-
1
-
-
34548133006
-
Acetaminophen hepatotoxicity
-
PMID: 17723918
-
Larson AM. Acetaminophen hepatotoxicity. Clin Liver Dis 2007; 11: 525-48, vi [PMID: 17723918 DOI: 10.1016/j.cld.2007.06.006]
-
(2007)
Clin Liver Dis
, vol.11
, pp. 525-548
-
-
Larson, A.M.1
-
2
-
-
32644474169
-
Acetaminophen-induced acute liver failure: Results of a United States multicenter, prospective study
-
PMID: 16317692
-
Larson AM, Polson J, Fontana RJ, Davern TJ, Lalani E, Hynan LS, Reisch JS, Schiødt FV, Ostapowicz G, Shakil AO, Lee WM. Acetaminophen-induced acute liver failure: results of a United States multicenter, prospective study. Hepatology 2005; 42: 1364-1372 [PMID: 16317692 DOI: 10.1002/hep.20948]
-
(2005)
Hepatology
, vol.42
, pp. 1364-1372
-
-
Larson, A.M.1
Polson, J.2
Fontana, R.J.3
Davern, T.J.4
Lalani, E.5
Hynan, L.S.6
Reisch, J.S.7
Schiødt, F.V.8
Ostapowicz, G.9
Shakil, A.O.10
Lee, W.M.11
-
3
-
-
29544448331
-
Intracellular signaling mechanisms of acetaminophen-induced liver cell death
-
PMID: 16177235
-
Jaeschke H, Bajt ML. Intracellular signaling mechanisms of acetaminophen-induced liver cell death. Toxicol Sci 2006; 89: 31-41 [PMID: 16177235 DOI: 10.1093/toxsci/kfi336]
-
(2006)
Toxicol Sci
, vol.89
, pp. 31-41
-
-
Jaeschke, H.1
Bajt, M.L.2
-
4
-
-
84859708101
-
The mechanism underlying acetaminophen-induced hepatotoxicity in humans and mice involves mitochondrial damage and nuclear DNA fragmentation
-
PMID: 22378043
-
McGill MR, Sharpe MR, Williams CD, Taha M, Curry SC, Jaeschke H. The mechanism underlying acetaminophen-induced hepatotoxicity in humans and mice involves mitochondrial damage and nuclear DNA fragmentation. J Clin Invest 2012; 122: 1574-1583 [PMID: 22378043 DOI: 10.1172/JCI59755]
-
(2012)
J Clin Invest
, vol.122
, pp. 1574-1583
-
-
McGill, M.R.1
Sharpe, M.R.2
Williams, C.D.3
Taha, M.4
Curry, S.C.5
Jaeschke, H.6
-
5
-
-
0021345926
-
N-acetyl-pbenzoquinone imine: A cytochrome P-450-mediated oxidation product of acetaminophen
-
PMID: 6424115
-
Dahlin DC, Miwa GT, Lu AY, Nelson SD. N-acetyl-pbenzoquinone imine: a cytochrome P-450-mediated oxidation product of acetaminophen. Proc Natl Acad Sci USA 1984; 81: 1327-1331 [PMID: 6424115 DOI: 10.1073/pnas.81.5.1327]
-
(1984)
Proc Natl Acad Sci USA
, vol.81
, pp. 1327-1331
-
-
Dahlin, D.C.1
Miwa, G.T.2
Lu, A.Y.3
Nelson, S.D.4
-
6
-
-
77749262361
-
Mechanisms of acetaminophen-induced liver necrosis
-
PMID: 20020268
-
Hinson JA, Roberts DW, James LP. Mechanisms of acetaminophen-induced liver necrosis. Handb Exp Pharmacol 2010; (196): 369-405 [PMID: 20020268 DOI: 10.1007/978-3-642-00663-0-12]
-
(2010)
Handb Exp Pharmacol
, Issue.196
, pp. 369-405
-
-
Hinson, J.A.1
Roberts, D.W.2
James, L.P.3
-
7
-
-
0036206777
-
