Chronic leucine supplementation improves glycemic control in etiologically distinct mouse models of obesity and diabetes mellitus

Nutrition and Metabolism

Volumn 7, Issue , 2010, Pages

  Guo, Kaiying ^a   Yu, Yi Hao ^a   Hou, Jue ^a   Zhang, Yiying ^a,b  

^a Howard Hughes Medical Institute   (United States)

^b New York Presbyterian Morgan Stanley Children's Hospital   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARNITINE ACETYLTRANSFERASE; DRINKING WATER; GLUCOSE; HEMOGLOBIN A1C; INSULIN; LEUCINE; MELANOCORTIN RECEPTOR; MONOCYTE CHEMOTACTIC PROTEIN 1; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; TAP WATER; TRANSCRIPTION FACTOR NRF1; UNCOUPLING PROTEIN 3;

ADIPOSE TISSUE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BODY COMPOSITION; BODY WEIGHT; CALORIMETRY; CELL INFILTRATION; CLINICAL ASSESSMENT; CONTROLLED STUDY; DIABETES MELLITUS; DIET SUPPLEMENTATION; DISEASE PREDISPOSITION; DISEASE SEVERITY; DRUG EFFICACY; ENERGY EXPENDITURE; FOOD; GENE EXPRESSION; GLUCOSE BLOOD LEVEL; GLUCOSE HOMEOSTASIS; GLYCEMIC CONTROL; HEMOGLOBIN BLOOD LEVEL; INFLAMMATION; INSULIN BLOOD LEVEL; INSULIN RESISTANCE; LIGHT DARK CYCLE; MACROPHAGE; MALE; METABOLIC PARAMETERS; MITOCHONDRIAL MEMBRANE; MOUSE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; OBESITY; OXIDATIVE STRESS; PANCREAS ISLET BETA CELL; PHYSICAL ACTIVITY; RISK FACTOR; SIGNAL TRANSDUCTION; SKELETAL MUSCLE; SOLEUS MUSCLE; TREATMENT OUTCOME;

MUS;

EID: 77954395002     PISSN: None     EISSN: 17437075     Source Type: Journal    
DOI: 10.1186/1743-7075-7-57     Document Type: Article

References (47)

