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Volumn 64, Issue 6, 2015, Pages 720-728

Effect of insulin sensitizer therapy on amino acids and their metabolites

Author keywords

Biomarkers; Diabetes; Insulin resistance; Metabolomics; Obesity

Indexed keywords

2 AMINOADIPIC ACID; ALANINE; AMINO ACID; ARGININE; AROMATIC AMINO ACID; ASPARAGINE; ASPARTIC ACID; BRANCHED CHAIN AMINO ACID; CITRULLINE; ETHANOLAMINE; GLUCOSE; GLUTAMIC ACID; GLUTAMINE; GLYCINE; HISTIDINE; INSULIN SENSITIZING AGENT; ISOLEUCINE; LEUCINE; LYSINE; METFORMIN; METHIONINE; ORNITHINE; PHENYLALANINE; PIOGLITAZONE; PLACEBO; SERINE; TAURINE; THREONINE; TYROSINE; VALINE; 2,4 THIAZOLIDINEDIONE DERIVATIVE; ANTIDIABETIC AGENT; GLUCOSE BLOOD LEVEL; INSULIN;

EID: 84927968070     PISSN: 00260495     EISSN: 15328600     Source Type: Journal    
DOI: 10.1016/j.metabol.2015.01.008     Document Type: Article
Times cited : (78)

References (57)
  • 1
    • 63449111894 scopus 로고    scopus 로고
    • A branched-chain amino acid-related metabolic signature that differentiates obese and lean humans and contributes to insulin resistance
    • C.B. Newgard, J. An, and J.R. Bain A branched-chain amino acid-related metabolic signature that differentiates obese and lean humans and contributes to insulin resistance Cell Metab 9 4 2009 311 326
    • (2009) Cell Metab , vol.9 , Issue.4 , pp. 311-326
    • Newgard, C.B.1    An, J.2    Bain, J.R.3
  • 2
    • 77949267650 scopus 로고    scopus 로고
    • Insulin resistance is associated with a metabolic profile of altered protein metabolism in Chinese and Asian-Indian men
    • E.S. Tai, M.L. Tan, and R.D. Stevens Insulin resistance is associated with a metabolic profile of altered protein metabolism in Chinese and Asian-Indian men Diabetologia 53 4 2010 757 767
    • (2010) Diabetologia , vol.53 , Issue.4 , pp. 757-767
    • Tai, E.S.1    Tan, M.L.2    Stevens, R.D.3
  • 3
    • 69549097700 scopus 로고    scopus 로고
    • Relationships between circulating metabolic intermediates and insulin action in overweight to obese, inactive men and women
    • K.M. Huffman, S.H. Shah, and R.D. Stevens Relationships between circulating metabolic intermediates and insulin action in overweight to obese, inactive men and women Diabetes Care 32 9 2009 1678 1683
    • (2009) Diabetes Care , vol.32 , Issue.9 , pp. 1678-1683
    • Huffman, K.M.1    Shah, S.H.2    Stevens, R.D.3
  • 4
    • 49449083937 scopus 로고    scopus 로고
    • Metabolic profiling of the human response to a glucose challenge reveals distinct axes of insulin sensitivity
    • O. Shaham, R. Wei, and T.J. Wang Metabolic profiling of the human response to a glucose challenge reveals distinct axes of insulin sensitivity Mol Syst Biol 4 2008 1 9
    • (2008) Mol Syst Biol , vol.4 , pp. 1-9
    • Shaham, O.1    Wei, R.2    Wang, T.J.3
  • 5
    • 84879550459 scopus 로고    scopus 로고
    • Branched chain amino acids are novel biomarkers for discrimination of metabolic wellness
    • B.C. Batch, S.H. Shah, and C.B. Newgard Branched chain amino acids are novel biomarkers for discrimination of metabolic wellness Metabolism 62 7 2013 961 969
    • (2013) Metabolism , vol.62 , Issue.7 , pp. 961-969
