Sertraline, an antidepressant, induces apoptosis in hepatic cells through the mitogen-activated protein kinase pathway

Toxicological Sciences

Volumn 137, Issue 2, 2014, Pages 404-415

  Chen, Si ^a   Xuan, Jiekun ^a   Wan, Liqing ^a,b   Lin, Haixia ^a   Couch, Letha ^a   Mei, Nan ^a   Dobrovolsky, Vasily N ^a   Guo, Lei ^a  

^a NATIONAL CENTER FOR TOXICOLOGICAL RESEARCH   (United States)

^b SHANGHAI INSTITUTE FOR FOOD AND DRUG CONTROL   (China)

Author keywords

Apoptosis; Cell death; Liver toxicity; MAPK pathway; Mitochondrial dysfunction; Sertraline

Indexed keywords

CASPASE 3 INHIBITOR; CASPASE 8; CASPASE 9 INHIBITOR; CYTOCHROME C; LACTATE DEHYDROGENASE; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN BCL 2; SERTRALINE; STRESS ACTIVATED PROTEIN KINASE; TUMOR NECROSIS FACTOR;

APOPTOSIS; ARTICLE; CELL STRAIN HEPG2; CELL VIABILITY; CYTOSOL; CYTOTOXICITY; DOSE RESPONSE; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; LIVER CELL; MITOCHONDRION; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION;

APOPTOSIS; CELL DEATH; LIVER TOXICITY; MAPK PATHWAY.; MITOCHONDRIAL DYSFUNCTION; SERTRALINE;

ANTIDEPRESSIVE AGENTS; APOPTOSIS; BLOTTING, WESTERN; CASPASE 3; CASPASE 7; CASPASE 9; CELL CULTURE TECHNIQUES; GENE SILENCING; HEP G2 CELLS; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MAP KINASE SIGNALING SYSTEM; MEMBRANE POTENTIAL, MITOCHONDRIAL; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS C-BCL-2; REAL-TIME POLYMERASE CHAIN REACTION; SERTRALINE;

EID: 84893356211     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kft254     Document Type: Article

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