The organochlorine o,p'-DDT plays a role in coactivator-mediated MAPK crosstalk in MCF-7 breast cancer cells

Environmental Health Perspectives

Volumn 120, Issue 9, 2012, Pages 1291-1296

  Bratton, Melyssa R ^a,b   Frigo, Daniel E ^c   Chris Segar, H ^d   Nephew, Kenneth P ^e   McLachlan, John A ^a,b   Wiese, Thomas E ^f   Burow, Matthew E ^b,d  

^a TULANE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b TULANE UNIVERSITY   (United States)

^c University of Houston   (United States)

^d TULANE UNIVERSITY HEALTH SCIENCES CENTER   (United States)

^e INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^f XAVIER UNIVERSITY OF LOUISIANA   (United States)

Author keywords

Breast cancer; CBP; Coactivator; Crosstalk; DDT; Dichlorodiphenyltrichloroethane; Endocrine disrupting chemical; HIF 1 ; MAPK; Organochlorine; p38 kinase; Vascular endothelial growth factor

Indexed keywords

1, 1, 1 TRICHLORO 2 (2 CHLOROPHENYL) 2 (4 CHLOROPHENYL) ETHANE; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN BINDING PROTEIN; ESTRADIOL; ESTROGEN RECEPTOR; FULVESTRANT; LUCIFERASE; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; UNCLASSIFIED DRUG; VASCULOTROPIN A;

ARTICLE; BREAST CANCER; CONTROLLED STUDY; ENZYME ACTIVITY; GENE EXPRESSION; HORMONE RESPONSIVE ELEMENT; HUMAN; HUMAN CELL; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PROTEIN PURIFICATION; SIGNAL TRANSDUCTION; TRANSCRIPTION INITIATION; UPREGULATION;

ANIMALIA;

EID: 84930482466     PISSN: 00916765     EISSN: 15529924     Source Type: Journal    
DOI: 10.1289/ehp.1104296     Document Type: Article

References (56)