Determination of acetaminophenprotein adducts in mouse liver and serum and human serum after hepatotoxic doses of acetaminophen using high-performance liquid chromatography with electrochemical detection
-
PMID: 11901099
-
Muldrew KL, James LP, Coop L, McCullough SS, Hendrickson HP, Hinson JA, Mayeux PR. Determination of acetaminophenprotein adducts in mouse liver and serum and human serum after hepatotoxic doses of acetaminophen using high-performance liquid chromatography with electrochemical detection. Drug Metab Dispos 2002; 30: 446-451 [PMID: 11901099 DOI: 10.1124/dmd.30.4.446]
-
(2002)
Drug Metab Dispos
, vol.30
, pp. 446-451
-
-
Muldrew, K.L.1
James, L.P.2
Coop, L.3
McCullough, S.S.4
Hendrickson, H.P.5
Hinson, J.A.6
Mayeux, P.R.7
-
8
-
-
84855892790
-
Oxidant stress, mitochondria, and cell death mechanisms in drug-induced liver injury: Lessons learned from acetaminophen hepatotoxicity
-
PMID: 22229890
-
Jaeschke H, McGill MR, Ramachandran A. Oxidant stress, mitochondria, and cell death mechanisms in drug-induced liver injury: lessons learned from acetaminophen hepatotoxicity. Drug Metab Rev 2012; 44: 88-106 [PMID: 22229890 DOI: 10.3109/03602532.2011.602688]
-
(2012)
Drug Metab Rev
, vol.44
, pp. 88-106
-
-
Jaeschke, H.1
McGill, M.R.2
Ramachandran, A.3
-
9
-
-
79953016028
-
Acetaminophen-induced hepatotoxicity in mice occurs with inhibition of activity and nitration of mitochondrial manganese superoxide dismutase
-
PMID: 21205919
-
Agarwal R, MacMillan-Crow LA, Rafferty TM, Saba H, Roberts DW, Fifer EK, James LP, Hinson JA. Acetaminophen-induced hepatotoxicity in mice occurs with inhibition of activity and nitration of mitochondrial manganese superoxide dismutase. J Pharmacol Exp Ther 2011; 337: 110-116 [PMID: 21205919 DOI: 10.1124/jpet.110.176321]
-
(2011)
J Pharmacol Exp Ther
, vol.337
, pp. 110-116
-
-
Agarwal, R.1
Macmillan-Crow, L.A.2
Rafferty, T.M.3
Saba, H.4
Roberts, D.W.5
Fifer, E.K.6
James, L.P.7
Hinson, J.A.8
-
10
-
-
33745522546
-
Pathophysiological role of the acute inflammatory response during acetaminophen hepatotoxicity
-
PMID: 16781746
-
Cover C, Liu J, Farhood A, Malle E, Waalkes MP, Bajt ML, Jaeschke H. Pathophysiological role of the acute inflammatory response during acetaminophen hepatotoxicity. Toxicol Appl Pharmacol 2006; 216: 98-107 [PMID: 16781746 DOI: 10.1016/j.taap.2006.04.010]
-
(2006)
Toxicol Appl Pharmacol
, vol.216
, pp. 98-107
-
-
Cover, C.1
Liu, J.2
Farhood, A.3
Malle, E.4
Waalkes, M.P.5
Bajt, M.L.6
Jaeschke, H.7
-
11
-
-
80051704387
-
Apoptosis-inducing factor modulates mitochondrial oxidant stress in acetaminophen hepatotoxicity
-
PMID: 21572097
-
Bajt ML, Ramachandran A, Yan HM, Lebofsky M, Farhood A, Lemasters JJ, Jaeschke H. Apoptosis-inducing factor modulates mitochondrial oxidant stress in acetaminophen hepatotoxicity. Toxicol Sci 2011; 122: 598-605 [PMID: 21572097 DOI: 10.1093/toxsci/kfr116]
