Human health implications from co-exposure to aflatoxins and fumonisins in maize-based foods in Latin America: Guatemala as a case study

World Mycotoxin Journal

Volumn 8, Issue 2, 2015, Pages 143-159

  Torres, O ^a   Matute, J ^b   Gelineau Van Waes, J ^c   Maddox, J R ^c   Gregory, S G ^d   Ashley Koch, A E ^d   Showker, J L ^e   Voss, K A ^e   Riley, R T ^e  

^a Edificio Multimédica Oficina 1009 Laboratorio Diagnóstico Molecular S A   (Guatemala)

^b Centro de Investigaciones en Nutrición y Salud   (Guatemala)

^c CREIGHTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d DUKE UNIVERSITY MEDICAL CENTER   (United States)

^e RUSSELL RESEARCH CENTER   (United States)

Author keywords

Aflatoxin; Corn; Fumonisin; Hepatocellular toxicity; Maize; Nixtamalization

Indexed keywords

AFLATOXIN B1; BIOLOGICAL MARKER; FUMONISIN B1; SPHINGOLIPID;

ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; BIOSYNTHESIS; CARCINOGENICITY; CELL PROLIFERATION; FOOD INTAKE; GUATEMALA; HEALTH HAZARD; HUMAN; LIVER TOXICITY; MAIZE; MEXICO; MOUSE; NONHUMAN; RABBIT; RAINBOW TROUT; RAT; REVIEW; SIGNAL TRANSDUCTION; SOUTH AND CENTRAL AMERICA;

ANIMALIA; ONCORHYNCHUS MYKISS; RATTUS; ZEA MAYS;

EID: 84928343699     PISSN: 18750710     EISSN: 18750796     Source Type: Journal    
DOI: 10.3920/WMJ2014.1736     Document Type: Review

References (84)

