Toll-like receptors: Key activators of leucocytes and regulator of haematopoiesis

British Journal of Haematology

Volumn 139, Issue 2, 2007, Pages 185-193

  McGettrick, Anne F ^a   O'Neill, Luke A J ^a  

^a TRINITY COLLEGE DUBLIN   (Ireland)

Author keywords

B cell and T cell proliferation; Chronic lymphocytic leukaemia; Haematopoiesis; Neutrophil apoptosis; Toll like receptors

Indexed keywords

ADAPTOR PROTEIN; HETERODIMER; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERFERON REGULATORY FACTOR 3; LIPOPEPTIDE; LIPOPOLYSACCHARIDE; MYELOID DIFFERENTIATION FACTOR 88; TOLL LIKE RECEPTOR; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 3; TOLL LIKE RECEPTOR 4; TOLL LIKE RECEPTOR 5; TOLL LIKE RECEPTOR 6; TOLL LIKE RECEPTOR 7; TOLL LIKE RECEPTOR 8; TOLL LIKE RECEPTOR 9;

APOPTOSIS; B LYMPHOCYTE; CELL ACTIVATION; CELL DIFFERENTIATION; CELL PROLIFERATION; DROSOPHILA; ENZYME INHIBITION; HEMATOPOIESIS; HEMATOPOIETIC STEM CELL; HUMAN; LEUKOCYTE; LYMPHATIC LEUKEMIA; MICROORGANISM DETECTION; MULTIPOTENT STEM CELL; NEUTROPHIL; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; REGULATORY MECHANISM; REVIEW; SIGNAL TRANSDUCTION; T LYMPHOCYTE;

APOPTOSIS; HEMATOPOIESIS; HUMANS; LEUKEMIA, LYMPHOCYTIC, CHRONIC, B-CELL; LYMPHOCYTE ACTIVATION; LYMPHOCYTES; NEUTROPHILS; TOLL-LIKE RECEPTORS;

EID: 34848852208     PISSN: 00071048     EISSN: 13652141     Source Type: Journal    
DOI: 10.1111/j.1365-2141.2007.06802.x     Document Type: Review

References (75)

