-
1
-
-
84861371612
-
Structural and energetic basis of allostery
-
Hilser, V.J., Wrabl, J.O. & Motlagh, H.N. Structural and energetic basis of allostery. Annu. Rev. Biophys. 41, 585-609 (2012).
-
(2012)
Annu. Rev. Biophys
, vol.41
, pp. 585-609
-
-
Hilser, V.J.1
Wrabl, J.O.2
Motlagh, H.N.3
-
2
-
-
84857190619
-
Evidence for dynamics in proteins as a mechanism for ligand dissociation
-
Carroll, M.J. et al. Evidence for dynamics in proteins as a mechanism for ligand dissociation. Nat. Chem. Biol. 8, 246-252 (2012).
-
(2012)
Nat. Chem. Biol
, vol.8
, pp. 246-252
-
-
Carroll, M.J.1
-
3
-
-
0032446607
-
The structural basis of estrogen receptor/coactivator recognition and the antagonism of this interaction by tamoxifen
-
Shiau, A.K. et al. The structural basis of estrogen receptor/coactivator recognition and the antagonism of this interaction by tamoxifen. Cell 95, 927-937 (1998).
-
(1998)
Cell
, vol.95
, pp. 927-937
-
-
Shiau, A.K.1
-
4
-
-
38749144353
-
CBP Is a dosage-dependent regulator of nuclear factor-κB suppression by the estrogen receptor
-
Nettles, K.W. et al. CBP Is a dosage-dependent regulator of nuclear factor-κB suppression by the estrogen receptor. Mol. Endocrinol. 22, 263-272 (2008).
-
(2008)
Mol. Endocrinol
, vol.22
, pp. 263-272
-
-
Nettles, K.W.1
-
5
-
-
77958157879
-
Coupling of receptor conformation and ligand orientation determine graded activity
-
Bruning, J.B. et al. Coupling of receptor conformation and ligand orientation determine graded activity. Nat. Chem. Biol. 6, 837-843 (2010).
-
(2010)
Nat. Chem. Biol
, vol.6
, pp. 837-843
-
-
Bruning, J.B.1
-
6
-
-
84855795379
-
Ligand and receptor dynamics contribute to the mechanism of graded PPARγ agonism
-
Hughes, T.S. et al. Ligand and receptor dynamics contribute to the mechanism of graded PPARγ agonism. Structure 20, 139-150 (2012).
-
(2012)
Structure
, vol.20
, pp. 139-150
-
-
Hughes, T.S.1
-
7
-
-
79955031227
-
Direct detection of structurally resolved dynamics in a multiconformation receptor-ligand complex
-
Carroll, M.J. et al. Direct detection of structurally resolved dynamics in a multiconformation receptor-ligand complex. J. Am. Chem. Soc. 133, 6422-6428 (2011).
-
(2011)
J. Am. Chem. Soc
, vol.133
, pp. 6422-6428
-
-
Carroll, M.J.1
-
8
-
-
0033637703
-
Cofactor dynamics and sufficiency in estrogen receptor-regulated transcription
-
Shang, Y., Hu, X., DiRenzo, J., Lazar, M.A. & Brown, M. Cofactor dynamics and sufficiency in estrogen receptor-regulated transcription. Cell 103, 843-852 (2000).
-
(2000)
Cell
, vol.103
, pp. 843-852
-
-
Shang, Y.1
Hu, X.2
Direnzo, J.3
Lazar, M.A.4
Brown, M.5
-
9
-
-
65249167505
-
DNA binding site sequence directs glucocorticoid receptor structure and activity
-
Meijsing, S.H. et al. DNA binding site sequence directs glucocorticoid receptor structure and activity. Science 324, 407-410 (2009).
-
(2009)
Science
, vol.324
, pp. 407-410
-
-
Meijsing, S.H.1
-
10
-
-
0029796605
-
Different regions in activation function-1 of the human estrogen receptor required for antiestrogen-and estradiol-dependent transcription activation
-
McInerney, E.M. & Katzenellenbogen, B.S. Different regions in activation function-1 of the human estrogen receptor required for antiestrogen-and estradiol-dependent transcription activation. J. Biol. Chem. 271, 24172-24178 (1996).
-
(1996)
J. Biol. Chem
, vol.271
, pp. 24172-24178
-
-
McInerney, E.M.1
Katzenellenbogen, B.S.2
-
11
-
-
15544371000
-
Ligand control of coregulator recruitment to nuclear receptors
-
Nettles, K.W. & Greene, G.L. Ligand control of coregulator recruitment to nuclear receptors. Annu. Rev. Physiol. 67, 309-333 (2005).
