le Dall J, Gomez D, et al. Early atheroma-derived agonists of peroxisome proliferator-activated receptor-gamma trigger intramedial angiogenesis in a smooth muscle cell-dependent manner. Circ Res. 2011;109(9):1003–14. doi:10.1161/CIRCRESAHA.110.235390.
    • (2011) Circ Res , vol.109 , Issue.9 , pp. 1003-1014
    • Ho-Tin-Noe, B.1    Le Dall, J.2    Gomez, D.3
  • 19
    • 70349652320 scopus 로고    scopus 로고
    • Prevention of vasa vasorum neovascularization attenuates early neointima formation in experimental hypercholesterolemia
    • PID: 19458984
    • Gossl M, Herrmann J, Tang H, et al. Prevention of vasa vasorum neovascularization attenuates early neointima formation in experimental hypercholesterolemia. Basic Res Cardiol. 2009;104(6):695–706. doi:10.1007/s00395-009-0036-0.
    • (2009) Basic Res Cardiol , vol.104 , Issue.6 , pp. 695-706
    • Gossl, M.1    Herrmann, J.2    Tang, H.3
  • 20
    • 40849086607 scopus 로고    scopus 로고
    • Hypoxia, hypoxia-inducible transcription factor, and macrophages in human atherosclerotic plaques are correlated with intraplaque angiogenesis
    • COI: 1:CAS:528:DC%2BD1cXktV2lt7g%3D, PID: 18371555
    • Sluimer JC, Gasc JM, van Wanroij JL, et al. Hypoxia, hypoxia-inducible transcription factor, and macrophages in human atherosclerotic plaques are correlated with intraplaque angiogenesis. J Am Coll Cardiol. 2008;51(13):1258–65. doi:10.1016/j.jacc.2007.12.025.
    • (2008) J Am Coll Cardiol , vol.51 , Issue.13 , pp. 1258-1265
    • Sluimer, J.C.1    Gasc, J.M.2    van Wanroij, J.L.3
  • 21
    • 80255131449 scopus 로고    scopus 로고
    • Hypoxia is present in murine atherosclerotic plaques and has multiple adverse effects on macrophage lipid metabolism
    • COI: 1:CAS:528:DC%2BC3MXhtlOnsLjJ, PID: 21921268
    • Parathath S, Mick SL, Feig JE, et al. Hypoxia is present in murine atherosclerotic plaques and has multiple adverse effects on macrophage lipid metabolism. Circ Res. 2011;109(10):1141–52. doi:10.1161/CIRCRESAHA.111.246363.
    • (2011) Circ Res , vol.109 , Issue.10 , pp. 1141-1152
    • Parathath, S.1    Mick, S.L.2    Feig, J.E.3
  • 22
    • 59849086158 scopus 로고    scopus 로고
    • Macrophages generate reactive oxygen species in response to minimally oxidized low-density lipoprotein: toll-like receptor 4- and spleen tyrosine kinase-dependent activation of NADPH oxidase 2
    • COI: 1:CAS:528:DC%2BD1MXntFahtw%3D%3D, PID: 19096031, 221p following 218
    • Bae YS, Lee JH, Choi SH, et al. Macrophages generate reactive oxygen species in response to minimally oxidized low-density lipoprotein: toll-like receptor 4- and spleen tyrosine kinase-dependent activation of NADPH oxidase 2. Circ Res. 2009;104(2):210–8. doi:10.1161/CIRCRESAHA.108.181040. 221p following 218.
    • (2009) Circ Res , vol.104 , Issue.2 , pp. 210-218
    • Bae, Y.S.1    Lee, J.H.2    Choi, S.H.3
  • 23
    • 36049010109 scopus 로고    scopus 로고
    • HIF-1 alpha expression is associated with an atheromatous inflammatory plaque phenotype and upregulated in activated macrophages
    • COI: 1:CAS:528:DC%2BD2sXhtlahtbjO, PID: 17606258
    • Vink A, Schoneveld AH, Lamers D, et al. HIF-1 alpha expression is associated with an atheromatous inflammatory plaque phenotype and upregulated in activated macrophages. Atherosclerosis. 2007;195(2):e69–75. doi:10.1016/j.atherosclerosis.2007.05.026.
    • (2007) Atherosclerosis , vol.195 , Issue.2 , pp. e69-e75
    • Vink, A.1    Schoneveld, A.H.2    Lamers, D.3
  • 24
    • 39749196227 scopus 로고    scopus 로고
    • LPS induces hypoxia-inducible factor 1 activation in macrophage-differentiated cells in a reactive oxygen species-dependent manner
    • COI: 1:CAS:528:DC%2BD1cXitlems70%3D, PID: 18199003
    • Nishi K, Oda T, Takabuchi S, et al. LPS induces hypoxia-inducible factor 1 activation in macrophage-differentiated cells in a reactive oxygen species-dependent manner. Antioxid Redox Signal. 2008;10(5):983–95. doi:10.1089/ars.2007.1825.
    • (2008) Antioxid Redox Signal , vol.10 , Issue.5 , pp. 983-995
    • Nishi, K.1    Oda, T.2    Takabuchi, S.3
  • 25
    • 84918827233 scopus 로고    scopus 로고
    • Reversal of hypoxia in murine atherosclerosis prevents necrotic core expansion by enhancing efferocytosis
    • COI: 1:CAS:528:DC%2BC2cXhvFGjs7zE, PID: 25256233, This article demonstrates that hypoxia may be indeed a contributing factor to the development atherosclerosis, whereas improved oxygenation reduces the development of atherosclerotic plaque lesions
    • Marsch E, Theelen TL, Demandt JA, et al. Reversal of hypoxia in murine atherosclerosis prevents necrotic core expansion by enhancing efferocytosis. Arterioscler Thromb Vasc Biol. 2014;34(12):2545–53. doi:10.1161/ATVBAHA.114.304023. This article demonstrates that hypoxia may be indeed a contributing factor to the development atherosclerosis, whereas improved oxygenation reduces the development of atherosclerotic plaque lesions.
    • (2014) Arterioscler Thromb Vasc Biol , vol.34 , Issue.12 , pp. 2545-2553
    • Marsch, E.1    Theelen, T.L.2    Demandt, J.A.3
  • 26
    • 33644852310 scopus 로고    scopus 로고
    • Chronic hypoxia accelerates the progression of atherosclerosis in apolipoprotein E-knockout mice
    • COI: 1:CAS:528:DC%2BD28XntlSjsA%3D%3D, PID: 16471178
    • Nakano D, Hayashi T, Tazawa N, et al. Chronic hypoxia accelerates the progression of atherosclerosis in apolipoprotein E-knockout mice. Hypertens Res. 2005;28(10):837–45. doi:10.1291/hypres.28.837.
