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Volumn 113, Issue 1, 2015, Pages 25-34

The effectiveness of leucine on muscle protein synthesis, lean body mass and leg lean mass accretion in older people: A systematic review and meta-Analysis

Author keywords

Dietary supplements; Elderly; Essential amino acids; Sarcopenia

Indexed keywords

LEUCINE; MUSCLE PROTEIN;

EID: 84927570837     PISSN: 00071145     EISSN: 14752662     Source Type: Journal    
DOI: 10.1017/S0007114514002475     Document Type: Review
Times cited : (91)

References (50)
  • 1
    • 84864994105 scopus 로고    scopus 로고
    • Exercise and nutritional interventions for improving aging muscle health
    • Forbes SC, Little JP &Candow DG (2012) Exercise and nutritional interventions for improving aging muscle health. Endocrine 42, 29-38
    • (2012) Endocrine , vol.42 , pp. 29-38
    • Forbes, S.C.1    Little, J.P.2    Candow, D.G.3
  • 2
    • 33748286777 scopus 로고    scopus 로고
    • Decreased muscle strength and quality in olDer adults with type 2 diabetes: The health, aging, and body composition study
    • Park SW, Goodpaster BH, Strotmeyer ES, et al. (2006) Decreased muscle strength and quality in olDer adults with type 2 diabetes: the health, aging, and body composition study. Diabetes 55, 1813-1818
    • (2006) Diabetes , vol.55 , pp. 1813-1818
    • Park, S.W.1    Goodpaster, B.H.2    Strotmeyer, E.S.3
  • 3
    • 84893733325 scopus 로고    scopus 로고
    • A cross-sectional study of loss of muscle mass corresponding to sarcopenia in healthy Chinese men and women: Reference values, prevalence, and association with bone mass
    • Cheng Q, Zhu X, Zhang X, et al. (2013) A cross-sectional study of loss of muscle mass corresponding to sarcopenia in healthy Chinese men and women: reference values, prevalence, and association with bone mass. J Bone Miner Metab 32, 78-88
    • (2013) J Bone Miner Metab , vol.32 , pp. 78-88
    • Cheng, Q.1    Zhu, X.2    Zhang, X.3
  • 4
    • 84860539930 scopus 로고    scopus 로고
    • Prevalence of sarcopenia in healthy community-dwelling elDerly in an urban area of Barcelona (Spain
    • Masanes F, Culla A, Navarro-Gonzalez M, et al. (2012) Prevalence of sarcopenia in healthy community-dwelling elDerly in an urban area of Barcelona (Spain). J Nutr Health Aging 16, 184-187
    • (2012) J Nutr Health Aging , vol.16 , pp. 184-187
    • Masanes, F.1    Culla, A.2    Navarro-Gonzalez, M.3
  • 5
    • 84856134433 scopus 로고    scopus 로고
    • Prevalence and risk factors of sarcopenia among nursing home olDer residents
    • Landi F, Liperoti R, Fusco D, et al. (2012) Prevalence and risk factors of sarcopenia among nursing home olDer residents. J Gerontol A Biol Sci Med Sci 67, 48-55
    • (2012) J Gerontol A Biol Sci Med Sci , vol.67 , pp. 48-55
    • Landi, F.1    Liperoti, R.2    Fusco, D.3
  • 6
    • 0346499181 scopus 로고    scopus 로고
    • The healthcare costs of sarcopenia in the United States
    • Janssen I, Shepard DS, Katzmarzyk PT, et al. (2004) The healthcare costs of sarcopenia in the United States. J Am Geriatr Soc 52, 80-85
    • (2004) J Am Geriatr Soc , vol.52 , pp. 80-85
    • Janssen, I.1    Shepard, D.S.2    Katzmarzyk, P.T.3
  • 7
    • 84865352578 scopus 로고    scopus 로고
    • Effect of nutritional interventions and resistance exercise on aging muscle mass and strength