1. Abbas, H.K., Mirocha, C.J., Rosiles, R. and Carvajal, M., 1988. Effect of tortilla preparation process on aflatoxin B1 and B2 in corn. Mycotoxin Research 4: 33-36.
2. Abbott, R., 2013. 2013 harvest hit hard by mycotoxin contamination. AllAboutFeed Magazine 21(10): 9-10.
3. Alvarez-Muñoz, T., Bustamante-Calvillo, E., Matinez-Garcia, C., Moreno-Altamirando, L., Guiscafre-Gallardo, H., Guiscafre, J.P. and Muñoz, O., 1989. Seroepidemiology of the hepatitis B and delta in the Southeast of Chiapas, Mexico. Archivos de Investigacion Medica (Mexico) 20: 189-195.
4. Amra, H.A., Aboul Enein, A., Ragab, A.A., Ayesh, A.M. and Mohamed, M.I., 2003. Effect of tortilla processing on fumonisin B1 destruction. Toxicology Letters 144 Suppl. 1: S62.
5. Anguiano-Ruvalcaba, G.L., Vervary Vargas-Cortina, A. and Guzmán-De Peña, D., 2005. Inactivation of aflatoxin B1 and aflatoxicol through traditional 'nixtamalización' of corn and their regeneration by acidification of corn dough. Salud Publica de México 47: 369-375.
6. Arriola, M.C., Porres, E., De Cabrera, S., De Zepeda, M. and Rolz, C., 1988. Aflatoxin fate during alkaline cooking of corn for tortilla preparation. Journal of Agricultural and Food Chemistry 36: 530-533.
7. Bressani, R., 1990. Chemistry, technology and nutritive value of maize tortillas. Food Reviews International 6: 225-264.
8. Bulder, A.S., Arcella, D., Bolger, M., Carrington, C., Kpodo, K., Resnik, S., Riley, R.T., Wolterink, G. and Wu, F., 2012. Fumonisins. In: Safety evaluation of certain food additives and contaminants. Seventy-fourth meeting of the Joint FAO/WHO Expert Committee on Food Additives (JECFA). WHO Food Additives Series No. 65. World Health Organization (WHO), Geneva, Switzerland, pp. 325-527.
9. Burns, T.D., Snook, M.E., Riley, R.T. and Voss, K.A., 2008. Fumonisin concentrations and in vivo toxicity of nixtamalized Fusarium verticillioides culture material: evidence for fumonisin-matrix interactions. Food and Chemical Toxicology 46: 2841-2848.
10. Caceres, A., Casaola, L., Valdez, O.I., Castillo, G. and Samayoa, E.A., 1982. Immunological diagnosis of hepatitis B viral infection in susceptible Guatemalan patients. Revista Latinoamericana de Microbiologia 24: 185-192.
11. Carlson, D.B., Williams, D.E., Spitsbergen, J.M., Ross, P.F., Bacon, C.W., Meredith, F.I. and Riley, R.T., 2001. Fumonisin B1 promotes aflatoxin B1 and n-methyl-n'-nitro-nitrosoguanidine-initiated liver tumors in rainbow trout. Toxicology and Applied Pharmacology 172: 29-36.
12. Casado, J.M., Theumer, M., Masih, D.T., Chulze, S. and Rubenstein, H.R., 2001. Experimental subchronic mycotoxicoses in mice: individual and combined effects of dietary exposure to fumonisins and aflatoxin B1. Food and Chemical Toxicology 39: 579-586.
13. Dall'Asta, C., Mangia, M., Berthiller, F., Molinelli, A., Sulyok, M., Schuhmacher, R., Krska, R., Galaverna, G., Dossena, A. and Marchelli, R., 2009. Difficulties in fumonisin determination: the issue of hidden fumonisins. Analytical and Bioanalytical Chemistry 395: 1335-1345.
14. De la Campa, R., Miller, J.D. and Hendricks, K. 2004. Fumonisin in tortillas produced in small scale facilities and effect of traditional masa production methods on this mycotoxin. Journal of Agricultural and Food Chemistry 52: 4432-4437.
15. Dilkin, P., Zorzete, P., Mallmann, C.A., Gomes, J.D.F., Utiyama, C.E., Oetting, L.L. and Corrêa, B., 2003. Toxicological effects of chronic low doses of aflatoxin B1 and fumonisin B1-containing Fusarium moniliforme culture material in weaned piglets. Food and Chemical Toxicology 41: 1345-1353.
16. Dombrink-Kurtzman, M.A., Dvorak, T.J., Barron, M.E. and Rooney, L.W., 2000. Effect of nixtamalization (alkaline cooking) on fumonisin-contaminated corn for production of masa and tortillas. Journal of Agricultural and Food Chemistry 48: 5781-5786.
