Effects of oral administration of aflatoxin B1 and fumonisin B1 in rabbits (Oryctolagus cuniculus)

Chemico-Biological Interactions

Volumn 170, Issue 3, 2007, Pages 201-208

  Orsi, R B ^a   Oliveira, C A F ^a   Dilkin, P ^a   Xavier, J G ^b   Direito, G M ^c   Correa B ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

^b UNIVERSIDADE METODISTA DE SÃO PAULO   (Brazil)

^c FEDERAL RURAL UNIVERSITY OF RIO DE JANEIRO   (Brazil)

Author keywords

Aflatoxin B1; Fumonisin B1; Interaction; Mycotoxins; Oral administration; Rabbits; Sphingolipids

Indexed keywords

AFLATOXIN B1; CREATININE; FUMONISIN B1; SPHINGOLIPID; UREA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHEMICAL ANALYSIS; CONTROLLED STUDY; CREATININE BLOOD LEVEL; HISTOPATHOLOGY; INTOXICATION; KIDNEY INJURY; KIDNEY MASS; LIVER FUNCTION; LIVER INJURY; LIVER WEIGHT; LONG TERM CARE; MALE; NONHUMAN; PATHOLOGY; RABBIT; UREA BLOOD LEVEL; WEIGHT GAIN;

ADMINISTRATION, ORAL; AFLATOXIN B1; ANIMALS; BODY WEIGHT; FUMONISINS; MALE; ORGAN SIZE; RABBITS; SPHINGOLIPIDS; SPHINGOSINE;

ANIMALIA; ORYCTOLAGUS CUNICULUS;

EID: 36049028075     PISSN: 00092797     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cbi.2007.08.002     Document Type: Article

References (43)

