Differential sensitivity of rat kidney and liver to fumonisin toxicity: Organ-specific differences in toxin accumulation and sphingoid base metabolism

Toxicological Sciences

Volumn 92, Issue 1, 2006, Pages 335-345

  Riley, Ronald T ^a   Voss, Kenneth A ^a  

^a AGRICULTURAL RESEARCH SERVICE   (United States)

Author keywords

Fumonisin; Sphinganine; Sphinganine 1 phosphate; Sphingolipids; Sphingosine 1 phosphate

Indexed keywords

FUMONISIN; SPHINGANINE; SPHINGOLIPID; SPHINGOSINE; SPHINGOSINE 1 PHOSPHATE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY SPECIFICITY; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CORRELATION COEFFICIENT; DIETARY INTAKE; DISEASE SEVERITY; HEART; HISTOPATHOLOGY; LIPID METABOLISM; LIVER TOXICITY; MALE; METABOLITE; NEPHROTOXICITY; NONHUMAN; RAT; RAT STRAIN; SERUM; TOXICITY TESTING;

ANIMALS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; FUMONISINS; KIDNEY; LIVER; MALE; RATS; RATS, SPRAGUE-DAWLEY; SPHINGOLIPIDS; TISSUE DISTRIBUTION;

SPHINGOIDEA; ZEA MAYS;

EID: 33745601650     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfj198     Document Type: Article

References (35)