17. Dragan, Y.P., Bidlack, W.R., Cohen, S.M., Goldsworthy, T.L., Hard, G.C., Howard, P.C., Riley, R.T. and Voss, K.A., 2001. Implications of apoptosis for toxicity, carcinogenicity and risk assessment: fumonisin B1 as an example. Toxicological Sciences 61: 6-17.
18. Eaton, D.L., Beima, K.M., Bammler, T.K., Riley, R.T. and Voss, K.A., 2010. Hepatic mycotoxins. In: Roth, R.A. and Ganey, P.E. (eds.) Comprehensive toxicology. Elsevier, New York, NY, USA, pp. 527-569.
19. Elias-Orozco, R., Castellanos-Nava, A., Gaytan-Martínez, M., Figueroa-Cardenas, J.D. and Loarca-Piña, G., 2002. Comparison of nixtamalization and extrusion processes for a reduction in aflatoxin content. Food Additives and Contaminants 19: 878-885.
20. Food and Agriculture Organization (FAO), 2013. FAOSTAT Food Balance Sheets. Available at: http://faostat3.fao.org/faostat-gateway/go/to/download/FB/∗/E.
21. Fuentes-López, M.R., Van Etten, J., Vivero Pol, J.L. and Ortega Aparicio, A., 2005. Maíz para Guatemala: Propuesta para la Reactivación de la Cadena Agroalimentaria del Maíz Blanco y Amarillo, SERIE 'PESA Investigación', no 1, FAO Guatemala, Guatemala. Available at: http://www.pesacentroamerica.org/biblioteca/02-Maiz-para-%20Guatemala.pdf.
22. Gelderblom, W.C.A., Jaskiewicz, K., Marasas, W.F.O., Thiel, P.G., Horak, R.M., Vleggaar, R., and Kriek, N.P., 1988. Fumonisins-Novel mycotoxins with cancer-promoting activity produced by Fusarium moniliforme. Applied and Environmental Microbiology 54: 1806-1811.
23. Gelderblom, W.C.A., Marasas, W.F.O., Lebepe-Mazure, S., Swanevelder, S., Vessey, C.J. and De la M Hall, P., 2002. Interaction of fumonisin B1 and aflatoxin B1 in a short-term carcinogenesis model in rat liver. Toxicology 171: 161-173.
24. Gelineau-Van Waes J., Rainey, M.A., Maddox, J.R., Voss, K.A., Sachs, A.J., Gardner, N.M., Wilberding, J.D. and Riley, R.T., 2012. Increased sphingoid base-1-phosphates and failure of neural tube closure after exposure tofumonisin or FTY720. Birth Defects Research Part A 94: 790-803.
25. Gelineau-Van Waes J., Starr, L., Maddox, J.R., Aleman, F., Voss, K.A., Wilberding, J. and Riley, R.T., 2005. Maternal fumonisin exposure and risk for neural tube defects: disruption of sphingolipid metabolism and folate transport in an in vivo mouse model. Birth Defects Research Part A 73: 487-497.
26. Gong, Y.Y., Torres-Sanchez, L., Lopez-Carrillo, L., Jian, H.P., Sutcliffe, A.E., White, K.L., Humpf, H.U., Turner, P.C. and Wild, C.P., 2008. Association between tortilla consumption and human urinary fumonisin B1 levels in a Mexican population. Cancer Epidemiology Biomarkers and Prevention 17: 688-694.
27. González, M., 2001. Transmision vertical de los virus de hepatitis B y C en Guatemala. Financiamiento Fondo para el Desarrollo Científico y Tecnológico, Reporte FODECYT 99-84.
28. Goss, P.E., Lee, B.L., Badovinac-Crnjevic, T., Strasser-Weippl, K., Chavarri-Guerra, Y., St Louis, J., Villarreal-Garza, C., Unger-Saldaña, K., Ferreyra, M., Debiasi, M., Liedke, P.E.R., Touya, D., Werutsky, G., Higgins, M., Fan, L., Vasconcelos, C., Cazap, E., Vallejos, C., Mohar, A., Knaul, F., Arreola, H., Batura, R., Luciani, S., Sullivan, R., Finkelstein, D., Simon, S., Barrios, C., Kightlinger, R., Gelrud, A., Bychkovsky, V., Lopes, G., Stefani, S., Blaya, M., Hahn Souza, F., Santos, F.S., Kaemmerer, A., De Azambuja, E., Zorilla, A.F.C., Murillo, R., Jeronimo, J., Tsu, V., Carvalho, A., Gil, C.F., Sternberg, C., Dueñas-Gonzalez, A., Sgroi, D., Cuello, M., Fresco, R., Reis, R.M., Masera, G., Gabús, R., Ribeiro, R., Knust, R., Ismael, G., Rosenblatt, E., Roth, B., Villa, L., Solares, A.L., Leon, M.X., Torres-Vigil, I., Covarrubias-Gomez, A., Hernández, A., Bertolino, M., Schwartsmann, G., Santillana, S., Esteva, F., Fein, L., Mano, M., Gomez, H., Hurlbert, M., Durstine, A. and Azenha, G., 2013. Planning cancer control in Latin America and the Caribbean. Lancet Oncology 14: 391-436.