-
(2011)
Toxicol Sci
, vol.122
, pp. 598-605
-
-
Bajt, M.L.1
Ramachandran, A.2
Yan, H.M.3
Lebofsky, M.4
Farhood, A.5
Lemasters, J.J.6
Jaeschke, H.7
-
12
-
-
0029058466
-
Role of proinflammatory cytokines in acetaminophen hepatotoxicity
-
PMID: 7597709
-
Blazka ME, Wilmer JL, Holladay SD, Wilson RE, Luster MI. Role of proinflammatory cytokines in acetaminophen hepatotoxicity. Toxicol Appl Pharmacol 1995; 133: 43-52 [PMID: 7597709 DOI: 10.1006/taap.1995.1125]
-
(1995)
Toxicol Appl Pharmacol
, vol.133
, pp. 43-52
-
-
Blazka, M.E.1
Wilmer, J.L.2
Holladay, S.D.3
Wilson, R.E.4
Luster, M.I.5
-
13
-
-
0344117500
-
Acetaminophen toxicity in mice lacking NADPH oxidase activity: Role of peroxynitrite formation and mitochondrial oxidant stress
-
PMID: 14753753
-
James LP, McCullough SS, Knight TR, Jaeschke H, Hinson JA. Acetaminophen toxicity in mice lacking NADPH oxidase activity: role of peroxynitrite formation and mitochondrial oxidant stress. Free Radic Res 2003; 37: 1289-1297 [PMID: 14753753 DOI: 10.1080/10715760310001617776]
-
(2003)
Free Radic Res
, vol.37
, pp. 1289-1297
-
-
James, L.P.1
McCullough, S.S.2
Knight, T.R.3
Jaeschke, H.4
Hinson, J.A.5
-
14
-
-
77249177588
-
Acetaminophen induced acute liver failure via oxidative stress and JNK activation: Protective role of taurine by the suppression of cytochrome P450 2E1
-
PMID: 20166895
-
Das J, Ghosh J, Manna P, Sil PC. Acetaminophen induced acute liver failure via oxidative stress and JNK activation: protective role of taurine by the suppression of cytochrome P450 2E1. Free Radic Res 2010; 44: 340-355 [PMID: 20166895 DOI: 10.3109/10715760903513017]
-
(2010)
Free Radic Res
, vol.44
, pp. 340-355
-
-
Das, J.1
Ghosh, J.2
Manna, P.3
Sil, P.C.4
-
15
-
-
0036330839
-
Effect of inhibitors of nitric oxide synthase on acetaminophen-induced hepatotoxicity in mice
-
PMID: 11890740
-
Hinson JA, Bucci TJ, Irwin LK, Michael SL, Mayeux PR. Effect of inhibitors of nitric oxide synthase on acetaminophen-induced hepatotoxicity in mice. Nitric Oxide 2002; 6: 160-167 [PMID: 11890740 DOI: 10.1006/niox.2001.0404]
-
(2002)
Nitric Oxide
, vol.6
, pp. 160-167
-
-
Hinson, J.A.1
Bucci, T.J.2
Irwin, L.K.3
Michael, S.L.4
Mayeux, P.R.5
-
16
-
-
0034802130
-
Acetaminophen induces apoptosis of C6 glioma cells by activating the c-Jun NH(2)-terminal protein kinaserelated cell death pathway
-
PMID: 11562448
-
Bae MA, Pie JE, Song BJ. Acetaminophen induces apoptosis of C6 glioma cells by activating the c-Jun NH(2)-terminal protein kinaserelated cell death pathway. Mol Pharmacol 2001; 60: 847-856 [PMID: 11562448]
-
(2001)
Mol Pharmacol
, vol.60
, pp. 847-856
-
-
Bae, M.A.1
Pie, J.E.2
Song, B.J.3
-
17
-
-
1642407845
-
Regulation of connexin biosyn
-
thesis, assembly, gap junction formation, and removal PMID: 15033576
-