1. Akashi, K., Traver, D., Miyamoto, T. Weissman, I.L. (2000) A clonogenic common myeloid progenitor that gives rise to all myeloid lineages. Nature, 404, 193 197.
2. Alexopoulou, L., Holt, A.C., Medzhitov, R. Flavell, R.A. (2001) Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3. Nature, 413, 732 738.
3. Aliprantis, A.O., Yang, R.B., Mark, M.R., Suggett, S., Devaux, B., Radolf, J.D., Klimpel, G.R., Godowski, P. Zychlinsky, A. (1999) Cell activation and apoptosis by bacterial lipoproteins through Toll-like receptor-2. Science, 285, 736 739.
4. Aliprantis, A.O., Yang, R.B., Weiss, D.S., Godowski, P. Zychlinsky, A. (2000) The apoptotic signaling pathway activated by Toll-like receptor-2. The EMBO Journal, 19, 3325 3336.
5. An, H., Xu, H., Yu, Y., Zhang, M., Qi, R., Yan, X., Liu, S., Wang, W., Guo, Z., Qin, Z. Cao, X. (2002) Up-regulation of TLR9 gene expression by LPS in mouse macrophages via activation of NF-kappaB, ERK and p38 MAPK signal pathways. Immunology Letters, 81, 165 169.
6. Anderson, K.V., Jurgens, G. Nusslein-Volhard, C. (1985) Establishment of dorsal-ventral polarity in the Drosophila embryo: genetic studies on the role of the Toll gene product. Cell, 42, 779 789.
7. Bernasconi, N.L., Onai, N. Lanzavecchia, A. (2003) A role for Toll-like receptors in acquired immunity: up-regulation of TLR9 by BCR triggering in naive B cells and constitutive expression in memory B cells. Blood, 101, 4500 4504.
8. Bourke, E., Bosisio, D., Golay, J., Polentarutti, N. Mantovani, A. (2003) The Toll-like receptor repertoire of human B lymphocytes: inducible and selective expression of TLR9 and TLR10 in normal and transformed cells. Blood, 102, 956 963.
9. Carty, M., Goodbody, R., Schroder, M., Stack, J., Moynagh, P.N. Bowie, A.G. (2006) The human adaptor SARM negatively regulates adaptor protein TRIF-dependent Toll-like receptor signaling. Nature Immunology, 7, 1074 1081.
10. Christensen, S.R., Kashgarian, M., Alexopoulou, L., Flavell, R.A., Akira, S. Shlomchik, M.J. (2005) Toll-like receptor 9 controls anti-DNA autoantibody production in murine lupus. The Journal of Experimental Medicine, 202, 321 331.
11. Cooper, C.L., Davis, H.L., Morris, M.L., Efler, S.M., Adhami, M.A., Krieg, A.M., Cameron, D.W. Heathcote, J. (2004) CPG 7909, an immunostimulatory TLR9 agonist oligodeoxynucleotide, as adjuvant to Engerix-B HBV vaccine in healthy adults: a double-blind phase I/II study. Journal of Clinical Immunology, 24, 693 701.
12. Cooper, C.L., Davis, H.L., Angel, J.B., Morris, M.L., Elfer, S.M., Seguin, I., Krieg, A.M. Cameron, D.W. (2005) CPG 7909 adjuvant improves hepatitis B virus vaccine seroprotection in antiretroviral-treated HIV-infected adults. AIDS, 19, 1473 1479.
13. Decker, T. Peschel, C. (2001) Effect of immunostimulatory CpG-oligonucleotides in chronic lymphocytic leukemia B cells. Leukemia & Lymphoma, 42, 301 307.
14. Decker, T., Schneller, F., Sparwasser, T., Tretter, T., Lipford, G.B., Wagner, H. Peschel, C. (2000) Immunostimulatory CpG-oligonucleotides cause proliferation, cytokine production, and an immunogenic phenotype in chronic lymphocytic leukemia B cells. Blood, 95, 999 1006.
15. Decker, T., Hipp, S., Kreitman, R.J., Pastan, I., Peschel, C. Licht, T. (2002) Sensitization of B-cell chronic lymphocytic leukemia cells to recombinant immunotoxin by immunostimulatory phosphorothioate oligodeoxynucleotides. Blood, 99, 1320 1326.
