Protective effects of scutellarin against cerebral ischemia in rats: Evidence for inhibition of the apoptosis-inducing factor pathway

Planta Medica

Volumn 75, Issue 2, 2009, Pages 121-126

  Zhang, Hua Feng ^a   Hu, Xia Min ^a   Wang, Lan Xin ^a   Xu, Shi Qiang ^a   Zeng, Fan Dian ^b  

^a WUHAN UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^b HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

Apoptosis; Apoptosis inducing factor; Cerebral ischemia; Erigeron breviscapus (Vant.) Hand Mazz (Compositae); Poly (ADP ribose) polymerase; Scutellarin

Indexed keywords

APOPTOSIS INDUCING FACTOR; DNA FRAGMENT; ERIGERON BREVISCAPUS EXTRACT; NICOTINAMIDE ADENINE DINUCLEOTIDE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; SCUTELLAREIN; APIGENIN; GLUCURONIC ACID; NEUROPROTECTIVE AGENT; PLANT EXTRACT; SCUTELLARIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN HOMOGENATE; BRAIN INFARCTION; BRAIN ISCHEMIA; BRAIN PROTECTION; CONTROLLED STUDY; DRUG MECHANISM; INHIBITION KINETICS; MALE; MIDDLE CEREBRAL ARTERY OCCLUSION; NEUROLOGIC DISEASE; NICK END LABELING; NONHUMAN; PROTEIN EXPRESSION; RAT; WESTERN BLOTTING; ANIMAL; APOPTOSIS; BRAIN; CELL NUCLEUS; CEREBRAL ARTERY DISEASE; DNA FRAGMENTATION; DRUG EFFECT; ERIGERON; GENETICS; METABOLISM; MITOCHONDRION; PHYTOTHERAPY; SPRAGUE DAWLEY RAT; TRANSPORT AT THE CELLULAR LEVEL;

ASTERACEAE; ERIGERON BREVISCAPUS; RATTUS;

ANIMALS; APIGENIN; APOPTOSIS; APOPTOSIS INDUCING FACTOR; BIOLOGICAL TRANSPORT; BRAIN; BRAIN ISCHEMIA; CELL NUCLEUS; DNA FRAGMENTATION; ERIGERON; GLUCURONIC ACIDS; INFARCTION, MIDDLE CEREBRAL ARTERY; MALE; MITOCHONDRIA; NAD; NEUROPROTECTIVE AGENTS; PHYTOTHERAPY; PLANT EXTRACTS; POLY(ADP-RIBOSE) POLYMERASES; RATS; RATS, SPRAGUE-DAWLEY;

EID: 63149085071     PISSN: 00320943     EISSN: 14390221     Source Type: Journal    
DOI: 10.1055/s-0028-1088368     Document Type: Article

References (25)

