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Volumn 28, Issue 10, 2008, Pages 651-658

Whey protein ingestion in elderly persons results in greater muscle protein accrual than ingestion of its constituent essential amino acid content

Author keywords

EAA; essential amino acids; Free amino acids; GCRC; General Clinical Research Center; GIP; glucose dependent insulinotropic polypeptide; Humans; Intact protein; NEAA; nonessential amino acids; PB; phenylalanine balance; Protein balance; Protein metabolism; Protein supplement; whey protein; WY

Indexed keywords

ESSENTIAL AMINO ACID; MUSCLE PROTEIN; NONESSENTIAL AMINO ACID; PHENYLALANINE;

EID: 53249087926     PISSN: 02715317     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.nutres.2008.06.007     Document Type: Article
Times cited : (128)

References (41)
  • 1
    • 0036790054 scopus 로고    scopus 로고
    • Regulation of muscle protein by amino acids
    • Wolfe R.R. Regulation of muscle protein by amino acids. J Nutr 132 (2002) 3219S-3224S
    • (2002) J Nutr , vol.132
    • Wolfe, R.R.1
  • 3
    • 0033948212 scopus 로고    scopus 로고
    • Sarcopenia and its implications for the elderly
    • Roubenoff R. Sarcopenia and its implications for the elderly. Eur J Clin Nutr 54 Suppl 3 (2000) S40-S47
    • (2000) Eur J Clin Nutr , vol.54 , Issue.SUPPL. 3
    • Roubenoff, R.1
  • 4
    • 0030897107 scopus 로고    scopus 로고
    • Splanchnic and whole-body leucine kinetics in young and elderly men
    • Boirie Y., Gachon P., and Beaufrere B. Splanchnic and whole-body leucine kinetics in young and elderly men. Am J Clin Nutr 65 (1997) 489-495
    • (1997) Am J Clin Nutr , vol.65 , pp. 489-495
    • Boirie, Y.1    Gachon, P.2    Beaufrere, B.3
  • 6
    • 33745853476 scopus 로고    scopus 로고
    • A high proportion of leucine is required for optimal stimulation of the rate of muscle protein synthesis by essential amino acids in the elderly
    • Katsanos C.S., Kobayashi H., Sheffield-Moore M., Aarsland A., and Wolfe R.R. A high proportion of leucine is required for optimal stimulation of the rate of muscle protein synthesis by essential amino acids in the elderly. Am J Physiol Endocrinol Metab 291 (2006) E381-E387
    • (2006) Am J Physiol Endocrinol Metab , vol.291
    • Katsanos, C.S.1    Kobayashi, H.2    Sheffield-Moore, M.3    Aarsland, A.4    Wolfe, R.R.5
  • 7
    • 31544482447 scopus 로고    scopus 로고
    • Aging is associated with diminished accretion of muscle proteins after the ingestion of a small bolus of essential amino acids
    • Katsanos C.S., Kobayashi H., Sheffield-Moore M., Aarsland A., and Wolfe R.R. Aging is associated with diminished accretion of muscle proteins after the ingestion of a small bolus of essential amino acids. Am J Clin Nutr 82 (2005) 1065-1073
    • (2005) Am J Clin Nutr , vol.82 , pp. 1065-1073
    • Katsanos, C.S.1    Kobayashi, H.2    Sheffield-Moore, M.3    Aarsland, A.4    Wolfe, R.R.5
  • 9
    • 0032835655 scopus 로고    scopus 로고
    • Oral amino acids stimulate muscle protein anabolism in the elderly despite higher first-pass splanchnic extraction
    • Volpi E., Mittendorfer B., Wolf S.E., and Wolfe R.R. Oral amino acids stimulate muscle protein anabolism in the elderly despite higher first-pass splanchnic extraction. Am J Physiol 277 (1999) E513-E520
    • (1999) Am J Physiol , vol.277
    • Volpi, E.1    Mittendorfer, B.2    Wolf, S.E.3    Wolfe, R.R.4
  • 10
    • 0042068305 scopus 로고    scopus 로고
    • Essential amino acids are primarily responsible for the amino acid stimulation of muscle protein anabolism in healthy elderly adults
    • Volpi E., Kobayashi H., Sheffield-Moore M., Mittendorfer B., and Wolfe R.R. Essential amino acids are primarily responsible for the amino acid stimulation of muscle protein anabolism in healthy elderly adults. Am J Clin Nutr 78 (2003) 250-258