16. Fitzgerald, K.A., Palsson-McDermott, E.M., Bowie, A.G., Jefferies, C.A., Mansell, A.S., Brady, G., Brint, E., Dunne, A., Gray, P., Harte, M.T., McMurray, D., Smith, D.E., Sims, J.E., Bird, T.A. O'Neill, L.A. (2001) Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction. Nature, 413, 78 83.
17. Francois, S., El Benna, J., Dang, P.M., Pedruzzi, E., Gougerot-Pocidalo, M.A. Elbim, C. (2005) Inhibition of neutrophil apoptosis by TLR agonists in whole blood: involvement of the phosphoinositide 3-kinase/Akt and NF-kappaB signaling pathways, leading to increased levels of Mcl-1, A1, and phosphorylated Bad. Journal of Immunology, 174, 3633 3642.
18. Gewirtz, A.T., Navas, T.A., Lyons, S., Godowski, P.J. Madara, J.L. (2001) Cutting edge: bacterial flagellin activates basolaterally expressed TLR5 to induce epithelial proinflammatory gene expression. Journal of Immunology, 167, 1882 1885.
19. Goodman, M.G., Wormsley, S.B., Spinosa, J.C. Piro, L.D. (1994) Loxoribine induces chronic lymphocytic leukemia B cells to traverse the cell cycle. Blood, 84, 3457 3464.
20. Haslett, C., Savill, J.S., Whyte, M.K., Stern, M., Dransfield, I. Meagher, L.C. (1994) Granulocyte apoptosis and the control of inflammation. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences, 345, 327 333.
21. Hayashi, F., Smith, K.D., Ozinsky, A., Hawn, T.R., Yi, E.C., Goodlett, D.R., Eng, J.K., Akira, S., Underhill, D.M. Aderem, A. (2001) The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5. Nature, 410, 1099 1103.
22. Hayashi, F., Means, T.K. Luster, A.D. (2003) Toll-like receptors stimulate human neutrophil function. Blood, 102, 2660 2669.
23. Hemmi, H., Takeuchi, O., Kawai, T., Kaisho, T., Sato, S., Sanjo, H., Matsumoto, M., Hoshino, K., Wagner, H., Takeda, K. Akira, S. (2000) A Toll-like receptor recognizes bacterial DNA. Nature, 408, 740 745.
24. Hirotani, T., Yamamoto, M., Kumagai, Y., Uematsu, S., Kawase, I., Takeuchi, O. Akira, S. (2005) Regulation of lipopolysaccharide-inducible genes by MyD88 and Toll/IL-1 domain containing adaptor inducing IFN-beta. Biochemical and Biophysical Research Communications, 328, 383 392.
25. Horng, T., Barton, G.M. Medzhitov, R. (2001) TIRAP: an adapter molecule in the Toll signaling pathway. Nature Immunology, 2, 835 841.
26. Horng, T., Barton, G.M., Flavell, R.A. Medzhitov, R. (2002) The adaptor molecule TIRAP provides signalling specificity for Toll-like receptors. Nature, 420, 329 333.
27. Hornung, V., Rothenfusser, S., Britsch, S., Krug, A., Jahrsdorfer, B., Giese, T., Endres, S. Hartmann, G. (2002) Quantitative expression of Toll-like receptor 1-10 mRNA in cellular subsets of human peripheral blood mononuclear cells and sensitivity to CpG oligodeoxynucleotides. Journal of Immunology, 168, 4531 4537.
28. Hoshino, K., Takeuchi, O., Kawai, T., Sanjo, H., Ogawa, T., Takeda, Y., Takeda, K. Akira, S. (1999) Cutting edge: Toll-like receptor mice are hyporesponsive to lipopolysaccharide: evidence for TLR4 as the Lps gene product. Journal of Immunology, 162, 3749 3752.
29. Igarashi, H., Gregory, S.C., Yokota, T., Sakaguchi, N. Kincade, P.W. (2002) Transcription from the RAG1 locus marks the earliest lymphocyte progenitors in bone marrow. Immunity, 17, 117 130.
30. Into, T., Kiura, K., Yasuda, M., Kataoka, H., Inoue, N., Hasebe, A., Takeda, K., Akira, S. Shibata, K. (2004) Stimulation of human Toll-like receptor (TLR) 2 and TLR6 with membrane lipoproteins of mycoplasma fermentans induces apoptotic cell death after NF-kappa B activation. Cellular Microbiology, 6, 187 199.
