Adipose tissue monomethyl branched-chain fatty acids and insulin sensitivity: Effects of obesity and weight loss

Obesity

Volumn 23, Issue 2, 2015, Pages 329-334

  Su, Xiong ^a   Magkos, Faidon ^b   Zhou, Dequan ^b   Eagon, J Christopher ^b   Fabbrini, Elisa ^b   Okunade, Adewole L ^b   Klein, Samuel ^b  

^a MEDICAL COLLEGE OF SOOCHOW UNIVERSITY   (China)

^b WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FATTY ACID; GLUCOSE; INSULIN; MONOMETHYL BRANCHED CHAIN FATTY ACID; UNCLASSIFIED DRUG;

ABDOMINAL SUBCUTANEOUS FAT; ADULT; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; CROSS-SECTIONAL STUDY; FAT CONTENT; FATTY ACID METABOLISM; FEMALE; GLUCOSE UTILIZATION; HUMAN; HUMAN TISSUE; INSULIN SENSITIVITY; LEAN BODY WEIGHT; LONGITUDINAL STUDY; MALE; OBESITY; POSTOPERATIVE PERIOD; PREOPERATIVE PERIOD; ROUX Y ANASTOMOSIS; SKELETAL MUSCLE; STOMACH BYPASS; WEIGHT REDUCTION; ADIPOSE TISSUE; GLUCOSE CLAMP TECHNIQUE; INSULIN RESISTANCE; METABOLISM; MIDDLE AGED; PHYSIOLOGY;

ADIPOSE TISSUE; ADULT; CROSS-SECTIONAL STUDIES; FATTY ACIDS; FEMALE; GASTRIC BYPASS; GLUCOSE CLAMP TECHNIQUE; HUMANS; INSULIN; INSULIN RESISTANCE; LONGITUDINAL STUDIES; MALE; MIDDLE AGED; OBESITY; WEIGHT LOSS;

EID: 84922635429     PISSN: 19307381     EISSN: 1930739X     Source Type: Journal    
DOI: 10.1002/oby.20923     Document Type: Article

References (29)

