Effects of exercise and amino acid supplementation on body composition and physical function in community-dwelling elderly Japanese sarcopenic women: A randomized controlled trial

Journal of the American Geriatrics Society

Volumn 60, Issue 1, 2012, Pages 16-23

  Kim, Hun Kyung ^a   Suzuki, Takao ^b   Saito, Kyoko ^a   Yoshida, Hideyo ^a   Kobayashi, Hisamine ^c   Kato, Hiroyuki ^c   Katayama, Miwa ^c  

^a TOKYO METROPOLITAN INSTITUTE OF GERONTOLOGY   (Japan)

^b NATIONAL CENTER FOR GERIATRICS AND GERONTOLOGY   (Japan)

^c AJINOMOTO CO INC   (Japan)

Author keywords

amino acid supplementation; exercise; muscle mass; muscle strength; sarcopenic women

Indexed keywords

ESSENTIAL AMINO ACID;

AGED; ARTICLE; BODY COMPOSITION; CLINICAL EFFECTIVENESS; CONTROLLED STUDY; DIET SUPPLEMENTATION; EXERCISE; FEMALE; GERIATRIC PATIENT; HEALTH EDUCATION; HUMAN; JAPANESE; KNEE; LEG MUSCLE; MAJOR CLINICAL STUDY; MUSCLE ATROPHY; MUSCLE MASS; MUSCLE STRENGTH; MUSCLE TRAINING; PHYSICAL PERFORMANCE; RANDOMIZED CONTROLLED TRIAL; URBAN POPULATION; WALKING SPEED;

AGED; AMINO ACIDS, ESSENTIAL; BODY COMPOSITION; DIETARY SUPPLEMENTS; EXERCISE; EXERCISE THERAPY; FEMALE; FOLLOW-UP STUDIES; GERIATRIC ASSESSMENT; HUMANS; INCIDENCE; JAPAN; MOTOR ACTIVITY; MUSCLE STRENGTH; PATIENT EDUCATION AS TOPIC; RETROSPECTIVE STUDIES; SARCOPENIA; TREATMENT OUTCOME;

EID: 84855853511     PISSN: 00028614     EISSN: 15325415     Source Type: Journal    
DOI: 10.1111/j.1532-5415.2011.03776.x     Document Type: Article

References (35)