    • Batch, B.C.1    Shah, S.H.2    Newgard, C.B.3
  • 6
    • 84903692940 scopus 로고    scopus 로고
    • Serum and adipose tissue amino acid homeostasis in the metabolically healthy obese
    • F. Badoud, K.P. Lam, and A. DiBattista Serum and adipose tissue amino acid homeostasis in the metabolically healthy obese J Proteome Res 13 7 2014 3455 3466
    • (2014) J Proteome Res , vol.13 , Issue.7 , pp. 3455-3466
    • Badoud, F.1    Lam, K.P.2    Dibattista, A.3
  • 7
    • 79953737332 scopus 로고    scopus 로고
    • Metabolite profiles and the risk of developing diabetes
    • T.J. Wang, M.G. Larson, and R.S. Vasan Metabolite profiles and the risk of developing diabetes Nat Med 17 4 2011 448 453
    • (2011) Nat Med , vol.17 , Issue.4 , pp. 448-453
    • Wang, T.J.1    Larson, M.G.2    Vasan, R.S.3
  • 9
    • 0036313574 scopus 로고    scopus 로고
    • Mechanism of amino acid-induced skeletal muscle insulin resistance in humans
    • M. Krebs, M. Krssak, and E. Bernroider Mechanism of amino acid-induced skeletal muscle insulin resistance in humans Diabetes 51 3 2002 599 605
    • (2002) Diabetes , vol.51 , Issue.3 , pp. 599-605
    • Krebs, M.1    Krssak, M.2    Bernroider, E.3
  • 11
    • 0023579118 scopus 로고
    • Decreased uptake of glucose by human forearm during infusion of leucine, isoleucine, or threonine
    • W.F. Schwenk, and M.W. Haymond Decreased uptake of glucose by human forearm during infusion of leucine, isoleucine, or threonine Diabetes 36 2 1987 199 204
    • (1987) Diabetes , vol.36 , Issue.2 , pp. 199-204
    • Schwenk, W.F.1    Haymond, M.W.2
  • 12
    • 84916639202 scopus 로고    scopus 로고
    • High insulin combined with essential amino acids stimulates skeletal muscle mitochondrial protein synthesis while decreasing insulin sensitivity in healthy humans
    • M.M. Robinson, M. Soop, and T.S. Sohn High insulin combined with essential amino acids stimulates skeletal muscle mitochondrial protein synthesis while decreasing insulin sensitivity in healthy humans J Clin Endocrinol Metab 99 12 2014 E2574 E2583
    • (2014) J Clin Endocrinol Metab , vol.99 , Issue.12 , pp. E2574-E2583
    • Robinson, M.M.1    Soop, M.2    Sohn, T.S.3
  • 13
    • 84901196741 scopus 로고    scopus 로고
    • Effects of individual branched-chain amino acids deprivation on insulin sensitivity and glucose metabolism in mice
    • F. Xiao, J. Yu, and Y. Guo Effects of individual branched-chain amino acids deprivation on insulin sensitivity and glucose metabolism in mice Metabolism 63 6 2014 841 850
    • (2014) Metabolism , vol.63 , Issue.6 , pp. 841-850
    • Xiao, F.1    Yu, J.2    Guo, Y.3
  • 14
    • 79955387227 scopus 로고    scopus 로고
    • Differential metabolic impact of gastric bypass surgery versus dietary intervention in obese diabetic subjects despite identical weight loss
    • B. Laferrere, D. Reilly, and S. Arias Differential metabolic impact of gastric bypass surgery versus dietary intervention in obese diabetic subjects despite identical weight loss Sci Transl Med 3 80 2011 1 9
    • (2011) Sci Transl Med , vol.3 , Issue.80 , pp. 1-9
    • Laferrere, B.1    Reilly, D.2    Arias, S.3
  • 15
    • 85018988272 scopus 로고    scopus 로고
