Cardiovascular effects of a labdenic diterpene isolated from Moldenhawera nutans in conscious, spontaneously hypertensive rats

Pharmaceutical Biology

Volumn 53, Issue 4, 2015, Pages 582-587

  De Barros Correia, Carlos Antônio ^a   De Siqueira, Rodrigo José Bezerra ^b   Interaminense, Leylliane Fátima Leal ^a   Alves Santos, Thayane Rebeca ^a   Duarte, Gloria Pinto ^a   David, Jorge Maurício ^c   David, Juceni Pereira ^c   Magalhães, Pedro Jorge Caldas ^b   Lahlou, Saad ^b  

^a FEDERAL UNIVERSITY OF PERNAMBUCO   (Brazil)

^b FEDERAL UNIVERSITY OF CEARÁ   (Brazil)

^c FEDERAL UNIVERSITY OF BAHIA   (Brazil)

Author keywords

Autonomic nervous system; Hypotension; Isolated rat aorta; Labd 8(17) en 15 oic acid; Relaxation; Tachycardia

Indexed keywords

ANTIHYPERTENSIVE AGENT; HEXAMETHONIUM; LABDENIC DITERPENE; METHYLATROPINE; N(G) NITROARGININE METHYL ESTER; PROPRANOLOL; UNCLASSIFIED DRUG; DITERPENE; LABD-8 (17)-EN-15-OIC ACID; PLANT EXTRACT;

ADVERSE OUTCOME; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIHYPERTENSIVE THERAPY; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG DETERMINATION; DRUG DOSE INCREASE; DRUG EFFECT; DRUG MECHANISM; DRUG STRUCTURE; HYPERTENSION; IC50; IN VITRO STUDY; IN VIVO STUDY; LEGUME; MALE; MEAN ARTERIAL PRESSURE; MOLDENHAWERA NUTANS; NONHUMAN; RAT; SPONTANEOUSLY HYPERTENSIVE RAT; TACHYCARDIA; ANIMAL; AUTONOMIC NERVOUS SYSTEM; CHEMICALLY INDUCED; CHEMISTRY; COMPLICATION; DRUG EFFECTS; FABACEAE; ISOLATION AND PURIFICATION; PATHOPHYSIOLOGY; PLANT STEM; SPECIES DIFFERENCE; WISTAR KYOTO RAT;

FABACEAE; RATTUS;

ANIMALS; ANTIHYPERTENSIVE AGENTS; AUTONOMIC NERVOUS SYSTEM; DITERPENES; FABACEAE; HYPERTENSION; PLANT EXTRACTS; PLANT STEMS; RATS, INBRED SHR; RATS, INBRED WKY; SPECIES SPECIFICITY; TACHYCARDIA;

EID: 84921907417     PISSN: 13880209     EISSN: 17445116     Source Type: Journal    
DOI: 10.3109/13880209.2014.934964     Document Type: Article

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