    • (2005) Hypertens Res , vol.28 , Issue.10 , pp. 837-845
    • Nakano, D.1    Hayashi, T.2    Tazawa, N.3
  • 27
    • 84879088784 scopus 로고    scopus 로고
    • Hypoxia induces netrin-1 and Unc5b in atherosclerotic plaques: mechanism for macrophage retention and survival
    • COI: 1:CAS:528:DC%2BC3sXps1ylu78%3D, PID: 23599441, This article presents data that hypoxia may promote the inflammatory responses in atherosclerotic plaque lesion by promoting the expression of macrophage retention proteins, thus keeping macrophages in plaque tissues where they contribute to further plaque growth
    • Ramkhelawon B, Yang Y, van Gils JM, et al. Hypoxia induces netrin-1 and Unc5b in atherosclerotic plaques: mechanism for macrophage retention and survival. Arterioscler Thromb Vasc Biol. 2013;33(6):1180–8. doi:10.1161/ATVBAHA.112.301008. This article presents data that hypoxia may promote the inflammatory responses in atherosclerotic plaque lesion by promoting the expression of macrophage retention proteins, thus keeping macrophages in plaque tissues where they contribute to further plaque growth.
    • (2013) Arterioscler Thromb Vasc Biol , vol.33 , Issue.6 , pp. 1180-1188
    • Ramkhelawon, B.1    Yang, Y.2    van Gils, J.M.3
  • 28
    • 84883767696 scopus 로고    scopus 로고
    • Hypoxia in atherosclerosis and inflammation
    • COI: 1:CAS:528:DC%2BC3sXhtlOqu7%2FN, PID: 23942270
    • Marsch E, Sluimer JC, Daemen MJ. Hypoxia in atherosclerosis and inflammation. Curr Opin Lipidol. 2013;24(5):393–400. doi:10.1097/MOL.0b013e32836484a4.
    • (2013) Curr Opin Lipidol , vol.24 , Issue.5 , pp. 393-400
    • Marsch, E.1    Sluimer, J.C.2    Daemen, M.J.3
  • 29
    • 82955246272 scopus 로고    scopus 로고
    • Inflammation contributes to the atherogenic role of intermittent hypoxia in apolipoprotein-E knock out mice
    • COI: 1:CAS:528:DC%2BC3MXhsFCru7bN, PID: 21917260
    • Arnaud C, Poulain L, Levy P, Dematteis M. Inflammation contributes to the atherogenic role of intermittent hypoxia in apolipoprotein-E knock out mice. Atherosclerosis. 2011;219(2):425–31. doi:10.1016/j.atherosclerosis.2011.07.122.
    • (2011) Atherosclerosis , vol.219 , Issue.2 , pp. 425-431
    • Arnaud, C.1    Poulain, L.2    Levy, P.3    Dematteis, M.4
  • 30
    • 84924842980 scopus 로고    scopus 로고
    • Hypoxia in plaque macrophages: a new danger signal for interleukin-1beta activation?
    • COI: 1:CAS:528:DC%2BC2cXhsl2msbvN, PID: 25342768
    • Sergin I, Evans TD, Bhattacharya S, Razani B. Hypoxia in plaque macrophages: a new danger signal for interleukin-1beta activation? Circ Res. 2014;115(10):817–20. doi:10.1161/CIRCRESAHA.114.305197.
    • (2014) Circ Res , vol.115 , Issue.10 , pp. 817-820
    • Sergin, I.1    Evans, T.D.2    Bhattacharya, S.3    Razani, B.4
  • 31
    • 0042510743 scopus 로고    scopus 로고
    • Inflammatory reactions in the pathogenesis of atherosclerosis
    • COI: 1:CAS:528:DC%2BD3sXksFOlurc%3D, PID: 12740479
    • Fan J, Watanabe T. Inflammatory reactions in the pathogenesis of atherosclerosis. J Atheroscler Thromb. 2003;10(2):63–71.
    • (2003) J Atheroscler Thromb , vol.10 , Issue.2 , pp. 63-71
    • Fan, J.1    Watanabe, T.2
  • 32
    • 0036798621 scopus 로고    scopus 로고
    • Normal and oxidized low density lipoproteins accumulate deep in physiologically thickened intima of human coronary arteries
    • COI: 1:CAS:528:DC%2BD38Xns1Cmu7s%3D, PID: 12379778
    • Fukuchi M, Watanabe J, Kumagai K, et al. Normal and oxidized low density lipoproteins accumulate deep in physiologically thickened intima of human coronary arteries. Lab Invest. 2002;82(10):1437–47.
    • (2002) Lab Invest , vol.82 , Issue.10 , pp. 1437-1447
    • Fukuchi, M.1    Watanabe, J.2    Kumagai, K.3
  • 33
    • 34247393620 scopus 로고    scopus 로고
    • Early human atherosclerosis: accumulation of lipid and proteoglycans in intimal thickenings followed by macrophage infiltration
    • COI: 1:CAS:528:DC%2BD2sXktFagtL4%3D, PID: 17303781
    • Nakashima Y, Fujii H, Sumiyoshi S, Wight TN, Sueishi K. Early human atherosclerosis: accumulation of lipid and proteoglycans in intimal thickenings followed by macrophage infiltration. Arterioscler Thromb Vasc Biol. 2007;27(5):1159–65. doi:10.1161/ATVBAHA.106.134080.
    • (2007) Arterioscler Thromb Vasc Biol , vol.27 , Issue.5 , pp. 1159-1165
    • Nakashima, Y.1    Fujii, H.2    Sumiyoshi, S.3    Wight, T.N.4    Sueishi, K.5
  • 34
    • 0036343331 scopus 로고    scopus 로고
    • Subnormal shear stress-induced intimal thickening requires medial smooth muscle cell proliferation and migration
    • COI: 1:CAS:528:DC%2BD38XhslyhtL4%3D, PID: 11890724
    • Sho M, Sho E, Singh TM, et al. Subnormal shear stress-induced intimal thickening requires medial smooth muscle cell proliferation and migration. Exp Mol Pathol. 2002;72(2):150–60. doi:10.1006/exmp.2002.2426.
