Scutellarin attenuates endothelium-dependent aasodilation impairment induced by hypoxia reoxygenation, through regulating the PKG signaling pathway in rat coronary artery

Chinese Journal of Natural Medicines

Volumn 13, Issue 4, 2015, Pages 264-0273

  Chen, Ya Juan ^a   Wang, Lei ^a   Zhou, Guang Yu ^a   Yu, Xian Lun ^c   Zhang, Yong Hui ^a   Hu, Na ^a   Li, Qing Qing ^a   Chen, Chen ^a   Qing, Chen ^a   Liu, Ying Ting ^b   Yang, Wei Min ^a  

^a KUNMING MEDICAL UNIVERSITY   (China)

^b KUNMING UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^c Forestry Research Institute of Zhaotong City   (China)

Author keywords

CGMP dependent protein kinase; Coronary artery; Endothelium dependent vasodilation; Hypoxia reoxygenation; Rat; Scutellarin

Indexed keywords

8 BROMO CYCLIC GMP; CYCLIC GMP; GLYCERYL TRINITRATE; NITRIC OXIDE SYNTHASE; PROTEIN KINASE; SCUTELLARIN; VASODILATOR STIMULATED PHOSPHOPROTEIN; 8-BROMOGUANOSINO-3',5'-CYCLIC MONOPHOSPHOROTHIOATE; ACTIN BINDING PROTEIN; APIGENIN; CELL ADHESION MOLECULE; CYCLIC GMP DEPENDENT PROTEIN KINASE; GLUCURONIC ACID; N(G) NITROARGININE METHYL ESTER; NUCLEOTIDE; PHOSPHOPROTEIN; VASODILATOR-STIMULATED PHOSPHOPROTEIN;

ANIMAL TISSUE; ARTICLE; BLOOD VESSEL TONE; CONTROLLED STUDY; CORONARY ARTERY; ENDOTHELIAL DYSFUNCTION; ENDOTHELIUM INJURY; HYPOXIA; MYOGRAPHY; NONHUMAN; PROTEIN EXPRESSION; RAT; REOXYGENATION; VASODILATATION; WESTERN BLOTTING; ANALOGS AND DERIVATIVES; ANIMAL; CELL HYPOXIA; COMPLICATION; CORONARY BLOOD VESSEL; DRUG EFFECTS; METABOLISM; PATHOPHYSIOLOGY; PHYSIOLOGY; REPERFUSION INJURY; SIGNAL TRANSDUCTION; SPRAGUE DAWLEY RAT;

ANIMALS; APIGENIN; CELL ADHESION MOLECULES; CELL HYPOXIA; CORONARY VESSELS; CYCLIC GMP; CYCLIC GMP-DEPENDENT PROTEIN KINASES; GLUCURONATES; MICROFILAMENT PROTEINS; NG-NITROARGININE METHYL ESTER; PHOSPHOPROTEINS; RATS; RATS, SPRAGUE-DAWLEY; REPERFUSION INJURY; SIGNAL TRANSDUCTION; THIONUCLEOTIDES; VASODILATION;

EID: 84928011225     PISSN: 20956975     EISSN: 18755364     Source Type: Journal    
DOI: 10.1016/S1875-5364(15)30013-3     Document Type: Article

References (43)

