Vinca alkaloids cause aberrant ROS-mediated JNK activation, Mcl-1 downregulation, DNA damage, mitochondrial dysfunction, and apoptosis in lung adenocarcinoma cells

Biochemical Pharmacology

Volumn 83, Issue 9, 2012, Pages 1159-1171

  Chiu, Wei Hsin ^a,b   Luo, Sheng Jei ^a   Chen, Chia Ling ^a   Cheng, Jai Hong ^c   Hsieh, Chia Yuan ^a   Wang, Chi Yun ^a   Huang, Wei Ching ^a   Su, Wu Chou ^a,b   Lin, Chiou Feng ^a  

^a NATIONAL CHENG KUNG UNIVERSITY   (Taiwan)

^b NATIONAL CHENG KUNG UNIVERSITY HOSPITAL   (Taiwan)

^c CHANG GUNG MEMORIAL HOSPITAL   (Taiwan)

Author keywords

Apoptosis; Caspase; JNK; Lung adenocarcinoma; Mcl 1; Mitochondria; Mitotic arrest; ROS; Vinca alkaloids

Indexed keywords

CISPLATIN; NAVELBINE; NOCODAZOLE; PROTEIN MCL 1; REACTIVE OXYGEN METABOLITE; STRESS ACTIVATED PROTEIN KINASE; VINCA ALKALOID;

APOPTOSIS; ARTICLE; CANCER INHIBITION; CELL CYCLE ARREST; CELL SIZE; CONTROLLED STUDY; DNA DAMAGE; HUMAN; HUMAN CELL; LUNG ADENOCARCINOMA; MICROTUBULE ASSEMBLY; MITOSIS INHIBITION; PRIORITY JOURNAL; PROMETAPHASE;

ADENOCARCINOMA; ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; CASPASES; CELL LINE, TUMOR; DNA DAMAGE; DOWN-REGULATION; HUMANS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; LUNG NEOPLASMS; MITOCHONDRIA; PROTO-ONCOGENE PROTEINS C-BCL-2; REACTIVE OXYGEN SPECIES; VINBLASTINE; VINCA ALKALOIDS;

EID: 84862808986     PISSN: 00062952     EISSN: 18732968     Source Type: Journal    
DOI: 10.1016/j.bcp.2012.01.016     Document Type: Article

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