Predicting hepatotoxicity using ToxCast in vitro bioactivity and chemical structure

Chemical Research in Toxicology

Volumn 28, Issue 4, 2015, Pages 738-751

  Liu, Jie ^a,b,c   Mansouri, Kamel ^a,c   Judson, Richard S ^a   Martin, Matthew T ^a   Hong, Huixiao ^d   Chen, Minjun ^d   Xu, Xiaowei ^b,d   Thomas, Russell S ^a   Shah, Imran ^a  

^a U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

^b University of Arkansas   (United States)

^c OAK RIDGE INSTITUTE FOR SCIENCE AND EDUCATION   (United States)

^d NATIONAL CENTER FOR TOXICOLOGICAL RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BENZODIAZEPINE RECEPTOR; BONE MORPHOGENETIC PROTEIN; CELL NUCLEUS RECEPTOR; CYTOCHROME P450 1A2; CYTOCHROME P450 2B6; CYTOCHROME P450 2C19; ENVIRONMENTAL CHEMICAL; ESTROGEN RECEPTOR ALPHA; NORADRENALIN TRANSPORTER; ORGANIC CATION TRANSPORTER 1; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR; PREGNANE X RECEPTOR; RETINOIC ACID RECEPTOR ALPHA; RETINOID X RECEPTOR BETA; STEROID RECEPTOR COACTIVATOR 1; VITAMIN D RECEPTOR;

ALGORITHM; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BAYESIAN LEARNING; BIOLOGICAL ACTIVITY; CHEMICAL INTERACTION; CHEMICAL STRUCTURE; CLASSIFICATION AND REGRESSION TREE; EMBRYO; ENSEMBLE OF THESE CLASSIFIER; HEPG2 CELL LINE; HISTOPATHOLOGY; HUMAN; HUMAN CELL; IN VITRO STUDY; K NEAREST NEIGHBOR; LINEAR DISCRIMINANT ANALYSIS; LIVER HYPERTROPHY; LIVER INJURY; LIVER TOXICITY; MACHINE LEARNING; MCF 7 CELL LINE; MITOCHONDRIAL TOXICITY; MITOSIS INHIBITION; NONHUMAN; PREDICTION; RAT; SENSITIVITY AND SPECIFICITY; STRESS; SUPPORT VECTOR MACHINE; XENOBIOTIC METABOLISM; ANIMAL; DRUG EFFECTS; LIVER; TOXICITY TESTING;

ANIMALIA; RATTUS; RODENTIA;

ANIMALS; IN VITRO TECHNIQUES; LIVER; MOLECULAR STRUCTURE; RATS; TOXICITY TESTS;

EID: 84928125522     PISSN: 0893228X     EISSN: 15205010     Source Type: Journal    
DOI: 10.1021/tx500501h     Document Type: Article

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