Nitric oxide and catalase-sensitive relaxation by scutellarin in the mouse thoracic aorta

Journal of Cardiovascular Pharmacology

Volumn 53, Issue 1, 2009, Pages 66-76

  Yang, Weimin ^a,b   Lust, Robert M ^a   Bofferding, April ^a   Wingard, Christopher J ^a  

^a EAST CAROLINA UNIVERSITY   (United States)

^b KUNMING MEDICAL UNIVERSITY   (China)

Author keywords

Endothelium; MLC20 phosphorylation; Smooth muscle relaxation

Indexed keywords

9 (TETRAHYDRO 2 FURYL)ADENINE; AMITROLE; CALCIUM ION; CATALASE; GUANYLATE CYCLASE INHIBITOR; MYOSIN; MYOSIN LIGHT CHAIN; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; PHENYLEPHRINE; SCUTELLAREIN; 1,2,4-TRIAZOLE; APIGENIN; ARGININE; CELL RECEPTOR; ENZYME INHIBITOR; GLUCURONIC ACID; GUANYLATE CYCLASE; SCUTELLARIN; SOLUBLE GUANYLYL CYCLASE; TRIAZOLE DERIVATIVE;

ANIMAL TISSUE; ARTERY CONSTRICTION; ARTERY DILATATION; ARTERY ENDOTHELIUM; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; MALE; MOUSE; MUSCLE FORCE; NONHUMAN; PH; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; THORACIC AORTA; ANIMAL; ANTAGONISTS AND INHIBITORS; DRUG EFFECTS; INSTITUTE FOR CANCER RESEARCH MOUSE; METABOLISM; PHYSIOLOGY;

AMITROLE; ANIMALS; AORTA, THORACIC; APIGENIN; ARGININE; CATALASE; ENZYME INHIBITORS; GLUCURONATES; GUANYLATE CYCLASE; MALE; MICE; MICE, INBRED ICR; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; PHENYLEPHRINE; RECEPTORS, CYTOPLASMIC AND NUCLEAR; TRIAZOLES;

EID: 67651108731     PISSN: 01602446     EISSN: None     Source Type: Journal    
DOI: 10.1097/FJC.0b013e318195d776     Document Type: Article

References (61)