1. Rosenberg IH,. Summary comments. Am J Clin Nutr 1989; 50: 1231-1233.
2. Evans WJ,. What is sarcopenia? J Gerontol A Bio Sci Med Sci 1995; 50A: 5-8.
3. Baumgartner RN,. Body composition in healthy aging. Ann N Y Acad Sci 2000; 904: 437-448.
4. Janssen I, Baumgartner RN, Ross R, et al. Skeletal muscle cutpoints associated with elevated physical disability risk in older men and women. Am J Epidemiol 2004; 159: 413-421.
5. Baumgartner RN, Waters DL, Gallagher D, et al. Predictors of skeletal muscle mass in elderly men and women. Mech Ageing Dev 1999; 107: 123-136.
6. Iannuzzi-Sucich M, Prestwook KM, Kenny AM,. Prevalence of sarcopenia and predictors of skeletal muscle mass in healthy, older men and women. J Gerontol A Biol Sci Med Sci 2002; 57A: M772-M777.
7. Bortz WM II,. Disuse and aging. JAMA 1982; 248: 1203-1208.
8. Fiatarone MA, O'Neill EF, Ryan ND, et al. Exercise training and nutritional supplementation for physical frailty in very elderly people. N Engl J Med 1994; 330: 1769-1775.
9. Peterson MD, Rhea MR, Sen A, et al. Resistance exercise for muscular strength in older adults: A meta-analysis. Ageing Res Rev 2010; 9: 226-237.
10. Paddon-Jones D, Sheffield-Moore M, Katsanos CS, et al. Differential stimulation of muscle protein synthesis in elderly humans following isocaloric ingestion of amino acids or whey protein. Exp Gerontol 2006; 41: 215-219.
11. Katsanos CS, Kobayashi H, Sheffield-Moore M, et al. Aging is associated with diminished accretion of muscle proteins after the ingestion of a small bolus of essential amino acids. Am J Clin Nutr 2005; 82: 1065-1073.
12. Drummond MJ, Dreyer HC, Pennings B, et al. Skeletal muscle protein anabolic response to resistance exercise and essential amino acids is delayed with aging. J Appl Physiol 2008; 104: 1452-1461.
13. Chien MY, Huang TY, Wu YT,. Prevalence of sarcopenia estimated using a bioelectrical impedance analysis prediction equation in community-dwelling elderly people in Taiwan. J Am Geriatr Soc 2008; 56: 1710-1715.
14. Manini TM, Visser M, Won-Park S, et al. Knee extension strength cutpoints for maintaining mobility. J Am Geriatr Soc 2007; 55: 451-457.
15. Kulminski AM, Arbeev KG, Kulminskaya IV, et al. Body mass index and nine-year mortality in disabled and nondisabled older U.S. individuals. J Am Geriatr Soc 2008; 56: 105-110.
16. Folstein MF, Folstein SE, McHugh PR,. "Mini-mental state". A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res 1975; 12: 189-198.
17. Janssen I, Heymsfield SB, Baumgartner RN, et al. Estimation of skeletal muscle mass by bioelectrical impedance analysis. J Appl Physiol 2000; 89: 465-471.
18. Tengvall M, Ellegard L, Malmros V, et al. Body composition in the elderly: Reference values and bioelectrical impedance spectroscopy to predict total body skeletal muscle mass. Clin Nutr 2009; 28: 52-58.
19. Kim H, Suzuki T, Yoshida Y, et al. Effectiveness of multidimensional exercise for the treatment of stress urinary incontinence in elderly community-dwelling Japanese women: A randomized, controlled, crossover trial. J Am Geriatr Soc 2007; 55: 1932-1939.
20. Suzuki T, Kim H, Yoshida H, et al. Randomized controlled trial of exercise intervention for the prevention of falls in community-dwelling elderly Japanese women. J Bone Miner Metab 2004; 22: 602-611.
21. Borg GA,. Psychophysical bases of perceived exertion. Med Sci Sports Exerc 1982; 14: 377-381.
22. Katsanos CS, Kobayashi H, Sheffield-Moore M, et al. A high proportion of leucine is required for optimal stimulation of the rate of muscle protein synthesis by essential amino acids in the elderly. Am J Physiol Endocrinol Metab 2006; 291: E381-E387.
23. Cohen J,. A power primer. Psychol Bull 1992; 112: 155-159.
24. Baumgartner RM, Koehler KM, Gallagher D, et al. Epidemiology of sarcopenia among the elderly in New Mexico. Am J Epidemiol 1998; 147: 755-763.
25. Cruz-Jentoft AJ, Baeyens JP, Bauer JM, et al. Sarcopenia: European consensus on definition and diagnosis. Age Ageing 2010; 39: 412-423.
26. Dillon EL, Moore MS, Jones DP, et al. Amino acid supplementation increases lean body mass, basal muscle protein synthesis, and insulin-like growth factor-I expression in older women. J Clin Endocrinol Metab 2009; 94: 1630-1637.
27. Liu C, Latham NK,. Progressive resistance strength training for improving physical function in older adults. Cochrane Database Syst Rev 2009; 3: CD002759.
28. Borst SE,. Interventions for sarcopenia and muscle weakness in older people. Age Ageing 2004; 33: 548-555.
29. Roth SM, Ivey FM, Martel GF, et al. Muscle size responses to strength training in young and older men and women. J Am Geriatr Soc 2001; 49: 1428-1433.
30. Wang Z, Visser M, Ma R, et al. Skeletal muscle mass: Evaluation of neutron activation and dual-energy X-ray absorptiometry methods. J Appl Physiol 1996; 80: 824-831.
31. Mitsiopoulos N, Baumgartner RN, Heymsfield SB, et al. Cadaver validation of skeletal muscle measurement by magnetic resonance imaging and computerized tomography. J Appl Physiol 1998; 85: 115-122.
32. Volpi E, Kobayashi H, Sheffield-Moore M, et al. Essential amino acids are primarily responsible for the amino acid stimulation of muscle protein anabolism in healthy elderly adults. Am J Clin Nutr 2003; 78: 250-258.
33. Herman A, Botser IB, Tenenbaum S, et al. Intention-to-treat analysis and accounting for missing data in orthopaedic randomized clinical trials. J Bone Joint Surg Am 2009; 91: 2137-2143.
34. Elliot TA, Cree MG, Sanford AP, et al. Milk ingestion stimulates net muscle protein synthesis following resistance exercise. Med Sci Sports Exerc 2006; 38: 667-674.
35. Wilkinson SB, Tarnopolsky MA, MacDonald MJ, et al. Consumption of fluid skim milk promotes greater muscle protein accretion after resistance exercise than does consumption of an isonitrogenous and isoenergetic soy-protein beverage. Am J Clin Nutr 2007; 85: 1031-1040.