-
(2005)
Annu. Rev. Physiol
, vol.67
, pp. 309-333
-
-
Nettles, K.W.1
Greene, G.L.2
-
12
-
-
0032213219
-
Structure and specificity of nuclear receptor-coactivator interactions
-
Darimont, B.D. et al. Structure and specificity of nuclear receptor-coactivator interactions. Genes Dev. 12, 3343-3356 (1998).
-
(1998)
Genes Dev
, vol.12
, pp. 3343-3356
-
-
Darimont, B.D.1
-
13
-
-
0029012163
-
Crystal structure of the ligand-binding domain of the human nuclear receptor RXR-α
-
Bourguet, W., Ruff, M., Chambon, P., Gronemeyer, H. & Moras, D. Crystal structure of the ligand-binding domain of the human nuclear receptor RXR-α. Nature 375, 377-382 (1995).
-
(1995)
Nature
, vol.375
, pp. 377-382
-
-
Bourguet, W.1
Ruff, M.2
Chambon, P.3
Gronemeyer, H.4
Moras, D.5
-
14
-
-
18244393501
-
Structural basis for antagonist-mediated recruitment of nuclear co-repressors by PPARα
-
Xu, H.E. et al. Structural basis for antagonist-mediated recruitment of nuclear co-repressors by PPARα. Nature 415, 813-817 (2002).
-
(2002)
Nature
, vol.415
, pp. 813-817
-
-
Xu, H.E.1
-
15
-
-
34547653666
-
Structural plasticity in the oestrogen receptor ligand-binding domain
-
erratum 8, 610 (2007)
-
Nettles, K.W. et al. Structural plasticity in the oestrogen receptor ligand-binding domain. EMBO Rep. 8, 563-568 (2007); erratum 8, 610 (2007).
-
(2007)
EMBO Rep.
, vol.8
, pp. 563-568
-
-
Nettles, K.W.1
-
16
-
-
20044371621
-
Identification of pathway-selective estrogen receptor ligands that inhibit NF-κB transcriptional activity
-
Chadwick, C.C. et al. Identification of pathway-selective estrogen receptor ligands that inhibit NF-κB transcriptional activity. Proc. Natl. Acad. Sci. USA 102, 2543-2548 (2005).
-
(2005)
Proc. Natl. Acad. Sci. USA
, vol.102
, pp. 2543-2548
-
-
Chadwick, C.C.1
-
17
-
-
1242294391
-
Allosteric control of ligand selectivity between estrogen receptors α and β: Implications for other nuclear receptors
-
Nettles, K.W. et al. Allosteric control of ligand selectivity between estrogen receptors α and β: implications for other nuclear receptors. Mol. Cell 13, 317-327 (2004).
-
(2004)
Mol. Cell
, vol.13
, pp. 317-327
-
-
Nettles, K.W.1
-
18
-
-
84870535838
-
Structural mechanisms of allostery and autoinhibition in JNK family kinases
-
Laughlin, J.D. et al. Structural mechanisms of allostery and autoinhibition in JNK family kinases. Structure 20, 2174-2184 (2012).
-
(2012)
Structure
, vol.20
, pp. 2174-2184
-
-
Laughlin, J.D.1
-
19
-
-
0037192501
-
Molecular determinants for the tissue specificity of SERMs
-
Shang, Y. & Brown, M. Molecular determinants for the tissue specificity of SERMs. Science 295, 2465-2468 (2002).
-
(2002)
Science
, vol.295
, pp. 2465-2468
-
-
Shang, Y.1
Brown, M.2
-
20
-
-
0031452274
-
Structures of Src-family tyrosine kinases
-
Sicheri, F. & Kuriyan, J. Structures of Src-family tyrosine kinases. Curr. Opin. Struct. Biol. 7, 777-785 (1997).
-
(1997)
Curr. Opin. Struct. Biol
, vol.7
, pp. 777-785
-
-
Sicheri, F.1
Kuriyan, J.2
-
21
-
-
0030986236
-
A signature motif in transcriptional co-activators mediates binding to nuclear receptors
-
Heery, D.M., Kalkhoven, E., Hoare, S. & Parker, M.G. A signature motif in transcriptional co-activators mediates binding to nuclear receptors. Nature 387, 733-736 (1997).