1. Ahlborg UG, Lipworth L, Titus-Ernstoff L, Hsieh CC, Hanberg A, Baron J, et al. 1995. Organochlorine compounds in relation to breast cancer, endometrial cancer, and endometriosis: an assessment of the biological and epidemiological evidence. Crit Rev Toxicol 25(6):463-531.
2. Aigner EJ, Leone AD, Falconer RL. 1998. Concentrations and enantiomeric ratios of organochlorine pesticides in soils from the U.S. Corn Belt. Environ Sci Technol 32(9):1162-1168.
3. Ait-Si-Ali S, Carlisi D, Ramirez S, Upegui-Gonzalez LC, Duquet A, Robin P, et al. 1999. Phosphorylation by p44 MAP kinase/ERK1 stimulates CBP histone acetyl transferase activity in vitro. Biochem Biophys Res Commun 262(1):157-162.
4. Arany Z, Huang LE, Eckner R, Bhattacharya S, Jiang C, Goldberg MA, et al. 1996. An essential role for p300/CBP in the cellular response to hypoxia. Proc Natl Acad Sci USA 93(23):12969-12973.
5. Bratton MR, Duong BN, Elliott S, Weldon CB, Beckman BS, McLachlan JA, et al. 2010. Regulation of ERα-mediated transcription of Bcl-2 by PI3K-AKT crosstalk: implications for breast cancer cell survival. Int J Oncol 37(3):541-550.
6. Bratton MR, Frigo DE, Vigh-Conrad KA, Fan D, Wadsworth S, McLachlan JA, et al. 2009. Organochlorine-mediated potentiation of the general coactivator p300 through p38 mitogen-activated protein kinase. Carcinogenesis 30(1):106-113.
7. Burow ME, Tang Y, Collins-Burow BM, Krajewski S, Reed JC, McLachlan JA, et al. 1999. Effects of environmental estrogens on tumor necrosis factor α-mediated apoptosis in MCF-7 cells. Carcinogenesis 20(11):2057-2061.
8. Burow ME, Weldon CB, Chiang TC, Tang Y, Collins-Burow BM, Rolfe K, et al. 2000. Differences in protein kinase C and estrogen receptor alpha, beta expression and signaling correlate with apoptotic sensitivity of MCF-7 breast cancer cell variants. Int J Oncol 16(6):1179-1187.
9. Cocco P, Kazerouni N, Zahm SH. 2000. Cancer mortality and environmental exposure to DDE in the United States. Environ Health Perspect 108:1-4.
10. Codru N, Schymura MJ, Negoita S, Rej R, Carpenter DO. 2007. Diabetes in relation to serum levels of polychlorinated biphenyls and chlorinated pesticides in adult Native Americans. Environ Health Perspect 115:1442-1447.
11. Cole DC, Wainman B, Sanin LH, Weber JP, Muggah H, Ibrahim S. 2006. Environmental contaminant levels and fecundability among non-smoking couples. Reprod Toxicol 22(1):13-19.
12. Constantinescu A, Wu M, Asher O, Diamond I. 2004. cAMP-dependent protein kinase type I regulates ethanol-induced cAMP response element-mediated gene expression via activation of CREB-binding protein and inhibition of MAPK. J Biol Chem 279(41):43321-43329.
13. Dairkee SH, Seok J, Champion S, Sayeed A, Mindrinos M, Xiao W, et al. 2008. Bisphenol A induces a profile of tumor aggressiveness in high-risk cells from breast cancer patients. Cancer Res 68(7):2076-2080.
14. Dames SA, Martinez-Yamout M, De Guzman RN, Dyson HJ, Wright PE. 2002. Structural basis for HIF-1α/CBP recognition in the cellular hypoxic response. Proc Natl Acad Sci USA 99(8):5271-5276.
15. Ema M, Hirota K, Mimura J, Abe H, Yodoi J, Sogawa K, et al. 1999. Molecular mechanisms of transcription activation by HLF and HIF1α in response to hypoxia: their stabilization and redox signal-induced interaction with CBP/p300. EMBO J 18(7):1905-1914.
16. Falconer RL, Bidleman TF, Szeto SY. 1997. Chiral pesticides in soils of the Fraser Valley, British Columbia. J Agric Food Chem 45(5):1946-1951.
17. Fan M, Yan PS, Hartman-Frey C, Chen L, Paik H, Oyer SL, et al. 2006. Diverse gene expression and DNA methylation profiles correlate with differential adaptation of breast cancer cells to the antiestrogens tamoxifen and fulvestrant. Cancer Res 66(24):11954-11966.