31. Jahrsdorfer, B., Hartmann, G., Racila, E., Jackson, W., Muhlenhoff, L., Meinhardt, G., Endres, S., Link, B.K., Krieg, A.M. Weiner, G.J. (2001) CpG DNA increases primary malignant B cell expression of costimulatory molecules and target antigens. Journal of Leukocyte Biology, 69, 81 88.
32. Jahrsdorfer, B., Jox, R., Muhlenhoff, L., Tschoep, K., Krug, A., Rothenfusser, S., Meinhardt, G., Emmerich, B., Endres, S. Hartmann, G. (2002) Modulation of malignant B cell activation and apoptosis by bcl-2 antisense ODN and immunostimulatory CpG ODN. Journal of Leukocyte Biology, 72, 83 92.
33. Kadowaki, N., Ho, S., Antonenko, S., Malefyt, R.W., Kastelein, R.A., Bazan, F. Liu, Y.J. (2001) Subsets of human dendritic cell precursors express different toll-like receptors and respond to different microbial antigens. The Journal of Experimental Medicine, 194, 863 869.
34. Kawai, T., Adachi, O., Ogawa, T., Takeda, K. Akira, S. (1999) Unresponsiveness of MyD88-deficient mice to endotoxin. Immunity, 11, 115 122.
35. Kawai, T., Takeuchi, O., Fujita, T., Inoue, J., Muhlradt, P.F., Sato, S., Hoshino, K. Akira, S. (2001) Lipopolysaccharide stimulates the MyD88-independent pathway and results in activation of IFN-regulatory factor 3 and the expression of a subset of lipopolysaccharide-inducible genes. Journal of Immunology, 167, 5887 5894.
36. Khor, C.C., Chapman, S.J., Vannberg, F.O., Dunne, A., Murphy, C., Ling, E.Y., Frodsham, A.J., Walley, A.J., Kyrieleis, O., Khan, A., Aucan, C., Segal, S., Moore, C.E., Knox, K., Campbell, S.J., Lienhardt, C., Scott, A., Aaby, P., Sow, O.Y., Grignani, R.T., Sillah, J., Sirugo, G., Peshu, N., Williams, T.N., Maitland, K., Davies, R.J., Kwiatkowski, D.P., Day, N.P., Yala, D., Crook, D.W., Marsh, K., Berkley, J.A., O'Neill, L.A. Hill, A.V. (2007) A Mal functional variant is associated with protection against invasive pneumococcal disease, bacteremia, malaria and tuberculosis. Nature Genetics, 39, 523 528.
37. Kondo, M., Weissman, I.L. Akashi, K. (1997) Identification of clonogenic common lymphoid progenitors in mouse bone marrow. Cell, 91, 661 672.
38. Kouro, T., Kumar, V. Kincade, P.W. (2002) Relationships between early B- and NK-lineage lymphocyte precursors in bone marrow. Blood, 100, 3672 3680.
39. Krieg, A.M. (2002) CpG motifs in bacterial DNA and their immune effects. Annual Review of Immunology, 20, 709 760.
40. Lemaitre, B., Nicolas, E., Michaut, L., Reichhart, J.M. Hoffmann, J.A. (1996) The dorsoventral regulatory gene cassette spatzle/Toll/cactus controls the potent antifungal response in Drosophila adults. Cell, 86, 973 983.
41. Lin, L., Gerth, A.J. Peng, S.L. (2004) CpG DNA redirects class-switching towards "Th1-like" Ig isotype production via TLR9 and MyD88. European Journal of Immunology, 34, 1483 1487.
42. Liu, N., Ohnishi, N., Ni, L., Akira, S. Bacon, K.B. (2003) CpG directly induces T-bet expression and inhibits IgG1 and IgE switching in B cells. Nature Immunology, 4, 687 693.
43. Lord, K.A., Abdollahi, A., Hoffman-Liebermann, B. Liebermann, D.A. (1990) Dissection of the immediate early response of myeloid leukemia cells to terminal differentiation and growth inhibitory stimuli. Cell Growth & Differentiation, 1, 637 645.
44. Mason, K.A., Ariga, H., Neal, R., Valdecanas, D., Hunter, N., Krieg, A.M., Whisnant, J.K. Milas, L. (2005) Targeting toll-like receptor 9 with CpG oligodeoxynucleotides enhances tumor response to fractionated radiotherapy. Clinical Cancer Research, 11, 361 369.