29. Groopman, J.D., Johnson, D. and Kensler, T.W., 2005. Aflatoxin and hepatitis B virus biomarkers: a paradigm for complex environmental exposures and cancer risk. Cancer Biomarkers 1: 5-14.
30. Groopman, J.D., Kensler, T.W. and Wild, C.P., 2008. Aflatoxin, hepatitis B virus and liver cancer: a paradigm for molecular epidemiology. In: Wild, C., Vineis, P. and Garte, S. (eds.) Molecular epidemiology of chronic disease. John Wiley and Sons, Hoboken, NJ, USA, pp. 323-342.
31. Guzman de Peña, D., Trudel, L. and Wogen G.N., 1995. Corn nixtamalization and the fate of radiolabelled aflatoxin B1 in the tortilla making process. Bulletin of Environmental Toxicology 55: 858-864.
32. Howard, P.C., Couch, L.H., Patton, R.E., Eppley, R.M., Doerge, D.R., Churchwell, M.I., Marques, M.M. and Okerberg, C.V., 2002. Comparison study of the toxicity of several fumonisin derivatives in a 28-day feeding study with female B6C3F1 mice. Toxicology and Applied Pharmacology 185: 153-165.
33. International Agency for Research on Cancer (IARC), 2002. Some traditional herbal medicines, some mycotoxins, naphthalene and styrene, Volume 82. Working group on the evaluation of carcinogenic risk to humans. IARC Press, Lyon, France, pp. 301-366.
34. International Agency for Research on Cancer (IARC), 2012. GLOBOCAN 2012: estimated cancer incidence, mortality and prevalence worldwide in 2012. The Global Cancer Atlas. Available at: http://globocan.iarc.fr/ia/TheAmericas/atlas.html.
35. Kensler, T.W., Roebuck, B.D., Wogan, G.N. and Groopman, J.D., 2011. Aflatoxin: a 50-year odyssey of mechanistic and translational toxicology. Toxicological Sciences 120: S28-S48.
36. Kershenobich, D., Razavi, H.A., Sánchez-Avila, J.F., Bessone, F., Coelho, H.S., Dagher, L., Gonçales, F.L., Quiroz, J.F., Rodriguez-Perez, F., Rosado, B., Wallace, C., Negro, F. and Silva, M., 2011. Trends and projections of hepatitis C virus epidemiology in Latin America. Liver International 31(2): 18-29.
37. Kimanya, M.E., De Meulenaer, B., Roberfroid, D., Lachat, C. and Kolsteren, P., 2010. Fumonisin exposure through maize in complementary foods is inversely associated with linear growth of infants in Tanzania. Molecular Nutrition and Food Research 54: 1659-1667.
38. Kitatani, K. and Luberto, L., 2010. Introduction to tools and techniques for ceramide-centered research. In: Chalfant, C. and Del Poeta, M. (eds.) Sphingolipids as signalling and regulatory molecules. Landes Bioscience, New York, NY, USA, pp. 276-285.
39. Kuniholm, M.H., Lesi, O.A., Mendy, M., Akano, A.O., Sam, O., Hall, A.J., Whittle, H., Bah, E., Goedert, J.J., Hainaut, P. and Kirk, G.D., 2008. Aflatoxin exposure and viral hepatitis in the etiology of liver cirrhosis in the Gambia, West Africa. Environmental Health Perspectives 116: 1553-1557.
40. Liu, Y. and Wu, F., 2010. Global burden of aflatoxin-induced hepatocellular carcinoma: a risk assessment. Environmental Health Perspectives 118: 818-824.
41. Marasas, W.F.O., Riley, R.T., Hendricks, K.A., Stevens, V.L., Sadler, T.W., Gelineau-Van Waes J., Missmer, S.A., Cabrera, J., Torres, O., Gelderblom, W.C.A., Allegood, J., Martínez, C., Maddox, J., Miller, J.D., Starr, L., Sullards, M.C., Roman, A.V., Voss, K.A., Wang, E. and Merrill, Jr., A.H., 2004. Fumonisins disrupt sphingolipid metabolism, folate transport, and neural tube development in embryo culture and in vivo: a potential risk factor for human neural tube defects among populations consuming fumonisin-contaminated maize. Journal of Nutrition 134: 711-716.