1. Ajay M, Gilani AU, Mustafa MR. Effects of flavonoids on vascular smooth muscle of the isolated rat thoracic aorta. Life Sci. 2003;74: 603-612. (Pubitemid 37410351)
2. Rice-Evans CA, Miller NJ. Antioxidant activities of flavonoids as bioactive components of food. Biochem Soc Trans. 1996;24:790-795. (Pubitemid 26306300)
3. Bors W, Heller W, Michel C, et al. Flavonoids as antioxidants: determination of radical-scavenging efficiencies. Methods Enzymol. 1990;186:343-355. (Pubitemid 20279976)
4. Kris-Etherton PM, Lefevre M, Beecher GR, et al. Bioactive compounds in nutrition and health-research methodologies for establishing biological function: the antioxidant and anti-inflammatory effects of flavonoids on atherosclerosis. Annu Rev Nutr. 2004;24:511-538. (Pubitemid 38938802)
5. Middleton E Jr, Kandaswami C, Theoharides TC. The effects of plant flavonoids on mammalian cells: implications for inflammation, heart disease, and cancer. Pharmacol Rev. 2000;52:673-751.
6. Balzer J, Heiss C, Schroeter H, et al. Flavanols and cardiovascular health: effects on the circulating NO pool in humans. J Cardiovasc Pharmacol. 2006;47(Suppl 2):S122-S127. (Pubitemid 44620202)
7. Nestel P. Isoflavones: their effects on cardiovascular risk and functions. Curr Opin Lipidol. 2003;14:3-8. (Pubitemid 36183094)
8. Mink PJ, Scrafford CG, Barraj LM, et al. Flavonoid intake and cardiovascular disease mortality: a prospective study in postmenopausal women. Am J Clin Nutr. 2007;85:895-909. (Pubitemid 46393524)
9. Riemersma RA, Rice-Evans CA, Tyrrell RM, et al. Tea flavonoids and cardiovascular health. QJM. 2001;94:277-282.
10. Brownson DM, Azios NG, Fuqua BK, et al. Flavonoid effects relevant to cancer. J Nutr. 2002;132(Suppl 11):3482S-3489S.
11. Zhang R, Zhang Y,Wang J. Isolation and identification of flavonoids from Erigeron breviscapus. Chin Tradit Herb Med. 1988;19:7-11.
12. Zhang W, Chen W, Wang Y, et al. Studies on flavone constituents of Erigeron breviscapus (Vant.) Hand.-Mazz. Zhongguo Zhong Yao Za Zhi. 2000;25:536-538.
13. Yang Z, Jin Y. Herb Erigeron breviscapus. In: Wang B, ed. Modern Pharmacology and Clinic of Chinese Traditional Medicine. 1st ed. Tianjing, China: Tianjing Technology and Translation Publishing Company; 2004:628-633.
14. Hong H, Liu GQ. Scutellarin attenuates oxidative glutamate toxicity in PC12 cells. Planta Med. 2004;70:427-431. (Pubitemid 38716475)
15. Liu H, Yang X, Tang R, et al. Effect of scutellarin on nitric oxide production in early stages of neuron damage induced by hydrogen peroxide. Pharmacol Res. 2005;51:205-210. (Pubitemid 40127211)
16. Yang XF, HeW, Lu WH, et al. Effects of scutellarin on liver function after brain ischemia/reperfusion in rats. Acta Pharmacol Sin. 2003;24: 1118-1124.
17. Hu XM, Zhou MM, Hu XM, et al. Neuroprotective effects of scutellarin on rat neuronal damage induced by cerebral ischemia/reperfusion. Acta Pharmacol Sin. 2005;26:1454-1459.
18. Lin LL, Liu AJ, Liu JG, et al. Protective effects of scutellarin and breviscapine on brain and heart ischemia in rats. J Cardiovasc Pharmacol. 2007;50:327-332. (Pubitemid 47428983)
19. Liu H, Yang X, Zhou L, et al. Study on effects of scutellarin on scavenging reactive oxygen. Zhong Yao Cai. 2002;25:491-493.
20. Liu H, Yang XL, Wang Y, et al. Protective effects of scutellarin on superoxide-induced oxidative stress in rat cortical synaptosomes. Acta Pharmacol Sin. 2003;24:1113-1117. (Pubitemid 37408672)
21. Huang JM, Weng WY, Huang XB, et al. Pharmacokinetics of scutellarin and its aglycone conjugated metabolites in rats. Eur J Drug Metab Pharmacokinet. 2005;30:165-170. (Pubitemid 41499257)