45. McGettrick, A.F. O'Neill, L.A. (2004) The expanding family of MyD88-like adaptors in Toll-like receptor signal transduction. Molecular Immunology, 41, 577 582.
46. McGettrick, A.F., Brint, E.K., Palsson-McDermott, E.M., Rowe, D.C., Golenbock, D.T., Gay, N.J., Fitzgerald, K.A. O'Neill, L.A. (2006) Trif-related adapter molecule is phosphorylated by PKC{ε} during Toll-like receptor 4 signaling. Proceedings of the National Academy of Sciences of the United States of America, 103, 9196 9201.
47. Medzhitov, R. (2001) Toll-like receptors and innate immunity. Nature Reviews. Immunology, 1, 135 145.
48. Muzio, M., Bosisio, D., Polentarutti, N., D'Amico, G., Stoppacciaro, A., Mancinelli, R., van't Veer, C., Penton-Rol, G., Ruco, L.P., Allavena, P. Mantovani, A. (2000) Differential expression and regulation of toll-like receptors (TLR) in human leukocytes: selective expression of TLR3 in dendritic cells. Journal of Immunology, 164, 5998 6004.
49. Nagai, Y., Garrett, K.P., Ohta, S., Bahrun, U., Kouro, T., Akira, S., Takatsu, K. Kincade, P.W. (2006) Toll-like receptors on hematopoietic progenitor cells stimulate innate immune system replenishment. Immunity, 24, 801 812.
50. O'Neill, L.A. Bowie, A.G. (2007) The family of five: TIR-domain- containing adaptors in Toll-like receptor signalling. Nature Reviews. Immunology, 7, 353 364.
51. Okamura, Y., Watari, M., Jerud, E.S., Young, D.W., Ishizaka, S.T., Rose, J., Chow, J.C. Strauss, III. J.F. 2001) The extra domain A of fibronectin activates Toll-like receptor4. The Journal of Biological Chemistry, 276, 10229 10233.
52. Oshiumi, H., Matsumoto, M., Funami, K., Akazawa, T. Seya, T. (2003) TICAM-1, an adaptor molecule that participates in Toll-like receptor 3-mediated interferon-beta induction. Nature Immunology, 4, 161 167.
53. Pellacani, A., Tosi, P., Zinzani, P.L., Ottaviani, E., Albertini, P., Magagnoli, M. Tura, S. (1999) Cytotoxic combination of loxoribine with fludarabine and mafosfamide on freshly isolated B-chronic lymphocytic leukemia cells. Leukemia & Lymphoma, 33, 147 153.
54. Poltorak, A., He, X., Smirnova, I., Liu, M.Y., Van Huffel, C., Du, X., Birdwell, D., Alejos, E., Silva, M., Galanos, C., Freudenberg, M., Ricciardi-Castagnoli, P., Layton, B. Beutler, B. (1998) Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 gene. Science, 282, 2085 2088.
55. Qiu, P., Pan, P.C. Govind, S. (1998) A role for the Drosophila Toll/Cactus pathway in larval hematopoiesis. Development, 125, 1909 1920.
56. Rowe, D.C., McGettrick, A.F., Latz, E., Monks, B.G., Gay, N.J., Yamamoto, M., Akira, S., O'Neill, L.A., Fitzgerald, K.A. Golenbock, D.T. (2006) The myristoylation of TRIF-related adaptor molecule is essential for Toll-like receptor 4 signal transduction. Proceedings of the National Academy of Sciences of the United States of America, 103, 6299 6304.
57. Savill, J., Dransfield, I., Gregory, C. Haslett, C. (2002) A blast from the past: clearance of apoptotic cells regulates immune responses. Nature Reviews. Immunology, 2, 965 975.
58. Seya, T., Shingai, M. Matsumoto, M. (2004) Toll-like receptors that sense viral infection. Uirusu, 54, 1 8.
59. Shi, Y., White, D., He, L., Miller, R.L. Spaner, D.E. (2007) Toll-like receptor-7 tolerizes malignant B cells and enhances killing by cytotoxic agents. Cancer Research, 67, 1823 1831.
60. Sioud, M., Floisand, Y., Forfang, L. Lund-Johansen, F. (2006) Signaling through toll-like receptor 7/8 induces the differentiation of human bone marrow CD34+ progenitor cells along the myeloid lineage. Journal of Molecular Biology, 364, 945 954.