1. Shephard G.S., Tiel P.G., Stockenstrom S., and Sydenham E.W. Wordwide survey of fumonisin contamination of corn and corn-based products. J. AOAC 79 (1996) 671-687
2. Cawood M.E., Gelderblom W.C.A., Vleggaar R., Berhend Y., Tiel P.G., and Marasas W.F.O. Isolation of the fumonisin mycotoxins: a quantitative approach. J. Agric. Food Chem. 39 (1991) 1958-1962
3. Merril A.H., Liota D.C., and Riley R.T. Fumonisins: fungal toxins that shed light on sphingolipid function. Trends Cell Biol. 6 (1996) 218-223
4. Jaskiewicz K., Van Renaburg S.J., Marasas W.F.O., and Gelderblom W.C.A. Carcinogenicity of Fusarium moniliforme culture material in rats. J. Natl. Cancer Inst. 78 (1987) 321-325
5. 1. Onderstepoort J. Vet. 57 (1990) 269-275
6. Ledoux D.R., Brown T.P., Weibking T.S., and Rottinghaus G.E. Fumonisin toxicity in broiler chicks. J. Vet. Diagn. Invest. 4 (1992) 330-333
7. 1. Nat. Toxins 1 (1993) 222-228
8. 1-containing Fusarium moniliforme culture material in weaned piglets. Food Chem. Toxicol. 41 (2003) 1345-1353
9. 1. Nat. Toxins 4 (1996) 51-52
10. Bucci T.J., Howard P.C., Tolleson W.H., LaBorde J.B., and Hansen D.K. Renal effects of fumonisin mycotoxins in animals. Toxicol. Pathol. 26 (1998) 160-164
11. 1 in rabbits: nephrotoxicity and sphingolipid alterations. Nat. Toxins 3 (1995) 395-403
12. Rheeder J.P., Marasas W.F.O., and Thiel P.G. Fusarium moniliforme and fumonisins in corn in relation to human esophageal cancer in Transkei. Phytopathology 82 (1992) 253-257
13. 2 and Fusarin C (Group 2B), Monographs on the Evaluation of Carcinogenic Risks to Humans, vol. 56, IARC, Lyon, 445 pp.
14. Smith J.E., and Moss M.O. Mycotoxins: Formation, Analysis and Significance (1985), John Wiley & Sons, Chichester p. 240
15. International Agency for Research on Cancer (IARC), Aflatoxins: Occurring Aflatoxins (Group 1), Aflatoxin M1 (Group 2B), vol. 56, IARC Scientific Publications, Lyon, 1993b, 445 pp.
16. Neal G.E. Participation of animal biotransformation in mycotoxin toxicity. Rev. Méd. Vét. 149 (1998) 555-560
17. Casado J.M., Theumer M., Masih D.T., Schulze S., and Rubinstein H.R. Experimental subchronic mycotoxicoses in mice: individual and combined effects of dietary exposure to fumonisis and aflatoxin B1. Food Chem. Toxicol. 39 (2001) 579-586
18. 1 and aflatoxin in a short-term carcinogenesis model in rat liver. Toxicology 171 (2002) 161-173
19. McKean C., Tang L., Tang M., Billam M., Wang Z., Theodorakis C.W., Kendall R.J., and Wang J.S. Comparative acute and combinative toxicity of aflatoxin B1 and fumonisin B1 in animals and human cells. Food Chem. Toxicol. 44 (2006) 868-876
20. 1 and N-methyl-N′-nitro-nitrosoguanidine-initiated liver tumors in Rainbow Trout. Toxicol. Appl. Pharmacol. 172 (2001) 29-36
21. 1 in Laying Japanese Quail. Poult. Sci. 83 (2004) 1953-1958
22. Soares L.M.V., and Rodrigues D.B. Survey of aflatoxins, ochratoxins A, zearalenone and sterigmatocystin in some Brazilian foods by using multitoxin thin layer chromatographic method. J. AOAC 72 (1989) 22-26
23. 3 in corn: AOAC-IUPAC collaborative study. J. AOAC 79 (1996) 688-696
24. Riley R.T., Wang E., and Merril Jr. A.H. Liquid chromatographic determination of sphinganine and sphingosine: use of the free sphinganine-to sphingosine ratio as a biomarker for consumption of fumonisinas. J. AOAC Int. 77 (1994) 533-540
25. Castegnaro M., Garren L., Galendo D., Gelderblom W.C.A., Chelule P., Dutton M.F., and Wild C.P. Analytical method for the determination of sphinganine and sphingosine in serum as a potential biomarker for fumonisin exposure. J. Chromatogr. B 720 (1998) 15-24
26. Castegnaro M., Garren L., Aucher I., and Wild C.P. Development of a new method for the analysis of sphinganine and sphingosine in urine and tissues. Nat. Toxins 4 (1996) 284-290
27. Shephard G.S., and Vand Der Westhuizen L. Liquid chromatographic determination of the sphinganine/sphingosine ratio in serum. J. Chromatogr. B 710 (1998) 219-222
28. 1 in New Zealand white rabbits. Fund. Appl. Toxicol. 40 (1997) 120-128
29. 3 cause hepato and nephrotoxicity in rats. Mycopathologia 141 (1998) 45-48
30. 1 present in Fusarium moniliforme culture material and aflatoxin single and in combination to turkey poults. Poult. Sci. 74 (1995) 1295-1303
31. 1 in rats. Mycopathologia 151 (2000) 21-27
32. 1 exposure in ducks. Chem. Biol. Interact. 146 (2003) 61-72
33. Norred W.P., Plattner R.D., Dombrink-Kurtzman M.A., Meredith F.I., and Riley R.T. Mycotoxin-induced elevation of free sphingoid bases in precision-cut rat liver slices: specificity of the response and structure-activity relationships. Toxicol. Appl. Pharmacol. 147 (1997) 63-70
34. 1. Progr. Lipid Res. 44 (2005) 345-356
35. Tran S.T., Tardieu D., Auvergne A., Bailly J.D., Babilé R., Durand S., Benard G., and Guerre P. Serum sphingosine and the sphinganine to sphingosine ratio as a biomarker of dietary fumonisins during chronic exposure in ducks. Chem.-Biol. Interact. 160 (2006) 41-50
36. Riley R.T., An N., Showker J.L., Yoo H., Norred W.P., Chamberlain W.J., Wang E., Merril Jr. A.H., Motelin G., Beasley V.R., and Haschek W.M. Alteration, of tissues and serum sphinganine to sphingosine ratio: an early biomarker of exposure to fumonisin-containing feeds in pigs. Toxicol. Appl. Pharm. 118 (1993) 105-112
37. Riley R.T., and Voss K.A. Differential sensitivity of rat kidney and liver to fumonisin toxicity: organ-specific differences in toxin accumulation and sphingoid base metabolism. Toxicol. Sci. 92 (2006) 335-345
38. Churamani C.P., Chattopadhyay S.K., Pawaiya R.V.S., and Johri T.S. Pathoanatomical studies on cumulative aflatoxicosis induced with low dose in rabbits. Indian J. Vet. Pathol. 19 (1995) 119-122
39. 1 in rabbits. Indian J. Anim. Sci. 68 (1998) 1290-1291
40. Krishna L., Dawra R.K., Vaid J., and Gupta V.K. An outbreak of aflatoxicosis in Angora rabbits. Vet. Hum. Toxicol. 33 (1991) 159-161
41. Harvey R.B., Edrington T.S., Kubena L.F., Elissalde M.H., and Rottinghaus G.E. Influence of aflatoxin and fumonisin B1 containing culture material on growing barrows. Am. J. Vet. Res. 56 (1995) 1668-1672
42. Confer A.W., and Panciera R.J. Urinary system. In: Carlton W.W., McGavin M.D., and Zachary J.F. (Eds). Thomson's Special Veterinary Pathology (2001), Oklahoma State University, St. Louis, Mosby p. 248
43. Counts R.S., Norwak G., Wyatt R.D., and Schnellmann R.G. Nephrotoxicant inhibition of renal proximal tubule cell regeneration. Am. J. Physiol. 269 (1995) 274-281