1. Yang WM, Lust RM, Bofferding A, et al. Nitric oxide and catalase-sensitive relaxation by scutellarin in the mouse thoracic aorta [J]. Cardiovasc Pharmacol 2009, 53(1):66-76.
2. Zhang HF, Hu XM, Wang LX, et al. Protective effects of scutellarin against cerebral ischemia in rats: evidence for inhibition of the apoptosis-inducing factor pathway [J]. Planta Med 2009, 75(2):121-126.
3. Lin LL, Liu AJ, Liu JG, et al. Protective effects of scutellarin and breviscapine on brain and heart ischemia in rats [J]. Cardiovasc Pharmacol 2007, 50(3):327-332.
4. Tang H, Tang Y, Li N, et al. Neuroprotective effects of scutellarin and scutellarein on repeatedly cerebral ischemia-reperfusion in rats [J]. Pharmacol Biochem Behav 2014, 3(118):51-59.
5. Balzer J, Heiss C, Schroeter H, et al. Flavanols and cardiovascular health:effects on the circulating NO pool in humans [J]. Cardiovasc Pharmacol 2006, 47(2):S122-S127.
6. Middleton E, Kandaswami C, Theoharides TC The effects of plant flavonoids on mammalian cells: implications for inflammation, heart disease, and cancer [J]. Pharmacol Rev 2000, 52(4):673-751.
7. Zhang W, Chen W, Wang Y, et al. Studies on flavone constituents of Erigeron breviscapus (Vant.) Hand.-Mazz [J]. China J Chin Mater Med 2000, 25(9):536-538.
8. Yang Z, Jin Y Herb Erigeron breviscapus. Modern Pharmacology and Clinic of Chinese Traditional Medicine [M] 2004, 1:628-663. Tianjin, Technology and Translation Publishing Company, China. 1st ed. B. Wang (Ed.).
9. Luo R, Wang J, Zhao L, et al. Synthesis and biological evaluation of baicalein derivatives as potent antitumor agents. [J]. Bioorg Med Chem Lett 2014, 24(5):1334-1338.
10. Kong X, Kong W, Miao G, et al. Pretreatment with scutellaria baicalensis stem-leaf total flavonoid protects against cerebral ischemia/reperfusion injury in hippocampal neurons [J]. Neural Regen Res 2014, 9(23):2066-2073.
11. Huang Y, Tsang SY, Yao X, et al. Biological properties of baicalein in cardiovascular system [J]. Curr Drug Targets Cardiovasc Haematol Disord 2005, 5(2):177-184.
12. Luo P, Tan ZH, Zhang ZF, et al. Scutellarin isolated from Erigeron multiradiatus inhibits high glucose-mediated vascular inflammation [J]. Yakugaku Zasshi 2008, 128(9):1293-1299.
13. Wang CZ, Mehendale SR, Calway T, et al. Botanical flavonoids on coronary heart disease [J]. Am J Chin Med 2011, 39(4):661-671.
14. Hong H, Liu GQ Scutellarin protects PC12 cells from oxidative stress-induced apoptosis [J]. Asian Nat Prod Res 2006, 8(6):471-479.
15. Ajay M, Gilani AU, Mustafa MR Effects of flavonoids on vascular smooth muscle of the isolated rat thoracic aorta [J]. Life Sci 2003, 74(5):603-612.
16. Morello S, Vellecco V, Alfieri A, et al. Vasorelaxant effect of the flavonoid galangin on isolated rat thoracic aorta [J]. Life Sci 2006, 78(8):825-830.
17. Fusi F, Durante M, Sgaragli G, et al. In Vitro Vasoactivity of Zerumbone from Zingiber zerumbet. [J]. Planta Med 2015, 81(4):298-304.
18. Chan EC, Pannangpetch P, Woodman OL Relaxation to flavones and flavonols in rat isolated thoracic aorta: mechanism of action and structure activity relationships [J]. J Cardiovasc Pharmacol 2000, 35(2):326-333.
19. Penso J, Cordeiro KC, da Cunha CR, et al. Vasorelaxant activity of 7-β-O-glycosides biosynthesized from flavonoids [J]. Eur J Pharmacol 2014, 15(733):75-80.
20. Radovits T, Zotkina J, Lin LN, et al. Endothelial dysfunction after hypoxia-reoxygenation: do in vitro models work [J]. J Vascul Pharmacol 2009, 51(1):37-43.
21. Eltzschig HK, Collard CD Vascular ischaemia and reperfusion injury [J]. J Br Med Bull 2004, 70(19):71-86.
22. Carden DL, Granger DN Pathophysiology of ischaemia-reperfusion injury [J]. J Pathol 2000, 190(3):255-266.