-
(1997)
Nature
, vol.387
, pp. 733-736
-
-
Heery, D.M.1
Kalkhoven, E.2
Hoare, S.3
Parker, M.G.4
-
22
-
-
0025062215
-
Role of the two activating domains of the oestrogen receptor in the cell-type and promoter-context dependent agonistic activity of the anti-oestrogen 4-hydroxytamoxifen
-
Berry, M., Metzger, D. & Chambon, P. Role of the two activating domains of the oestrogen receptor in the cell-type and promoter-context dependent agonistic activity of the anti-oestrogen 4-hydroxytamoxifen. EMBO J. 9, 2811-2818 (1990).
-
(1990)
EMBO J.
, vol.9
, pp. 2811-2818
-
-
Berry, M.1
Metzger, D.2
Chambon, P.3
-
23
-
-
0026341234
-
Antiestrogen can establish nonproductive receptor complexes and alter chromatin structure at target enhancers
-
Pham, T.A. et al. Antiestrogen can establish nonproductive receptor complexes and alter chromatin structure at target enhancers. Proc. Natl. Acad. Sci. USA 88, 3125-3129 (1991).
-
(1991)
Proc. Natl. Acad. Sci. USA
, vol.88
, pp. 3125-3129
-
-
Pham, T.A.1
-
24
-
-
34247898925
-
Raloxifene and ICI182,780 increase estrogen receptor-α association with a nuclear compartment via overlapping sets of hydrophobic amino acids in activation function 2 helix 12
-
Lupien, M. et al. Raloxifene and ICI182,780 increase estrogen receptor-α association with a nuclear compartment via overlapping sets of hydrophobic amino acids in activation function 2 helix 12. Mol. Endocrinol. 21, 797-816 (2007).
-
(2007)
Mol. Endocrinol
, vol.21
, pp. 797-816
-
-
Lupien, M.1
-
25
-
-
0035872489
-
AIB1 enhances estrogen-dependent induction of cyclin D1 expression
-
Planas-Silva, M.D., Shang, Y., Donaher, J.L., Brown, M. & Weinberg, R.A. AIB1 enhances estrogen-dependent induction of cyclin D1 expression. Cancer Res. 61, 3858-3862 (2001).
-
(2001)
Cancer Res
, vol.61
, pp. 3858-3862
-
-
Planas-Silva, M.D.1
Shang, Y.2
Donaher, J.L.3
Brown, M.4
Weinberg, R.A.5
-
26
-
-
69249110003
-
Normal and cancer-related functions of the p160 steroid receptor co-activator (SRC) family
-
Xu, J., Wu, R.C. & O'Malley, B.W. Normal and cancer-related functions of the p160 steroid receptor co-activator (SRC) family. Nat. Rev. Cancer 9, 615-630 (2009).
-
(2009)
Nat. Rev. Cancer
, vol.9
, pp. 615-630
-
-
Xu, J.1
Wu, R.C.2
O'Malley, B.W.3
-
27
-
-
21644489751
-
GREB 1 is a critical regulator of hormone dependent breast cancer growth
-
Rae, J.M. et al. GREB 1 is a critical regulator of hormone dependent breast cancer growth. Breast Cancer Res. Treat. 92, 141-149 (2005).
-
(2005)
Breast Cancer Res. Treat
, vol.92
, pp. 141-149
-
-
Rae, J.M.1
-
28
-
-
33748679908
-
A cell-type-specific transcriptional network required for estrogen regulation of cyclin D1 and cell cycle progression in breast cancer
-
Eeckhoute, J., Carroll, J.S., Geistlinger, T.R., Torres-Arzayus, M.I. & Brown, M. A cell-type-specific transcriptional network required for estrogen regulation of cyclin D1 and cell cycle progression in breast cancer. Genes Dev. 20, 2513-2526 (2006).
-
(2006)
Genes Dev
, vol.20
, pp. 2513-2526
-
-
Eeckhoute, J.1
Carroll, J.S.2
Geistlinger, T.R.3
Torres-Arzayus, M.I.4
Brown, M.5
-
29
-
-
23844448634
-
Knockdown of c-Myc expression by RNAi inhibits MCF-7 breast tumor cells growth in vitro and in vivo
-
Wang, Y.H. et al. Knockdown of c-Myc expression by RNAi inhibits MCF-7 breast tumor cells growth in vitro and in vivo. Breast Cancer Res. 7, R220-R228 (2005).
-
(2005)
Breast Cancer Res
, vol.7
-
-
Wang, Y.H.1
-
30
-
-
80052290466
-
Estrogen induces c-myc gene expression via an upstream enhancer activated by the estrogen receptor and the AP-1 transcription factor
-
Wang, C. et al. Estrogen induces c-myc gene expression via an upstream enhancer activated by the estrogen receptor and the AP-1 transcription factor. Mol. Endocrinol. 25, 1527-1538 (2011).