Segretain D, Falk MM. Regulation of connexin biosynthesis, assembly, gap junction formation, and removal. Biochim Biophys Acta 2004; 1662: 3-21 [PMID: 15033576 DOI: 10.1016/j.bbamem.2004.01.007]
-
(2004)
Biochim Biophys Acta
, vol.1662
, pp. 3-21
-
-
Segretain, D.1
Falk, M.M.2
-
18
-
-
69149107146
-
DNA-triggered innate immune responses are propagated by gap junction communication
-
PMID: 19617563
-
Patel SJ, King KR, Casali M, Yarmush ML. DNA-triggered innate immune responses are propagated by gap junction communication. Proc Natl Acad Sci USA 2009; 106: 12867-12872 [PMID: 19617563 DOI: 10.1073/pnas.0809292106]
-
(2009)
Proc Natl Acad Sci USA
, vol.106
, pp. 12867-12872
-
-
Patel, S.J.1
King, K.R.2
Casali, M.3
Yarmush, M.L.4
-
19
-
-
84863012267
-
Gap junction inhibition prevents drug-induced liver toxicity and fulminant hepatic failure
-
PMID: 22252509
-
Patel SJ, Milwid JM, King KR, Bohr S, Iracheta-Velle A, Li M, Vitalo A, Parekkadan B, Jindal R, Yarmush ML. Gap junction inhibition prevents drug-induced liver toxicity and fulminant hepatic failure. Nat Biotechnol 2012; 30: 179-183 [PMID: 22252509 DOI: 10.1038/nbt.2089]
-
(2012)
Nat Biotechnol
, vol.30
, pp. 179-183
-
-
Patel, S.J.1
Milwid, J.M.2
King, K.R.3
Bohr, S.4
Iracheta-Velle, A.5
Li, M.6
Vitalo, A.7
Parekkadan, B.8
Jindal, R.9
Yarmush, M.L.10
-
20
-
-
34250021071
-
Hydrogen acts as a therapeutic antioxidant by selectively reducing cytotoxic oxygen radicals
-
PMID: 17486089
-
Ohsawa I, Ishikawa M, Takahashi K, Watanabe M, Nishimaki K, Yamagata K, Katsura K, Katayama Y, Asoh S, Ohta S. Hydrogen acts as a therapeutic antioxidant by selectively reducing cytotoxic oxygen radicals. Nat Med 2007; 13: 688-694 [PMID: 17486089 DOI: 10.1038/nm1577]
-
(2007)
Nat Med
, vol.13
, pp. 688-694
-
-
Ohsawa, I.1
Ishikawa, M.2
Takahashi, K.3
Watanabe, M.4
Nishimaki, K.5
Yamagata, K.6
Katsura, K.7
Katayama, Y.8
Asoh, S.9
Ohta, S.10
-
21
-
-
84861391786
-
A review of hydrogen as a new medical therapy
-
PMID: 22328284
-
Zhang JY, Liu C, Zhou L, Qu K, Wang R, Tai MH, Lei Lei JC,Wu QF, Wang ZX. A review of hydrogen as a new medical therapy. Hepatogastroenterology 2012; 59: 1026-1032 [PMID: 22328284 DOI: 10.5754/hge11883]
-
(2012)
Hepatogastroenterology
, vol.59
, pp. 1026-1032
-
-
Zhang, J.Y.1
Liu, C.2
Zhou, L.3
Qu, K.4
Wang, R.5
Tai, M.H.6
Lei Lei Jcwu, Q.F.7
Wang, Z.X.8
-
22
-
-
79951670028
-
The protective role of hydrogen-rich saline in experimental liver injury in mice
-
PMID: 21145612
-
Sun H, Chen L, Zhou W, Hu L, Li L, Tu Q, Chang Y, Liu Q, Sun X, Wu M, Wang H. The protective role of hydrogen-rich saline in experimental liver injury in mice. J Hepatol 2011; 54: 471-480 [PMID: 21145612 DOI: 10.1016/j.jhep.2010.08.011]
-
(2011)
J Hepatol
, vol.54
, pp. 471-480
-
-
Sun, H.1
Chen, L.2
Zhou, W.3
Hu, L.4
Li, L.5
