Homologous ligands accommodated by discrete conformations of a buried cavity

Proceedings of the National Academy of Sciences of the United States of America

Volumn 112, Issue 16, 2015, Pages 5039-5044

  Merski, Matthew ^a,b   Fischer, Marcus ^a   Balius, Trent E ^a   Eidam, Oliv ^a,c   Shoichet, Brian K ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF PORTO   (Portugal)

^c F HOFFMANN LA ROCHE LTD   (Switzerland)

Author keywords

Conformational change; Congeneric series; Homologous series; Protein ligand complexes; T4 lysozyme

Indexed keywords

BENZENE; BENZENE DERIVATIVE; CARBENE; LIGAND; LYSOZYME;

ARTICLE; BINDING AFFINITY; CHEMICAL STRUCTURE; CONFORMATIONAL TRANSITION; DENSITY; ELECTRON DENSITY; ENZYME ANALYSIS; LIGAND BINDING; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN DATA BANK; AMINO ACID SUBSTITUTION; CHEMISTRY; ENTEROBACTERIA PHAGE T4; ENZYMOLOGY; PROTEIN SECONDARY STRUCTURE; STATIC ELECTRICITY; THERMODYNAMICS;

AMINO ACID SUBSTITUTION; BACTERIOPHAGE T4; BENZENE; LIGANDS; MODELS, MOLECULAR; MURAMIDASE; PROTEIN STRUCTURE, SECONDARY; STATIC ELECTRICITY; THERMODYNAMICS;

EID: 84928136107     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1500806112     Document Type: Article

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