Branched chain and aromatic amino acids change acutely following two medical therapies for type 2 diabetes mellitus

Metabolism: Clinical and Experimental

Volumn 62, Issue 12, 2013, Pages 1772-1778

  Walford, Geoffrey A ^a,b   Davis, Jaclyn ^a   Warner, A Sofia ^a   Ackerman, Rachel J ^a   Billings, Liana K ^a,b   Chamarthi, Bindu ^b,c   Fanelli, Rebecca R ^a   Hernandez, Alicia M ^a   Huang, Chunmei ^a,b   Khan, Sabina Q ^a   Littleton, Katherine R ^a   Lo, Janet ^a,b   McCarthy, Rita M ^b,c   Rhee, Eugene P ^a,b,d   Deik, Amy ^d   Stolerman, Elliot ^a   Taylor, Andrew ^a   Hudson, Margo S ^b,c   Wang, Thomas J ^e   Altshuler, David ^a,b   Grant, Richard W ^f   Clish, Clary B ^d   Gerszten, Robert E ^a,b,d   Florez, Jose C ^a,b   more..

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c BRIGHAM AND WOMEN S HOSPITAL   (United States)

^d BROAD INSTITUTE OF MIT AND HARVARD   (United States)

^e VANDERBILT UNIVERSITY   (United States)

^f DIVISION OF RESEARCH   (United States)

Author keywords

aromatic amino acids; branched chain amino acids

Indexed keywords

AROMATIC AMINO ACID; BIOLOGICAL MARKER; BRANCHED CHAIN AMINO ACID; GLIPIZIDE; GLUCOSE; INSULIN; METFORMIN;

ADULT; AMINO ACID BLOOD LEVEL; ARTICLE; CONTROLLED STUDY; FEMALE; GLUCOSE BLOOD LEVEL; HUMAN; INSULIN RESISTANCE; LABORATORY TEST; LIQUID CHROMATOGRAPHY; MAJOR CLINICAL STUDY; MALE; MASS SPECTROMETRY; NON INSULIN DEPENDENT DIABETES MELLITUS; ORAL GLUCOSE TOLERANCE TEST; PRIORITY JOURNAL;

AAAS; AROMATIC AMINO ACIDS; BCAAS; BMI; BODY MASS INDEX; BRANCHED CHAIN AMINO ACIDS; HOMA-IR; HOMEOSTATIC MODEL ASSESSMENT OF INSULIN RESISTANCE; T2D; TYPE 2 DIABETES MELLITUS;

AGED; AMINO ACIDS, AROMATIC; AMINO ACIDS, BRANCHED-CHAIN; BIOLOGICAL MARKERS; BLOOD GLUCOSE; DIABETES MELLITUS, TYPE 2; FEMALE; GLIPIZIDE; HUMANS; HYPOGLYCEMIC AGENTS; INSULIN; INSULIN RESISTANCE; MALE; METFORMIN; MIDDLE AGED; SPECTRUM ANALYSIS;

EID: 84888008448     PISSN: 00260495     EISSN: 15328600     Source Type: Journal    
DOI: 10.1016/j.metabol.2013.07.003     Document Type: Article

References (15)

1. S.E. Inzucchi, R.M. Bergenstal, and J.B. Buse Management of hyperglycemia in type 2 diabetes: a patient-centered approach: position statement of the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD) Diabetes Care 35 6 2012 1364 1379
2. S.E. Kahn, S.M. Haffner, and M.A. Heise Glycemic durability of rosiglitazone, metformin, or glyburide monotherapy N Engl J Med 355 23 2006 2427 2443
3. P. Felig, E. Marliss, and G.F. Cahill Jr. Plasma amino acid levels and insulin secretion in obesity N Engl J Med 281 15 1969 811 816
4. K.M. Huffman, S.H. Shah, and R.D. Stevens Relationships between circulating metabolic intermediates and insulin action in overweight to obese, inactive men and women Diabetes Care 32 9 2009 1678 1683
5. C.B. Newgard, J. An, and J.R. Bain A branched-chain amino acid-related metabolic signature that differentiates obese and lean humans and contributes to insulin resistance Cell Metab 9 4 2009 311 326
6. E.S. Tai, M.L. Tan, and R.D. Stevens Insulin resistance is associated with a metabolic profile of altered protein metabolism in Chinese and Asian-Indian men Diabetologia 53 4 2010 757 767
7. A. Stancakova, M. Civelek, and N.K. Saleem Hyperglycemia and a common variant of GCKR are associated with the levels of eight amino acids in 9,369 Finnish men Diabetes 61 7 2012 1895 1902
8. T.J. Wang, M.G. Larson, and R.S. Vasan Metabolite profiles and the risk of developing diabetes Nat Med 17 4 2011 448 453
9. O. Shaham, R. Wei, and T.J. Wang Metabolic profiling of the human response to a glucose challenge reveals distinct axes of insulin sensitivity Mol Syst Biol 4 2008 214
10. J.E. Ho, M.G. Larson, and R.S. Vasan Metabolite profiles during oral glucose challenge Diabetes 62 2013 2689
11. B.C. Batch, S.H. Shah, and C.B. Newgard Branched chain amino acids are novel biomarkers for discrimination of metabolic wellness Metabolism 62 7 2013 961 969
12. F. Magkos, D. Bradley, and G.G. Schweitzer Effect of Roux-en-Y gastric bypass and laparoscopic adjustable gastric banding on branched-chain amino acid metabolism Diabetes 62 2013 2757 2761
13. P. Wurtz, P. Soininen, and A.J. Kangas Branched-chain and aromatic amino acids are predictors of insulin resistance in young adults Diabetes Care 36 3 2013 648 655
14. S.E. McCormack, O. Shaham, and M.A. McCarthy Circulating branched-chain amino acid concentrations are associated with obesity and future insulin resistance in children and adolescents Pediatr Obes 8 1 2013 52 61
15. B. Laferrere, D. Reilly, and S. Arias Differential metabolic impact of gastric bypass surgery versus dietary intervention in obese diabetic subjects despite identical weight loss Sci Translational Med 3 80 2011 80re2