22. Xia H, Qiu F, Zhu S, et al. Isolation and identification of ten metabolites of breviscapine in rat urine. Biol Pharm Bull. 2007;30:1308-1316. (Pubitemid 47037661)
23. Jiang XH, Li SH, Lan K, et al. [Study on the pharmacokinetics of scutellarin in dogs]. Yao Xue Xue Bao. 2003;38:371-373.
24. Chen X, Cui L, Duan X, et al. Pharmacokinetics and metabolism of the flavonoid scutellarin in humans after a single oral administration. Drug Metab Dispos. 2006;34:1345-1352. (Pubitemid 44079875)
25. Chen J, Lin J, Wang T, et al. The relaxation effects of six extracts from Chinese herbs on the corpus cavernosum tissue of rabbit in vitro. Zhonghua Nan Ke Xue. 2005;11:793-795.
26. Zheng G,Wang X, Li X, et al. Effects of breviscapine on isolated thoracic aorta rings of rats. Acad J Guangdong Coll Pharm. 1997;13:215-218.
27. Zhu BH, Guan YY, He H, et al. Erigeron breviscapus prevents defective endothelium-dependent relaxation in diabetic rat aorta. Life Sci. 1999;65: 1553-1559. (Pubitemid 29468899)
28. Lo YC, Tsou HH, Lin RJ, et al. Endothelium-dependent and -independent vasorelaxation by a theophylline derivative MCPT: roles of cyclic nucleotides, potassium channel opening and phosphodiesterase inhibition. Life Sci. 2005;76:931-944.
29. Morello S, Vellecco V, Alfieri A, et al. Vasorelaxant effect of the flavonoid galangin on isolated rat thoracic aorta. Life Sci. 2006;78:825-830. (Pubitemid 43082305)
30. Chen CK, Pace-Asciak CR. Vasorelaxing activity of resveratrol and quercetin in isolated rat aorta. Gen Pharmacol. 1996;27:363-366. (Pubitemid 26129194)
31. Chan EC, Pannangpetch P, Woodman OL. Relaxation to flavones and flavonols in rat isolated thoracic aorta: mechanism of action and structureactivity relationships. J Cardiovasc Pharmacol. 2000;35:326-333. (Pubitemid 30073828)
32. Tawfik HE, Schnermann J, Oldenburg PJ, et al. Role of A1 adenosine receptors in regulation of vascular tone. Am J Physiol Heart Circ Physiol. 2005;288:H1411-H1416. (Pubitemid 40270052)
33. Iwama Y, Kato T, Muramatsu M, et al. Correlation with blood pressure of the acetylcholine-induced endothelium-derived contracting factor in the rat aorta. Hypertension. 1992;19:326-332.
34. Vanhoutte PM. Endothelial dysfunction in hypertension. J Hypertens Suppl. 1996;14:S83-S93.
35. Yang D, Levens N, Zhang JN, et al. Specific potentiation of endotheliumdependent contractions in SHR by tetrahydrobiopterin. Hypertension. 2003;41:136-142. (Pubitemid 36056805)
36. Ge T, Hughes H, Junquero DC, et al. Endothelium-dependent contractions are associated with both augmented expression of prostaglandin H synthase-1 and hypersensitivity to prostaglandin H2 in the SHR aorta. Circ Res. 1995;76:1003-1010.
37. Jaffe E, Levin R, Weksler B, et al. Synthesis of prostacyclin by cultured endothelial cells. In: Nossel H, Vogel H, eds. Pathobiology of Endothelial Cells. New York, NY: Academic Press; 1982: 301-309.
38. Droge W. Free radicals in the physiological control of cell function. Physiol Rev. 2002;82:47-95. (Pubitemid 34654215)
39. Lucchesi PA, Belmadani S, Matrougui K. Hydrogen peroxide acts as both vasodilator and vasoconstrictor in the control of perfused mouse mesenteric resistance arteries. J Hypertens. 2005;23:571-579. (Pubitemid 40684716)
40. Ellis A, Pannirselvam M, Anderson TJ, et al. Catalase has negligible inhibitory effects on endothelium-dependent relaxations in mouse isolated aorta and small mesenteric artery. Br J Pharmacol. 2003;140: 1193-1200. (Pubitemid 38117423)
41. Hong H, Liu GQ. Protection against hydrogen peroxide-induced cytotoxicity in PC12 cells by scutellarin. Life Sci. 2004;74:2959-2973. (Pubitemid 38402293)
