Controlled induction of DNA double-strand breaks in the mouse liver induces features of tissue ageing

Nature Communications

Volumn 6, Issue , 2015, Pages

  White, Ryan R ^a   Milholland, Brandon ^a   De Bruin, Alain ^b   Curran, Samuel ^c,f   Laberge, Remi Martin ^c   Van Steeg, Harry ^d   Campisi, Judith ^c,e   Maslov, Alexander Y ^a   Vijg, Jan ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^b UTRECHT UNIVERSITY   (Netherlands)

^c BUCK INSTITUTE FOR RESEARCH ON AGING   (United States)

^d NATIONAL INSTITUTE FOR PUBLIC HEALTH AND THE ENVIRONMENT   (Netherlands)

^e LAWRENCE BERKELEY NATIONAL LABORATORY   (United States)

^f UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; DOXYCYCLINE; RESTRICTION ENDONUCLEASE; SACI RESTRICTION ENZYME; TETRACYCLINE; UNCLASSIFIED DRUG; BIOLOGICAL MARKER; ENDODEOXYRIBONUCLEASE SACI; TYPE II SITE SPECIFIC DEOXYRIBONUCLEASE;

DNA; ENZYME ACTIVITY; GENE EXPRESSION; GENETIC MARKER; MOLECULAR ANALYSIS; PATHOLOGY; PHENOTYPE; RODENT;

ADENOVIRIDAE; AGED; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL AGING; CELL FUNCTION; CELL PROLIFERATION; CONTROLLED STUDY; DNA DAMAGE; DOUBLE STRANDED DNA BREAK; GENE EXPRESSION; GENE EXPRESSION PROFILING; IN VITRO STUDY; IN VIVO STUDY; LIVER; MALE; MITOCHONDRION; MOLECULAR BIOLOGY; MOUSE; NONHUMAN; PHENOTYPE; AGING; ANIMAL; BAGG ALBINO MOUSE; CHEMISTRY; DNA REPAIR; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENE VECTOR; GENETICS; GROWTH, DEVELOPMENT AND AGING; METABOLISM; PATHOLOGY; TRANSGENE;

ADENOVIRIDAE; ANIMALIA; MUS;

ADENOVIRIDAE; AGING; ANIMALS; BIOMARKERS; DEOXYRIBONUCLEASES, TYPE II SITE-SPECIFIC; DNA; DNA BREAKS, DOUBLE-STRANDED; DNA REPAIR; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENETIC VECTORS; LIVER; MALE; MICE; MICE, INBRED BALB C; TETRACYCLINE; TRANSGENES;

EID: 84927630671     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/ncomms7790     Document Type: Article

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