    • Candow DG, Forbes SC, Little JP, et al. (2012) Effect of nutritional interventions and resistance exercise on aging muscle mass and strength. Biogerontology 13, 345-358
    • (2012) Biogerontology , vol.13 , pp. 345-358
    • Candow, D.G.1    Forbes, S.C.2    Little, J.P.3
  • 8
    • 0034485454 scopus 로고    scopus 로고
    • The response of muscle protein anabolism to combined hyperaminoacidemia and glucose-induced hyperinsulinemia is impaired in the elDerly
    • Volpi E, Mittendorfer B, Rasmussen BB, et al. (2000) The response of muscle protein anabolism to combined hyperaminoacidemia and glucose-induced hyperinsulinemia is impaired in the elDerly. J Clin Endocrinol Metab 85, 4481-4490
    • (2000) J Clin Endocrinol Metab , vol.85 , pp. 4481-4490
    • Volpi, E.1    Mittendorfer, B.2    Rasmussen, B.B.3
  • 9
    • 33745853476 scopus 로고    scopus 로고
    • A high proportion of leucine is required for optimal stimulation of the rate of muscle protein synthesis by essential amino acids in the elDerly
    • Katsanos CS, Kobayashi H, Sheffield-Moore M, et al. (2006) A high proportion of leucine is required for optimal stimulation of the rate of muscle protein synthesis by essential amino acids in the elDerly. Am J Physiol Endocrinol Metab 291, E381-E387
    • (2006) Am J Physiol Endocrinol Metab , vol.291 , pp. E381-E387
    • Katsanos, C.S.1    Kobayashi, H.2    Sheffield-Moore, M.3
  • 10
    • 14644444464 scopus 로고    scopus 로고
    • Anabolic signaling deficits unDerlie amino acid resistance of wasting, aging muscle
    • Cuthbertson D, Smith K, Babraj J, et al. (2005) Anabolic signaling deficits unDerlie amino acid resistance of wasting, aging muscle. FASEB J 19, 422-424
    • (2005) FASEB J , vol.19 , pp. 422-424
    • Cuthbertson, D.1    Smith, K.2    Babraj, J.3
  • 11
    • 84855853511 scopus 로고    scopus 로고
    • Effects of exercise and amino acid supplementation on body composition and physical function in community-dwelling elDerly Japanese sarcopenic women: A randomized controlled trial
    • Kim HK, Suzuki T, Saito K, et al. (2012) Effects of exercise and amino acid supplementation on body composition and physical function in community-dwelling elDerly Japanese sarcopenic women: a randomized controlled trial. J Am Geriatr Soc 60, 16-23
    • (2012) J Am Geriatr Soc , vol.60 , pp. 16-23
    • Kim, H.K.1    Suzuki, T.2    Saito, K.3
  • 12
    • 44449084604 scopus 로고    scopus 로고
    • Nutritional supplements with oral amino acid mixtures increases wholebody lean mass and insulin sensitivity in elDerly subjects with sarcopenia
    • Solerte SB, Gazzaruso C, Bonacasa R, et al. (2008) Nutritional supplements with oral amino acid mixtures increases wholebody lean mass and insulin sensitivity in elDerly subjects with sarcopenia. Am J Cardiol 101, 69E-77E
    • (2008) Am J Cardiol , vol.101 , pp. 69E-77E
    • Solerte, S.B.1    Gazzaruso, C.2    Bonacasa, R.3
  • 13
    • 65549171522 scopus 로고    scopus 로고
    • Long-term leucine supplementation does not increase muscle mass or strength in healthy elDerly men
    • Verhoeven S, Vanschoonbeek K, Verdijk LB, et al. (2009) Long-term leucine supplementation does not increase muscle mass or strength in healthy elDerly men. Am J Clin Nutr 89, 1468-1475