1. The significance of protein in food intake and body weight regulation. MS Westerterp-Plantenga, Curr Opin Clin Nutr Metab Care 2003 6 635 638 10.1097/00075197-200311000-00005 14557793
2. A reduced ratio of dietary carbohydrate to protein improves body composition and blood lipid profiles during weight loss in adult women. DK Layman RA Boileau DJ Erickson JE Painter H Shiue C Sather DD Christou, J Nutr 2003 133 411 417 12566476
3. Increased dietary protein modifies glucose and insulin homeostasis in adult women during weight loss. DK Layman H Shiue C Sather DJ Erickson J Baum, J Nutr 2003 133 405 410 12566475
4. A randomized trial of a low-carbohydrate diet for obesity. GD Foster HR Wyatt JO Hill BG McGuckin C Brill BS Mohammed PO Szapary DJ Rader JS Edman S Klein, N Engl J Med 2003 348 2082 2090 10.1056/NEJMoa022207 12761365
5. A reduced carbohydrate, increased protein diet stabilizes glycemic control and minimizes adipose tissue glucose disposal in rats. JI Baum DK Layman GG Freund KA Rahn MT Nakamura BE Yudell, J Nutr 2006 136 1855 1861 16772449
6. Potential importance of leucine in treatment of obesity and the metabolic syndrome. DK Layman DA Walker, J Nutr 2006 136 319S 323S 16365106
7. Increasing dietary leucine intake reduces diet-induced obesity and improves glucose and cholesterol metabolism in mice via multimechanisms. Y Zhang K Guo RE LeBlanc D Loh GJ Schwartz YH Yu, Diabetes 2007 56 1647 1654 10.2337/db07-0123 17360978
8. Disruption of BCATm in mice leads to increased energy expenditure associated with the activation of a futile protein turnover cycle. P She TM Reid SK Bronson TC Vary A Hajnal CJ Lynch SM Hutson, Cell Metab 2007 6 181 194 10.1016/j.cmet.2007.08.003 17767905
9. Effects of leucine supplementation on the body composition and protein status of rats submitted to food restriction. J Donato Jr RG Pedrosa VF Cruzat IS Pires J Tirapegui, Nutrition 2006 22 520 527 10.1016/j.nut.2005.12.008 16600817
10. Effect of chronic supplementation with branched-chain amino acids on the performance and hepatic and muscle glycogen content in trained rats. JA de Araujo Jr G Falavigna MM Rogero IS Pires RG Pedrosa IA Castro J Donato Jr J Tirapegui, Life Sci 2006 79 1343 1348 Epub 2006 Apr 1322 10.1016/j.lfs.2006.03. 045 16698042
11. A branched-chain amino acid-related metabolic signature that differentiates obese and lean humans and contributes to insulin resistance. CB Newgard J An JR Bain MJ Muehlbauer RD Stevens LF Lien AM Haqq SH Shah M Arlotto CA Slentz, et al. Cell Metab 2009 9 311 326 10.1016/j.cmet.2009.02.002 19356713
12. Leucine supplementation of drinking water does not alter susceptibility to diet-induced obesity in mice. A Nairizi P She TC Vary CJ Lynch, J Nutr 2009 139 715 719 10.3945/jn.108.100081 19244380
13. Differential levels of diabetogenic stress in two new mouse models of obesity and type 2 diabetes. EH Leiter PC Reifsnyder, Diabetes 2004 53 4 11 10.2337/diabetes.53.2007.S4 14749259
14. Hyperglycemia, maturity-onset obesity, and insulin resistance in NONcNZO10/LtJ males, a new mouse model of type 2 diabetes. YR Cho HJ Kim SY Park HJ Ko EG Hong T Higashimori Z Zhang DY Jung MS Ola KF Lanoue, et al. Am J Physiol Endocrinol Metab 2007 293 327 336 10.1152/ajpendo.00376.2006 17616608
15. Agouti protein is an antagonist of the melanocyte-stimulating-hormone receptor. D Lu D Willard IR Patel S Kadwell L Overton T Kost M Luther W Chen RP Woychik WO Wilkison, et al. Nature 1994 371 799 802 10.1038/371799a0 7935841
16. Tissue-specific effects of chronic dietary leucine and norleucine supplementation on protein synthesis in rats. CJ Lynch SM Hutson BJ Patson A Vaval TC Vary, Am J Physiol Endocrinol Metab 2002 283 824 835 12217901
17. Determinants of leptin gene expression in fat depots of lean mice. Y Zhang KY Guo PA Diaz M Heo RL Leibel, Am J Physiol Regul Integr Comp Physiol 2002 282 226 R234 11742842
18. Obesity is associated with macrophage accumulation in adipose tissue. SP Weisberg D McCann M Desai M Rosenbaum RL Leibel AW Ferrante Jr, J Clin Invest 2003 112 1796 1808 14679176
19. Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance. H Xu GT Barnes Q Yang G Tan D Yang CJ Chou J Sole A Nichols JS Ross LA Tartaglia, et al. J Clin Invest 2003 112 1821 1830 14679177
20. Monocyte chemoattractant protein-1 is produced in isolated adipocytes, associated with adiposity and reduced after weight loss in morbid obese subjects. T Christiansen B Richelsen JM Bruun, Int J Obes (Lond) 2005 29 146 150 10.1038/sj.ijo.0802839 15520826
21. Role of macrophage tissue infiltration in metabolic diseases. A Bouloumie CA Curat C Sengenes K Lolmede A Miranville R Busse, Curr Opin Clin Nutr Metab Care 2005 8 347 354 10.1097/01.mco.0000172571.41149.52 15930956
22. Obesity-induced inflammation: a metabolic dialogue in the language of inflammation. AW Ferrante Jr, J Intern Med 2007 262 408 414 10.1111/j.1365-2796. 2007.01852.x 17875176
23. Glucose regulation of glutaminolysis and its role in insulin secretion. ZY Gao G Li H Najafi BA Wolf FM Matschinsky, Diabetes 1999 48 1535 1542 10.2337/diabetes.48.8.1535 10426370
24. Stimulation of insulin secretion by amino acids. JC Floyd Jr SS Fajans JW Conn RF Knopf J Rull, J Clin Invest 1966 45 1487 1502 10.1172/JCI105456 5919350
