Modification of immune function through exposure to dietary aflatoxin in Gambian children

Environmental Health Perspectives

Volumn 111, Issue 2, 2003, Pages 217-220

  Turner, Paul C ^a   Moore, Sophie E ^b,c   Hall, Andrew J ^d   Prentice, Andrew M ^b,c   Wild, Christopher P ^a  

^a UNIVERSITY OF LEEDS   (United Kingdom)

^b MEDICAL RESEARCH COUNCIL   (United Kingdom)

^c SOUTH AFRICAN MEDICAL RESEARCH COUNCIL   (South Africa)

^d LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AFLATOXIN; ASCORBIC ACID; HUMAN SERUM ALBUMIN; IMMUNOGLOBULIN A; PNEUMOCOCCUS POLYSACCHARIDE; PNEUMOCOCCUS VACCINE; RABIES VACCINE; RETINOID DERIVATIVE; TRACE ELEMENT; ZINC;

ANTHROPOMETRY; ANTIBODY RESPONSE; ARTICLE; BIRTH WEIGHT; CELLULAR IMMUNITY; CHILD; CHILD HEALTH; COHORT ANALYSIS; CONTROLLED STUDY; DIETARY INTAKE; EXPOSURE; FEMALE; FOOD CONTAMINATION; GAMBIA; HUMAN; HUMAN EXPERIMENT; IMMUNE FUNCTION TEST; IMMUNOLOGICAL PARAMETERS; IMMUNOMODULATION; MALE; MORTALITY; MULTIVARIATE ANALYSIS; NUTRITIONAL STATUS; PRIORITY JOURNAL; RURAL AREA; SALIVA; SEROTYPE; SKIN TEST;

PNEUMOCOCCUS;

EID: 0345700867     PISSN: 00916765     EISSN: None     Source Type: Journal    
DOI: 10.1289/ehp.5753     Document Type: Article

References (36)

