Common pesticide, dichlorodiphenyltrichloroethane (DDT), increases amyloid-β levels by impairing the function of ABCA1 and IDE: Implication for Alzheimer's disease

Journal of Alzheimer's Disease

Volumn 46, Issue 1, 2015, Pages 109-122

  Li, Gongbo ^a,b   Kim, Chaeyoung ^b   Kim, Jaekwang ^b   Yoon, Hyejin ^b,c   Zhou, Huadong ^a   Kim, Jungsu ^b,c  

^a THIRD MILITARY MEDICAL UNIVERSITY   (China)

^b MAYO CLINIC   (United States)

^c MAYO GRADUATE SCHOOL   (United States)

Author keywords

Alzheimer's disease; amyloid ; amyloid protein precursor; ATP binding cassette transporter A1; dichlorodiphenyldichloroethylene; dichlorodiphenyltrichloroethane; insulin degrading enzyme; pesticides; site A PPcleaving enzyme1

Indexed keywords

ABC TRANSPORTER A1; AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; BETA SECRETASE 1; CHLORPHENOTANE; INSULINASE; MESSENGER RNA; PESTICIDE;

ABCA1 GENE; ALZHEIMER DISEASE; ARTICLE; CLEARANCE; CONTROLLED STUDY; ENVIRONMENTAL EXPOSURE; ENVIRONMENTAL FACTOR; GENE; HUMAN; HUMAN CELL; IDE GENE; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN METABOLISM; PROTEIN SYNTHESIS; RISK ASSESSMENT; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETIC TRANSFECTION; GENETICS; GLIOMA; METABOLISM; MUTATION; NEUROBLASTOMA; NONPARAMETRIC TEST; PATHOLOGY; TUMOR CELL LINE;

AMYLOID BETA-PEPTIDES; AMYLOID BETA-PROTEIN PRECURSOR; ATP BINDING CASSETTE TRANSPORTER 1; CELL LINE, TUMOR; DDT; GENE EXPRESSION REGULATION; GLIOMA; HUMANS; INSULYSIN; MUTATION; NEUROBLASTOMA; PESTICIDES; RNA, MESSENGER; STATISTICS, NONPARAMETRIC; TRANSFECTION;

EID: 84927592661     PISSN: 13872877     EISSN: 18758908     Source Type: Journal    
DOI: 10.3233/JAD-150024     Document Type: Article

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