25. Regulation of leucine-stimulated insulin secretion and glutamine metabolism in isolated rat islets. C Li H Najafi Y Daikhin IB Nissim HW Collins M Yudkoff FM Matschinsky CA Stanley, J Biol Chem 2003 278 2853 2858 Epub 2002 Nov 2819 10.1074/jbc.M210577200 12444083
26. Amino acid ingestion strongly enhances insulin secretion in patients with long-term type 2 diabetes. LJ van Loon M Kruijshoop PP Menheere AJ Wagenmakers WH Saris HA Keizer, Diabetes Care 2003 26 625 630 10.2337/diacare.26.3.625 12610012
27. Diet-genotype interactions in the development of the obese, insulin-resistant phenotype of C57BL/6J mice lacking melanocortin-3 or -4 receptors. GM Sutton JL Trevaskis MW Hulver RP McMillan NJ Markward MJ Babin EA Meyer AA Butler, Endocrinology 2006 147 2183 2196 10.1210/en.2005-1209 16469808
28. High fat diet induced hepatic insulin resistance is not related to changes in hypothalamic mRNA expression of NPY, AgRP, POMC and CART in mice. AC Heijboer PJ Voshol E Donga CG van Eden LM Havekes JA Romijn H Pijl EP Corssmit, Peptides 2005 26 2554 2558 10.1016/j.peptides.2005.05.013 15979206
29. Tumor necrosis factor alpha inhibits signaling from the insulin receptor. GS Hotamisligil DL Murray LN Choy BM Spiegelman, Proc Natl Acad Sci USA 1994 91 4854 4858 10.1073/pnas.91.11.4854 8197147
30. TLR4 links innate immunity and fatty acid-induced insulin resistance. H Shi MV Kokoeva K Inouye I Tzameli H Yin JS Flier, J Clin Invest 2006 116 3015 3025 Epub 2006 Oct 3019 10.1172/JCI28898 17053832
31. MCP-1 contributes to macrophage infiltration into adipose tissue, insulin resistance, and hepatic steatosis in obesity. H Kanda S Tateya Y Tamori K Kotani K Hiasa R Kitazawa S Kitazawa H Miyachi S Maeda K Egashira, et al. J Clin Invest 2006 116 1494 1505 Epub 2006 May 1411 10.1172/JCI26498 16691291
32. The TSC-mTOR signaling pathway regulates the innate inflammatory response. T Weichhart G Costantino M Poglitsch M Rosner M Zeyda KM Stuhlmeier T Kolbe TM Stulnig WH Horl M Hengstschlager, et al. Immunity 2008 29 565 577 10.1016/j.immuni.2008.08.012 18848473
33. Amino acid-sensing mTOR signaling is involved in modulation of lipolysis by chronic insulin treatment in adipocytes. C Zhang MS Yoon J Chen, Am J Physiol Endocrinol Metab 2009 296 862 868 10.1152/ajpendo.90651.2008 19190264
34. CCR2 modulates inflammatory and metabolic effects of high-fat feeding. SP Weisberg D Hunter R Huber J Lemieux S Slaymaker K Vaddi I Charo RL Leibel AW Ferrante Jr, J Clin Invest 2006 116 115 124 Epub 2005 Dec 2008 10.1172/JCI24335 16341265
35. Tissue-specific overexpression of lipoprotein lipase causes tissue-specific insulin resistance. JK Kim JJ Fillmore Y Chen C Yu IK Moore M Pypaert EP Lutz Y Kako W Velez-Carrasco IJ Goldberg, et al. Proc Natl Acad Sci USA 2001 98 7522 7527 10.1073/pnas.121164498 11390966
36. Mitochondrial overload and incomplete fatty acid oxidation contribute to skeletal muscle insulin resistance. TR Koves JR Ussher RC Noland D Slentz M Mosedale O Ilkayeva J Bain R Stevens JR Dyck CB Newgard, et al. Cell Metab 2008 7 45 56 10.1016/j.cmet.2007.10.013 18177724
37. mTOR controls mitochondrial oxidative function through a YY1-PGC-1alpha transcriptional complex. JT Cunningham JT Rodgers DH Arlow F Vazquez VK Mootha P Puigserver, Nature 2007 450 736 740 10.1038/nature06322 18046414
38. The mammalian target of rapamycin (mTOR) pathway regulates mitochondrial oxygen consumption and oxidative capacity. SM Schieke D Phillips JP McCoy Jr AM Aponte RF Shen RS Balaban T Finkel, J Biol Chem 2006 281 27643 27652 10.1074/jbc.M603536200 16847060
39. Mitochondrial remodeling in adipose tissue associated with obesity and treatment with rosiglitazone. L Wilson-Fritch S Nicoloro M Chouinard MA Lazar PC Chui J Leszyk J Straubhaar MP Czech S Corvera, J Clin Invest 2004 114 1281 1289 15520860
40. Paradoxical coupling of triglyceride synthesis and fatty acid oxidation in skeletal muscle overexpressing DGAT1. L Liu X Shi CS Choi GI Shulman K Klaus KS Nair GJ Schwartz Y Zhang IJ Goldberg YH Yu, Diabetes 2009 58 2516 2524 10.2337/db08-1096 19675136
41. Mitochondrial dysfunction and type 2 diabetes. BB Lowell GI Shulman, Science 2005 307 384 387 10.1126/science.1104343 15662004
42. Basal and postprandial substrate oxidation rates in obese women receiving two test meals with different protein content. I Labayen N Diez D Parra A Gonzalez JA Martinez, Clin Nutr 2004 23 571 578 10.1016/j.clnu.2003.10.004 15297093
43. Diet induced thermogenesis measured over 24 h in a respiration chamber: effect of diet composition. KR Westerterp SA Wilson V Rolland, Int J Obes Relat Metab Disord 1999 23 287 292 10.1038/sj.ijo.0800810 10193874
44. Hypothalamic mTOR signaling regulates food intake. D Cota K Proulx KA Smith SC Kozma G Thomas SC Woods RJ Seeley, Science 2006 312 927 930 10.1126/science.1124147 16690869
45. Mediobasal hypothalamic leucine sensing regulates food intake through activation of a hypothalamus-brainstem circuit. C Blouet YH Jo X Li GJ Schwartz, J Neurosci 2009 29 8302 8311 10.1523/JNEUROSCI.1668-09.2009 19571121
46. Is the energy homeostasis system inherently biased toward weight gain? MW Schwartz SC Woods RJ Seeley GS Barsh DG Baskin RL Leibel, Diabetes 2003 52 232 238 10.2337/diabetes.52.2.232 12540591
47. Molecular physiology of weight regulation in mice and humans. RL Leibel, Int J Obes (Lond) 2008 32 98 108 10.1038/ijo.2008.245 19136999