Effects of flavonoids on vascular smooth muscle of the isolated rat thoracic aorta

Life Sciences

Volumn 74, Issue 5, 2003, Pages 603-612

  Ajay, Machha ^a   Gilani, Anwar Ul Hassan ^b   Mustafa, Mohd Rais ^a  

^a UNIVERSITY OF MALAYA   (Malaysia)

^b AGA KHAN UNIVERSITY MEDICAL COLLEGE   (Pakistan)

Author keywords

Flavonoids; Rat aorta; Structure activity relationship; Vasorelaxant

Indexed keywords

AURANTIIN; BAICALEIN; CHRYSIN; DAIDZEIN; EPIGALLOCATECHIN GALLATE; FISETIN; FLAVAN DERIVATIVE; FLAVANONE DERIVATIVE; FLAVONE DERIVATIVE; FLAVONOL DERIVATIVE; INDOMETACIN; ISOFLAVONE DERIVATIVE; N(G) NITROARGININE METHYL ESTER; NARINGENIN; QUERCETIN; RUTOSIDE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CALCIUM CELL LEVEL; CALCIUM TRANSPORT; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; DRUG POTENCY; MALE; NONHUMAN; PROSTAGLANDIN RELEASE; RAT; SMOOTH MUSCLE CONTRACTION; STRUCTURE ACTIVITY RELATION; THORACIC AORTA; VASCULAR ENDOTHELIUM; VASCULAR SMOOTH MUSCLE; VASODILATATION;

EID: 0242667857     PISSN: 00243205     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.lfs.2003.06.039     Document Type: Article

References (20)

1. Beretz A., Stoclet J., Anton R. Inhibition of isolated rat aorta contraction by flavonoids. Possible correlation with cAMP-phosphodiesterase inhibition. Planta Medica. 39:1980;236.
2. Bolton T.B. Mechanism of action of transmitters and other substances on smooth muscles. Physiological Reviews. 59:1979;606-718.
3. Cauvin C., Malik S. Induction of calcium influx and intracellular calcium release in isolated rat aorta and mesenteric resistance vessels by norepinephrine activation of α-receptors. Journal of Pharmacology and Experimental Therapeutics. 230:1984;413-418.
4. Chen C.K., Pace-Asciak C.R. Vasorelaxing activity of resveratrol and quercetin in isolated rat aorta. General Pharmacology. 27(2):1996;363-366.
5. Chan E.C.H., Pannangpetch P., Woodman O.L. Relaxation of flavones and flavonols in rat isolated thoracic aorta: mechanism of action and structure-activity relationships. Journal of cardiovascular pharmacology. 35:2000;326-333.
6. Di Carlo G., Autore G., Izzo A.A., Maiolino P., Mascolo N., Viola P., Diurno M.V., Capasso F. Inhibition of intestinal motility and secretion by flavonoids in mice and rats: structure-activity relationships. Journal of Pharmacy and Pharmacology. 45(12):1993;1054-1059.
7. Duarte J., Perez-Vizcaino F., Utrilla P., Jimenez J., Tamargo J., Zarzuelo A. Vasodilatory effects of flavonoids in rat aortic smooth muscle. Structure-activity relationships. General Pharmacology. 24:1993;857-862.
8. Duarte J., Perez-Vizcaino F., Zarzuelo A., Jimeneze J., Tamargo J. Vasodilator effects of quercetin in isolated rat vascular smooth muscle. European Journal of Pharmacology. 239:1993;1-7.
9. Duke J.A. Handbook of phytochemical constituents in GRAS herbs and other economical plants. 1992;CRC press, London.
10. Fitzpatrick D.F., Hirschfield S.L., Coffey R.G. Endothelium-dependent vasorelaxing activity of wine and other grape products. Annual Journal of Physiology. 265:1993;H774-H778.
11. Formica J.V., Regelson W. Review of the biology of quercetin and related bioflavonoids. Food and Chemical Toxicology. 33:1995;1061-1080.
12. Hammad H.M., Abdalla S.S. Pharmacological effects of selected flavonoids on rat isolated ileum: structure-activity relationship. General Pharmacology. 28:1997;767-771.
13. Herrera M.D., Duarte J., Jimenez J., Marhuehda E. Effect of flavonoids on rat thoracic muscle contractility. Structure_activity relationships. General Pharmacology. 27:1996;273-277.
14. Hertog M.G.L., Feskens E.J.M., Hollman P.C.H., Katan M.B., Klomhout D. Dietary antioxidant flavonoids and risk of coronary heart disease: The Zutphen Elderly study. Lancet. 342:1993;1007-1011.
15. Jaffe E.A., Levin R.I., Weksler B.B., Marcus A.J. Synthesis of prostacyclin by cultured endothelial cells. Nossel H.L., Vogel H.J. Pathobiology of endothelial cells. 1982;301-309 Academic Press, New York.
16. Karaki H., Weiss G.B. Calcium channels in smooth muscle. Gastroenterology. 87:1984;960-970.
17. Knekt P., Jarvinen R., Reunanen A., Maatela J. Flavonoid intake and coronary mortality in Finland: a comparative study. British Medical Journal. 312:1996;478-481.
18. Lunte S.M. Structural classification of flavonoids in beverages by liquid chromatography with UV/visible and electrochemical detection. Journal of Chromatography. 384:1981;371-382.
19. Middleton E. Jr. The flavonoids. Trends in Pharmacological Sciences. 5:1984;335-338.
20. Vanhoutte P.M., Rubavyi G.M., Miller V.M., Houstan D.S. Modulation of vascular smooth muscle contraction by endothelium. Annual Review of Physiology. 48:1986;307-330.