    • (2009) Am J Clin Nutr , vol.89 , pp. 1468-1475
    • Verhoeven, S.1    Vanschoonbeek, K.2    Verdijk, L.B.3
  • 14
    • 75949099307 scopus 로고    scopus 로고
    • EAA supplementation to increase nitrogen intake improves muscle function during bed rest in the elDerly
    • Ferrando AA, Paddon-Jones D, Hays NP, et al. (2010) EAA supplementation to increase nitrogen intake improves muscle function during bed rest in the elDerly. Clin Nutr 29, 18-23
    • (2010) Clin Nutr , vol.29 , pp. 18-23
    • Ferrando, A.A.1    Paddon-Jones, D.2    Hays, N.P.3
  • 15
    • 79958226936 scopus 로고    scopus 로고
    • Prolonged leucine supplementation does not augment muscle mass or affect glycemic control in elDerly type 2 diabetic men
    • LeenDers M, Verdijk LB, Van Der Hoeven L, et al. (2011) Prolonged leucine supplementation does not augment muscle mass or affect glycemic control in elDerly type 2 diabetic men. J Nutr 141, 1070-1076
    • (2011) J Nutr , vol.141 , pp. 1070-1076
    • Leenders, M.1    Verdijk, L.B.2    Van Der Hoeven, L.3
  • 16
    • 84866754137 scopus 로고    scopus 로고
    • Protein supplementation increases muscle mass gain during prolonged resistance-type exercise training in frail elDerly people: A randomized, double-blind, placebo-controlled trial
    • Tieland M, Dirks ML, Van Der Zwaluw N, et al. (2012) Protein supplementation increases muscle mass gain during prolonged resistance-type exercise training in frail elDerly people: a randomized, double-blind, placebo-controlled trial. J Am Med Dir Assoc 13, 713-719
    • (2012) J Am Med Dir Assoc , vol.13 , pp. 713-719
    • Tieland, M.1    Dirks, M.L.2    Van Der Zwaluw, N.3
  • 17
    • 66149141889 scopus 로고    scopus 로고
    • Amino acid supplementation increases lean body mass, basal muscle protein syn thesis, and insulin-like growth factor-I expression in olDer women
    • Dillon EL, Sheffield-Moore M, Paddon-Jones D, et al. (2009) Amino acid supplementation increases lean body mass, basal muscle protein synthesis, and insulin-like growth factor-I expression in olDer women. J Clin Endocrinol Metab 94, 1630-1637
    • (2009) J Clin Endocrinol Metab , vol.94 , pp. 1630-1637
    • Dillon, E.L.1    Sheffield-Moore, M.2    Paddon-Jones, D.3
  • 18
    • 84878320758 scopus 로고    scopus 로고
    • Efficacy of whey protein supplementation on resistance exercise-induced changes in lean mass, muscle strength, and physical function in mobility-limited olDer adults
    • Chale A, Cloutier GJ, Hau C, et al. (2013) Efficacy of whey protein supplementation on resistance exercise-induced changes in lean mass, muscle strength, and physical function in mobility-limited olDer adults. J Gerontol A Biol Sci Med Sci 68, 682-690
    • (2013) J Gerontol A Biol Sci Med Sci , vol.68 , pp. 682-690
    • Chale, A.1    Cloutier, G.J.2    Hau, C.3
  • 19
    • 0028341292 scopus 로고
    • Exercise training and nutritional supplementation for physical frailty in very elDerly people
    • Fiatarone MA, ONeill EF, Ryan ND, et al. (1994) Exercise training and nutritional supplementation for physical frailty in very elDerly people. N Engl J Med 330, 1769-1775
    • (1994) N Engl J Med , vol.330 , pp. 1769-1775
    • Fiatarone, M.A.1    Oneill, E.F.2    Ryan, N.D.3
  • 20
    • 83455176892 scopus 로고    scopus 로고