Tu, Q.6
Chang, Y.7
Liu, Q.8
Sun, X.9
Wu, M.10
Wang, H.11
-
23
-
-
84865554978
-
Hydrogen-rich water prevents progression of nonalcoholic steatohepatitis and accompanying hepatocarcinogenesis in mice
-
PMID: 22505328
-
Kawai D, Takaki A, Nakatsuka A, Wada J, Tamaki N, YasunakaT, Koike K, Tsuzaki R, Matsumoto K, Miyake Y, Shiraha H, Morita M, Makino H, Yamamoto K. Hydrogen-rich water prevents progression of nonalcoholic steatohepatitis and accompanying hepatocarcinogenesis in mice. Hepatology 2012; 56: 912-921 [PMID: 22505328 DOI: 10.1002/hep.25782]
-
(2012)
Hepatology
, vol.56
, pp. 912-921
-
-
Kawai, D.1
Takaki, A.2
Nakatsuka, A.3
Wada, J.4
Tamaki, N.5
Yasunakat Koike, K.6
Tsuzaki, R.7
Matsumoto, K.8
Miyake, Y.9
Shiraha, H.10
Morita, M.11
Makino, H.12
Yamamoto, K.13
-
24
-
-
84906934199
-
Molecular hydrogen as a preventive and therapeutic medical gas: Initiation, development and potential of hydrogen medicine
-
PMID: 24769081
-
Ohta S. Molecular hydrogen as a preventive and therapeutic medical gas: initiation, development and potential of hydrogen medicine. Pharmacol Ther 2014; 144: 1-11 [PMID: 24769081 DOI: 10.1016/j.pharmthera.2014.04.006]
-
(2014)
Pharmacol Ther
, vol.144
, pp. 1-11
-
-
Ohta, S.1
-
25
-
-
84900408227
-
Effect of hydrogen-rich water on acute peritonitis of rat models
-
PMID: 24793096
-
Zhang J, Wu Q, Song S, Wan Y, Zhang R, Tai M, Liu C. Effect of hydrogen-rich water on acute peritonitis of rat models. Int Immunopharmacol 2014; 21: 94-101 [PMID: 24793096 DOI: 10.1016/j.intimp.2014.04.011]
-
(2014)
Int Immunopharmacol
, vol.21
, pp. 94-101
-
-
Zhang, J.1
Wu, Q.2
Song, S.3
Wan, Y.4
Zhang, R.5
Tai, M.6
Liu, C.7
-
26
-
-
84893788446
-
Protective role of hydrogen-rich water on aspirin-induced gastric mucosal damage in rats
-
PMID: 24587639
-
Zhang JY, Wu QF, Wan Y, Song SD, Xu J, Xu XS, Chang HL, Tai MH, Dong YF, Liu C. Protective role of hydrogen-rich water on aspirin-induced gastric mucosal damage in rats. World J Gastroenterol 2014; 20: 1614-1622 [PMID: 24587639 DOI: 10.3748/wjg.v20.i6.1614]
-
(2014)
World J Gastroenterol
, vol.20
, pp. 1614-1622
-
-
Zhang, J.Y.1
Wu, Q.F.2
Wan, Y.3
Song, S.D.4
Xu, J.5
Xu, X.S.6
Chang, H.L.7
Tai, M.H.8
Dong, Y.F.9
Liu, C.10
-
27
-
-
84873522022
-
Negative regulation of transcription factor FoxM1 by p53 enhances oxaliplatin-induced senescence in hepatocellular carcinoma
-
PMID: 23262037
-
Qu K, Xu X, Liu C, Wu Q, Wei J, Meng F, Zhou L, Wang Z, Lei L, Liu P. Negative regulation of transcription factor FoxM1 by p53 enhances oxaliplatin-induced senescence in hepatocellular carcinoma. Cancer Lett 2013; 331: 105-114 [PMID: 23262037 DOI: 10.1016/j.canlet.2012.12.008]
-
(2013)
Cancer Lett
, vol.331
, pp. 105-114
-
-
Qu, K.1
Xu, X.2
Liu, C.3
Wu, Q.4
Wei, J.5
Meng, F.6
Zhou, L.7
Wang, Z.8
Lei, L.9
