Oxidized low-density lipoprotein stimulates macrophage 18F-FDG uptake via hypoxia-inducible factor-1α activation through Nox2-dependent reactive oxygen species generation

Journal of Nuclear Medicine

Volumn 55, Issue 10, 2014, Pages 1699-1705

  Lee, Su Jin ^a   Quach, Cung Hoa Thien ^b   Jung, Kyung Ho ^b   Paik, Jin Young ^b   Lee, Jin Hee ^b   Park, Jin Won ^b   Lee, Kyung Han ^b  

^a Ajou University School of Medicine   (South Korea)

^b Sungkyunkwan University School of Medicine   (South Korea)

Author keywords

18F FDG; HIF 1 ; Macrophage; Oxidized LDL; PET; Reactive oxygen species

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 2 MORPHOLINO 8 PHENYLCHROMONE; 4 (2 AMINOETHYL)BENZENESULFONYL FLUORIDE; 4 AMINO 7 TERT BUTYL 5 (4 CHLOROPHENYL)PYRAZOLO[3,4 D]PYRIMIDINE; ACETYLCYSTEINE; DIPHENYLIODONIUM SALT; FLUORODEOXYGLUCOSE F 18; GLUCOSE TRANSPORTER 1; HEXOKINASE; HYPOXIA INDUCIBLE FACTOR 1ALPHA; LACTIC ACID; LIPOPOLYSACCHARIDE; LOW DENSITY LIPOPROTEIN; OXIDIZED LOW DENSITY LIPOPROTEIN; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 2; SMALL INTERFERING RNA; CYBB PROTEIN, HUMAN; CYBB PROTEIN, MOUSE; HIF1A PROTEIN, HUMAN; HIF1A PROTEIN, MOUSE; MEMBRANE PROTEIN; RADIOPHARMACEUTICAL AGENT; SLC2A1 PROTEIN, HUMAN; SLC2A1 PROTEIN, MOUSE;

ANIMAL CELL; ARTICLE; BIOACCUMULATION; CONTROLLED STUDY; DRUG EFFECT; DRUG UPTAKE; ENZYME ACTIVITY; ENZYME INHIBITION; GENE SILENCING; GLUCOSE METABOLISM; GLYCOLYSIS; HUMAN; HUMAN CELL; MACROPHAGE; MOUSE; NONHUMAN; PERITONEUM MACROPHAGE; PROTEIN EXPRESSION; PROTEIN FUNCTION; ANIMAL; C57BL MOUSE; CELL LINE; CELL MEMBRANE; CHEMISTRY; DIAGNOSTIC USE; DISEASE COURSE; METABOLISM; SCINTISCANNING;

ANIMALS; CELL LINE; CELL MEMBRANE; DISEASE PROGRESSION; FLUORODEOXYGLUCOSE F18; GLUCOSE TRANSPORTER TYPE 1; HEXOKINASE; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; LACTIC ACID; LIPOPROTEINS, LDL; MACROPHAGES; MEMBRANE GLYCOPROTEINS; MICE; MICE, INBRED C57BL; NADPH OXIDASE; RADIOPHARMACEUTICALS; REACTIVE OXYGEN SPECIES;

EID: 84907535524     PISSN: 01615505     EISSN: 2159662X     Source Type: Journal    
DOI: 10.2967/jnumed.114.139428     Document Type: Article

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