Danshensu inhibits β-adrenergic receptors-mediated cardiac fibrosis by ROS/p38 MAPK axis

Biological and Pharmaceutical Bulletin

Volumn 37, Issue 6, 2014, Pages 961-967

  Lu, Haiyan ^b   Tian, Aiju ^a   Wu, Jimin ^a   Yang, Chengzhi ^a   Xing, Rui ^a   Jia, Pu ^b   Yang, Lingjian ^b   Zhang, Youyi ^a   Zheng, Xiaohui ^b   Li, Zijian ^a  

^a PEKING UNIVERSITY THIRD HOSPITAL   (China)

^b NORTHWEST UNIVERSITY   (China)

Author keywords

Cardiac fibrosis; Danshensu; p38 MAPK; Reactive oxygen specy; Adrenergic receptor

Indexed keywords

3 (3,4 DIHYDROXYPHENYL)LACTIC ACID; BETA ADRENERGIC RECEPTOR; COLLAGEN TYPE 1; ISOPRENALINE; MITOGEN ACTIVATED PROTEIN KINASE P38; REACTIVE OXYGEN METABOLITE; 3,4-DIHYDROXYPHENYLLACTIC ACID; BETA ADRENERGIC RECEPTOR STIMULATING AGENT; LACTIC ACID DERIVATIVE;

ANIMAL CELL; ARTICLE; BETA ADRENERGIC RECEPTOR BLOCKING; CELL PROLIFERATION; COLLAGEN SYNTHESIS; CONTROLLED STUDY; DRUG MECHANISM; ENZYME PHOSPHORYLATION; FIBROBLAST; HEART MUSCLE FIBROSIS; NEWBORN; NONHUMAN; RAT; SIGNAL TRANSDUCTION; ANIMAL; BIOSYNTHESIS; CARDIOMYOPATHIES; CELL CULTURE; DRUG EFFECTS; ENZYMOLOGY; FIBROSIS; METABOLISM; PATHOLOGY; SPRAGUE DAWLEY RAT;

ADRENERGIC BETA-AGONISTS; ANIMALS; CARDIOMYOPATHIES; CELL PROLIFERATION; CELLS, CULTURED; COLLAGEN TYPE I; FIBROBLASTS; FIBROSIS; ISOPROTERENOL; LACTATES; MAP KINASE SIGNALING SYSTEM; RATS, SPRAGUE-DAWLEY; REACTIVE OXYGEN SPECIES; RECEPTORS, ADRENERGIC, BETA;

EID: 84901850611     PISSN: 09186158     EISSN: 13475215     Source Type: Journal    
DOI: 10.1248/bpb.b13-00921     Document Type: Article

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