    • Effect of Roux-en-Y gastric bypass and laparoscopic adjustable gastric banding on branched-chain amino acid metabolism
    • F. Magkos, D. Bradley, and G.G. Schweitzer Effect of Roux-en-Y gastric bypass and laparoscopic adjustable gastric banding on branched-chain amino acid metabolism Diabetes 62 8 2013 2757 2761
    • (2013) Diabetes , vol.62 , Issue.8 , pp. 2757-2761
    • Magkos, F.1    Bradley, D.2    Schweitzer, G.G.3
  • 16
    • 84911892896 scopus 로고    scopus 로고
    • Roux-en-Y gastric bypass surgery, but Not calorie restriction, reduces plasma branched-chain amino acids in obese women independent of weight loss or the presence of type 2 diabetes
    • M.A. Lips, J.B. Van Klinken, and V. van Harmelen Roux-en-Y gastric bypass surgery, but Not calorie restriction, reduces plasma branched-chain amino acids in obese women independent of weight loss or the presence of type 2 diabetes Diabetes Care 37 12 2014 3150 3156
    • (2014) Diabetes Care , vol.37 , Issue.12 , pp. 3150-3156
    • Lips, M.A.1    Van Klinken, J.B.2    Van Harmelen, V.3
  • 17
    • 62749130523 scopus 로고    scopus 로고
    • Metabonomic study of biochemical changes in the serum of type 2 diabetes mellitus patients after the treatment of metformin hydrochloride
    • T. Huo, S. Cai, X. Lu, Y. Sha, M. Yu, and F. Li Metabonomic study of biochemical changes in the serum of type 2 diabetes mellitus patients after the treatment of metformin hydrochloride J Pharm Biomed Anal 49 4 2009 976 982
    • (2009) J Pharm Biomed Anal , vol.49 , Issue.4 , pp. 976-982
    • Huo, T.1    Cai, S.2    Lu, X.3    Sha, Y.4    Yu, M.5    Li, F.6
  • 18
    • 84888008448 scopus 로고    scopus 로고
    • Branched chain and aromatic amino acids change acutely following two medical therapies for type 2 diabetes mellitus
    • G.A. Walford, J. Davis, and A.S. Warner Branched chain and aromatic amino acids change acutely following two medical therapies for type 2 diabetes mellitus Metabolism 62 12 2013 1772 1778
    • (2013) Metabolism , vol.62 , Issue.12 , pp. 1772-1778
    • Walford, G.A.1    Davis, J.2    Warner, A.S.3
  • 19
    • 84862282554 scopus 로고    scopus 로고
    • Emerging perspectives on essential amino acid metabolism in obesity and the insulin-resistant state
    • S.H. Adams Emerging perspectives on essential amino acid metabolism in obesity and the insulin-resistant state Adv Nutr 2 6 2011 445 456
    • (2011) Adv Nutr , vol.2 , Issue.6 , pp. 445-456
    • Adams, S.H.1
  • 20
    • 0022338995 scopus 로고
    • Insulin-mediated reduction of whole body protein breakdown. Dose-response effects on leucine metabolism in postabsorptive men
    • N.K. Fukagawa, K.L. Minaker, and J.W. Rowe Insulin-mediated reduction of whole body protein breakdown. Dose-response effects on leucine metabolism in postabsorptive men J Clin Invest 76 6 1985 2306 2311
    • (1985) J Clin Invest , vol.76 , Issue.6 , pp. 2306-2311
    • Fukagawa, N.K.1    Minaker, K.L.2    Rowe, J.W.3
  • 21
    • 0031793982 scopus 로고    scopus 로고
    • Differential regulation of amino acid exchange and protein dynamics across splanchnic and skeletal muscle beds by insulin in healthy human subjects
