Normal and oxidized low density lipoproteins accumulate deep in physiologically thickened intima of human coronary arteries

Laboratory Investigation

Volumn 82, Issue 10, 2002, Pages 1437-1447

  Fukuchi, Mitsumasa ^a   Watanabe, Jun ^a   Kumagai, Koji ^a   Baba, Shigeo ^a   Shinozaki, Tsuyoshi ^a   Miura, Masahito ^a   Kagaya, Yutaka ^a   Shirato, Kunio ^a  

^a TOHOKU UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

8 ISOPROSTAGLANDIN F2 ALPHA; APOLIPOPROTEIN B100; COLLAGEN TYPE 1; COLLAGEN TYPE 2; DECORIN; LOW DENSITY LIPOPROTEIN; OXIDIZED LOW DENSITY LIPOPROTEIN; PROTEOGLYCAN; SUBSTANCE P;

APOPTOSIS; ARTERY INTIMA PROLIFERATION; ARTICLE; ATHEROGENESIS; CONTROLLED STUDY; CORONARY ARTERY; ELASTIC FIBER; EXTRACELLULAR MATRIX; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LIPID STORAGE; MACROPHAGE; PRIORITY JOURNAL; PROTEIN LOCALIZATION; VASCULAR ENDOTHELIUM; VASODILATATION;

EID: 0036798621     PISSN: 00236837     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.LAB.0000032546.01658.5D     Document Type: Article

References (47)