-
(2011)
Mol. Endocrinol
, vol.25
, pp. 1527-1538
-
-
Wang, C.1
-
31
-
-
84863066879
-
Identification of estrogen receptor dimer selective ligands reveals growth-inhibitory effects on cells that co-express ERα and ERβ
-
Powell, E. et al. Identification of estrogen receptor dimer selective ligands reveals growth-inhibitory effects on cells that co-express ERα and ERβ. PLoS ONE 7, e30993 (2012).
-
(2012)
PLoS ONE
, vol.7
-
-
Powell, E.1
-
32
-
-
33646728919
-
GREB1 is a novel androgen-regulated gene required for prostate cancer growth
-
Rae, J.M. et al. GREB1 is a novel androgen-regulated gene required for prostate cancer growth. Prostate 66, 886-894 (2006).
-
(2006)
Prostate
, vol.66
, pp. 886-894
-
-
Rae, J.M.1
-
33
-
-
0035976933
-
Estrogen response elements alter coactivator recruitment through allosteric modulation of estrogen receptor β conformation
-
Loven, M.A., Likhite, V.S., Choi, I. & Nardulli, A.M. Estrogen response elements alter coactivator recruitment through allosteric modulation of estrogen receptor β conformation. J. Biol. Chem. 276, 45282-45288 (2001).
-
(2001)
J. Biol. Chem
, vol.276
, pp. 45282-45288
-
-
Loven, M.A.1
Likhite, V.S.2
Choi, I.3
Nardulli, A.M.4
-
34
-
-
0036185782
-
Allosteric regulation of estrogen receptor structure, function, and coactivator recruitment by different estrogen response elements
-
Hall, J.M., McDonnell, D.P. & Korach, K.S. Allosteric regulation of estrogen receptor structure, function, and coactivator recruitment by different estrogen response elements. Mol. Endocrinol. 16, 469-486 (2002).
-
(2002)
Mol. Endocrinol
, vol.16
, pp. 469-486
-
-
Hall, J.M.1
McDonnell, D.P.2
Korach, K.S.3
-
35
-
-
33644996796
-
Novel arylpyrazole compounds selectively modulate glucocorticoid receptor regulatory activity
-
Wang, J.C. et al. Novel arylpyrazole compounds selectively modulate glucocorticoid receptor regulatory activity. Genes Dev. 20, 689-699 (2006).
-
(2006)
Genes Dev
, vol.20
, pp. 689-699
-
-
Wang, J.C.1
-
36
-
-
0141963219
-
Full-length estrogen receptor α and its ligand-binding domain adopt different conformations upon binding ligand
-
Bapat, A.R. & Frail, D.E. Full-length estrogen receptor α and its ligand-binding domain adopt different conformations upon binding ligand. J. Steroid Biochem. Mol. Biol. 86, 143-149 (2003).
-
(2003)
J. Steroid Biochem. Mol. Biol
, vol.86
, pp. 143-149
-
-
Bapat, A.R.1
Frail, D.E.2
-
37
-
-
14844353602
-
Delineation of a unique protein-protein interaction site on the surface of the estrogen receptor
-
Kong, E.H. et al. Delineation of a unique protein-protein interaction site on the surface of the estrogen receptor. Proc. Natl. Acad. Sci. USA 102, 3593-3598 (2005).
-
(2005)
Proc. Natl. Acad. Sci. USA
, vol.102
, pp. 3593-3598
-
-
Kong, E.H.1
-
38
-
-
56749130032
-
Structure of the intact PPAR-γ-RXR-nuclear receptor complex on DNA
-
Chandra, V. et al. Structure of the intact PPAR-γ-RXR-nuclear receptor complex on DNA. Nature 456, 350-356 (2008).
-
(2008)
Nature
, vol.456
, pp. 350-356
-
-
Chandra, V.1
-
39
-
-
79955581636
-
Common architecture of nuclear receptor heterodimers on DNA direct repeat elements with different spacings
-
Rochel, N. et al. Common architecture of nuclear receptor heterodimers on DNA direct repeat elements with different spacings. Nat. Struct. Mol. Biol. 18, 564-570 (2011).
-
(2011)
Nat. Struct. Mol. Biol
, vol.18
, pp. 564-570
-
-
Rochel, N.1
-
40
-
-
1942425955
-
Interaction of estrogen receptor α with 3-methyladenine DNA glycosylase modulates transcription and DNA repair
-
Likhite, V.S., Cass, E.I., Anderson, S.D., Yates, J.R. & Nardulli, A.M. Interaction of estrogen receptor α with 3-methyladenine DNA glycosylase modulates transcription and DNA repair. J. Biol. Chem. 279, 16875-16882 (2004).
