Intrathecal heat shock protein 60 mediates neurodegeneration and demyelination in the CNS through a TLR4- and MyD88-dependent pathway

Molecular Neurodegeneration

Volumn 10, Issue 1, 2015, Pages

  Rosenberger, Karen ^a   Dembny, Paul ^a   Derkow, Katja ^a   Engel, Odilo ^a   Krüger, Christina ^a   Wolf, Susanne A ^b   Kettenmann, Helmut ^b   Schott, Eckart ^a   Meisel, Andreas ^a   Lehnardt, Seija ^a  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^b MAX DELBRÜCK CENTER FOR MOLECULAR MEDICINE   (Germany)

Author keywords

Cerebral ischemia; Heat shock protein 60; Innate immunity; Intrathecal injection; Neurodegeneration; Toll like receptor

Indexed keywords

CHAPERONIN 60; LIPOPOLYSACCHARIDE; MYELOID DIFFERENTIATION FACTOR 88; TOLL LIKE RECEPTOR 4; IMMUNOGLOBULIN RECEPTOR; MYD88 PROTEIN, MOUSE; TLR4 PROTEIN, MOUSE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AXONAL INJURY; BRAIN CORTEX; CELL LOSS; CENTRAL NERVOUS SYSTEM; CEREBROSPINAL FLUID; CEREBROVASCULAR ACCIDENT; CONTROLLED STUDY; DEMYELINATION; IN VIVO STUDY; INFLAMMATION; INNATE IMMUNITY; MOUSE; NERVE CELL LESION; NERVE CELL NECROSIS; NERVE DEGENERATION; NONHUMAN; OLIGODENDROGLIA; PROTEIN EXPRESSION; ANIMAL; C57BL MOUSE; CELL CULTURE; CELL DEATH; DEGENERATIVE DISEASE; DEMYELINATING DISEASE; METABOLISM; MICROGLIA; NERVE CELL; PHYSIOLOGY; SIGNAL TRANSDUCTION;

ANIMALS; CELL DEATH; CELLS, CULTURED; CENTRAL NERVOUS SYSTEM; CHAPERONIN 60; DEMYELINATING DISEASES; MICE, INBRED C57BL; MICROGLIA; MYELOID DIFFERENTIATION FACTOR 88; NEURODEGENERATIVE DISEASES; NEURONS; OLIGODENDROGLIA; RECEPTORS, IMMUNOLOGIC; SIGNAL TRANSDUCTION; TOLL-LIKE RECEPTOR 4;

EID: 84928265677     PISSN: None     EISSN: 17501326     Source Type: Journal    
DOI: 10.1186/s13024-015-0003-1     Document Type: Article

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