    • Intragastric protein administration stimulates overnight muscle protein synthesis in elDerly men
    • Groen BB, Res PT, Pennings B, et al. (2012) Intragastric protein administration stimulates overnight muscle protein synthesis in elDerly men. Am J Physiol Endocrinol Metab 302, E52-E60
    • (2012) Am J Physiol Endocrinol Metab , vol.302 , pp. E52-E60
    • Groen, B.B.1    Res, P.T.2    Pennings, B.3
  • 21
    • 60349095217 scopus 로고    scopus 로고
    • Year-long changes in protein metabolism in elDerly men and women supplemented with a nutrition cocktail of b-hydroxyb-methylbutyrate (HMB), L-Arginine, and L-lysine
    • Baier S, Johannsen D, Abumrad N, et al. (2009) Year-long changes in protein metabolism in elDerly men and women supplemented with a nutrition cocktail of b-hydroxyb-methylbutyrate (HMB), L-Arginine, and L-lysine. JPEN J Parenter Enteral Nutr 33, 71-82
    • (2009) JPEN J Parenter Enteral Nutr , vol.33 , pp. 71-82
    • Baier, S.1    Johannsen, D.2    Abumrad, N.3
  • 22
    • 84875146949 scopus 로고    scopus 로고
    • Influence of amino acids, dietary protein, and physical activity on muscle mass development in humans
    • DiDeriksen K, ReitelseDer S &Holm L (2013) Influence of amino acids, dietary protein, and physical activity on muscle mass development in humans. Nutrients 5, 852-876
    • (2013) Nutrients , vol.5 , pp. 852-876
    • Dideriksen, K.1    Reitelseder, S.2    Holm, L.3
  • 23
    • 38949086515 scopus 로고    scopus 로고
    • Co-ingestion of leucine with protein does not further augment postexercise muscle protein synthesis rates in elDerly men
    • Koopman R, Verdijk LB, Beelen M, et al. (2008) Co-ingestion of leucine with protein does not further augment postexercise muscle protein synthesis rates in elDerly men. Br J Nutr 99, 571-580
    • (2008) Br J Nutr , vol.99 , pp. 571-580
    • Koopman, R.1    Verdijk, L.B.2    Beelen, M.3
  • 24
    • 33750102079 scopus 로고    scopus 로고
    • Co-ingestion of protein and leucine stimulates muscle protein synthesis rates to the same extent in young and elDerly lean men
    • Koopman R, Verdijk L, ManDers RJ, et al. (2006) Co-ingestion of protein and leucine stimulates muscle protein synthesis rates to the same extent in young and elDerly lean men. Am J Clin Nutr 84, 623-632
    • (2006) Am J Clin Nutr , vol.84 , pp. 623-632
    • Koopman, R.1    Verdijk, L.2    Manders, R.J.3
  • 25
    • 84856448344 scopus 로고    scopus 로고
    • Leucine as a pharmaconutrient to prevent and treat sarcopenia and type 2 diabetes
    • LeenDers M &Van Loon LJ (2011) Leucine as a pharmaconutrient to prevent and treat sarcopenia and type 2 diabetes. Nutr Rev 69, 675-689
    • (2011) Nutr Rev , vol.69 , pp. 675-689
    • Leenders, M.1    Van Loon, L.J.2
  • 26
    • 33746876019 scopus 로고    scopus 로고
    • Leucine supplementation improves muscle protein synthesis in elDerly men independently of hyperaminoacidaemia
    • Rieu I, Balage M, Sornet C, et al. (2006) Leucine supplementation improves muscle protein synthesis in elDerly men independently of hyperaminoacidaemia. J Physiol 575, 305-315
    • (2006) J Physiol , vol.575 , pp. 305-315
    • Rieu, I.1    Balage, M.2    Sornet, C.3
  • 27
    • 31544472848 scopus 로고    scopus 로고