    • S.E. Meek, M. Persson, G.C. Ford, and K.S. Nair Differential regulation of amino acid exchange and protein dynamics across splanchnic and skeletal muscle beds by insulin in healthy human subjects Diabetes 47 1998 1824 1835
    • (1998) Diabetes , vol.47 , pp. 1824-1835
    • Meek, S.E.1    Persson, M.2    Ford, G.C.3    Nair, K.S.4
  • 22
    • 33749249371 scopus 로고    scopus 로고
    • Mechanism of insulin's anabolic effect on muscle: Measurements of muscle protein synthesis and breakdown using aminoacyl-tRNA and other surrogate measures
    • L.S. Chow, R.C. Albright, M.L. Bigelow, G. Toffolo, C. Cobelli, and K.S. Nair Mechanism of insulin's anabolic effect on muscle: measurements of muscle protein synthesis and breakdown using aminoacyl-tRNA and other surrogate measures Am J Physiol 291 4 2006 E729 E736
    • (2006) Am J Physiol , vol.291 , Issue.4 , pp. E729-E736
    • Chow, L.S.1    Albright, R.C.2    Bigelow, M.L.3    Toffolo, G.4    Cobelli, C.5    Nair, K.S.6
  • 23
    • 0028807373 scopus 로고
    • Insulin and insulin-like growth factor-I enhance human skeletal muscle protein anabolism during hyperaminoacidemia by different mechanisms
    • D.A. Fryburg, L.A. Jahn, S.A. Hill, D.M. Oliveras, and E.J. Barrett Insulin and insulin-like growth factor-I enhance human skeletal muscle protein anabolism during hyperaminoacidemia by different mechanisms J Clin Invest 96 4 1995 1722 1729
    • (1995) J Clin Invest , vol.96 , Issue.4 , pp. 1722-1729
    • Fryburg, D.A.1    Jahn, L.A.2    Hill, S.A.3    Oliveras, D.M.4    Barrett, E.J.5
  • 24
    • 0028837394 scopus 로고
    • Physiologic hyperinsulinemia stimulates protein synthesis and enhances transport of selected amino acids in human skeletal muscle
    • G. Biolo, R.Y. Declan Fleming, and R.R. Wolfe Physiologic hyperinsulinemia stimulates protein synthesis and enhances transport of selected amino acids in human skeletal muscle J Clin Invest 95 2 1995 811 819
    • (1995) J Clin Invest , vol.95 , Issue.2 , pp. 811-819
    • Biolo, G.1    Declan Fleming, R.Y.2    Wolfe, R.R.3
  • 25
    • 0021039123 scopus 로고
    • Effect of poor diabetic control and obesity on whole body protein metabolism in man
    • K.S. Nair, J.S. Garrow, C. Ford, R.F. Mahler, and D. Halliday Effect of poor diabetic control and obesity on whole body protein metabolism in man Diabetologia 25 5 1983 400 403
    • (1983) Diabetologia , vol.25 , Issue.5 , pp. 400-403
    • Nair, K.S.1    Garrow, J.S.2    Ford, C.3    Mahler, R.F.4    Halliday, D.5
  • 26
    • 0029073033 scopus 로고
    • Protein dynamics in whole body and in splanchnic and leg tissues in type i diabetic patients
    • K.S. Nair, G.C. Ford, K. Ekberg, E. Fernqvist-Forbes, and J. Wahren Protein dynamics in whole body and in splanchnic and leg tissues in type I diabetic patients J Clin Invest 95 6 1995 2926 2937
    • (1995) J Clin Invest , vol.95 , Issue.6 , pp. 2926-2937
    • Nair, K.S.1    Ford, G.C.2    Ekberg, K.3    Fernqvist-Forbes, E.4    Wahren, J.5
  • 27
    • 84870940825 scopus 로고    scopus 로고
    • Effects of type 2 diabetes and insulin on whole-body, splanchnic, and leg protein metabolism