42. Martínez, M.L., Elias, L.G., Rodriguez, J.F., Jarquin, R. and Bressani, R., 1970. Valor nutritivo del maíz infectado con hongos en pollos y de tortilla de maíz fungoso en rates. Archivos Latinoamericas de Nutrición 20: 217-240.
43. McKean, C., Tang, L., Tang, M., Bollam, M., Wang, Z., Theodorakis, C.W., Kendall, R.J. and Wang, J.S., 2006. Comparative acute and combinative toxicity of aflatoxin B1 and fumonisin B1 in animals and human cells. Food and Chemical Toxicology 44: 868-876.
44. Mèndez-Albores, J.A., Arámbula-Villa, G., Loarca-Piña, M.G., González-Hernándex, J. Castaño-Tostado, E. and Moreno-Martínez, E., 2004a. Aflatoxins' fate during the nixtamalization of contaminated maize by two tortilla-making processes. Journal of Stored Products Research 40: 87-94.
45. Mèndez-Albores, J.A., Villa, G.A., Del Rio-García, J.C. and Martínez, E.M., 2004b. Aflatoxin-detoxification achieved with Mexican traditional nixtamalization process (MTNP) is reversible. Journal of the Science of Food and Agriculture 84: 1611-1614.
46. Mora, M. and Lacey, J., 1997. Handling and aflatoxin contamination of white maize in Costa Rica. Mycopathologia 138: 77-89.
47. Navas, M.C., Suarez, I., Carreño, A., Uribe, D., Rios, W.A., Cortes-Mancera, F., Martel, G., Vieco, B., Lozano, D., Jimenez, C., Gouas, D., Osorio, G., Hoyos, S., Restrepo, J.C., Correa, G., Jaramillo, S., Lopez, R., Bravo, L.E., Arbelaez, M.P., Scoazec, J.Y, Abedi-Ardekani, B., Santella, R.M., Chemin, I. and Hainaut, P., 2011. Hepatitis B and hepatitis C infection biomarkers and TP53 mutations in hepatocellular carcinomas from Colombia. Hepatitis Research and Treatment 2011: 582945.
48. Nogueira, J.A., Ono-Nita, S.K., Nita, M.E., De Souza, M.M.T., Do Carmo, E.P., Mello, E.S. and Scapulatempo, C., 2009. 249 TP53 mutation has high prevalence and is correlated with larger and poorly differentiated HCC in Brazilian patients. BMC Cancer 9: 204.
49. Orsi, R.B., Oliveira, C.A.F., Dilkin, P., Xavier, J.G., Direito, G.M. and Corrêa, B., 2007. Effects of oral administration of aflatoxin B1 and fumonisin B1 in rabbits (Oryctolagus cuniculus). Chemico-Biological Interactions 170: 201-208.
50. Palencia, E., Torres, O., Hagler, W., Meredith, F.I., Williams, L.D. and Riley, R.T., 2003. Total fumonisins are reduced in tortillas using the traditional nixtamalization method of Mayan communities. Journal of Nutrition 133: 3200-3203.
51. Pan American Health Organization (PAHO), 2010. Health information and analysis project. Regional core health data initiative. Regional Office of the World Health Organization (WHO), Washington, DC, USA. Available at: http://tinyurl.com/lcf2g2u.
52. Pan American Health Organization (PAHO), 2013. Supply of blood for transfusion in Latin American and Caribbean countries 2010 and 2011. Regional Office of the World Health Organization (WHO), Washington, DC, USA. Available at: http://tinyurl.com/n7dr44k.
53. Pewzner-Jung, Y., Brenner, O., Braunn, S., Laviad, E.L., Ben-Dor, S., Feldmesser, E., Horn-Saban, S., Amann-Zalcenstein, D., Raanan, C., Berkutzki, T., Erez-Roman, R., Ben-David, O., Levy, M., Holzman, D., Park, H., Nyska, A., Merrill, A.H. and Futerman, A.H., 2010. A critical role for ceramide synthase 2 in liver homeostasis: II. Insights into molecular changes leading to hepatopathy. Journal of Biological Chemistry 285: 10911-10923.
54. Pitt, J.I., Wild, C.P., Bann, R.A., Gelderblom, W.C.A., Miller, J.D., Riley, R.T. and Wu, F., 2012. Improving public health through mycotoxin control. International Agency for Research on Cancer, Lyon, France. IARC Science Publication No. 156, 151 pp.
