Hypoxia is present in murine atherosclerotic plaques and has multiple adverse effects on macrophage lipid metabolism

Circulation Research

Volumn 109, Issue 10, 2011, Pages 1141-1152

  Parathath, Sajesh ^a   Mick, Stephanie L ^a   Feig, Jonathan E ^a   Joaquin, Victor ^a   Grauer, Lisa ^a   Habiel, David M ^a   Gassmann, Max ^b   Gardner, Lawrence B ^a   Fisher, Edward A ^a,c  

^a NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF ZURICH   (Switzerland)

^c UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

atherosclerosis; cholesterol efflux; hypoxia; macrophage; mouse; sterol synthesis

Indexed keywords

ABC TRANSPORTER A1; APOLIPOPROTEIN E; CHOLESTEROL; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE; HYPOXIA INDUCIBLE FACTOR 1ALPHA; MESSENGER RNA; STEROL; TRIACYLGLYCEROL;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; AORTA ATHEROSCLEROSIS; ARTICLE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; ENZYME ACTIVITY; GENE EXPRESSION; HYPOXIA; LASER CAPTURE MICRODISSECTION; LIPID METABOLISM; MACROPHAGE; MOUSE; NONHUMAN; PRIORITY JOURNAL; STEROL SYNTHESIS; WESTERN BLOTTING;

ANIMALS; ANOXIA; APOLIPOPROTEINS E; ATHEROSCLEROSIS; ATP-BINDING CASSETTE TRANSPORTERS; BIOLOGICAL TRANSPORT; CELL LINE; CHOLESTEROL; DISEASE MODELS, ANIMAL; GENE EXPRESSION REGULATION; HYDROXYMETHYLGLUTARYL COA REDUCTASES; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; LIPID METABOLISM; MACROPHAGES; MICE; MICE, KNOCKOUT; PLAQUE, ATHEROSCLEROTIC; RNA INTERFERENCE; RNA, MESSENGER; TRANSFECTION;

EID: 80255131449     PISSN: 00097330     EISSN: 15244571     Source Type: Journal    
DOI: 10.1161/CIRCRESAHA.111.246363     Document Type: Article

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