    • (2002) Exp Mol Pathol , vol.72 , Issue.2 , pp. 150-160
    • Sho, M.1    Sho, E.2    Singh, T.M.3
  • 35
    • 84896543112 scopus 로고    scopus 로고
    • Vascular endothelial growth factor signaling in hypoxia and inflammation
    • COI: 1:STN:280:DC%2BC2crit1Wjtw%3D%3D, PID: 24610033
    • Ramakrishnan S, Anand V, Roy S. Vascular endothelial growth factor signaling in hypoxia and inflammation. J Neuroimmune Pharmacol. 2014;9(2):142–60. doi:10.1007/s11481-014-9531-7.
    • (2014) J Neuroimmune Pharmacol , vol.9 , Issue.2 , pp. 142-160
    • Ramakrishnan, S.1    Anand, V.2    Roy, S.3
  • 36
    • 57149144229 scopus 로고    scopus 로고
    • Lipid levels in patients hospitalized with coronary artery disease: an analysis of 136,905 hospitalizations in Get With The Guidelines
    • COI: 1:CAS:528:DC%2BD1cXhsV2nsrfF, PID: 19081406
    • Sachdeva A, Cannon CP, Deedwania PC, et al. Lipid levels in patients hospitalized with coronary artery disease: an analysis of 136,905 hospitalizations in Get With The Guidelines. Am Heart J. 2009;157(1):111–7 e112. doi:10.1016/j.ahj.2008.08.010.
    • (2009) Am Heart J , vol.157 , Issue.1 , pp. 111-110
    • Sachdeva, A.1    Cannon, C.P.2    Deedwania, P.C.3
  • 37
    • 27744522317 scopus 로고    scopus 로고
    • The forgotten majority: unfinished business in cardiovascular risk reduction
    • PID: 16198835
    • Libby P. The forgotten majority: unfinished business in cardiovascular risk reduction. J Am Coll Cardiol. 2005;46(7):1225–8. doi:10.1016/j.jacc.2005.07.006.
    • (2005) J Am Coll Cardiol , vol.46 , Issue.7 , pp. 1225-1228
    • Libby, P.1
  • 38
    • 77950020024 scopus 로고    scopus 로고
    • Effect of intermittent hypoxia on atherosclerosis in apolipoprotein E-deficient mice
    • COI: 1:CAS:528:DC%2BC3cXjvF2ktbo%3D, PID: 19897196
    • Jun J, Reinke C, Bedja D, et al. Effect of intermittent hypoxia on atherosclerosis in apolipoprotein E-deficient mice. Atherosclerosis. 2010;209(2):381–6. doi:10.1016/j.atherosclerosis.2009.10.017.
    • (2010) Atherosclerosis , vol.209 , Issue.2 , pp. 381-386
    • Jun, J.1    Reinke, C.2    Bedja, D.3
  • 39
    • 84907535524 scopus 로고    scopus 로고
    • Oxidized low-density lipoprotein stimulates macrophage 18F-FDG uptake via hypoxia-inducible factor-1alpha activation through Nox2-dependent reactive oxygen species generation
    • COI: 1:CAS:528:DC%2BC2cXhvFyqtbjI, PID: 25214643, This paper links three aspects of atherosclerosis: oxLDL uptake, hypoxia, and glucose uptake for glycolysis
    • Lee SJ, Thien Quach CH, Jung KH, et al. Oxidized low-density lipoprotein stimulates macrophage 18F-FDG uptake via hypoxia-inducible factor-1alpha activation through Nox2-dependent reactive oxygen species generation. J Nucl Med. 2014;55(10):1699–705. doi:10.2967/jnumed.114.139428. This paper links three aspects of atherosclerosis: oxLDL uptake, hypoxia, and glucose uptake for glycolysis.
    • (2014) J Nucl Med , vol.55 , Issue.10 , pp. 1699-1705
    • Lee, S.J.1    Thien Quach, C.H.2    Jung, K.H.3
  • 40
    • 84918536491 scopus 로고    scopus 로고
    • LOX-1 plays an important role in ischemia-induced angiogenesis of limbs
    • PID: 25514797
    • Shiraki T, Aoyama T, Yokoyama C, et al. LOX-1 plays an important role in ischemia-induced angiogenesis of limbs. PLoS One. 2014;9(12):e114542. doi:10.1371/journal.pone.0114542.
    • (2014) PLoS One , vol.9 , Issue.12 , pp. e114542
    • Shiraki, T.1    Aoyama, T.2    Yokoyama, C.3
  • 41
    • 4544346656 scopus 로고    scopus 로고
    • JunD reduces tumor angiogenesis by protecting cells from oxidative stress
    • COI: 1:CAS:528:DC%2BD2cXnvFehtbk%3D, PID: 15369676
    • Gerald D, Berra E, Frapart YM, et al. JunD reduces tumor angiogenesis by protecting cells from oxidative stress. Cell. 2004;118(6):781–94. doi:10.1016/j.cell.2004.08.025.
    • (2004) Cell , vol.118 , Issue.6 , pp. 781-794
    • Gerald, D.1    Berra, E.2    Frapart, Y.M.3
  • 42
    • 0038115172 scopus 로고    scopus 로고
    • Oxidized low-density lipoprotein (oxLDL) triggers hypoxia-inducible factor-1alpha (HIF-1alpha) accumulation via redox-dependent mechanisms
    • COI: 1:CAS:528:DC%2BD3sXkslCjs7g%3D, PID: 12586627
    • Shatrov VA, Sumbayev VV, Zhou J, Brune B. Oxidized low-density lipoprotein (oxLDL) triggers hypoxia-inducible factor-1alpha (HIF-1alpha) accumulation via redox-dependent mechanisms. Blood. 2003;101(12):4847–9. doi:10.1182/blood-2002-09-2711.
    • (2003) Blood , vol.101 , Issue.12 , pp. 4847-4849
    • Shatrov, V.A.1    Sumbayev, V.V.2    Zhou, J.3    Brune, B.4
  • 43
    • 17944375360 scopus 로고    scopus 로고
    • C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation
    • COI: 1:CAS:528:DC%2BD3MXnsFOntL0%3D, PID: 11595184
    • Epstein AC, Gleadle JM, McNeill LA, et al. C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation. Cell. 2001;107(1):43–54.