    • Differential stimulation of muscle protein synthesis in elDerly humans following isocaloric ingestion of amino acids or whey protein
    • Paddon-Jones D, Sheffield-Moore M, Katsanos CS, et al. (2006) Differential stimulation of muscle protein synthesis in elDerly humans following isocaloric ingestion of amino acids or whey protein. Exp Gerontol 41, 215-219
    • (2006) Exp Gerontol , vol.41 , pp. 215-219
    • Paddon-Jones, D.1    Sheffield-Moore, M.2    Katsanos, C.S.3
  • 28
    • 84863087931 scopus 로고    scopus 로고
    • Nutrient-rich meat proteins in offsetting age-related muscle loss
    • Phillips SM (2012) Nutrient-rich meat proteins in offsetting age-related muscle loss. Meat Sci 92, 174-178
    • (2012) Meat Sci , vol.92 , pp. 174-178
    • Phillips, S.M.1
  • 29
    • 84878247818 scopus 로고    scopus 로고
    • Protein and amino acid supplementation in olDer humans
    • Fukagawa NK (2013) Protein and amino acid supplementation in olDer humans. Amino Acids 44, 1493-1509
    • (2013) Amino Acids , vol.44 , pp. 1493-1509
    • Fukagawa, N.K.1
  • 30
    • 0037098199 scopus 로고    scopus 로고
    • Quantifying heterogeneity in a meta-Analysis
    • Higgins JP &Thompson SG (2002) Quantifying heterogeneity in a meta-Analysis. Stat Med 21, 1539-1558
    • (2002) Stat Med , vol.21 , pp. 1539-1558
    • Higgins, J.P.1    Thompson, S.G.2
  • 31
    • 0034631415 scopus 로고    scopus 로고
    • Empirical assessment of effect of publication bias on meta-Analyses
    • Sutton AJ, Duval SJ, Tweedie RL, et al. (2000) Empirical assessment of effect of publication bias on meta-Analyses. BMJ 320, 1574-1577
    • (2000) BMJ , vol.320 , pp. 1574-1577
    • Sutton, A.J.1    Duval, S.J.2    Tweedie, R.L.3
  • 32
    • 0030693603 scopus 로고    scopus 로고
    • Quantitative synthesis in systematic reviews
    • Lau J, Ioannidis JP &Schmid CH (1997) Quantitative synthesis in systematic reviews. Ann Intern Med 127, 820-826
    • (1997) Ann Intern Med , vol.127 , pp. 820-826
    • Lau, J.1    Ioannidis, J.P.2    Schmid, C.H.3
  • 34
    • 79960127222 scopus 로고    scopus 로고
    • Similar effects of leucine rich and regular dairy products on muscle mass and functions of olDer polymyalgia rheumatica patients: A randomized crossover trial
    • Bjorkman MP, Pilvi TK, Kekkonen RA, et al. (2011) Similar effects of leucine rich and regular dairy products on muscle mass and functions of olDer polymyalgia rheumatica patients: a randomized crossover trial. J Nutr Health Aging 15, 462-467
    • (2011) J Nutr Health Aging , vol.15 , pp. 462-467
    • Bjorkman, M.P.1    Pilvi, T.K.2    Kekkonen, R.A.3
  • 35
    • 82255162980 scopus 로고    scopus 로고
    • Muscle protein synthesis in cancer patients can be stimulated with a specially formulated medical food
    • Deutz NE, Safar A, Schutzler S, et al. (2011) Muscle protein synthesis in cancer patients can be stimulated with a specially formulated medical food. Clin Nutr 30, 759-768
    • (2011) Clin Nutr , vol.30 , pp. 759-768
    • Deutz, N.E.1    Safar, A.2    Schutzler, S.3
  • 36
    • 53249087926 scopus 로고    scopus 로고
    • Whey protein ingestion in elDerly persons results in greater muscle protein accrual than ingestion of its constituent essential amino acid content