55. Plasencia, J. 2005. Aflatoxins in maize: a Mexican perspective. In: Abbas, H.K. (ed.) Aflatoxin and food safety. Taylor and Francis, Boca Raton, FL, USA, pp. 59-75.
56. Price R.L. and Jorgensen, K.V., 1985. Effects of processing on aflatoxin levels and mutagenic potential of tortillas made from naturally contaminated corn. Journal of Food Science 50: 347-357.
57. Probst, C., Bandyopadhyay, R. and Cotty, P.J., 2014. Diversity of aflatoxin-producing fungi and their impact on food safety in sub-Saharan Africa. International Journal of Food Microbiology 174: 113-122.
58. Probst, C., Njapau, H. and Cotty, P.J., 2007. Outbreak of an acute aflatoxicosis in Kenya in 2004: identification of the causal agent. Applied and Environmental Microbiology 73: 2762-2764.
59. Reurings, M., Vossenaar, M., Doak, C.M. and Solomons, N.W., 2013. Stunting rates in infants and toddlers born in metropolitan Quetzaltenango, Guatemala. Nutrition 29: 655-660.
60. Riley, R.T. and Voss, K.A., 2006. Differential sensitivity of rat kidney and liver to fumonisin toxicity: Organ specific differences in toxin accumulation and sphingoid base metabolism. Toxicological Sciences 92: 335-345.
61. Riley, R.T., Torres, O., Showker, J.L., Zitomer, N.C., Matute, J., Voss, K.A., Gelineau-Van Waes J., Maddox, J.R., Gregory, S.G. and Ashley-Koch, A.E., 2012a. The kinetics of urinary fumonisin B1 excretion in humans consuming maize-based diets. Molecular Nutrition and Food Research 56: 1445-1455.
62. Riley, R.T., Voss, K.A., Showker, J.L., Torres, O., Matute, J., Maddox, J.R., Rainey, M.A., Gardner, N.M., Sachs, A., Gregory, S.G., Ashley-Koch, A.E., Krupp, D. and Gelineau-Van Waes, J., 2012b. Development of biomarkers to assess fumonisin exposure and birth defects. In: Binder, E.M. (ed.) Proceedings of the World Nutrition Forum. October 10-13, 2012. Anytime Publishing, Leicestershire, UK, pp. 249-256.
63. Rodrigues, I. and Naehrer, K., 2013. Mycotoxin survey report 2012 (part II). AllAboutFeed Magazine 21(4): 14-15.
64. Roman, S., Fierro, N.A., Moreno-Luna, L.E. and Panduro, A., 2013. Hepatitis B virus genotype H and environmental factors associated to the low prevalence of hepatocellular carcinoma in Mexico. Journal of Cancer Therapy 4: 367-376.
65. Shirima, C.P., Kimanya, M.E., Kinabo, J.L., Routledge, M.N., Srey, C., Wild, C.P. and Gong, Y.Y., 2013. Dietary exposure to aflatoxin and fumonisin among Tanzanian children as determined using biomarkers of exposure. Molecular Nutrition and Food Research 57: 1874-1881.
66. Soini, Y., Chia, S.C., Bennett, W.P., Groopman, J.D., Wang, J.S., DeBenedetti, V.M., Cawley, H., Welsh, J.A., Hansen, C., Bergasa, N.V., Jones, E.A., DiBisceglie, A.M., Trivers, G.E., Sandoval, C.A., Calderone, I.E., Espinoza, L.E. and Harris, C.C., 1996. An aflatoxin-associated mutational hotspot at codon 249 in the p53 tumor suppressor gene occurs in hepatocellular carcinoma from Mexico. Carcinogenesis 17(5): 1007-1012.
67. Stevens, V.L. and Tang, J., 1997. Fumonisin B1-induced sphingolipid depletion inhibits vitamin uptake via the glycosylphosphatidylinositol-anchored folate receptor. Journal of Biological Chemistry 272: 18020-18025.
68. Theise, N.D. 2014. Liver cancer. In: Stewart, B.W. and Wild, C.P. (eds.) World Cancer Report 2014. International Agency for Research on Cancer, Lyon, France, pp. 575-588.
69. Theumer, M.G., López, A.G., Aoki, M.P., Cánepa, M.C. and Rubenstein, H.R., 2008. Subchronic mycotoxicoses in rats. Histopathologcal changes and modulation of the sphinganine to sphingosine (Sa/ So) ratio imbalance induced by Fusarium verticillioides culture material, due to the coexistence of aflatoxin B1 in the diet. Food and Chemical Toxicology 46: 967-977.