    • (2001) Cell , vol.107 , Issue.1 , pp. 43-54
    • Epstein, A.C.1    Gleadle, J.M.2    McNeill, L.A.3
  • 44
    • 84927690073 scopus 로고    scopus 로고
    • Alternatively spliced tissue factor promotes plaque angiogenesis through the activation of hypoxia-inducible factor-1alpha and vascular endothelial growth factor signaling
    • COI: 1:CAS:528:DC%2BC2cXhsleitLzJ, PID: 25116956
    • Giannarelli C, Alique M, Rodriguez DT, et al. Alternatively spliced tissue factor promotes plaque angiogenesis through the activation of hypoxia-inducible factor-1alpha and vascular endothelial growth factor signaling. Circulation. 2014;130(15):1274–86. doi:10.1161/CIRCULATIONAHA.114.006614.
    • (2014) Circulation , vol.130 , Issue.15 , pp. 1274-1286
    • Giannarelli, C.1    Alique, M.2    Rodriguez, D.T.3
  • 45
    • 66749187756 scopus 로고    scopus 로고
    • Novel concepts in atherogenesis: angiogenesis and hypoxia in atherosclerosis
    • PID: 19309025
    • Sluimer JC, Daemen MJ. Novel concepts in atherogenesis: angiogenesis and hypoxia in atherosclerosis. J Pathol. 2009;218(1):7–29. doi:10.1002/path.2518.
    • (2009) J Pathol , vol.218 , Issue.1 , pp. 7-29
    • Sluimer, J.C.1    Daemen, M.J.2
  • 46
    • 34247187576 scopus 로고    scopus 로고
    • Reactive oxygen species activate the HIF-1alpha promoter via a functional NFkappaB site
    • COI: 1:CAS:528:DC%2BD2sXislCrsrc%3D, PID: 17272744
    • Bonello S, Zahringer C, BelAiba RS, et al. Reactive oxygen species activate the HIF-1alpha promoter via a functional NFkappaB site. Arterioscler Thromb Vasc Biol. 2007;27(4):755–61. doi:10.1161/01.ATV.0000258979.92828.bc.
    • (2007) Arterioscler Thromb Vasc Biol , vol.27 , Issue.4 , pp. 755-761
    • Bonello, S.1    Zahringer, C.2    BelAiba, R.S.3
  • 47
    • 10044226094 scopus 로고    scopus 로고
    • The expression of macrophage migration inhibitory factor 1alpha (MIF 1alpha) in human atherosclerotic plaques is induced by different proatherogenic stimuli and associated with plaque instability
    • COI: 1:CAS:528:DC%2BD2cXhtVCltLzL, PID: 15585204
    • Schmeisser A, Marquetant R, Illmer T, et al. The expression of macrophage migration inhibitory factor 1alpha (MIF 1alpha) in human atherosclerotic plaques is induced by different proatherogenic stimuli and associated with plaque instability. Atherosclerosis. 2005;178(1):83–94. doi:10.1016/j.atherosclerosis.2004.08.038.
    • (2005) Atherosclerosis , vol.178 , Issue.1 , pp. 83-94
    • Schmeisser, A.1    Marquetant, R.2    Illmer, T.3
  • 48
    • 77955682356 scopus 로고    scopus 로고
    • Hypoxia stimulates the expression of macrophage migration inhibitory factor in human vascular smooth muscle cells via HIF-1alpha dependent pathway
    • PID: 20727156
    • Fu H, Luo F, Yang L, Wu W, Liu X. Hypoxia stimulates the expression of macrophage migration inhibitory factor in human vascular smooth muscle cells via HIF-1alpha dependent pathway. BMC Cell Biol. 2010;11:66. doi:10.1186/1471-2121-11-66.
    • (2010) BMC Cell Biol , vol.11 , pp. 66
    • Fu, H.1    Luo, F.2    Yang, L.3    Wu, W.4    Liu, X.5
  • 49
    • 70849117295 scopus 로고    scopus 로고
    • Hypoxic regulation of secreted proteoglycans in macrophages
    • COI: 1:CAS:528:DC%2BD1MXhsV2itLrN, PID: 19748976
    • Asplund A, Stillemark-Billton P, Larsson E, et al. Hypoxic regulation of secreted proteoglycans in macrophages. Glycobiology. 2010;20(1):33–40. doi:10.1093/glycob/cwp139.
    • (2010) Glycobiology , vol.20 , Issue.1 , pp. 33-40
    • Asplund, A.1    Stillemark-Billton, P.2    Larsson, E.3
  • 50
    • 84917736664 scopus 로고    scopus 로고
    • Moderate hypoxia potentiates interleukin-1beta production in activated human macrophages
    • COI: 1:CAS:528:DC%2BC2cXhsl2msbnN, PID: 25185259
    • Folco EJ, Sukhova GK, Quillard T, Libby P. Moderate hypoxia potentiates interleukin-1beta production in activated human macrophages. Circ Res. 2014;115(10):875–83. doi:10.1161/CIRCRESAHA.115.304437.
    • (2014) Circ Res , vol.115 , Issue.10 , pp. 875-883
    • Folco, E.J.1    Sukhova, G.K.2    Quillard, T.3    Libby, P.4
  • 51
    • 84876292187 scopus 로고    scopus 로고
    • Neuroimmune guidance cue Semaphorin 3E is expressed in atherosclerotic plaques and regulates macrophage retention
    • COI: 1:CAS:528:DC%2BC3sXlslals7o%3D, PID: 23430613
    • Wanschel A, Seibert T, Hewing B, et al. Neuroimmune guidance cue Semaphorin 3E is expressed in atherosclerotic plaques and regulates macrophage retention. Arterioscler Thromb Vasc Biol. 2013;33(5):886–93. doi:10.1161/ATVBAHA.112.300941.
    • (2013) Arterioscler Thromb Vasc Biol , vol.33 , Issue.5 , pp. 886-893
    • Wanschel, A.1    Seibert, T.2    Hewing, B.3
  • 52
    • 84879421653 scopus 로고    scopus 로고
    • Hypoxia enhances lipid uptake in macrophages: role of the scavenger receptors Lox1, SRA, and CD36
    • COI: 1:CAS:528:DC%2BC3sXot1Kmsrw%3D, PID: 23706521, This publication illustrates an example how hypoxia may promote the uptake of oxLDL into macrophages. This represents one of the multiple mechanisms by which hypoxia activates processes that lead to the growth of atherosclerotic plaques
    • Crucet M, Wust SJ, Spielmann P, Luscher TF, Wenger RH, Matter CM. Hypoxia enhances lipid uptake in macrophages: role of the scavenger receptors Lox1, SRA, and CD36. Atherosclerosis. 2013;229(1):110–7. doi:10.1016/j.atherosclerosis.2013.04.034. This publication illustrates an example how hypoxia may promote the uptake of oxLDL into macrophages. This represents one of the multiple mechanisms by which hypoxia activates processes that lead to the growth of atherosclerotic plaques.