    • Katsanos CS, Chinkes DL, Paddon-Jones D, et al. (2008) Whey protein ingestion in elDerly persons results in greater muscle protein accrual than ingestion of its constituent essential amino acid content. Nutr Res 28, 651-658
    • (2008) Nutr Res , vol.28 , pp. 651-658
    • Katsanos, C.S.1    Chinkes, D.L.2    Paddon-Jones, D.3
  • 37
    • 20544440861 scopus 로고    scopus 로고
    • Aging muscle
    • Nair KS (2005) Aging muscle. Am J Clin Nutr 81, 953-963
    • (2005) Am J Clin Nutr , vol.81 , pp. 953-963
    • Nair, K.S.1
  • 38
    • 0346996344 scopus 로고    scopus 로고
    • Regulation of global and specific mRNA translation by oral administration of branched-chain amino acids
    • Kimball SR &Jefferson LS (2004) Regulation of global and specific mRNA translation by oral administration of branched-chain amino acids. Biochem Biophys Res Commun 313, 423-427
    • (2004) Biochem Biophys Res Commun , vol.313 , pp. 423-427
    • Kimball, S.R.1    Jefferson, L.S.2
  • 39
    • 0026476465 scopus 로고
    • Leucine as a regulator of whole body and skeletal muscle protein metabolism in humans
    • Nair KS, Schwartz RG &Welle S (1992) Leucine as a regulator of whole body and skeletal muscle protein metabolism in humans. Am J Physiol 263, E928-E934
    • (1992) Am J Physiol , vol.263 , pp. E928-E934
    • Nair, K.S.1    Schwartz, R.G.2    Welle, S.3
  • 40
    • 0024567234 scopus 로고
    • Increase in anterior tibialis muscle protein synthesis in healthy man during mixed amino acid infusion: Studies of incorporation of [1-13C]leucine
    • Bennet WM, Connacher AA &Scrimgeour CM (1989) Increase in anterior tibialis muscle protein synthesis in healthy man during mixed amino acid infusion: studies of incorporation of [1-13C]leucine. Clin Sci 76, 447-454
    • (1989) Clin Sci , vol.76 , pp. 447-454
    • Bennet, W.M.1    Connacher, A.A.2    Scrimgeour, C.M.3
  • 41
    • 0031831344 scopus 로고    scopus 로고
    • Effects of flooding amino acids on incorporation of labeled amino acids into human muscle protein
    • Smith K, Reynolds N, Downie S, et al. (1998) Effects of flooding amino acids on incorporation of labeled amino acids into human muscle protein. Am J Physiol 275, E73-E78
    • (1998) Am J Physiol , vol.275 , pp. E73-E78
    • Smith, K.1    Reynolds, N.2    Downie, S.3
  • 42
    • 0026558203 scopus 로고
    • Flooding with L-[1-13C]leucine stimulates human muscle protein incorporation of continuously infused L-[1-13C]valine
    • Smith K, Barua JM, Watt PW, et al. (1992) Flooding with L-[1-13C]leucine stimulates human muscle protein incorporation of continuously infused L-[1-13C]valine. Am J Physiol 262, E372-E376
    • (1992) Am J Physiol , vol.262 , pp. E372-E376
    • Smith, K.1    Barua, J.M.2    Watt, P.W.3
  • 43
    • 0025201970 scopus 로고
    • Effect of infused branched-chain amino acids on muscle and whole-body amino acid metabolism in man
    • Louard RJ, Barrett EJ &Gelfand RA (1990) Effect of infused branched-chain amino acids on muscle and whole-body amino acid metabolism in man. Clin Sci 79, 457-466
    • (1990) Clin Sci , vol.79 , pp. 457-466
    • Louard, R.J.1    Barrett, E.J.2    Gelfand, R.A.3
  • 44
    • 84872766505 scopus 로고    scopus 로고
    • Muscle wasting and resistance of muscle anabolism: The anabolic threshold concept for adapted nutritional strategies during sarcopenia