Liu, P.10
-
28
-
-
22744448180
-
Mitochondria-targeted redox probes as tools in the study of oxidative damage and ageing
-
PMID: 15923020
-
James AM, Cochemé HM, Murphy MP. Mitochondria-targeted redox probes as tools in the study of oxidative damage and ageing. Mech Ageing Dev 2005; 126: 982-986 [PMID: 15923020 DOI: 10.1016/j.mad.2005.03.026]
-
(2005)
Mech Ageing Dev
, vol.126
, pp. 982-986
-
-
James, A.M.1
Cochemé, H.M.2
Murphy, M.P.3
-
29
-
-
84882528592
-
Acetaminophen: Pathology and clinical presentation of hepatotoxicity
-
Lee WM, Ostapowicz G. Acetaminophen: pathology and clinical presentation of hepatotoxicity. Drug induced liver disease 2007; 389-405
-
(2007)
Drug Induced Liver Disease
, pp. 389-405
-
-
Lee, W.M.1
Ostapowicz, G.2
-
30
-
-
7044226521
-
Mitochondrial permeability transition in acetaminophen-induced necrosis and apoptosis of cultured mouse hepatocytes
-
PMID: 15486922
-
Kon K, Kim JS, Jaeschke H, Lemasters JJ. Mitochondrial permeability transition in acetaminophen-induced necrosis and apoptosis of cultured mouse hepatocytes. Hepatology 2004; 40: 1170-1179 [PMID: 15486922 DOI: 10.1002/hep.20437]
-
(2004)
Hepatology
, vol.40
, pp. 1170-1179
-
-
Kon, K.1
Kim, J.S.2
Jaeschke, H.3
Lemasters, J.J.4
-
31
-
-
15844419997
-
Role of CYP2E1 in the hepatotoxicity of acetaminophen
-
PMID: 8662637
-
Lee SS, Buters JT, Pineau T, Fernandez-Salguero P, Gonzalez FJ. Role of CYP2E1 in the hepatotoxicity of acetaminophen. J Biol Chem 1996; 271: 12063-12067 [PMID: 8662637 DOI: 10.1074/jbc.271.20.12063]
-
(1996)
J Biol Chem
, vol.271
, pp. 12063-12067
-
-
Lee, S.S.1
Buters, J.T.2
Pineau, T.3
Fernandez-Salguero, P.4
Gonzalez, F.J.5
-
32
-
-
77956919580
-
The oxygen tension modulates acetaminophen-induced mitochondrial oxidant stress and cell injury in cultured hepatocytes
-
PMID: 20616211
-
Yan HM, Ramachandran A, Bajt ML, Lemasters JJ, Jaeschke H. The oxygen tension modulates acetaminophen-induced mitochondrial oxidant stress and cell injury in cultured hepatocytes. Toxicol Sci 2010; 117: 515-523 [PMID: 20616211 DOI: 10.1093/toxsci/kfq208]
-
(2010)
Toxicol Sci
, vol.117
, pp. 515-523
-
-
Yan, H.M.1
Ramachandran, A.2
Bajt, M.L.3
Lemasters, J.J.4
Jaeschke, H.5
-
33
-
-
79958033756
-
Drug bioactivation and protein adduct formation in the pathogenesis of drug-induced toxicity
-
PMID: 20846520
-
Park BK, Laverty H, Srivastava A, Antoine DJ, Naisbitt D, Williams DP. Drug bioactivation and protein adduct formation in the pathogenesis of drug-induced toxicity. Chem Biol Interact 2011; 192: 30-36 [PMID: 20846520 DOI: 10.1016/j.cbi.2010.09.011]
-
(2011)
Chem Biol Interact
, vol.192
, pp. 30-36
-
-
Park, B.K.1
Laverty, H.2
Srivastava, A.3
Antoine, D.J.4
Naisbitt, D.5
Williams, D.P.6
-
34
-
-
46649084880
-