    • (2013) Atherosclerosis , vol.229 , Issue.1 , pp. 110-117
    • Crucet, M.1    Wust, S.J.2    Spielmann, P.3    Luscher, T.F.4    Wenger, R.H.5    Matter, C.M.6
  • 53
    • 78649805641 scopus 로고    scopus 로고
    • Hypoxia-inducible protein 2 is a novel lipid droplet protein and a specific target gene of hypoxia-inducible factor-1
    • COI: 1:CAS:528:DC%2BC3cXhsVWqu7jN, PID: 20624928
    • Gimm T, Wiese M, Teschemacher B, et al. Hypoxia-inducible protein 2 is a novel lipid droplet protein and a specific target gene of hypoxia-inducible factor-1. FASEB J. 2010;24(11):4443–58. doi:10.1096/fj.10-159806.
    • (2010) FASEB J , vol.24 , Issue.11 , pp. 4443-4458
    • Gimm, T.1    Wiese, M.2    Teschemacher, B.3
  • 54
    • 67349119514 scopus 로고    scopus 로고
    • Regulation of angiogenesis by oxygen sensing mechanisms
    • COI: 1:CAS:528:DC%2BD1MXmsFWksb0%3D
    • Fong GH. Regulation of angiogenesis by oxygen sensing mechanisms. J Mol Med (Berl). 2009;87(6):549–60. doi:10.1007/s00109-009-0458-z.
    • (2009) J Mol Med (Berl) , vol.87 , Issue.6 , pp. 549-560
    • Fong, G.H.1
  • 55
    • 34547905406 scopus 로고    scopus 로고
    • Essential role for prolyl hydroxylase domain protein 2 in oxygen homeostasis of the adult vascular system
    • COI: 1:CAS:528:DC%2BD2sXos1agu7w%3D, PID: 17646578
    • Takeda K, Cowan A, Fong GH. Essential role for prolyl hydroxylase domain protein 2 in oxygen homeostasis of the adult vascular system. Circulation. 2007;116(7):774–81. doi:10.1161/CIRCULATIONAHA.107.701516.
    • (2007) Circulation , vol.116 , Issue.7 , pp. 774-781
    • Takeda, K.1    Cowan, A.2    Fong, G.H.3
  • 56
    • 84860703232 scopus 로고    scopus 로고
    • Role of reactive oxygen species in the regulation of HIF-1 by prolyl hydroxylase 2 under mild hypoxia
    • COI: 1:CAS:528:DC%2BC38Xms12gsr8%3D, PID: 22360728
    • Niecknig H, Tug S, Reyes BD, Kirsch M, Fandrey J, Berchner-Pfannschmidt U. Role of reactive oxygen species in the regulation of HIF-1 by prolyl hydroxylase 2 under mild hypoxia. Free Radic Res. 2012;46(6):705–17. doi:10.3109/10715762.2012.669041.
    • (2012) Free Radic Res , vol.46 , Issue.6 , pp. 705-717
    • Niecknig, H.1    Tug, S.2    Reyes, B.D.3    Kirsch, M.4    Fandrey, J.5    Berchner-Pfannschmidt, U.6
  • 57
    • 84900418884 scopus 로고    scopus 로고
    • Noninvasive assessment of hypoxia in rabbit advanced atherosclerosis using (1)(8)F-fluoromisonidazole positron emission tomographic imaging
    • PID: 24508668
    • Mateo J, Izquierdo-Garcia D, Badimon JJ, Fayad ZA, Fuster V. Noninvasive assessment of hypoxia in rabbit advanced atherosclerosis using (1)(8)F-fluoromisonidazole positron emission tomographic imaging. Circ Cardiovasc Imaging. 2014;7(2):312–20. doi:10.1161/CIRCIMAGING.113.001084.
    • (2014) Circ Cardiovasc Imaging , vol.7 , Issue.2 , pp. 312-320
    • Mateo, J.1    Izquierdo-Garcia, D.2    Badimon, J.J.3    Fayad, Z.A.4    Fuster, V.5
  • 58
    • 79955642031 scopus 로고    scopus 로고
    • Detection of hypoxia by [18F]EF5 in atherosclerotic plaques in mice
    • COI: 1:CAS:528:DC%2BC3MXkvFantbY%3D, PID: 21372297
    • Silvola JM, Saraste A, Forsback S, et al. Detection of hypoxia by [18F]EF5 in atherosclerotic plaques in mice. Arterioscler Thromb Vasc Biol. 2011;31(5):1011–5. doi:10.1161/ATVBAHA.110.221440.
    • (2011) Arterioscler Thromb Vasc Biol , vol.31 , Issue.5 , pp. 1011-1015
    • Silvola, J.M.1    Saraste, A.2    Forsback, S.3
  • 59
    • 84904730036 scopus 로고    scopus 로고
    • PET imaging of inflammation in atherosclerosis
    • COI: 1:CAS:528:DC%2BC2cXpslCht7w%3D, PID: 24913061
    • Tarkin JM, Joshi FR, Rudd JH. PET imaging of inflammation in atherosclerosis. Nat Rev Cardiol. 2014;11(8):443–57. doi:10.1038/nrcardio.2014.80.
    • (2014) Nat Rev Cardiol , vol.11 , Issue.8 , pp. 443-457
    • Tarkin, J.M.1    Joshi, F.R.2    Rudd, J.H.3
  • 60
    • 84899787561 scopus 로고    scopus 로고
    • Increased metabolite levels of glycolysis and pentose phosphate pathway in rabbit atherosclerotic arteries and hypoxic macrophage
    • PID: 24466087
    • Yamashita A, Zhao Y, Matsuura Y, et al. Increased metabolite levels of glycolysis and pentose phosphate pathway in rabbit atherosclerotic arteries and hypoxic macrophage. PLoS One. 2014;9(1):e86426. doi:10.1371/journal.pone.0086426.
    • (2014) PLoS One , vol.9 , Issue.1 , pp. e86426
    • Yamashita, A.1    Zhao, Y.2    Matsuura, Y.3
  • 61
    • 84870515691 scopus 로고    scopus 로고
    • Molecular imaging in atherosclerosis: FDG PET
    • PID: 22872371
    • Rosenbaum D, Millon A, Fayad ZA. Molecular imaging in atherosclerosis: FDG PET. Curr Atheroscler Rep. 2012;14(5):429–37. doi:10.1007/s11883-012-0264-x.