1. Adams CW and Bayliss OB (1969). The relationship between diffuse intimal thickening, medial enzyme failure and intimal lipid deposition in various human arteries. J Atheroscler Res 10:327-339.
2. Bachem MG, Wendelin D, Schneiderhan W, Haug C, Zorn U, Gross HJ, Schmid-Kotsas A, and Grünert A (1999). Depending on their concentration oxidized low density lipoproteins stimulate extracellular matrix synthesis or induce apoptosis in human coronary artery smooth muscle cells. Clin Chem Lab Med 37:319-326.
3. Bocan TM and Guyton JR (1985). Human aortic fibrolipid lesions: Progenitor lesions for fibrous plaques, exhibiting early formation of the cholesterol-rich core. Am J Pathol 120:193-206.
4. Brown MS and Goldstein JL (1986). A receptor-mediated pathway for cholesterol homeostasis. Science 232:34-47.
5. Chin JH, Azhar S, and Hoffman BB (1992). Inactivation of endothelial derived relaxing factor by oxidized lipoproteins. J Clin Invest 89:10-18.
6. Eggen DA and Solberg LA (1968). Variation of atherosclerosis with age. Lab Invest 18:571-579.
7. Fong LG, Parthasarathy S, Witztum JL, and Steinberg D (1987). Nonenzymatic oxidative cleavage of peptide bonds in apoprotein B-100. J Lipid Res 28:1466-1477.
8. Fukuchi M and Giaid A (1999). Endothelial expression of endothelial nitric oxide synthase and endothelin-1 in human coronary artery disease. Lab Invest 79:659-670.
9. Gavrieli Y, Sherman Y, and Ben-Sasson SA (1992). Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation. J Cell Biol 119:493-501.
10. 2 isoprostanes, are present in increased amounts in human atherosclerotic lesions. Arterioscler Thromb Vasc Biol 17:3236-3241.
11. Gordon D, Reidy MA, Benditt EP, and Schwartz SM (1990). Cell proliferation in human coronary arteries. Proc Natl Acad Sci USA 87:4600-4604.
12. Gown AM, Tsukada T, and Ross R (1986) Human atherosclerosis II immunocytochemical analysis of the cellular composition of human atherosclerotic lesions. Am J Pathol 125:191-207.
13. Guyton JR, Bocan TMA, and Schifani TA (1985) Quantitative ultrastructural analysis of perifibrous lipid and its association with elastin in nonatherosclerotic human aorta. Arteriosclerosis 5:644-652.
14. Guyton JR and Klemp KF (1994). Development of the atherosclerotic core region: Chemical and ultrastructural analysis of microdissected atherosclerotic lesions from human aorta. Arterioscler Thromb 14:1305-1314.
15. Ikari Y, McManus BM, Kenyon J, and Schwartz SM (1999). Neonatal intima formation in the human coronary artery. Arterioscler Thromb Vasc Biol 19:2036-2040.
16. Ishikawa Y, Ishii T, Akasaka Y, Masuda T, Strong JP, Zieske AW, Takei H, Malcom GT, Taniyama M, Choi-Miura NH, and Tomita M (2001). Immunolocalization of apolipoproteins in aortic atherosclerosis in American youths and young adults: Findings from the PDAY study. Atherosclerosis 158:215-225.
17. Jimi S, Saku K, Uesugi N, Sakata N, and Takebayashi S (1995). Oxidized low density lipoprotein stimulates collagen production in cultured arterial smooth muscle cells. Atherosclerosis 116:15-26.
18. Keitoku M, Okayama H, Satoh Y, Maruyama Y, and Takishima T (1990). Supersensitivity to histamine in early atherosclerotic human coronary arteries: Intimal thickening attenuates endothelium-dependent relaxation. J Appl Cardiol 5:101-114.
19. Kockx MM, De Meyer GR, Buyssens N, Knaapen MW, Bult H, and Herman AG (1998). Cell composition, replication, and apoptosis in atherosclerotic plaques after 6 months of cholesterol withdrawal. Circ Res 83:378-387.
20. Kovanen PT and Pentikäinen MO (1999). Decorin links low-density lipoproteins (LDL) to collagen: A novel mechanism for retention of LDL in the atherosclerotic plaque. Trends Cardiovasc Med 9:86-91.
21. 2- isoprostanes) in plasma and low density lipoprotein exposed to oxidative stress in vitro. J Clin Invest 93:998-1004.
22. 2α, is accumulated in coronary arteries isolated from patients with coronary heart disease. Cardiovasc Res 43:492-499.
23. Montenegro MR and Eggen DA (1968). Topography of atherosclerosis in the coronary arteries. Lab Invest 18:586-593.
24. 2- isoprostanes) are formed in situ on phospholipids. Proc Natl Acad Sci USA 89:10721-10725.
25. Napoli C, D'Armiento FP, Mancini FP, Postiglione A, Witztum JL, Palumbo G, and Palinski W (1997). Fatty streak formation occurs in human fetal aortas and is greatly enhanced by maternal hypercholesterolemia. J Clin Invest 100:2680-2690.
26. Neufeld HN, Wagenvoort CA, and Edwards JE (1962). Coronary arteries in fetuses, infants, juveniles, and young adults. Lab Invest 11:837-844.
27. Nielsen LB (1999). Atherogenicity of lipoprotein (a) and oxidized low density lipoprotein: Insight from in vivo studies of arterial wall influx, degradation and efflux. Atherosclerosis 143:229-243.
28. O'Brien KD, Olin KL, Alpers CE, Chiu W, Ferguson M, Hudkins K, Wight TN, and Chait A (1998). Comparison of apolipoprotein and proteoglycan deposits in human coronary atherosclerotic plaques. Circulation 98:519-527.
29. Pathobiological Determinants of Atherosclerosis in Youth (PDAY) Research Group (1993). Natural history of aortic and coronary atherosclerotic lesions in youth: Findings from the PDAY study. Arterioscler Thromb 13:1291-1298.
30. Pietilä K and Jaakkola O (1984). Effect of hypoxia on the synthesis of glycosaminoglycans and collagen by rabbit aortic smooth muscle cells in culture. Atherosclerosis 50:183-190.
31. Podet EJ, Shaffer DR, Gianturco SH, Bradley WA, Yang CY, and Guyton JR (1991). Interaction of low density lipoproteins with human aortic elastin. Arterioscler Thromb 11:116-122.
32. 2-isoprostanes in human atherosclerotic lesions. J Clin Invest 100:2028-2034.
33. Riessen R, Isner JM, Blessing E, Loushin C, Nikol S, and Wight TN (1994). Regional differences in the distribution of the proteoglycans biglycan and decorin in the extracellular matrix of atherosclerotic and restenotic human coronary arteries. Am J Pathol 144:962-974.
34. Ross R (1999). Atherosclerosis: An inflammatory disease. N Engl J Med 340:115-126.
35. Schwartz SM, deBlois D, and O'Brien ER (1995). The intima: Soil for atherosclerosis and restenosis. Circ Res 77:445-465.
36. Shiomi M, Ito T, Tsukada T, Yata T, Watanabe Y, Tsujita Y, Fukami M, Fukushige J, Hosokawa T, and Tamura A (1995). Reduction of serum cholesterol levels alters lesional composition of atherosclerotic plaques: Effect of pravastatin sodium on atherosclerosis in mature WHHL rabbits. Arterioscler Thromb Vasc Biol 15:1938-1944.
37. Sims FH (1989). A comparison of structural features of the walls of coronary arteries from 10 different species. Pathology 21:115-124.
38. Small DM, Bond MG, Waugh D, Prack M, and Sawyer JK (1984). Physicochemical and histological changes in the arterial wall of nonhuman primates during progression and regression of atherosclerosis. J Clin Invest 73:1590-1605.
39. Smith EB, Evans PH, and Downham MD (1967). Lipid in the aortic intima: The correlation of morphological and chemical characteristics. J Atheroscler Res 7:171-186.
40. Spring PM and Hoff HF (1989). LDL accumulation in the grossly normal human iliac bifurcation and common iliac arteries. Exp Mol Pathol 51:179-185.
41. Stary HC (1989). Evolution and progression of atherosclerotic lesions in coronary arteries of children and young adults. Arteriosclerosis (Suppl 19):119-132.
42. Stary HC, Blankenhorn DH, Chandler AB, Glagov S, Insull W Jr, Richardson M, Rosenfeld ME, Schaffer SA, Schwartz CJ, Wagner WD, and Wissler RW (1992). A definition of the intima of human arteries and of its atherosclerosis-prone regions: A report from the Committee on Vascular Lesions of the Council on Arteriosclerosis, American Heart Association. Arterioscler Thromb 12:120-134.
43. Steinberg D and Lewis A (1997). Oxidative modification of LDL and atherogenesis. Circulation 95:1062-1071.
44. Velican C and Velican D (1979). Some particular aspects of the microarchitecture of human coronary arteries. Atherosclerosis 33:191-200.
45. Williams KJ and Tabas I (1995) The response-to-retention hypothesis of early atherogenesis. Arterioscler Thromb Vasc Biol 15:551-561.
46. Wosu L, Parisella R, and Kalant N (1983). Effect of low density lipoprotein on glycosaminoglycan secretion by cultured human smooth muscle cells and fibroblasts: Influence of serum concentration and cell proliferation rate. Atherosclerosis 48:205-220.
47. Yamauchi Y and Hoff HF (1984). Apolipoprotein B accumulation and development of foam cell lesions in coronary arteries of hypercholesterolemic swine. Lab Invest 51:325-332.