    • Dardevet D, Remond D, Peyron MA, et al. (2012) Muscle wasting and resistance of muscle anabolism: the anabolic threshold concept for adapted nutritional strategies during sarcopenia. ScientificWorldJournal 2012, 269531
    • (2012) ScientificWorldJournal , vol.2012 , pp. 269531
    • Dardevet, D.1    Remond, D.2    Peyron, M.A.3
  • 45
    • 78149304854 scopus 로고    scopus 로고
    • Muscle full effect after oral protein: Time-dependent concordance and discordance between human muscle protein synthesis and mTORC1 signaling
    • Atherton PJ, Etheridge T, Watt PW, et al. (2010) Muscle full effect after oral protein: time-dependent concordance and discordance between human muscle protein synthesis and mTORC1 signaling. Am J Clin Nutr 92, 1080-1088
    • (2010) Am J Clin Nutr , vol.92 , pp. 1080-1088
    • Atherton, P.J.1    Etheridge, T.2    Watt, P.W.3
  • 46
    • 84899145525 scopus 로고    scopus 로고
    • Leucine modulates dynamic phosphorylation events in insulin signaling pathway and enhances insulin-dependent glycogen synthesis in human skeletal muscle cells
    • Di Camillo B, Eduati F, Nair SK, et al. (2014) Leucine modulates dynamic phosphorylation events in insulin signaling pathway and enhances insulin-dependent glycogen synthesis in human skeletal muscle cells. BMC Cell Biol 15, 9
    • (2014) BMC Cell Biol , vol.15 , pp. 9
    • Di Camillo, B.1    Eduati, F.2    Nair, S.K.3
  • 47
    • 77955890920 scopus 로고    scopus 로고
    • Leucine metabolism in regulation of insulin secretion from pancreatic beta cells
    • Yang J, Chi Y, Burkhardt BR, et al. (2010) Leucine metabolism in regulation of insulin secretion from pancreatic beta cells. Nutr Rev 68, 270-279
    • (2010) Nutr Rev , vol.68 , pp. 270-279
    • Yang, J.1    Chi, Y.2    Burkhardt, B.R.3
  • 48
    • 84865278230 scopus 로고    scopus 로고
    • Effects of a leucine and pyridoxine-containing nutraceutical on fat oxidation, and oxidative and inflammatory stress in overweight and obese subjects
    • Zemel MB &Bruckbauer A (2012) Effects of a leucine and pyridoxine-containing nutraceutical on fat oxidation, and oxidative and inflammatory stress in overweight and obese subjects. Nutrients 4, 529-541
    • (2012) Nutrients , vol.4 , pp. 529-541
    • Zemel, M.B.1    Bruckbauer, A.2
  • 49
    • 84857910457 scopus 로고    scopus 로고
    • Differential effect of long-term leucine supplementation on skeletal muscle and adipose tissue in old rats: An insulin signaling pathway approach
    • Zeanandin G, Balage M, SchneiDer SM, et al. (2012) Differential effect of long-term leucine supplementation on skeletal muscle and adipose tissue in old rats: an insulin signaling pathway approach. Age (Dordr) 34, 371-387
    • (2012) Age (Dordr , vol.34 , pp. 371-387
    • Zeanandin, G.1    Balage, M.2    Schneider, S.M.3
  • 50
    • 77954395002 scopus 로고    scopus 로고
    • Chronic leucine supplementation improves glycemic control in etiologically distinct mouse models of obesity and diabetes mellitus
    • Guo K, Yu YH, Hou J, et al. (2010) Chronic leucine supplementation improves glycemic control in etiologically distinct mouse models of obesity and diabetes mellitus. Nutr Metab (Lond) 7, 57
    • (2010) Nutr Metab (Lond , vol.7 , pp. 57
    • Guo, K.1    Yu, Y.H.2    Hou, J.3


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