Insulin fails to enhance mTOR phosphorylation, mitochondrial protein synthesis, and ATP production in human skeletal muscle without amino acid replacement

American Journal of Physiology - Endocrinology and Metabolism

Volumn 303, Issue 9, 2012, Pages

  Barazzoni, Rocco ^a   Short, Kevin R ^a   Asmann, Yan ^a   Coenen Schimke, Jill M ^a   Robinson, Matthew M ^a   Nair, K Sreekumaran ^a  

^a MAYO CLINIC   (United States)

Author keywords

Amino acids; Insulin; Mammalian target of rapamycin; Mitochondria; Protein synthesis

Indexed keywords

2 OXOISOCAPROIC ACID; ADENOSINE TRIPHOSPHATE; AMINO ACID; CITRATE SYNTHASE; CYTOCHROME C OXIDASE; ESSENTIAL AMINO ACID; GLUCOSE; INITIATION FACTOR 4E BINDING PROTEIN 1; INSULIN; LEUCINE; MAMMALIAN TARGET OF RAPAMYCIN; MESSENGER RNA; MITOCHONDRIAL PROTEIN; MUSCLE PROTEIN; NONESSENTIAL AMINO ACID; PROTEIN KINASE B; S6 KINASE; TRACER;

ADULT; AMINO ACID BLOOD LEVEL; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; FEMALE; GENE EXPRESSION; GLUCOSE BLOOD LEVEL; HORMONAL REGULATION; HUMAN; HUMAN EXPERIMENT; HUMAN TISSUE; INSULIN BLOOD LEVEL; MALE; MITOCHONDRIAL GENE; MITOCHONDRIAL RESPIRATION; MUSCLE MITOCHONDRION; NORMAL HUMAN; PHYSIOLOGICAL PROCESS; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PROTEIN SYNTHESIS; SARCOPLASM; SKELETAL MUSCLE;

ADENOSINE TRIPHOSPHATE; ADULT; AMINO ACIDS; CARBON ISOTOPES; FEMALE; GENE EXPRESSION REGULATION; HUMANS; HYPERINSULINISM; INFUSIONS, INTRAVENOUS; INSULIN; INSULIN, REGULAR, HUMAN; LEUCINE; MALE; MITOCHONDRIA, MUSCLE; MITOCHONDRIAL PROTEINS; MUSCLE, SKELETAL; PHOSPHORYLATION; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTO-ONCOGENE PROTEINS C-AKT; RNA, MESSENGER; TOR SERINE-THREONINE KINASES; YOUNG ADULT;

EID: 84868323581     PISSN: 01931849     EISSN: 15221555     Source Type: Journal    
DOI: 10.1152/ajpendo.00067.2012     Document Type: Article

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