42. Ardanaz N, Beierwaltes WH, Pagano PJ. Distinct hydrogen peroxideinduced constriction in multiple mouse arteries: potential influence of vascular polarization. Pharmacol Rep. 2008;60:61-67. (Pubitemid 351586543)
43. Mohazzab H, Agarwal R, Wolin MS. Influence of glutathione peroxidase on coronary artery responses to alterations in PO2 and H2O2. Am J Physiol. 1999;276:H235-H241.
44. Drouin A, Thorin-Trescases N, Hamel E, et al. Endothelial nitric oxide synthase activation leads to dilatory H2O2 production in mouse cerebral arteries. Cardiovasc Res. 2007;73:73-81. (Pubitemid 44937186)
45. Takaki A, Morikawa K, Tsutsui M, et al. Crucial role of nitric oxide synthases system in endothelium-dependent hyperpolarization in mice. J Exp Med. 2008;205:2053-2063.
46. Iesaki T, Gupte SA, Kaminski PM, et al. Inhibition of guanylate cyclase stimulation by NO and bovine arterial relaxation to peroxynitrite and H2O2. Am J Physiol. 1999;277:H978-H985. (Pubitemid 29459612)
47. Nagaoka T, Hein TW, Yoshida A, et al. Resveratrol, a component of red wine, elicits dilation of isolated porcine retinal arterioles: role of nitric oxide and potassium channels. Invest Ophthalmol Vis Sci. 2007;48: 4232-4239. (Pubitemid 351261054)
48. Liu Y, Gutterman DD. Oxidative stress and potassium channel function. Clin Exp Pharmacol Physiol. 2002;29:305-311. (Pubitemid 34227065)
49. Das S, Cordis GA, Maulik N, et al. Pharmacological preconditioning with resveratrol: role of CREB-dependent Bcl-2 signaling via adenosine A3 receptor activation. Am J Physiol Heart Circ Physiol. 2005;288: H328-H335. (Pubitemid 40023863)
50. Salamanca DA, Khalil RA. Protein kinase C isoforms as specific targets for modulation of vascular smooth muscle function in hypertension. Biochem Pharmacol. 2005;70:1537-1547. (Pubitemid 41540347)
51. Zhang Y, Moreland S, Moreland RS. Regulation of vascular smooth muscle contraction: myosin light chain phosphorylation dependent and independent pathways. Can J Physiol Pharmacol. 1994;72: 1386-1391.
52. Hori M, Sato K, Sakata K, et al. Receptor agonists induce myosin phosphorylation-dependent and phosphorylation-independent contractions in vascular smooth muscle. J Pharmacol Exp Ther. 1992;261:506-512.
53. Tsuneyoshi I, Zhang D, BoyleWA III. Ca2+- and myosin phosphorylationindependent relaxation by halothane in K+-depolarized rat mesenteric arteries. Anesthesiology. 2003;99:656-665. (Pubitemid 37051982)
54. Abdel-Latif AA. Cross talk between cyclic nucleotides and polyphosphoinositide hydrolysis, protein kinases, and contraction in smooth muscle. Exp Biol Med (Maywood). 2001;226:153-163.
55. Aalkjaer C, Poston L. Effects of pH on vascular tension: which are the important mechanisms? J Vasc Res. 1996;33:347-359.
56. Aalkjaer C, Peng HL. pH and smooth muscle. Acta Physiol Scand. 1997; 161:557-566.
57. Otter D, Austin C. Simultaneous monitoring of vascular contractility, intracellular pH and intracellular calcium in isolated rat mesenteric arteries; effects of weak bases. Exp Physiol. 2000;85:349-351. (Pubitemid 30333049)
58. Wray S, Smith RD. Mechanisms of action of pH-induced effects on vascular smooth muscle. Mol Cell Biochem. 2004;263:163-172. (Pubitemid 39256155)
59. Austin C, Wray S. Extracellular pH signals affect rat vascular tone by rapid transduction into intracellular pH changes. J Physiol. 1993;466:1-8. (Pubitemid 23225214)
60. Austin C, Wray S. The effects of extracellular pH and calcium change on force and intracellular calcium in rat vascular smooth muscle. J Physiol. 1995;488:281-291.
61. Smith MP, Dombkowski RA, Wincko JT, et al. Effect of pH on trout blood vessels and gill vascular resistance. J Exp Biol. 2006;209: 2586-2594.