    • K.R. Short, B.A. Irving, A. Basu, C.M. Johnson, K.S. Nair, and R. Basu Effects of type 2 diabetes and insulin on whole-body, splanchnic, and leg protein metabolism J Clin Endocrinol Metab 97 12 2012 4733 4741
    • (2012) J Clin Endocrinol Metab , vol.97 , Issue.12 , pp. 4733-4741
    • Short, K.R.1    Irving, B.A.2    Basu, A.3    Johnson, C.M.4    Nair, K.S.5    Basu, R.6
  • 28
    • 84922635429 scopus 로고    scopus 로고
    • Adipose tissue monomethyl branched-chain fatty acids and insulin sensitivity: Effects of obesity and weight loss
    • X. Su, F. Magkos, and D. Zhou Adipose tissue monomethyl branched-chain fatty acids and insulin sensitivity: Effects of obesity and weight loss Obesity (Silver Spring) 23 2 2015 329 334
    • (2015) Obesity (Silver Spring) , vol.23 , Issue.2 , pp. 329-334
    • Su, X.1    Magkos, F.2    Zhou, D.3
  • 29
    • 84863492238 scopus 로고    scopus 로고
    • Effect of insulin sensitizer therapy on atherothrombotic and inflammatory profiles associated with insulin resistance
    • R.G. McCoy, B.A. Irving, and M. Soop Effect of insulin sensitizer therapy on atherothrombotic and inflammatory profiles associated with insulin resistance Mayo Clin Proc 87 6 2012 561 570
    • (2012) Mayo Clin Proc , vol.87 , Issue.6 , pp. 561-570
    • McCoy, R.G.1    Irving, B.A.2    Soop, M.3
  • 30
    • 0018520840 scopus 로고
    • Glucose clamp technique: A method for quantifying insulin secretion and resistance
    • R.A. DeFronzo, J.D. Tobin, and R. Andres Glucose clamp technique: a method for quantifying insulin secretion and resistance Am J Physiol 237 3 1979 E214 E223
    • (1979) Am J Physiol , vol.237 , Issue.3 , pp. E214-E223
    • Defronzo, R.A.1    Tobin, J.D.2    Andres, R.3
  • 31
    • 0034456568 scopus 로고    scopus 로고
    • Quantitative insulin sensitivity check index: A simple, accurate method for assessing insulin sensitivity in humans
    • A. Katz, S.S. Nambi, and K. Mather Quantitative insulin sensitivity check index: a simple, accurate method for assessing insulin sensitivity in humans J Clin Endocrinol Metab 85 7 2000 2402 2410
    • (2000) J Clin Endocrinol Metab , vol.85 , Issue.7 , pp. 2402-2410
    • Katz, A.1    Nambi, S.S.2    Mather, K.3
  • 32
    • 77956276702 scopus 로고    scopus 로고
    • Quantitative metabolomics by H-NMR and LC-MS/MS confirms altered metabolic pathways in diabetes
    • I.R. Lanza, S. Zhang, L.E. Ward, H. Karakelides, D. Raftery, and K.S. Nair Quantitative metabolomics by H-NMR and LC-MS/MS confirms altered metabolic pathways in diabetes PLoS One 5 5 2010 1 10
    • (2010) PLoS One , vol.5 , Issue.5 , pp. 1-10
    • Lanza, I.R.1    Zhang, S.2    Ward, L.E.3    Karakelides, H.4    Raftery, D.5    Nair, K.S.6
  • 33
    • 84885031125 scopus 로고    scopus 로고
    • 2-Aminoadipic acid is a biomarker for diabetes risk
    • T.J. Wang, D. Ngo, and N. Psychogios 2-Aminoadipic acid is a biomarker for diabetes risk J Clin Invest 123 10 2013 4309 4317
    • (2013) J Clin Invest , vol.123 , Issue.10 , pp. 4309-4317
    • Wang, T.J.1    Ngo, D.2    Psychogios, N.3
  • 34
    • 84868323581 scopus 로고    scopus 로고
    • Insulin fails to enhance mTOR phosphorylation, mitochondrial protein synthesis, and ATP production in human skeletal muscle without amino acid replacement
