Identifying off-target effects and hidden phenotypes of drugs in human cells

Nature Chemical Biology

Volumn 2, Issue 6, 2006, Pages 329-337

  MacDonald, Marnie L ^a   Lamerdin, Jane ^a   Owens, Stephen ^a   Keon, Brigitte H ^a   Bilter, Graham K ^a   Shang, Zhidi ^a   Huang, Zhengping ^a   Yu, Helen ^a   Dias, Jennifer ^a   Minami, Tomoe ^a   Michnick, Stephen W ^b   Westwick, John K ^a  

^a Odyssey Thera Incorporated   (United States)

^b UNIVERSITÉ DE MONTRÉAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 2 AMINO 6 BROMO 4 (1 CYANO 2 ETHOXY 2 OXOETHYL) 4H CHROMENE 3 CARBOXYLIC ACID ETHYL ESTER; 2 MORPHOLINO 8 PHENYLCHROMONE; 2 [[2 [[2 [(2 AMINO 3 MERCAPTOPROPYL)AMINO] 3 METHYLPENTYL]OXY] 1 OXO 3 PHENYLPROPYL]AMINO] 4 (METHYLSULFONYL)BUTANOIC ACID ISOPROPYL ESTER; 3 (4 METHYLPHENYLSULFONYL) 2 PROPENENITRILE; 4 (1 AMINOETHYL) N (4 PYRIDYL)CYCLOHEXANECARBOXAMIDE; 4 (3 BROMOANILINO) 6 (METHYLAMINO)PYRIDO[3,4 D]PYRIMIDINE; 4 (3 BROMOANILINO) 6,7 DIMETHOXYQUINAZOLINE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; 5 (4 CHLOROPHENYL) 1 (4 METHOXYPHENYL) 3 TRIFLUOROMETHYL 1H PYRAZOLE; 6,7 DIMETHOXY 2 PHENYLQUINOXALINE; ADRENERGIC RECEPTOR STIMULATING AGENT; ANTINEOPLASTIC AGENT; APIGENIN; AROMATASE INHIBITOR; BENZYLOXYCARBONYLLEUCYLLEUCYLLEUCINAL; CALYCULIN A; CINNARIZINE; CLOFIBRATE; CLOTRIMAZOLE; FENOFIBRATE; GELDANAMYCIN; GGTI 2133; GP 6976; HEAT SHOCK PROTEIN 90 INHIBITOR; HISTONE DEACETYLASE INHIBITOR; HORMONE RECEPTOR AFFECTING AGENT; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; IMATINIB; INDIRUBIN; N (2 BENZOYLPHENYL) O [2 (METHYL 2 PYRIDINYLAMINO)ETHYL]TYROSINE; N [5 (3 DIMETHYLAMINOBENZAMIDO) 2 METHYLPHENYL] 4 HYDROXYBENZAMIDE; NICLOSAMIDE; PATULIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA AGONIST; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA AGONIST; PIFITHRIN ALPHA; PROTEASOME INHIBITOR; ROTENONE; SERTRALINE; TRICHOSTATIN A; UNCLASSIFIED DRUG; UNINDEXED DRUG; YELLOW FLUORESCENT PROTEIN;

ALGORITHM; ANTINEOPLASTIC ACTIVITY; ARTICLE; BIOASSAY; BIOCHEMISTRY; CANCER CELL CULTURE; CELL FUNCTION; CELL MEMBRANE POTENTIAL; CELL STRAIN HEK293; CONTROLLED STUDY; CYTOTOXICITY; DRUG EFFECT; DRUG MECHANISM; DRUG POTENCY; DRUG PROTEIN BINDING; DRUG RESEARCH; DRUG RESPONSE; DRUG SCREENING; DRUG TARGETING; EMBRYO; HUMAN; HUMAN CELL; MEASUREMENT; MITOCHONDRIAL MEMBRANE; PHENOTYPE; PREDICTION; PRIORITY JOURNAL; REGULATORY MECHANISM; REPRODUCIBILITY; STRUCTURE ACTIVITY RELATION; VALIDATION STUDY;

EID: 33646893689     PISSN: 15524450     EISSN: 15524469     Source Type: Journal    
DOI: 10.1038/nchembio790     Document Type: Article

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