18. Frigo DE, Basu A, Nierth-Simpson EN, Weldon CB, Dugan CM, Elliott S, et al. 2006. p38 mitogen-activated protein kinase stimulates estrogen-mediated transcription and proliferation through the phosphorylation and potentiation of the p160 coactivator glucocorticoid receptor-interacting protein 1. Mol Endocrinol 20(5):971-983.
19. Frigo DE, Burow ME, Mitchell KA, Chiang TC, McLachlan JA. 2002. DDT and its metabolites alter gene expression in human uterine cell lines through estrogen receptor-independent mechanisms. Environ Health Perspect 110:1239-1245.
20. Frigo DE, Tang Y, Beckman BS, Scandurro AB, Alam J, Burow ME, et al. 2004. Mechanism of AP-1-mediated gene expression by select organochlorines through the p38 MAPK pathway. Carcinogenesis 25(2):249-261.
21. Giordano A, Avantaggiati ML. 1999. p300 and CBP: partners for life and death. J Cell Physiol 181(2):218-230.
22. Goodman RH, Smolik S. 2000. CBP/p300 in cell growth, transformation, and development. Genes Dev 14(13):1553-1577.
23. Goodson WH III, Luciani MG, Sayeed SA, Jaffee IM, Moore DH II, Dairkee SH. 2011. Activation of the mTOR pathway by low levels of xenoestrogens in breast epithelial cells from high-risk women. Carcinogenesis 32(11):1724-1733.
24. Gulledge CC, Burow ME, McLachlan JA. 2001. Endocrine disruption in sexual differentiation and puberty. What do pseudohermaphroditic polar bears have to do with the practice of pediatrics? Pediatr Clin North Am 48(5):1223-1240.
25. Han EH, Kim HG, Hwang YP, Choi JH, Im JH, Park B, et al. 2010. The role of cyclooxygenase-2-dependent signaling via cyclic AMP response element activation on aromatase up-regulation by o,p'-DDT in human breast cancer cells. Toxicol Lett 198(3):331-341.
26. Hardell L, van Bavel B, Lindström G, Björnfoth H, Orgum P, Carlberg M, et al. 2004. Adipose tissue concentrations of p,p'-DDE and the risk for endometrial cancer. Gynecol Oncol 95(3):706-711.
27. Hyder SM, Murthy L, Stancel GM. 1998. Progestin regulation of vascular endothelial growth factor in human breast cancer cells. Cancer Res 58(3):392-395.
28. Hyder SM, Stancel GM, Chiappetta C, Murthy L, Boettger-Tong HL, Makela S. 1996. Uterine expression of vascular endothelial growth factor is increased by estradiol and tamoxifen. Cancer Res 56(17):3954-3960.
29. Janknecht R, Nordheim A. 1996. MAP kinase-dependent transcriptional coactivation by Elk-1 and its cofactor CBP. Biochem Biophys Res Commun 228(3):831-837.
30. Kazi AA, Jones JM, Koos RD. 2005. Chromatin immunoprecipitation analysis of gene expression in the rat uterus in vivo: estrogen-induced recruitment of both estrogen receptor α and hypoxia-inducible factor 1 to the vascular endothelial growth factor promoter. Mol Endocrinol 19(8):2006-2019.
31. Kelly BC, Gobas FA, McLachlan MS. 2004. Intestinal absorption and biomagnification of organic contaminants in fish, wildlife, and humans. Environ Toxicol Chem 23(10):2324-2336.
32. Klotz DM, Beckman BS, Hill SM, McLachlan JA, Walters MR, Arnold SF. 1996. Identification of environmental chemicals with estrogenic activity using a combination of in vitro assays. Environ Health Perspect 104:1084-1089.
33. Kuiper GG, Lemmen JG, Carlsson B, Corton JC, Safe SH, van der Saag PT, et al. 1998. Interaction of estrogenic chemicals and phytoestrogens with estrogen receptor β. Endocrinology 139(10):4252-4263.
34. Liu Y, Cox SR, Morita T, Kourembanas S. 1995. Hypoxia regulates vascular endothelial growth factor gene expression in endothelial cells. Identification of a 5' enhancer. Circ Res 77(3):638-643.
35. Longnecker MP, Klebanoff MA, Brock JW, Zhou H, Gray KA, Needham LL, et al. 2002. Maternal serum level of 1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene and risk of cryptorchidism, hypospadias, and polythelia among male offspring. Am J Epidemiol 155(4):313-322.