    • (2012) Curr Atheroscler Rep , vol.14 , Issue.5 , pp. 429-437
    • Rosenbaum, D.1    Millon, A.2    Fayad, Z.A.3
  • 62
    • 0344921396 scopus 로고    scopus 로고
    • Inhibition of plaque neovascularization reduces macrophage accumulation and progression of advanced atherosclerosis
    • COI: 1:CAS:528:DC%2BD3sXjt12nsLo%3D, PID: 12682294
    • Moulton KS, Vakili K, Zurakowski D, et al. Inhibition of plaque neovascularization reduces macrophage accumulation and progression of advanced atherosclerosis. Proc Natl Acad Sci U S A. 2003;100(8):4736–41. doi:10.1073/pnas.0730843100.
    • (2003) Proc Natl Acad Sci U S A , vol.100 , Issue.8 , pp. 4736-4741
    • Moulton, K.S.1    Vakili, K.2    Zurakowski, D.3
  • 63
    • 33748579995 scopus 로고    scopus 로고
    • Angiogenesis in atherosclerosis: gathering evidence beyond speculation
    • COI: 1:CAS:528:DC%2BD28XptF2rtLY%3D, PID: 16960504
    • Moulton KS. Angiogenesis in atherosclerosis: gathering evidence beyond speculation. Curr Opin Lipidol. 2006;17(5):548–55. doi:10.1097/01.mol.0000245261.71129.f0.
    • (2006) Curr Opin Lipidol , vol.17 , Issue.5 , pp. 548-555
    • Moulton, K.S.1
  • 64
    • 64649093618 scopus 로고    scopus 로고
    • Thin-walled microvessels in human coronary atherosclerotic plaques show incomplete endothelial junctions relevance of compromised structural integrity for intraplaque microvascular leakage
    • COI: 1:CAS:528:DC%2BD1MXltVCns7g%3D, PID: 19389562
    • Sluimer JC, Kolodgie FD, Bijnens AP, et al. Thin-walled microvessels in human coronary atherosclerotic plaques show incomplete endothelial junctions relevance of compromised structural integrity for intraplaque microvascular leakage. J Am Coll Cardiol. 2009;53(17):1517–27. doi:10.1016/j.jacc.2008.12.056.
    • (2009) J Am Coll Cardiol , vol.53 , Issue.17 , pp. 1517-1527
    • Sluimer, J.C.1    Kolodgie, F.D.2    Bijnens, A.P.3
  • 65
    • 57649135172 scopus 로고    scopus 로고
    • A role for VEGF as a negative regulator of pericyte function and vessel maturation
    • COI: 1:CAS:528:DC%2BD1cXhsVymt77I, PID: 18997771
    • Greenberg JI, Shields DJ, Barillas SG, et al. A role for VEGF as a negative regulator of pericyte function and vessel maturation. Nature. 2008;456(7223):809–13. doi:10.1038/nature07424.
    • (2008) Nature , vol.456 , Issue.7223 , pp. 809-813
    • Greenberg, J.I.1    Shields, D.J.2    Barillas, S.G.3
  • 66
    • 79953045376 scopus 로고    scopus 로고
    • Augmented angiogenesis in adventitia promotes growth of atherosclerotic plaque in apolipoprotein E-deficient mice
    • COI: 1:CAS:528:DC%2BC3MXkt1egt78%3D, PID: 21306712
    • Tanaka K, Nagata D, Hirata Y, Tabata Y, Nagai R, Sata M. Augmented angiogenesis in adventitia promotes growth of atherosclerotic plaque in apolipoprotein E-deficient mice. Atherosclerosis. 2011;215(2):366–73. doi:10.1016/j.atherosclerosis.2011.01.016.
    • (2011) Atherosclerosis , vol.215 , Issue.2 , pp. 366-373
    • Tanaka, K.1    Nagata, D.2    Hirata, Y.3    Tabata, Y.4    Nagai, R.5    Sata, M.6
  • 67
    • 78149296324 scopus 로고    scopus 로고
    • OX40 ligand plays an important role in the development of atherosclerosis through vasa vasorum neovascularization
    • COI: 1:CAS:528:DC%2BC3cXhsVSltL3F, PID: 20584752
    • Nakano M, Fukumoto Y, Satoh K, et al. OX40 ligand plays an important role in the development of atherosclerosis through vasa vasorum neovascularization. Cardiovasc Res. 2010;88(3):539–46. doi:10.1093/cvr/cvq211.
    • (2010) Cardiovasc Res , vol.88 , Issue.3 , pp. 539-546
    • Nakano, M.1    Fukumoto, Y.2    Satoh, K.3
  • 68
    • 77955430489 scopus 로고    scopus 로고
    • Endothelial cell-selective adhesion molecule modulates atherosclerosis through plaque angiogenesis and monocyte-endothelial interaction
    • COI: 1:CAS:528:DC%2BC3cXpvVartL8%3D, PID: 20406651
    • Inoue M, Ishida T, Yasuda T, et al. Endothelial cell-selective adhesion molecule modulates atherosclerosis through plaque angiogenesis and monocyte-endothelial interaction. Microvasc Res. 2010;80(2):179–87. doi:10.1016/j.mvr.2010.04.005.
    • (2010) Microvasc Res , vol.80 , Issue.2 , pp. 179-187
    • Inoue, M.1    Ishida, T.2    Yasuda, T.3
  • 69
    • 77249130073 scopus 로고    scopus 로고
    • Controlling the angiogenic switch in developing atherosclerotic plaques: possible targets for therapeutic intervention
    • PID: 19946412
    • Slevin M, Krupinski J, Badimon L. Controlling the angiogenic switch in developing atherosclerotic plaques: possible targets for therapeutic intervention. J Angiogenes Res. 2009;1:4. doi:10.1186/2040-2384-1-4.
    • (2009) J Angiogenes Res , vol.1 , pp. 4
    • Slevin, M.1    Krupinski, J.2    Badimon, L.3
  • 70
    • 61949266686 scopus 로고    scopus 로고
    • The antiangiogenic activity of rPAI-1(23) inhibits vasa vasorum and growth of atherosclerotic plaque
    • COI: 1:CAS:528:DC%2BD1MXhsV2jsbk%3D, PID: 19122176
    • Drinane M, Mollmark J, Zagorchev L, et al. The antiangiogenic activity of rPAI-1(23) inhibits vasa vasorum and growth of atherosclerotic plaque. Circ Res. 2009;104(3):337–45. doi:10.1161/CIRCRESAHA.108.184622.