1. Liu PK. Ischemia-reperfusion-related repair deficit after oxidative stress: implications of faulty transcripts in neuronal sensitivity after brain injury. J Biomed Sci 2003; 10: 4-13
2. Hurn PD, Vannucci SJ, Hagberg H. Adult or perinatal brain injury: does sex matter? Stroke 2005; 36: 193-195
3. Lennmyr F, Karlsson S, Gerwins P, Ata KA, Terent A. Activation of mitogen-activated protein kinases in experimental cerebral ischemia. Acta Neurol Scand 2002; 106: 333-340 (Pubitemid 36020739)
4. Kao H, Takasawa R, Fukuda K, Shiokawa D, Sadanaga-Akiyoshi F, Ibayashi S et al. DNA fragmentation in ischemic core and penumbra in focal cerebral ischemia in rats. Mol Brain Res 2001; 91: 112-118 (Pubitemid 32702009)
5. Chan PH. Reactive oxygen radicals in signaling and damage in the ischemic brain. J Cereb Blood Flow Metab 2001; 21: 2-14
6. Yu SW, Wang H, Poitras MF, Coombs C, Bowers WJ, Federoff HJ et al. Mediation of poly(ADP-ribose) polymerase-1-dependent cell death by apoptosis-inducing factor. Science 2002; 297: 259-263 (Pubitemid 34761289)
7. Cipriani G, Rapizzi E, Vannacci A, Rizzuto R, Moroni F, Chiarugi A. Nuclear poly (ADP-ribose) polymerase-1 rapidly triggers mitochondrial dysfunction. J Biol Chem 2005; 280: 17227-17234 (Pubitemid 41389190)
8. Ju BG, Solum D, Song EJ, Lee KJ, Rose DW, Glass CK et al. Activating the PARP-1 sensor component of the groucho/TLE1 corepressor complex mediates a CaMKinase IIdelta-dependent neurogenic gene activation pathway. Cell 2004; 119: 815-829 (Pubitemid 40017688)
9. Daugas E, Susin SA, Zamzami N, Ferri KF, Irinopoulou T, Larochette N et al. Mitochondrio-nuclear translocation of AIF in apoptosis and necrosis. FASEB J 2000; 14: 729-739 (Pubitemid 30198571)
10. Cheung EC, Melanson-Drapeau L, Cregan SP, Vanderluit JL, Ferguson KL, McIntosh WC et al. Apoptosis-inducing factor is a key factor in neuronal cell death propagated by BAX-dependent and BAX-independent mechanisms. J Neurosci 2005; 25: 1324-1334 (Pubitemid 40250708)
11. Plesnila N, Zhu C, Culmsee C, Groger M, Moskowitz MA, Blomgren K. Nuclear translocation of apoptosis-inducing factor after focal cerebral ischemia. J Cereb Blood Flow Metab 2004; 24: 458-466 (Pubitemid 38452237)
12. Culmsee C, Zhu C, Landshamer S, Becattini B, Wagner E, Pellechia M et al. Apoptosis-inducing factor triggered by poly (ADP-ribose) polymerase and Bid mediates neuronal cell death after oxygen-glucose deprivation and focal cerebral ischemia. J Neurosci 2005; 25: 10262-10272 (Pubitemid 41636223)
13. Liu H, Yang XL, Wang Y, Tang XQ, Jiang DY, Xu HB. Protective effects of scutellarin on superoxide-induced oxidative stress in rat cortical synaptosomes. Acta Pharmacol Sin 2003; 24: 1113-1117 (Pubitemid 37408672)
14. Yang XF, He W, Lu WH, Zeng FD. Effects of scutellarin on liver function after brain I/R in rats. Acta Pharmacol Sin 2003; 24: 1118-1124 (Pubitemid 37408673)
15. Hu XM, Zhou MM, Zeng FD. Neuroprotective effects of scutellarin on rat neuronal damage induced by cerebral ischemia/reperfusion. Acta Pharmacol Sin 2005; 26: 1454-1459
16. Zea Longa E, Weinstein PR, Carlson S, Cummins R. Reversible middle cerebral artery occlusion without craniotomy in rats. Stroke 1989; 20: 84-91 (Pubitemid 19040218)
17. Nisselbaum JS, Green S. A simple ultramicro method for determination of pyridine nucleotides in tissues. Anal Biochem 1969; 27: 212-217
18. Cao G, Pei W, Ge H, Liang Q, Luo Y, Sharp FR et al. In vivo delivery of a Bcl-xL fusion protein containing the TAT protein transduction domain protects against ischemic brain injury and neuronal apoptosis. J Neurosci 2002; 22: 5423-5431
19. Wang H, Yu SW, Koh DW, Lew J, Coombs C, Bowers W et al. Apoptosis-inducing factor substitutes for caspase executioners in NMDA-triggered excitotoxic neuronal death. J Neurosci 2004; 24: 10963-10973 (Pubitemid 39602407)
20. Nakajima H, Kakui N, Ohkuma K, Ishikawa M, Hasegawa T. A newly synthesized poly (ADP-ribose) polymerase inhibitor, 2-methyl-3, 5, 7, 8-tetrahydrothiopyrano [4, 3-d] pyrimidine-4-one (DR2313): pharmacological profiles, neuroprotective effects and therapeutic time window in cerebral ischemia in rats. J Pharmacol Exp Ther 2004; 1: 472-481
21. LaPlaca MC, Zhang J, Raghupathi R, Li JH, Smith F, Bareyre FM et al. Pharmacologic inhibition of poly (ADP-ribose) polymerase is neuroprotective following traumatic brain injury in rats. J Neurotrauma 2001; 18: 369-376 (Pubitemid 32336543)
22. Hong SJ, Dawson TM, Dawson VL. Nuclear and mitochondrial conversations in cell death: PARP-1 and AIF signaling. Trends Pharmacol Sci 2004; 25: 259-264
23. Li X, Nemoto M, Xu Z, Yu SW, Shimoji M, Andrabi SA et al. Influence of duration of focal cerebral ischemia and neuronal nitric oxide synthase on translocation of apoptosis-inducing factor to the nucleus. Cell Neurosci 2007; 144: 56-65
24. Alberto Chiarugi. Poly (ADP-ribosyl)ation and stroke. Pharmacol Res 2005; 52: 15-24
25. Ye H, Cande C, Stephanou NC, Jiang S, Gurbuxani S, Larochette N et al. DNA binding is required for the apoptogenic action of apoptosis inducing factor. NatuStruct Mol Biol 2002; 9: 680-684 (Pubitemid 34977301)