Local conformational fluctuations can modulate the coupling between proton binding and global structural transitions in proteins

Proceedings of the National Academy of Sciences of the United States of America

Volumn 102, Issue 12, 2005, Pages 4282-4287

  Whitten, Steven T ^a,b   García Moreno E , Bertrand ^c   Hilser, Vincent J ^a  

^a University of Texas Medical Branch School of Medicine   (United States)

^b RedStorm Scientific Inc Galveston   (United States)

^c JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Cooperativity; Dynamics; Electrostatics; Ensemble; Linkage

Indexed keywords

PROTEIN; PROTON;

ALLOSTERISM; ARTICLE; BINDING AFFINITY; CONFORMATIONAL TRANSITION; DYNAMICS; ELECTRICITY; ENERGY; ENZYME CONFORMATION; LIGAND BINDING; MACROMOLECULE; NONHUMAN; PRIORITY JOURNAL; PROTEIN FOLDING; STRUCTURE ANALYSIS; THERMODYNAMICS;

BINDING SITES; ELECTROSTATICS; ENZYME STABILITY; HYDROGEN-ION CONCENTRATION; LIGANDS; MICROCOCCAL NUCLEASE; MODELS, MOLECULAR; PROTEIN BINDING; PROTEIN CONFORMATION; PROTONS; THERMODYNAMICS;

EID: 15444362906     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0407499102     Document Type: Article

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