36. López-Carrillo L, Torres-Sánchez L, Moline J, Ireland K, Wolff MS. 2001. Breast-feeding and serum p,p'DDT levels among Mexican women of childbearing age: a pilot study. Environ Res 87(3):131-135.
37. Martin SA Jr, Harlow SD, Sowers MF, Longnecker MP, Garabrant D, Shore DL, et al. 2002. DDT metabolite and androgens in African-American farmers. Epidemiology 13(4):454-458.
38. McGlynn KA, Quraishi SM, Graubard BI, Weber JP, Rubertone MV, Erickson RL. 2008. Persistent organochlorine pesticides and risk of testicular germ cell tumors. J Natl Cancer Inst 100(9):663-671.
39. McLachlan JA. 2001. Environmental signaling: what embryos and evolution teach us about endocrine disrupting chemicals. Endocr Rev 22(3):319-341.
40. McLachlan JA, Simpson E, Martin M. 2006. Endocrine disrupters and female reproductive health. Best Pract Res Clin Endocrinol Metab 20(1):63-75.
41. Nakamura J, Lu Q, Aberdeen G, Albrecht E, Brodie A. 1999. The effect of estrogen on aromatase and vascular endothelial growth factor messenger ribonucleic acid in the normal nonhuman primate mammary gland. J Clin Endocrinol Metab 84(4):1432-1437.
42. Nakamura J, Savinov A, Lu Q, Brodie A. 1996. Estrogen regulates vascular endothelial growth/permeability factor expression in 7,12-dimethylbenz(a)anthracene-induced rat mammary tumors. Endocrinology 137(12):5589-5596.
43. Porta M, Bosch de Basea M, Benavides FG, Lopez T, Fernandez E, Marco E, et al. 2008. Differences in serum concentrations of organochlorine compounds by occupational social class in pancreatic cancer. Environ Res 108(3):370-379.
44. Rhodes LV, Muir SE, Elliott S, Guillot LM, Antoon JW, Penfornis P, et al. 2010. Adult human mesenchymal stem cells enhance breast tumorigenesis and promote hormone independence. Breast Cancer Res Treat 121(2):293-300.
45. Rier S, Foster WG. 2002. Environmental dioxins and endometriosis. Toxicol Sci 70(2):161-170.
46. Rignell-Hydbom A, Rylander L, Hagmar L. 2007. Exposure to persistent organochlorine pollutants and type 2 diabetes mellitus. Hum Exp Toxicol 26(5):447-452.
47. Safe SH, Zacharewski T. 1997. Organochlorine exposure and risk for breast cancer. Prog Clin Biol Res 396:133-145.
48. Sasco AJ. 2003. Breast cancer and the environment. Horm Res 60(suppl 3):50.
49. Stoner M, Wang F, Wormke M, Nguyen T, Samudio I, Vyhlidal C, et al. 2000. Inhibition of vascular endothelial growth factor expression in HEC1A endometrial cancer cells through interactions of estrogen receptor α and Sp3 proteins. J Biol Chem 275(30):22769-22779.
50. Stoner M, Wormke M, Saville B, Samudio I, Qin C, Abdelrahim M, et al. 2004. Estrogen regulation of vascular endothelial growth factor gene expression in ZR-75 breast cancer cells through interaction of estrogen receptor α and SP proteins. Oncogene 23(5):1052-1063.
51. Tilghman SL, Bratton MR, Segar HC, Martin EC, Rhodes LV, Li M, et al. 2012. Endocrine disruptor regulation of microRNA expression in breast carcinoma cells. PloS one 7(3):e32754; doi:10.1371/journal.pone.0032754 [Online 5 March 2012].
52. Tilghman SL, Nierth-Simpson EN, Wallace R, Burow ME, McLachlan JA. 2010. Environmental hormones: multiple pathways for response may lead to multiple disease outcomes. Steroids 75(8-9):520-523.
53. Tullner WW. 1961. Uterotrophic action of the insecticide methoxychlor. Science 133:647-648.
54. U.S. Geological Survey. 2001. Summary Statistics for Organochlorine Compounds in Whole Fish. Reston, VA:U.S. Geological Survey.
55. Wolff MS, Toniolo PG, Lee EW, Rivera M, Dubin N. 1993. Blood levels of organochlorine residues and risk of breast cancer. J Natl Cancer Inst 85(8):648-652.
56. Zhang HT, Craft P, Scott PA, Ziche M, Weich HA, Harris AL, et al. 1995. Enhancement of tumor growth and vascular density by transfection of vascular endothelial cell growth factor into MCF-7 human breast carcinoma cells. J Natl Cancer Inst 87(3):213-219.