61. Spaner, D.E., Shi, Y., White, D., Mena, J., Hammond, C., Tomic, J., He, L., Tomai, M.A., Miller, R.L., Booth, J. Radvanyi, L. (2006) Immunomodulatory effects of Toll-like receptor-7 activation on chronic lymphocytic leukemia cells. Leukemia, 20, 286 295.
62. Takeshita, F., Gursel, I., Ishii, K.J., Suzuki, K., Gursel, M. Klinman, D.M. (2004) Signal transduction pathways mediated by the interaction of CpG DNA with Toll-like receptor 9. Seminars in Immunology, 16, 17 22.
63. Takeuchi, O., Kawai, T., Muhlradt, P.F., Morr, M., Radolf, J.D., Zychlinsky, A., Takeda, K. Akira, S. (2001) Discrimination of bacterial lipoproteins by Toll-like receptor 6. International Immunology, 13, 933 940.
64. Takeuchi, O., Sato, S., Horiuchi, T., Hoshino, K., Takeda, K., Dong, Z., Modlin, R.L. Akira, S. (2002) Cutting edge: role of Toll-like receptor 1 in mediating immune response to microbial lipoproteins. Journal of Immunology, 169, 10 14.
65. Tosi, P., Zinzani, P.L., Pellacani, A., Ottaviani, E., Magagnoli, M. Tura, S. (1997) Loxoribine affects fludarabine activity on freshly isolated B-chronic lymphocytic leukemia cells. Leukemia & Lymphoma, 26, 343 348.
66. Traggiai, E., Becker, S., Subbarao, K., Kolesnikova, L., Uematsu, Y., Gismondo, M.R., Murphy, B.R., Rappuoli, R. Lanzavecchia, A. (2004) An efficient method to make human monoclonal antibodies from memory B cells: potent neutralization of SARS coronavirus. Nature Medicine, 10, 871 875.
67. Ueda, Y., Yang, K., Foster, S.J., Kondo, M. Kelsoe, G. (2004) Inflammation controls B lymphopoiesis by regulating chemokine CXCL12 expression. The Journal of Experimental Medicine, 199, 47 58.
68. Ueda, Y., Kondo, M. Kelsoe, G. (2005) Inflammation and the reciprocal production of granulocytes and lymphocytes in bone marrow. The Journal of Experimental Medicine, 201, 1771 1780.
69. Viglianti, G.A., Lau, C.M., Hanley, T.M., Miko, B.A., Shlomchik, M.J. Marshak-Rothstein, A. (2003) Activation of autoreactive B cells by CpG dsDNA. Immunity, 19, 837 847.
70. Wang, J., Shao, Y., Bennett, T.A., Shankar, R.A., Wightman, P.D. Reddy, L.G. (2006) The functional effects of physical interactions among Toll-like receptors 8, and 9. The Journal of Biological Chemistry, 7, 281.
71. Xu, D., Komai-Koma, M. Liew, F.Y. (2005) Expression and function of Toll-like receptor on T cells. Cellular Immunology, 233, 85 89.
72. Yamamoto, M., Sato, S., Hemmi, H., Sanjo, H., Uematsu, S., Kaisho, T., Hoshino, K., Takeuchi, O., Kobayashi, M., Fujita, T., Takeda, K. Akira, S. (2002a) Essential role for TIRAP in activation of the signalling cascade shared by TLR2 and TLR4. Nature, 420, 324 329.
73. Yamamoto, M., Sato, S., Mori, K., Hoshino, K., Takeuchi, O., Takeda, K. Akira, S. (2002b) Cutting edge: a novel Toll/IL-1 receptor domain-containing adapter that preferentially activates the IFN-beta promoter in the Toll-like receptor signaling. Journal of Immunology, 169, 6668 6672.
74. Yamamoto, M., Sato, S., Hemmi, H., Hoshino, K., Kaisho, T., Sanjo, H., Takeuchi, O., Sugiyama, M., Okabe, M., Takeda, K. Akira, S. (2003a) Role of adaptor TRIF in the MyD88-independent toll-like receptor signaling pathway. Science, 301, 640 643.
75. Yamamoto, M., Sato, S., Hemmi, H., Uematsu, S., Hoshino, K., Kaisho, T., Takeuchi, O., Takeda, K. Akira, S. (2003b) TRAM is specifically involved in the Toll-like receptor 4-mediated MyD88-independent signaling pathway. Nature Immunology, 4, 1144 1150.