    • (2009) Circ Res , vol.104 , Issue.3 , pp. 337-345
    • Drinane, M.1    Mollmark, J.2    Zagorchev, L.3
  • 71
    • 84896284184 scopus 로고    scopus 로고
    • Local inhibition of hypoxia-inducible factor reduces neointima formation after arterial injury in ApoE-/- mice
    • COI: 1:CAS:528:DC%2BC2cXks1WntrY%3D, PID: 24561491, This article directly demonstrates that atherosclerotic plaque growth can be inhibited by suppressing the expression of hypoxia-inducible factor in injured arterial wall tissues
    • Christoph M, Ibrahim K, Hesse K, et al. Local inhibition of hypoxia-inducible factor reduces neointima formation after arterial injury in ApoE-/- mice. Atherosclerosis. 2014;233(2):641–7. doi:10.1016/j.atherosclerosis.2014.01.048. This article directly demonstrates that atherosclerotic plaque growth can be inhibited by suppressing the expression of hypoxia-inducible factor in injured arterial wall tissues.
    • (2014) Atherosclerosis , vol.233 , Issue.2 , pp. 641-647
    • Christoph, M.1    Ibrahim, K.2    Hesse, K.3
  • 72
    • 20244375128 scopus 로고    scopus 로고
    • SDF-1alpha/CXCR4 axis is instrumental in neointimal hyperplasia and recruitment of smooth muscle progenitor cells
    • COI: 1:CAS:528:DC%2BD2MXjtVWnur0%3D, PID: 15761195
    • Zernecke A, Schober A, Bot I, et al. SDF-1alpha/CXCR4 axis is instrumental in neointimal hyperplasia and recruitment of smooth muscle progenitor cells. Circ Res. 2005;96(7):784–91. doi:10.1161/01.RES.0000162100.52009.38.
    • (2005) Circ Res , vol.96 , Issue.7 , pp. 784-791
    • Zernecke, A.1    Schober, A.2    Bot, I.3
  • 73
    • 33846002305 scopus 로고    scopus 로고
    • Vascular endothelial growth factor-A induces plaque expansion in ApoE knock-out mice by promoting de novo leukocyte recruitment
    • COI: 1:CAS:528:DC%2BD2sXivVyrtb4%3D, PID: 16990600
    • Lucerna M, Zernecke A, de Nooijer R, et al. Vascular endothelial growth factor-A induces plaque expansion in ApoE knock-out mice by promoting de novo leukocyte recruitment. Blood. 2007;109(1):122–9. doi:10.1182/blood-2006-07-031773.
    • (2007) Blood , vol.109 , Issue.1 , pp. 122-129
    • Lucerna, M.1    Zernecke, A.2    de Nooijer, R.3
  • 74
    • 79959813724 scopus 로고    scopus 로고
    • Cytokines, macrophage lipid metabolism and foam cells: implications for cardiovascular disease therapy
    • COI: 1:CAS:528:DC%2BC3MXht1OisL7P, PID: 21601592
    • McLaren JE, Michael DR, Ashlin TG, Ramji DP. Cytokines, macrophage lipid metabolism and foam cells: implications for cardiovascular disease therapy. Prog Lipid Res. 2011;50(4):331–47. doi:10.1016/j.plipres.2011.04.002.
    • (2011) Prog Lipid Res , vol.50 , Issue.4 , pp. 331-347
    • McLaren, J.E.1    Michael, D.R.2    Ashlin, T.G.3    Ramji, D.P.4
  • 75
    • 0037137305 scopus 로고    scopus 로고
    • Anti-monocyte chemoattractant protein-1 gene therapy limits progression and destabilization of established atherosclerosis in apolipoprotein E-knockout mice
    • COI: 1:CAS:528:DC%2BD38XosFCrsr4%3D, PID: 12438296
    • Inoue S, Egashira K, Ni W, et al. Anti-monocyte chemoattractant protein-1 gene therapy limits progression and destabilization of established atherosclerosis in apolipoprotein E-knockout mice. Circulation. 2002;106(21):2700–6.
    • (2002) Circulation , vol.106 , Issue.21 , pp. 2700-2706
    • Inoue, S.1    Egashira, K.2    Ni, W.3
  • 76
    • 84904605889 scopus 로고    scopus 로고
    • Oxidized low-density lipoprotein induces long-term proinflammatory cytokine production and foam cell formation via epigenetic reprogramming of monocytes
    • COI: 1:CAS:528:DC%2BC2cXhtFGmt7%2FJ, PID: 24903093
    • Bekkering S, Quintin J, Joosten LA, van der Meer JW, Netea MG, Riksen NP. Oxidized low-density lipoprotein induces long-term proinflammatory cytokine production and foam cell formation via epigenetic reprogramming of monocytes. Arterioscler Thromb Vasc Biol. 2014;34(8):1731–8. doi:10.1161/ATVBAHA.114.303887.
    • (2014) Arterioscler Thromb Vasc Biol , vol.34 , Issue.8 , pp. 1731-1738
    • Bekkering, S.1    Quintin, J.2    Joosten, L.A.3    van der Meer, J.W.4    Netea, M.G.5    Riksen, N.P.6
  • 77
    • 84888990675 scopus 로고    scopus 로고
    • oxLDL induces inflammatory responses in vascular smooth muscle cells via urokinase receptor association with CD36 and TLR4
    • COI: 1:CAS:528:DC%2BC2cXksFOiug%3D%3D, PID: 24239845, 10.1016/j.yjmcc.2013.11.005
    • Kiyan Y, Tkachuk S, Hilfiker-Kleiner D, Haller H, Fuhrman B, Dumler I. oxLDL induces inflammatory responses in vascular smooth muscle cells via urokinase receptor association with CD36 and TLR4. J Mol Cell Cardiol. 2014;66:72–82. 10.1016/j.yjmcc.2013.11.005.
    • (2014) J Mol Cell Cardiol , vol.66 , pp. 72-82
    • Kiyan, Y.1    Tkachuk, S.2    Hilfiker-Kleiner, D.3    Haller, H.4    Fuhrman, B.5    Dumler, I.6
  • 78
    • 84908376176 scopus 로고    scopus 로고
    • Red blood cell, hemoglobin and heme in the progression of atherosclerosis
    • PID: 25324785
    • Jeney V, Balla G, Balla J. Red blood cell, hemoglobin and heme in the progression of atherosclerosis. Front Physiol. 2014;5:379. doi:10.3389/fphys.2014.00379.