1. Bischoff, A., Czyborra, P., Meyer Zu Heringdorf, D., Jakobs, K. H., and Michel, M. C. (2000). Sphingosine-1-phosphate reduces rat renal and mesenteric blood flow in vivo in a pertussis toxin-sensitive manner. Br. J. Pharmacol. 130, 1878-1883.
2. Bolger, M., Coker, R. D., Dinovi, M., Gaylor, D., Gelderblom, W. C. A., Paster, N., Riley, R. T., Shephard, G., and Speijers, J. A. (2001). Fumonisins. In Safety Evaluation of Certain Mycotoxins in Food. Food and Agriculture Organization of the United Nations Paper 74. World Health Organization Food Additives Series, No. 47, pp. 103-279. International Programme on Chemical Safety World Health Organization, Geneva.
3. 1. Proc. Natl. Acad. Sci. U.S.A. 97, 4961-4966.
4. 1. AOAC International Midwest Section Final Program, pp. 63-64 AOAC International, Gaithersburg, MD (Abstract).
5. Enongene, E. N., Sharma, R. P., Bhandari, N., Miller, J. D., Meredith, F. I., Voss, K. A., and Riley, R. T. (2002). Persistence and reversibility of the elevation in free sphingoid bases induced by fumonisin inhibition of ceramide synthase. Toxicol. Sci. 67, 173-181.
6. 1 in rats. Carcinogenesis 12, 1247-1251.
7. Gon, Y., Wood, M. R., Kiosses, W. B., Jo, E., Sanna, G., Chun, J., and Rosen, H. (2005). S1P3 receptor-induced reorganization of epithelial tight junctions compromises lung barrier integrity and is potentiated by TNF. Proc. Natl. Acad. Sci. U.S.A. 102, 9270-9275.
8. Hla, T. (2003). Signaling and biological actions of sphingosine 1-phosphate. Pharmacol. Res. 47, 401-407.
9. Howard, P. C., Warbritton, A., Voss, K. A., Lorentzen, R. J., Thurman, J. D., Kovach, R. M., and Bucci, T. J. (2001). Compensatory regeneration as a mechanism for renal tubule carcinogenesis of fumonisin B1 in F344/N/ Nctr BR rats. Environ. Health Perspect. 109(Suppl. 2), 309-314.
10. Hsiao, S.-H., Constable, P. D., Smith, G. W., and Haschek, W. M. (2005). Effects of exogenous sphinganine, sphingosine, and sphingosine-1-phosphate on relaxation and contraction of porcine thoracic aortic and pulmonary arterial rings. Toxicol. Sci. 86, 194-199.
11. IARC (2002). Some Traditional Herbal Medicines, Some Mycotoxins, Naphthalene and Styrene, Vol. 82, pp. 301-366. International Agency for Research on Cancer Press, Lyon.
12. Kim, S., Fyrst, H., and Saba, J. (2000). Accumulation of phosphorylated sphingoid long chain bases results in cell growth inhibition in Saccharomyces cerevisiae. Genetics 156, 1519-1529.
13. Lynch, D. V., and Dunn, T. M. (2004). An introduction to plant sphingolipids and a review of recent advances in understanding their metabolism and function. New Phytol. 161, 677-702.
14. Marasas, W. F. O. (2001). Discovery and occurrence of the fumonisins: A historical perspective. Environ. Health Perspect. 109(Suppl. 2), 239-243.
15. 1. Vet. Hum Toxicol. 41, 357-362.
16. Merrill, A. H., Jr, Schmelz, E.-M., Dillehay, D. L., Spiegel, S., Shayman, J. A., Schroeder, J. J., Riley, R. T., Voss, K. A., and Wang, E. (1997). Sphingolipids - The enigmatic lipid class: Biochemistry, physiology, and pathophysiology. Toxicol. Appl. Pharmacol. 142, 208-225.
17. Merrill, A. H., Jr, Sullards, M. C., Wang, E., Voss, K. A., and Riley, R. T. (2001). Sphingolipid metabolism: Roles in signal transduction and disruption by fumonisins. Environ. Health Perspect. 109(Suppl. 2), 283-289.
18. 1 (CAS No 116355-83-0) in F344/N Rats and B6C3F1 Mice (Feed Studies). NTP technical report TR 496 (NIH Publication No. 01-3955). Research Triangle Park, NC.
19. 1 in male Sprague-Dawley rats. Nat. Toxins 1, 341-346.
20. 1 on sphingoid base elevation in precision-cut rat liver and kidney slices. Toxicol. In Vitro 10, 349-358.
21. 1 when fed to weaned piglets. J. Anim. Sci. 83, 1939-1947.
22. Rice, L. G., Ross, P. F., Dejong, J., Plattner, R. D., and Coats, J. R. (1995). Evaluation of a liquid chromatographic method for the determination of famonisins in corn, poultry feed, and Fusarium culture material. J. AOAC Int. 78, 1002-1009.
23. Riebeling, C., Allegood, J. C, Wang, E., Merrill, A. H., Jr, and Futerman, A. H. (2003). Two mammalian longevity assurance gene (LAGI) family members, trh1 and trh4, regulate dihydroceramide synthesis using different fatty acyl-CoA donors. J. Biol. Chem. 278, 43452-43459.
24. Riley, R. T., Enongene, E., Voss, K. A., Norred, W. P., Meredith, F. I., Sharma, R. P., Spitsbergen, J., Williams, D. E., Carlson, D. B., and Merrill, A. H., Jr. (2001). Sphingolipid perturbations as mechanisms for fumonisin carcinogenesis. Environ. Health Perspect. 109(Suppl. 2), 301-308.
25. 1 induces disruption of sphingolipid metabolism in Sprague-Dawley rats: A new mechanism of nephrotoxicity. J. Nutr. 124, 594-603.
26. Sharma, R. P., He, Q., Meredith, F. I., Riley, R. T., and Voss, K. A. (2002). Paradoxical role of tumor necrosis factor α in fumonisin-induced hepatotoxicity in mice. Toxicology 180, 221-232.
27. 1, in rats. Toxicon 30, 768-770.
28. Spiegel, S., and Milstien, S. (2002). Sphingosine 1-phosphate: A key cell signaling molecule. J. Biol. Chem. 277, 25851-25854.
29. Sullard, M. C., and Merrill, A. H., Jr (2001). Analysis of sphingosine 1-phosphate, ceramides, and other bioactive sphingolipids by high-performance liquid chromatography-tandem mass spectrometry. Science's stke. http://stke.sciencemag.org/cgi/content/full/ OC_sigtrans;2001/67/P11. Accessed January 30, 2001.
30. i-coupled receptor Edg-1 and intracellular to regulate proliferation and survival. J. Cell Biol. 142, 229-240.
31. 1 in pregnant rats. Nat. Toxins 4, 24-33.
32. Voss, K. A., Riley, R. T., Norred, W. P., Bacon, C. W., Meredith, F. I., Howard, P. C., Plattner, R. D., Collins, T. F. X., Hansen, D. K., and Porter, J. K. (2001). An overview of rodent toxicities: Liver and kidney effects of Fusarium moniliforme and fumonisins. Environ. Health Perspect. 109, (Suppl. 2), 259-266.
33. Wang, E., Norred, W. P., Bacon, C. W., Riley, R. T., and Merrill, A. H., Jr. (1991). Inhibition of sphingolipid biosynthesis by fumonisins. J. Biol. Chem. 266, 14486-14490.
34. WHO (2000). Environmental Health Criteria 219: Fumonisin B1, 153 p. International Programme on Chemical Safety, Geneva.
35. Williams, L. D., Bacon, C. W., Meredith, F. I., Franzluebbers, A. J., Wyatt, R. D., Smith, M. A., and Riley, R. T. (2003). Leaching and binding of fumonisins in soil microcosms. J. Agric. Food Chem. 51, 685-690.