Role of JNK translocation to mitochondria leading to inhibition of mitochondria bioenergetics in acetaminopheninduced liver injury
-
PMID: 18337250
-
Hanawa N, Shinohara M, Saberi B, Gaarde WA, Han D, Kaplowitz N. Role of JNK translocation to mitochondria leading to inhibition of mitochondria bioenergetics in acetaminopheninduced liver injury. J Biol Chem 2008; 283: 13565-13577 [PMID: 18337250 DOI: 10.1074/jbc.M708916200]
-
(2008)
J Biol Chem
, vol.283
, pp. 13565-13577
-
-
Hanawa, N.1
Shinohara, M.2
Saberi, B.3
Gaarde, W.A.4
Han, D.5
Kaplowitz, N.6
-
35
-
-
33847750361
-
Mitochondrial protection by the JNK inhibitor leflunomide rescues mice from acetaminophen-induced liver injury
-
PMID: 17366662
-
Latchoumycandane C, Goh CW, Ong MM, Boelsterli UA. Mitochondrial protection by the JNK inhibitor leflunomide rescues mice from acetaminophen-induced liver injury. Hepatology 2007; 45: 412-421 [PMID: 17366662 DOI: 10.1002/hep.21475]
-
(2007)
Hepatology
, vol.45
, pp. 412-421
-
-
Latchoumycandane, C.1
Goh, C.W.2
Ong, M.M.3
Boelsterli, U.A.4
-
36
-
-
0032080283
-
Mammalian thioredoxin is a direct inhibitor of apoptosis signal-regulating kinase (ASK) 1
-
PMID: 9564042
-
Saitoh M, Nishitoh H, Fujii M, Takeda K, Tobiume K, Sawada Y, Kawabata M, Miyazono K, Ichijo H. Mammalian thioredoxin is a direct inhibitor of apoptosis signal-regulating kinase (ASK) 1. EMBO J 1998; 17: 2596-2606 [PMID: 9564042 DOI: 10.1093/emboj/17.9.2596]
-
(1998)
EMBO J
, vol.17
, pp. 2596-2606
-
-
Saitoh, M.1
Nishitoh, H.2
Fujii, M.3
Takeda, K.4
Tobiume, K.5
Sawada, Y.6
Kawabata, M.7
Miyazono, K.8
Ichijo, H.9
-
37
-
-
33644862368
-
JNK signaling pathway is a key modulator in cell death mediated by reactive oxygen and nitrogen species
-
PMID: 16540388
-
Shen HM, Liu ZG. JNK signaling pathway is a key modulator in cell death mediated by reactive oxygen and nitrogen species. Free Radic Biol Med 2006; 40: 928-939 [PMID: 16540388 DOI: 10.1016/j.freeradbiomed.2005.10.056]
-
(2006)
Free Radic Biol Med
, vol.40
, pp. 928-939
-
-
Shen, H.M.1
Liu, Z.G.2
-
38
-
-
32044436238
-
Liver regeneration
-
PMID: 16447274
-
Fausto N, Campbell JS, Riehle KJ. Liver regeneration. Hepatology 2006; 43: S45-S53 [PMID: 16447274 DOI: 10.1002/hep.20969]
-
(2006)
Hepatology
, vol.43
, pp. S45-S53
-
-
Fausto, N.1
Campbell, J.S.2
Riehle, K.J.3
-
39
-
-
84860632523
-
High mobility group B1 impairs hepatocyte regeneration in acetaminophen hepatotoxicity
-
PMID: 22569100
-
Yang R, Zhang S, Cotoia A, Oksala N, Zhu S, Tenhunen J. High mobility group B1 impairs hepatocyte regeneration in acetaminophen hepatotoxicity. BMC Gastroenterol 2012; 12: 45 [PMID: 22569100 DOI: 10.1186/1471-230X-12-45]
-
(2012)
BMC Gastroenterol
, vol.12
, pp. 45
-
-
Yang, R.1
Zhang, S.2
Cotoia, A.3
Oksala, N.4
Zhu, S.5
Tenhunen, J.6
-
40
-
-
34250899722
-
Signal integration in the endoplasmic reticulum unfolded protein response