    • (2014) Front Physiol , vol.5 , pp. 379
    • Jeney, V.1    Balla, G.2    Balla, J.3
  • 79
    • 26244463577 scopus 로고    scopus 로고
    • Atherosclerotic plaque progression and vulnerability to rupture: angiogenesis as a source of intraplaque hemorrhage
    • COI: 1:CAS:528:DC%2BD2MXhtVCltrvL, PID: 16037567
    • Virmani R, Kolodgie FD, Burke AP, et al. Atherosclerotic plaque progression and vulnerability to rupture: angiogenesis as a source of intraplaque hemorrhage. Arterioscler Thromb Vasc Biol. 2005;25(10):2054–61. doi:10.1161/01.ATV.0000178991.71605.18.
    • (2005) Arterioscler Thromb Vasc Biol , vol.25 , Issue.10 , pp. 2054-2061
    • Virmani, R.1    Kolodgie, F.D.2    Burke, A.P.3
  • 80
    • 67649207249 scopus 로고    scopus 로고
    • Hypoxia prolongs monocyte/macrophage survival and enhanced glycolysis is associated with their maturation under aerobic conditions
    • COI: 1:CAS:528:DC%2BD1MXmslCntLg%3D, PID: 19494322
    • Roiniotis J, Dinh H, Masendycz P, et al. Hypoxia prolongs monocyte/macrophage survival and enhanced glycolysis is associated with their maturation under aerobic conditions. J Immunol. 2009;182(12):7974–81. doi:10.4049/jimmunol.0804216.
    • (2009) J Immunol , vol.182 , Issue.12 , pp. 7974-7981
    • Roiniotis, J.1    Dinh, H.2    Masendycz, P.3
  • 81
    • 33748086766 scopus 로고    scopus 로고
    • ATP depletion in macrophages in the core of advanced rabbit atherosclerotic plaques in vivo
    • PID: 16405894
    • Leppanen O, Bjornheden T, Evaldsson M, Boren J, Wiklund O, Levin M. ATP depletion in macrophages in the core of advanced rabbit atherosclerotic plaques in vivo. Atherosclerosis. 2006;188(2):323–30. doi:10.1016/j.atherosclerosis.2005.11.017.
    • (2006) Atherosclerosis , vol.188 , Issue.2 , pp. 323-330
    • Leppanen, O.1    Bjornheden, T.2    Evaldsson, M.3    Boren, J.4    Wiklund, O.5    Levin, M.6
  • 82
    • 79958180641 scopus 로고    scopus 로고
    • Gene delivery of soluble vascular endothelial growth factor receptor-1 (sFlt-1) inhibits intra-plaque angiogenesis and suppresses development of atherosclerotic plaque
    • PID: 20821246
    • Wang Y, Zhou Y, He L, et al. Gene delivery of soluble vascular endothelial growth factor receptor-1 (sFlt-1) inhibits intra-plaque angiogenesis and suppresses development of atherosclerotic plaque. Clin Exp Med. 2011;11(2):113–21. doi:10.1007/s10238-010-0112-7.
    • (2011) Clin Exp Med , vol.11 , Issue.2 , pp. 113-121
    • Wang, Y.1    Zhou, Y.2    He, L.3
  • 83
    • 0033528660 scopus 로고    scopus 로고
    • Angiogenesis inhibitors endostatin or TNP-470 reduce intimal neovascularization and plaque growth in apolipoprotein E-deficient mice
    • COI: 1:CAS:528:DyaK1MXisFalsbg%3D, PID: 10190883
    • Moulton KS, Heller E, Konerding MA, Flynn E, Palinski W, Folkman J. Angiogenesis inhibitors endostatin or TNP-470 reduce intimal neovascularization and plaque growth in apolipoprotein E-deficient mice. Circulation. 1999;99(13):1726–32.
    • (1999) Circulation , vol.99 , Issue.13 , pp. 1726-1732
    • Moulton, K.S.1    Heller, E.2    Konerding, M.A.3    Flynn, E.4    Palinski, W.5    Folkman, J.6
  • 84
    • 84894669118 scopus 로고    scopus 로고
    • Panax notoginseng saponins inhibits atherosclerotic plaque angiogenesis by down-regulating vascular endothelial growth factor and nicotinamide adenine dinucleotide phosphate oxidase subunit 4 expression
    • Qiao Y, Zhang PJ, Lu XT, et al. Panax notoginseng saponins inhibits atherosclerotic plaque angiogenesis by down-regulating vascular endothelial growth factor and nicotinamide adenine dinucleotide phosphate oxidase subunit 4 expression. Chin J Integr Med. 2014. doi:10.1007/s11655-014-1832-4.
    • (2014) Chin J Integr Med
    • Qiao, Y.1    Zhang, P.J.2    Lu, X.T.3
  • 85
    • 67349273285 scopus 로고    scopus 로고
    • Vaccination against TIE2 reduces atherosclerosis
    • COI: 1:CAS:528:DC%2BD1MXmtl2lsbk%3D, PID: 19022447
    • Hauer AD, Habets KL, van Wanrooij EJ, et al. Vaccination against TIE2 reduces atherosclerosis. Atherosclerosis. 2009;204(2):365–71. doi:10.1016/j.atherosclerosis.2008.09.039.
    • (2009) Atherosclerosis , vol.204 , Issue.2 , pp. 365-371
    • Hauer, A.D.1    Habets, K.L.2    van Wanrooij, E.J.3
  • 86
    • 34548174479 scopus 로고    scopus 로고
    • Vaccination against VEGFR2 attenuates initiation and progression of atherosclerosis
    • COI: 1:CAS:528:DC%2BD2sXpt1CisrY%3D, PID: 17600223
    • Hauer AD, van Puijvelde GH, Peterse N, et al. Vaccination against VEGFR2 attenuates initiation and progression of atherosclerosis. Arterioscler Thromb Vasc Biol. 2007;27(9):2050–7. doi:10.1161/ATVBAHA.107.143743.
    • (2007) Arterioscler Thromb Vasc Biol , vol.27 , Issue.9 , pp. 2050-2057
    • Hauer, A.D.1    van Puijvelde, G.H.2    Peterse, N.3


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