-
(2004)
J. Biol. Chem
, vol.279
, pp. 16875-16882
-
-
Likhite, V.S.1
Cass, E.I.2
Anderson, S.D.3
Yates, J.R.4
Nardulli, A.M.5
-
41
-
-
84857145742
-
The nuclear receptor signalling scaffold: Insights from full-length structures
-
Nwachukwu, J.C. & Nettles, K.W. The nuclear receptor signalling scaffold: insights from full-length structures. EMBO J. 31, 251-253 (2012).
-
(2012)
EMBO J.
, vol.31
, pp. 251-253
-
-
Nwachukwu, J.C.1
Nettles, K.W.2
-
42
-
-
79953164697
-
ERα-associated protein networks
-
Schultz-Norton, J.R., Ziegler, Y.S. & Nardulli, A.M. ERα-associated protein networks. Trends Endocrinol. Metab. 22, 124-129 (2011).
-
(2011)
Trends Endocrinol. Metab
, vol.22
, pp. 124-129
-
-
Schultz-Norton, J.R.1
Ziegler, Y.S.2
Nardulli, A.M.3
-
43
-
-
82355163442
-
Minireview: Recent advances in extranuclear steroid receptor actions
-
Hammes, S.R. & Levin, E.R. Minireview: recent advances in extranuclear steroid receptor actions. Endocrinology 152, 4489-4495 (2011).
-
(2011)
Endocrinology
, vol.152
, pp. 4489-4495
-
-
Hammes, S.R.1
Levin, E.R.2
-
44
-
-
84867665597
-
The orphan nuclear receptor Nur77 regulates LKB1 localization and activates AMPK
-
Zhan, Y.Y. et al. The orphan nuclear receptor Nur77 regulates LKB1 localization and activates AMPK. Nat. Chem. Biol. 8, 807-904 (2012).
-
(2012)
Nat. Chem. Biol
, vol.8
, pp. 807-904
-
-
Zhan, Y.Y.1
-
45
-
-
84861528159
-
Inhibition of β-catenin signaling by nongenomic action of orphan nuclear receptor Nur77
-
Sun, Z. et al. Inhibition of β-catenin signaling by nongenomic action of orphan nuclear receptor Nur77. Oncogene 31, 2653-2667 (2012).
-
(2012)
Oncogene
, vol.31
, pp. 2653-2667
-
-
Sun, Z.1
-
46
-
-
84879122903
-
-
National Research Council (U.S.). (eds. Connelly, T. & Sharp, P.) 12 (National Academies Press, Washington, D.C.)
-
National Research Council (U.S.). A New Biology for the 21st Century (eds. Connelly, T. & Sharp, P.) 12 (National Academies Press, Washington, D.C., 2009).
-
(2009)
A New Biology for the 21st Century
-
-
-
47
-
-
76449098262
-
PHENIX: A comprehensive Python-based system for macromolecular structure solution
-
Adams, P.D. et al. PHENIX: a comprehensive Python-based system for macromolecular structure solution. Acta Crystallogr. D Biol. Crystallogr. 66, 213-221 (2010).
-
(2010)
Acta Crystallogr. D Biol. Crystallogr
, vol.66
, pp. 213-221
-
-
Adams, P.D.1
-
48
-
-
7544226311
-
PRODRG: A tool for high-throughput crystallography of protein-ligand complexes
-
Schüttelkopf, A.W. & van Aalten, D.M. PRODRG: a tool for high-throughput crystallography of protein-ligand complexes. Acta Crystallogr. D Biol. Crystallogr. 60, 1355-1363 (2004).
-
(2004)
Acta Crystallogr. D Biol. Crystallogr
, vol.60
, pp. 1355-1363
-
-
Schüttelkopf, A.W.1
Van Aalten, D.M.2
-
50
-
-
79953765276
-
Presenting your structures: The CCP4mg molecular-graphics software
-
McNicholas, S., Potterton, E., Wilson, K.S. & Noble, M.E. Presenting your structures: the CCP4mg molecular-graphics software. Acta Crystallogr. D Biol. Crystallogr. 67, 386-394 (2011).
-
(2011)
Acta Crystallogr. D Biol. Crystallogr
, vol.67
, pp. 386-394
-
-
McNicholas, S.1
Potterton, E.2
Wilson, K.S.3
Noble, M.E.4
|