70. Torres, O., Matute, J., Gelineau-Van Waes J., Maddox, J.R., Gregory, S.G., Ashley-Koch, A.E., Showker, J.L., Zitomer, N.C., Voss, K.A. and Riley, R.T., 2014. Urinary fumonisin B1 and estimated fumonisin intake in women from high and low exposure communities in Guatemala. Molecular Nutrition and Food Research 58: 973-983.
71. Torres, O., Palencia, E., Lopez de Pratdesaba, L., Grajeda, R., Fuentes, M., Speer, M., Merrill, J.r., A.H., O'Donnell, K., Bacon, C.W., Glenn, A.E. and Riley, R.T., 2007. Estimated fumonisin exposure in Guatemala is greatest in consumers of lowland maize. Journal of Nutrition 137: 2723-2729.
72. Torres, P, Guzmán-Ortiz, M. and Ramírez-Wong, B., 2001. Revising the role of pH and thermal treatments in aflatoxin content reduction during the tortilla and deep frying process. Journal of Agricultural and Food Chemistry 49: 2825-2829.
73. Torres-Espinoza, E., Askar-Acuña, K., Naccha-Torres, L.R., Montoya-Olvera, R. and Castellon-Santa Anna, J.P., 1995. Quantification of aflatoxin in corn distributed in the city of Monterrey, Mexico. Food Additives and Contaminants 12: 383-386.
74. Torres-Poveda, K., Burguete-García, A.I. and Madrid-Marina, V., 2011. Liver cirrhosis and hepatocellular carcinoma in Mexico: impact of chronic infection by hepatitis viruses B and C. Annals of Hepatology 10: 556-558.
75. Turner, P.C., 2013. The molecular epidemiology of chronic aflatoxin driven impaired child growth. Scientifica 2013: 152879.
76. Turner, P.C., Moore, S.E., Hall, A.J., Prentice, A.M. and Wild, C.P., 2003. Modification of immune function through exposure to dietary aflatoxin in Gambian children. Environmental Health Perspectives 111: 217-220.
77. Voss, K.A. and Riley, R.T., 2013. Fumonisin toxicity and mechanism of action: overview and current perspectives. Food Safety 1: 49-69.
78. Voss, K.A., Norred, W.P., Meredith, F.I., Riley, R.T. and Saunders, D.S., 2006. Fumonisin concentration and ceramide synthase inhibitory activity of corn, masa and tortilla chips. Journal of Toxicology and Environmental Health Part A 69: 1387-1397.
79. Voss, K.A., Poling, S.M., Meredith, F.I., Bacon, C.W. and Saunders, D.S., 2001. Fate of fumonisins during the production of fried tortilla chips. Journal of Agricultural and Food Chemistry 49: 3120-3126.
80. Voss, K.A., Riley, R.T., Moore, N.D. and Burns, T.D., 2013. Alkaline cooking (nixtamalization) reduced the in vivo toxicity of fumonisin-contaminated corn in a rat feeding bioassay. Food Additives and Contaminants Part A 30: 1415-1421.
81. Voss, K.A., Riley, R.T., Snook, M.E. and Gelineau-Van Waes, J., 2009. Comparing the reproductive and sphingolipid metabolic effects of fumonisin B1 and its alkaline hydrolysis product in LM/Bc mice: hydrolyzed fumonisin B1 did not cause neural tube defects. Toxicological Sciences 112: 459-467.
82. Wang, E., Norred, W.P., Bacon, C.W., Riley, R.T. and Merrill, JR., A.H., 1991. Inhibition of sphingolipid biosynthesis by fumonisins: Implications for diseases associated with Fusarium moniliforme. Journal of Biological Chemistry 266: 14486-14490.
83. Watterson, K., Sankala, H., Milstein, S. and Spiegel, S., 2003. Pleiotropic actions of sphingosine-1-phosphate. Progress in Lipid Research 42: 1789-1799.
84. Zitomer, N.C., Mitchell, T., Voss, K.A., Bondy, G.S., Pruett, S.T., Garnier-Amblard, E.C., Liebeskind, L.S., Park, H., Wang, E., Sullards, M.C., Merrill, JR., A.H. and Riley, R.T., 2009. Ceramide synthase inhibition by fumonisin B1 causes accumulation of 1-deoxy-sphinganine: a novel category of bioactive 1-deoxy-sphingoid bases and 1-deoxy-dihydroceramides biosynthesized by mammalian cell lines and animals. Journal of Biological Chemistry 284: 4786-4795.