    • R. Barazzoni, K.R. Short, Y. Asmann, J.M. Coenen-Schimke, M.M. Robinson, and K.S. Nair Insulin fails to enhance mTOR phosphorylation, mitochondrial protein synthesis, and ATP production in human skeletal muscle without amino acid replacement Am J Physiol 303 9 2012 E1117 E1125
    • (2012) Am J Physiol , vol.303 , Issue.9 , pp. E1117-E1125
    • Barazzoni, R.1    Short, K.R.2    Asmann, Y.3    Coenen-Schimke, J.M.4    Robinson, M.M.5    Nair, K.S.6
  • 35
    • 0021666221 scopus 로고
    • Procedures for comparing samples with multiple endpoints
    • P.C. O'Brien Procedures for comparing samples with multiple endpoints Biometrics 40 4 1984 1079 1087
    • (1984) Biometrics , vol.40 , Issue.4 , pp. 1079-1087
    • O'Brien, P.C.1
  • 37
    • 84879844053 scopus 로고    scopus 로고
    • The influence of pioglitazone on the plasma amino acid profile in patients with nonalcoholic steatohepatitis (NASH)
    • E. Kakazu, Y. Kondo, and M. Ninomiya The influence of pioglitazone on the plasma amino acid profile in patients with nonalcoholic steatohepatitis (NASH) Hepatol Int 7 2 2013 577 585
    • (2013) Hepatol Int , vol.7 , Issue.2 , pp. 577-585
    • Kakazu, E.1    Kondo, Y.2    Ninomiya, M.3
  • 38
    • 77951232682 scopus 로고    scopus 로고
    • Adipose tissue branched chain amino acid (BCAA) metabolism modulates circulating BCAA levels
    • M.A. Herman, P. She, O.D. Peroni, C.J. Lynch, and B.B. Kahn Adipose tissue branched chain amino acid (BCAA) metabolism modulates circulating BCAA levels J Biol Chem 285 15 2010 11348 11356
    • (2010) J Biol Chem , vol.285 , Issue.15 , pp. 11348-11356
    • Herman, M.A.1    She, P.2    Peroni, O.D.3    Lynch, C.J.4    Kahn, B.B.5
  • 39
    • 73249123069 scopus 로고    scopus 로고
    • Mechanisms of human insulin resistance and thiazolidinedione-mediated insulin sensitization
    • D.D. Sears, G. Hsiao, and A. Hsiao Mechanisms of human insulin resistance and thiazolidinedione-mediated insulin sensitization Proc Natl Acad Sci U S A 106 44 2009 18745 18750
    • (2009) Proc Natl Acad Sci U S A , vol.106 , Issue.44 , pp. 18745-18750
    • Sears, D.D.1    Hsiao, G.2    Hsiao, A.3
  • 40
    • 65249113837 scopus 로고    scopus 로고
    • Metabonomic variations in the drug-treated type 2 diabetes mellitus patients and healthy volunteers
    • Y. Bao, T. Zhao, and X. Wang Metabonomic variations in the drug-treated type 2 diabetes mellitus patients and healthy volunteers J Proteome Res 8 4 2009 1623 1630
    • (2009) J Proteome Res , vol.8 , Issue.4 , pp. 1623-1630
    • Bao, Y.1    Zhao, T.2    Wang, X.3
  • 41
    • 84914155689 scopus 로고    scopus 로고
    • The amino acid response to a mixed meal in patients with type 2 diabetes: Effect of sitagliptin treatment
    • E. Muscelli, S. Frascerra, and A. Casolaro The amino acid response to a mixed meal in patients with type 2 diabetes: effect of sitagliptin treatment Diabetes Obes Metab 16 11 2014 1140 1147
    • (2014) Diabetes Obes Metab , vol.16 , Issue.11 , pp. 1140-1147
    • Muscelli, E.1    Frascerra, S.2    Casolaro, A.3
  • 43
    • 0036328175 scopus 로고    scopus 로고