1. Fenske W, Athanasiou T, Harling L, Drechsler C, Darzi A, Ashrafian H,. Obesity-related cardiorenal disease: the benefits of bariatric surgery. Nat Rev Nephrol 2013; 9: 539-551.
2. Turer AT, Hill, JA, Elmquist JK, Scherer PE,. Adipose tissue biology and cardiomyopathy: translational implications. Circ Res 2012; 111: 1565-1577.
3. Huffman KM, Shah SH, Stevens RD, et al. Relationships between circulating metabolic intermediates and insulin action in overweight to obese, inactive men and women. Diabetes Care 2009; 32: 1678-1683.
4. Newgard CB, An J, Bain JR, et al. A branched-chain amino acid-related metabolic signature that differentiates obese and lean humans and contributes to insulin resistance. Cell Metab 2009; 9: 311-326.
5. Magkos F, Bradley D, Schweitzer GG, et al. Effect of Roux-en-Y gastric bypass and laparoscopic adjustable gastric banding on branched-chain amino acid metabolism. Diabetes 2013; 62: 2757-2761.
6. Shah SH, Crosslin DR, Haynes CS, et al. Branched-chain amino acid levels are associated with improvement in insulin resistance with weight loss. Diabetologia 2012; 55: 321-330.
7. Wahren J, Felig P, Hagenfeldt L,. Effect of protein ingestion on splanchnic and leg metabolism in normal man and in patients with diabetes mellitus. J Clin Invest 1976; 57: 987-999.
8. Adams SH,. Emerging perspectives on essential amino acid metabolism in obesity and the insulin-resistant state. Adv Nutr 2011; 2: 445-456.
9. Violante S, Ijlst L, Te Brinke H, et al. Carnitine palmitoyltransferase 2 and carnitine/acylcarnitine translocase are involved in the mitochondrial synthesis and export of acylcarnitines. FASEB J 2013; 27: 2039-2044.
10. Oku H, Kaneda T,. Biosynthesis of branched-chain fatty acids in Bacillus subtilis. A decarboxylase is essential for branched-chain fatty acid synthetase. J Biol Chem 1988; 263: 18386-18396.
11. Hiltunen JK, Chen Z, Haapalainen AM, Wierenga RK, Kastaniotis AJ,. Mitochondrial fatty acid synthesis-an adopted set of enzymes making a pathway of major importance for the cellular metabolism. Prog Lipid Res 2010; 49: 27-45.
12. Rosenthal J, Angel A, Farkas J,. Metabolic fate of leucine: a significant sterol precursor in adipose tissue and muscle. Am J Physiol 1974; 226: 411-418.
13. Herman MA, She P, Peroni OD, Lynch CJ, Kahn BB,. Adipose tissue branched chain amino acid (BCAA) metabolism modulates circulating BCAA levels. J Biol Chem 2010; 285: 11348-11356.
14. Felig P, Marliss E, Cahill GF, Jr,. Plasma amino acid levels and insulin secretion in obesity. N Engl J Med 1969; 281: 811-816.
15. Brosnan JT, Brosnan ME,. Branched-chain amino acids: enzyme and substrate regulation. J Nutr 2006; 136: 207S-211S.
16. Patterson BW, Horowitz JF, Wu G, Watford M, Coppack SW, Klein S,. Regional muscle and adipose tissue amino acid metabolism in lean and obese women. Am J Physiol Endocrinol Metab 2002; 282: E931-E936.
17. She P, Van Horn C, Reid T, Hutson SM, Cooney RN, Lynch CJ,. Obesity-related elevations in plasma leucine are associated with alterations in enzymes involved in branched-chain amino acid metabolism. Am J Physiol Endocrinol Metab 2007; 293: E1552-E1563.
18. Lackey DE, Lynch CJ, Olson KC, et al. Regulation of adipose branched-chain amino acid catabolism enzyme expression and cross-adipose amino acid flux in human obesity. Am J Physiol Endocrinol Metab 2013; 304: E1175-E1187.
19. Fabbrini E, Cella M, McCartney SA, et al. Association between specific adipose tissue CD4+ T-cell populations and insulin resistance in obese individuals. Gastroenterology 2013; 145: 366-374.
20. Korenblat KM, Fabbrini E, Mohammed BS, Klein S,. Liver, muscle, and adipose tissue insulin action is directly related to intrahepatic triglyceride content in obese subjects. Gastroenterology 2008; 134: 1369-1375.
21. Magkos F, Fabbrini E, Korenblat K, Okunade AL, Patterson BW, Klein S,. Reproducibility of glucose, fatty acid and VLDL kinetics and multi-organ insulin sensitivity in obese subjects with non-alcoholic fatty liver disease. Int J Obes (Lond) 2011; 35: 1233-1240.
22. Steele, R,. Influences of glucose loading and of injected insulin on hepatic glucose output. Ann N Y Acad Sci 1959; 82: 420-430.
23. Liu Y, Zhou D, Abumrad NA, Su X,. ADP-ribosylation factor 6 modulates adrenergic stimulated lipolysis in adipocytes. Am J Physiol Cell Physiol 2010; 298: C921-C928.
24. Bradley D, Conte C, Mittendorfer B, et al. Gastric bypass and banding equally improve insulin sensitivity and beta cell function. J Clin Invest 2012; 122: 4667-4674.
25. Ramsay RR, Gandour RD, van der Leij FR,. Molecular enzymology of carnitine transfer and transport. Biochim Biophys Acta 2001; 1546: 21-43.
26. Costa ND, Snoswell AM,. Enzymic hydrolysis of acetylcarnitine in liver from rats, sheep and cows. Biochem J 1975; 152: 161-166.
27. Ran-Ressler RR, Bae S, Lawrence P, Wang DH, Brenna JT,. Branched-chain fatty acid content of foods and estimated intake in the USA. Br J Nutr 2014; 112: 565-572.
28. Kaneda T,. Iso- and anteiso-fatty acids in bacteria: biosynthesis, function, and taxonomic significance. Microbiol Rev 1991; 55: 288-302.
29. Krebs M, Krssak M, Bernroider E, et al. Mechanism of amino acid-induced skeletal muscle insulin resistance in humans. Diabetes 2002; 51: 599-605.