-
PMID: 17565364
-
Ron D, Walter P. Signal integration in the endoplasmic reticulum unfolded protein response. Nat Rev Mol Cell Biol 2007; 8: 519-529 [PMID: 17565364 DOI: 10.1038/nrm2199]
-
(2007)
Nat Rev Mol Cell Biol
, vol.8
, pp. 519-529
-
-
Ron, D.1
Walter, P.2
-
41
-
-
84882855544
-
CHOP is a critical regulator of acetaminophen-induced hepatotoxicity
-
PMID: 23665281
-
Uzi D, Barda L, Scaiewicz V, Mills M, Mueller T, Gonzalez-Rodriguez A, Valverde AM, Iwawaki T, Nahmias Y, Xavier R, Chung RT, Tirosh B, Shibolet O. CHOP is a critical regulator of acetaminophen-induced hepatotoxicity. J Hepatol 2013; 59: 495-503 [PMID: 23665281 DOI: 10.1016/j.jhep.2013.04.024]
-
(2013)
J Hepatol
, vol.59
, pp. 495-503
-
-
Uzi, D.1
Barda, L.2
Scaiewicz, V.3
Mills, M.4
Mueller, T.5
Gonzalez-Rodriguez, A.6
Valverde, A.M.7
Iwawaki, T.8
Nahmias, Y.9
Xavier, R.10
Chung, R.T.11
Tirosh, B.12
Shibolet, O.13
-
42
-
-
77955353208
-
MacMillan-Crow LA, Hinson JA. Reactive nitrogen species in acetaminophen-induced mitochondrial damage and toxicity in mouse hepatocytes
-
PMID: 20578685
-
Burke AS, MacMillan-Crow LA, Hinson JA. Reactive nitrogen species in acetaminophen-induced mitochondrial damage and toxicity in mouse hepatocytes. Chem Res Toxicol 2010; 23: 1286-1292 [PMID: 20578685 DOI: 10.1021/tx1001755]
-
(2010)
Chem Res Toxicol
, vol.23
, pp. 1286-1292
-
-
Burke, A.S.1
-
43
-
-
27144508153
-
Peroxynitrite-induced mitochondrial and endonuclease-mediated nuclear DNA damage in acetaminophen hepatotoxicity
-
PMID: 16081675
-
Cover C, Mansouri A, Knight TR, Bajt ML, Lemasters JJ, Pessayre D, Jaeschke H. Peroxynitrite-induced mitochondrial and endonuclease-mediated nuclear DNA damage in acetaminophen hepatotoxicity. J Pharmacol Exp Ther 2005; 315: 879-887 [PMID: 16081675 DOI: 10.1124/jpet.105.088898]
-
(2005)
J Pharmacol Exp Ther
, vol.315
, pp. 879-887
-
-
Cover, C.1
Mansouri, A.2
Knight, T.R.3
Bajt, M.L.4
Lemasters, J.J.5
Pessayre, D.6
Jaeschke, H.7
-
44
-
-
84864370670
-
Closing the gap on drug-induced liver injury
-
PMID: 22833250
-
Maurel M, Rosenbaum J. Closing the gap on drug-induced liver injury. Hepatology 2012; 56: 781-783 [PMID: 22833250 DOI: 10.1002/hep.25779]
-
(2012)
Hepatology
, vol.56
, pp. 781-783
-
-
Maurel, M.1
Rosenbaum, J.2
-
45
-
-
3042821628
-
Connexin 32 dominant-negative mutant transgenic rats are resistant to hepatic damage by chemicals
-
PMID: 15239104
-
Asamoto M, Hokaiwado N, Murasaki T, Shirai T. Connexin 32 dominant-negative mutant transgenic rats are resistant to hepatic damage by chemicals. Hepatology 2004; 40: 205-210 [PMID: 15239104 DOI: 10.1002/hep.20256]
-
(2004)
Hepatology
, vol.40
, pp. 205-210
-
-
Asamoto, M.1
Hokaiwado, N.2
Murasaki, T.3
Shirai, T.4
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