    • Synthesis rate of muscle proteins, muscle functions, and amino acid kinetics in type 2 diabetes
    • P. Halvatsiotis, K.R. Short, M. Bigelow, and K.S. Nair Synthesis rate of muscle proteins, muscle functions, and amino acid kinetics in type 2 diabetes Diabetes 51 8 2002 2395 2404
    • (2002) Diabetes , vol.51 , Issue.8 , pp. 2395-2404
    • Halvatsiotis, P.1    Short, K.R.2    Bigelow, M.3    Nair, K.S.4
  • 45
    • 79959453305 scopus 로고    scopus 로고
    • Dietary leucine-an environmental modifier of insulin resistance acting on multiple levels of metabolism
    • Y. Macotela, B. Emanuelli, and A.M. Bang Dietary leucine-an environmental modifier of insulin resistance acting on multiple levels of metabolism PLoS One 6 6 2011 1 13
    • (2011) PLoS One , vol.6 , Issue.6 , pp. 1-13
    • Macotela, Y.1    Emanuelli, B.2    Bang, A.M.3
  • 46
    • 84869192260 scopus 로고    scopus 로고
    • Leucine supplementation increases SIRT1 expression and prevents mitochondrial dysfunction and metabolic disorders in high-fat diet-induced obese mice
    • H. Li, M. Xu, J. Lee, C. He, and Z. Xie Leucine supplementation increases SIRT1 expression and prevents mitochondrial dysfunction and metabolic disorders in high-fat diet-induced obese mice Am J Physiol 303 10 2012 E1234 E1244
    • (2012) Am J Physiol , vol.303 , Issue.10 , pp. E1234-E1244
    • Li, H.1    Xu, M.2    Lee, J.3    He, C.4    Xie, Z.5
  • 47
    • 84873947174 scopus 로고    scopus 로고
    • Synergistic effects of metformin, resveratrol, and hydroxymethylbutyrate on insulin sensitivity
    • A. Bruckbauer, and M.B. Zemel Synergistic effects of metformin, resveratrol, and hydroxymethylbutyrate on insulin sensitivity Diabetes Metab Syndr Obes Target Ther 6 2013 93 102
    • (2013) Diabetes Metab Syndr Obes Target Ther , vol.6 , pp. 93-102
    • Bruckbauer, A.1    Zemel, M.B.2
  • 48
    • 84895893720 scopus 로고    scopus 로고
    • Synergistic effects of polyphenols and methylxanthines with Leucine on AMPK/Sirtuin-mediated metabolism in muscle cells and adipocytes
    • A. Bruckbauer, and M.B. Zemel Synergistic effects of polyphenols and methylxanthines with Leucine on AMPK/Sirtuin-mediated metabolism in muscle cells and adipocytes PLoS One 9 2 2014 1 11
    • (2014) PLoS One , vol.9 , Issue.2 , pp. 1-11
    • Bruckbauer, A.1    Zemel, M.B.2
  • 49
    • 84865296096 scopus 로고    scopus 로고
    • Synergistic effects of leucine and resveratrol on insulin sensitivity and fat metabolism in adipocytes and mice
    • A. Bruckbauer, M.B. Zemel, and T. Thorpe Synergistic effects of leucine and resveratrol on insulin sensitivity and fat metabolism in adipocytes and mice Nutr Metab 9 1 2012 1 12
    • (2012) Nutr Metab , vol.9 , Issue.1 , pp. 1-12
    • Bruckbauer, A.1    Zemel, M.B.2    Thorpe, T.3
  • 50
    • 84899428110 scopus 로고    scopus 로고
    • Associations between dairy foods, diabetes, and metabolic health: Potential mechanisms and future directions
    • K.M. Hirahatake, J.L. Slavin, K.C. Maki, and S.H. Adams Associations between dairy foods, diabetes, and metabolic health: potential mechanisms and future directions Metabolism 63 5 2014 618 627
    • (2014) Metabolism , vol.63 , Issue.5 , pp. 618-627