23. El Messaoudi S, Schreuder TH, Kengen RD, et al. Impact of metformin on endothelial ischemia-reperfusion injury in humans in vivo: a prospective randomized open, blinded-endpoint study [J]. PLoS One 2014, 9(4):e96062.
24. Laude K, Beauchamp P, Thuillez C, et al. Endothelial protective effects of preconditioning [J]. J Cardiovasc Res 2002, 55(3):466-473.
25. de Souza Md, Conde CM, Laflôr CM, et al. n-3 PUFA induce microvascular protective changes during ischemia/reperfusion [J]. Lipids 2015, 50(1):23-37.
26. Grover-Paez F, Zavalza-Gomez AB Endothelial dysfunction and cardiovascular risk factors [J]. Diabetes Res Clin Pract 2009, 84(1):1-10.
27. 1 [J]. J Mol Cancer Ther 2002, 1(10):803-809.
28. Chettimada S, Rawat DK, Dey N, et al. Glc-6-PD and PKG contribute to hypoxia-induced decrease in smooth muscle cell contractile phenotype proteins in pulmonary artery [J]. Am J Physiol Lung Cell Mol Physiol 2012, 303(1):64-74.
29. + channels via cyclic nucleotide-dependent protein kinases in mesenteric artery [J]. J Phytomedicine 2010, 17(10):760-770.
30. Bhayadia R, Schmidt BM, Melk A Senescence-Induced Oxidative Stress Causes Endothelial Dysfunction [J]. J Gerontol A Biol Sci Med Sci 2015, 3(1):8.
31. de Barros Correia Junior CA, Bezerra de Siqueira RJ, et al. Cardiovascular effects of a labdenic diterpene isolated from Moldenhawera nutans in conscious, spontaneously hypertensive rats [J]. Pharm Biol 2015, 53(4):582. 527.
32. Das R, Balonan L, Ballard HJ, et al. Chronic hypoxia inhibits the antihypertensive effect of melatonin on pulmonary artery [J]. Int J Cardiol 2008, 126(3):340-345.
33. Luca MC, Liuni A, McLaughlin K, et al. Daily ischemic preconditioning provides sustained protection from ischemia-reperfusion induced endothelial dysfunction: a human study [J]. J Am Heart Assoc 2013, 2(1):e000075.
34. Francis BN, Hale A, Channon KM, et al. Effects of tetrahydrobiopterin oral treatment in hypoxia-induced pulmonary hypertension in rat [J]. Pulm Circ 2014, 4(3):462-470.
35. LI Lai-Hong, WANG Jun-Song, KONG Ling-Yi, et al. Protective effects of Shengmai San and its three fractions on cerebral ischemia-reperfusion injury [J]. Chin J Nat Med 2013, 11(3):222-230.
36. WANG SB, PANG XB, Gao M, et al. Pinocembrin protects rats against cerebral ischemic damage through soluble epoxide hydrolase and epoxyeicosatrienoic acids [J]. Chin J Nat Med 2013, 11(3):207-213.
37. Richie-Jannetta R, Francis SH, Corbin JD Dimerization of cGMP-dependent protein kinase I beta is mediated by an extensive amino-terminal leucine zipper motif, and dimerization modulates enzyme function [J]. J Biol Chem 2003, 278(50):50070-50079.
38. Gambaryan S, Butt E, Marcus K, et al. cGMP-dependent protein kinase type ii regulates basal level of aldosterone production by zona glomerulosa cells without increasing expression of the steroidogenic acute regulatory protein gene [J]. J Biol Chem 2003, 278(32):29640-29648.
39. Liang YP, Ma J Blocking JAK-STAT channel on ischemia-reperfusion myocardial apoptosis and expression of Bcl-2_Bax [J]. J Chin Drugs Clin 2010, 10(4):425-426.
40. Aalkjaer C, Poston L Effects of pH on vascular tension: which are the important mechanisms [J]. J Vasc Res 1996, 33(5):347-359.
41. Aalkjaer C, Peng HL PH and smooth muscle [J]. Acta Physiol Scand 1997, 161(4):557-566.
42. Otter D, Austin C Simultaneous monitoring of vascular contractility intracellular pH and intracellular calcium in isolated rat mesenteric arteries effects of weak bases [J]. Exp Physiol 2000, 85(3):349-351.
43. Wray S, Smith RD Mechanisms of action of pH-induced effects on vascular smooth muscle [J]. Mol Cell Biochem 2004, 263(1-2):163-172.