1. Allen SJ, Wild CP, Wheeler JG, Riley EM, Montesano R, Bennett S, et al. 1992. Aflatoxin exposure, malaria and hepatitis B infection in rural Gambian children. Trans R Soc Trop Med Hyg 86;426-430.
2. Azzam AH, Gabal MA. 1997. Interaction aflatoxin in the feed and immunisation against selected infectious diseases. 1. Infectious bursal disease. Avian Pathol 26:317-325.
3. Beier-Holgersen R, Brandstrup B. (1999) Influence of early postoperative enteral nutrition versus placebo on cell mediated immunity, as measured with the Multitest (R) CMI. Scand J Gastroenterol 34 (1):98-102.
4. Bondy GS, Pestka JJ. 2000. Immunomodulation by fungal toxins. J Toxicol Environ Health B- Crit Rev 3:109-143.
5. Ceesay SM, Prentice AM, Cole TJ, Foord F, Weaver LT, Postkitt EME, et al. 1997 Effects on birth weight and perinatal mortality of maternal dietary supplements in rural Gambia: 5 year randomised controlled trial. Br Med J 315-786-790.
6. Chapot B, Wild CP, 1991. ELISA for quantification of afflatoxin-albumin adducts and their application to human exposure assessment. In: Techniques in Diagnostic Pathology (Warhol M, van Velzen D, Bullock GR, eds). San Diego CA:Academic Press, 135-155.
7. Cole TJ. 1993. Seasonal effects on physical growth and development. In: Seasonally and Human Ecology (Ulijaszek SJ, Strickland SS, eds). Cambridge, UK:Cambridge University Press, 89-106.
8. Coulombe RA. 1994. Non-hepatic disposition and effects of aflatoxin B1. In: The Toxicology of Aflatoxins: Human Health, Veterinary and Agricultural Significance (Eaton DA, Groopman JD, eds). San Diego, CA: Academic Press, 89-98.
9. Cusumano V, Rossano F, Merendino RA, Arena A, Costa GB, Mancuso G, et al. 1996. Immunobiological activities of mould products: functional impairment of human monocytes exposed to aflatoxin B1. Rev Microbiol 147:385-391.
10. Denning DW. 1987. Aflatoxin and human disease. Adverse Drug React Acute Poisoning Rev 6:175-209.
11. Denning DW, Onwubalili JK, Wilkinson AP, Morgan MR. 1988. Measurement of aflatoxin in Nigerian sera by enzyme-linked immunosorbent assay. Trans R Soc Trop Med Hyg 82:169-171.
12. Dimiti RA, Gabal MA. 1996. Immunosuppressant activity of aflatoxin ingestion in rabbits measured by response to Mycobacterium bovis antigen. I. Cell mediated immune response measured by skin test reaction. Vet Hum Toxicol 38:333-336.
13. Fernandez A, Hernandez M, Verde MT, Sanz M. 2000. Effect of aflatoxin on performance, hematology, and clinical immunology in lambs. Can J Vet Res 64:53-58.
14. Gabal MA, Dimitri R. 1998. Humoral immunosuppressant activity of aflatoxin ingestion in rabbits measured by response to Mycobacterium bovis antigens using enzyme-linked immunosorbent assay and serum protein electrophoresis. Mycoses 41(7-8):303-308.
15. Gong YY, Cardwell K, Hounsa A, Egal S, Turner PC, Hall AJ, et al. 2002. Cross-sectional study of dietary aflatoxin exposure and impaired growth in young children from Benin and Togo, West Africa. Br Med J 235:20-21.
16. 7-guanine in human urine obtained in The Gambia, West Africa. Cancer Epidemiol Biomarkers Prev 1:221-227.
17. Hall AJ, Wild CP. 1994. Epidemiology of aflatoxin-related disease. In: The Toxicology of Aflatoxins: Human Health, Veterinary and Agricultural Significance (Eaton DA, Groopman JD, eds). San Diego, CA:Academic Press, 233-258.
18. IARC. 1993. Some Naturally Occurring Substances: Food Items and Constituents, Heterocyclic Aromatic Amines and Mycotoxins. IARC Monogr Eval Carcinog Risks Hum 56:245-395.
19. Montesano R, Hainaut P, Wild CP. 1997. Hepatocellular carcinoma: from gene to public health. J Natl Cancer Inst 89:1844-1851.
20. Moore SE, Cole TJ, Collinson AC, Poskitt EME, McGregor IA, Prentice AM. 1999. Prenatal or early postnatal events predict infectious deaths in young adulthood in rural Africa. Int J Epidemiol 28:1088-1095.
21. Moore SE, Cole TJ, Poskitt EME, Sonko BJ, Whitehead RG, McGregor IA, et al. 1997. Season of birth predicts mortality in rural Gambia [Letter]. Nature 388:434.
22. Moore SE, Collinson AC, Prentice AE. 2001. Immune function in rural Gambian children is not related to season of birth, birth size, or maternal supplementation status. Am J Clin Nutr 74:840-847.
23. Pier AC, Fichtner RE, Cysewski SJ. 1977. Effects of aflatoxin on the cellular immune system. Ann Nutr Aliment 31:781-787.
24. Pier AC, McLoughlin ME, 1995. Mycotoxic suppression of immunity. In: Tricothecenes and Other Mycotoxins (Lacey J, ed) New York:John Wiley, 507-519.
25. Prentice AE, Stirling DM, Sullivan PB, Northrop-Clewes CA, Lunn PG. 1991. Raised urinary secretory IgA in chronic diarrhoea. Arch Dis Child 66:223-236.
26. Prentice AE, Watkinson M., Prentice AM, Cole TJ, Whitehead RG. 1984. Breast milk antimicrobial factors of rural Gambian mothers. II. Influence of season and prevalence of infection. Acta Paediatr Scand. 73:803-809.
27. Richard JL. 1998. Mycotoxins, toxicity and metabolism in animals: a systems approach overview In: Mycotoxins and Phytotoxins-Developments in Chemistry, Toxicology and Food Safety (van Egmond H, Brera C, Gilbert J, eds). Fort Collins, CO:Alaken, Inc., 363-397.
28. Rossano F, DeLuna LO, Buommino E, Cusumano V, Losi E, Catania MR. 1999. Secondary metabolites of Aspergillus exert immunobiological effects on human nocytes. Res Microbiol 150:13-19.
29. Shaheen SO, Aaby P, Hall AJ, Barker DJ, Heyes CB, Shiell AW, et al. 1996. Cell-mediated immunity after measles in Guinea-Bissau: historical cohort study. Br Med J 313:969-974.
30. Smith JS, Yagar PA, Baer GM. 1973. A rapid reproducible test for the determining rabies neutralizing antibody. Bull WHO 48:535-541.
31. Turner PC, Mendy M, Whittle H, Fortuin M, Hall AJ, Wild CP. 2000. Hepatitis B infection and aflatoxin biomarker levels in Gambian children. Trope Med Int Health 5:837-841.
32. WHO Working Group, World Health Organization. 1986. Use and interpretation of anthropometric indicators of nutritional status. Bull WHO 64:929-941.
33. Wild CP, Fortuin M, Donato F, Whittle HC, Hall AJ, Wolf CR, et al. 1993. Aflatoxin, liver enzymes, and hepatitis B virus infection in Gambian children. Cancer Epidemiol Biomark Prev 2:555-561.
34. Wild CP, Hudson GJ, Sabbioni G, Chapot B, Hall AJ, Wogan GN, et al. 1992. Dietary intake of aflatoxins and the level of albumin-bound aflatoxin in peripheral blood in the Gambia, West Africa. Cancer Epidemiol Biomark Prev 1:229-234.
35. Wild CP, Rasheed FN, Jawla MF, Hall AJ, Jansen LA, Montesano R. 1991. In-utero exposure to aflatoxin in West Africa [Letter]. Lancet 3337:1602.
36. Wild CP, Yin F, Turner PC, Chemin I, Chapot B, Mendy M, et al. 2000. Environmental and genetic determinants of aflatoxin-albumin adducts in the Gambia. Int J Cancer 86:1-7.