    • Hirahatake, K.M.1    Slavin, J.L.2    Maki, K.C.3    Adams, S.H.4
  • 51
    • 0036441178 scopus 로고    scopus 로고
    • Oxidative deamination of lysine residue in plasma protein of diabetic rats. Novel mechanism via the Maillard reaction
    • M. Akagawa, T. Sasaki, and K. Suyama Oxidative deamination of lysine residue in plasma protein of diabetic rats. Novel mechanism via the Maillard reaction Eur J Biochem 269 22 2002 5451 5458
    • (2002) Eur J Biochem , vol.269 , Issue.22 , pp. 5451-5458
    • Akagawa, M.1    Sasaki, T.2    Suyama, K.3
  • 52
    • 71749103906 scopus 로고    scopus 로고
    • Mechanism of lysine oxidation in human lens crystallins during aging and in diabetes
    • X. Fan, J. Zhang, and M. Theves Mechanism of lysine oxidation in human lens crystallins during aging and in diabetes J Biol Chem 284 50 2009 34618 34627
    • (2009) J Biol Chem , vol.284 , Issue.50 , pp. 34618-34627
    • Fan, X.1    Zhang, J.2    Theves, M.3
  • 53
    • 34249816781 scopus 로고    scopus 로고
    • 2-aminoadipic acid is a marker of protein carbonyl oxidation in the aging human skin: Effects of diabetes, renal failure and sepsis
    • D.R. Sell, C.M. Strauch, W. Shen, and V.M. Monnier 2-aminoadipic acid is a marker of protein carbonyl oxidation in the aging human skin: effects of diabetes, renal failure and sepsis Biochem J 404 2 2007 269 277
    • (2007) Biochem J , vol.404 , Issue.2 , pp. 269-277
    • Sell, D.R.1    Strauch, C.M.2    Shen, W.3    Monnier, V.M.4
  • 54
    • 77957598060 scopus 로고    scopus 로고
    • Identification of de novo synthesized and relatively older proteins: Accelerated oxidative damage to de novo synthesized apolipoprotein A-1 in type 1 diabetes
    • A. Jaleel, G.C. Henderson, and B.J. Madden Identification of de novo synthesized and relatively older proteins: accelerated oxidative damage to de novo synthesized apolipoprotein A-1 in type 1 diabetes Diabetes 59 10 2010 2366 2374
    • (2010) Diabetes , vol.59 , Issue.10 , pp. 2366-2374
    • Jaleel, A.1    Henderson, G.C.2    Madden, B.J.3
  • 55
    • 0016419551 scopus 로고
    • Amino acid metabolism in man
    • P. Felig Amino acid metabolism in man Annu Rev Biochem 44 1975 933 955
    • (1975) Annu Rev Biochem , vol.44 , pp. 933-955
    • Felig, P.1
  • 56
    • 0029133235 scopus 로고
    • Metabolic effects of metformin in non-insulin-dependent diabetes mellitus
    • M. Stumvoll, N. Nurjhan, G. Perriello, G. Dailey, and J.E. Gerich Metabolic effects of metformin in non-insulin-dependent diabetes mellitus N Engl J Med 333 9 1995 550 554
    • (1995) N Engl J Med , vol.333 , Issue.9 , pp. 550-554
    • Stumvoll, M.1    Nurjhan, N.2    Perriello, G.3    Dailey, G.4    Gerich, J.E.5
  • 57
    • 84903524608 scopus 로고    scopus 로고
    • Metformin suppresses gluconeogenesis by inhibiting mitochondrial glycerophosphate dehydrogenase
    • A.K. Madiraju, D.M. Erion, and Y. Rahimi Metformin suppresses gluconeogenesis by inhibiting mitochondrial glycerophosphate dehydrogenase Nature 510 7506 2014 542 546
    • (2014) Nature , vol.510 , Issue.7506 , pp. 542-546
    • Madiraju, A.K.1    Erion, D.M.2    Rahimi, Y.3


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