    • (2003) Am J Clin Nutr , vol.78 , pp. 250-258
    • Volpi, E.1    Kobayashi, H.2    Sheffield-Moore, M.3    Mittendorfer, B.4    Wolfe, R.R.5
  • 12
    • 33750102079 scopus 로고    scopus 로고
    • Co-ingestion of protein and leucine stimulates muscle protein synthesis rates to the same extent in young and elderly lean men
    • Koopman R., Verdijk L., Manders R.J., Gijsen A.P., Gorselink M., Pijpers E., et al. Co-ingestion of protein and leucine stimulates muscle protein synthesis rates to the same extent in young and elderly lean men. Am J Clin Nutr 84 (2006) 623-632
    • (2006) Am J Clin Nutr , vol.84 , pp. 623-632
    • Koopman, R.1    Verdijk, L.2    Manders, R.J.3    Gijsen, A.P.4    Gorselink, M.5    Pijpers, E.6
  • 13
    • 38949086515 scopus 로고    scopus 로고
    • Co-ingestion of leucine with protein does not further augment post-exercise muscle protein synthesis rates in elderly men
    • Koopman R., Verdijk L.B., Beelen M., Gorselink M., Kruseman A.N., Wagenmakers A.J., et al. Co-ingestion of leucine with protein does not further augment post-exercise muscle protein synthesis rates in elderly men. Br J Nutr 99 (2008) 571-580
    • (2008) Br J Nutr , vol.99 , pp. 571-580
    • Koopman, R.1    Verdijk, L.B.2    Beelen, M.3    Gorselink, M.4    Kruseman, A.N.5    Wagenmakers, A.J.6
  • 14
    • 31544472848 scopus 로고    scopus 로고
    • Differential stimulation of muscle protein synthesis in elderly humans following isocaloric ingestion of amino acids or whey protein
    • Paddon-Jones D., Sheffield-Moore M., Katsanos C.S., Zhang X.J., and Wolfe R.R. Differential stimulation of muscle protein synthesis in elderly humans following isocaloric ingestion of amino acids or whey protein. Exp Gerontol 41 (2006) 215-219
    • (2006) Exp Gerontol , vol.41 , pp. 215-219
    • Paddon-Jones, D.1    Sheffield-Moore, M.2    Katsanos, C.S.3    Zhang, X.J.4    Wolfe, R.R.5
  • 15
    • 0017891046 scopus 로고
    • The influence of ethanol on splanchnic and skeletal muscle metabolism in man
    • Jorfeldt L., and Juhlin-Dannfelt A. The influence of ethanol on splanchnic and skeletal muscle metabolism in man. Metabolism 27 (1978) 97-106
    • (1978) Metabolism , vol.27 , pp. 97-106
    • Jorfeldt, L.1    Juhlin-Dannfelt, A.2
  • 16
    • 0015146747 scopus 로고
    • Leg blood flow during exercise in man
    • Jorfeldt L., and Wahren J. Leg blood flow during exercise in man. Clin Sci 41 (1971) 459-473
    • (1971) Clin Sci , vol.41 , pp. 459-473
    • Jorfeldt, L.1    Wahren, J.2
  • 17
    • 33644700640 scopus 로고    scopus 로고
    • Method for the determination of the arteriovenous muscle protein balance during non-steady-state blood and muscle amino acid concentrations
    • Katsanos C.S., Chinkes D.L., Sheffield-Moore M., Aarsland A., Kobayashi H., and Wolfe R.R. Method for the determination of the arteriovenous muscle protein balance during non-steady-state blood and muscle amino acid concentrations. Am J Physiol Endocrinol Metab 289 (2005) E1064-E1070
    • (2005) Am J Physiol Endocrinol Metab , vol.289
    • Katsanos, C.S.1    Chinkes, D.L.2    Sheffield-Moore, M.3    Aarsland, A.4    Kobayashi, H.5    Wolfe, R.R.6
  • 18
    • 0026699650 scopus 로고
    • Stable isotope tracer analysis by GC-MS, including quantification of isotopomer effects
    • Rosenblatt J., Chinkes D., Wolfe M., and Wolfe R.R. Stable isotope tracer analysis by GC-MS, including quantification of isotopomer effects. Am J Physiol 263 (1992) E584-E596
    • (1992) Am J Physiol , vol.263
    • Rosenblatt, J.1    Chinkes, D.2    Wolfe, M.3    Wolfe, R.R.4
  • 20
    • 0016220406 scopus 로고
    • Intracellular free amino acid concentration in human muscle tissue
    • Bergstrom J., Furst P., Noree L.O., and Vinnars E. Intracellular free amino acid concentration in human muscle tissue. J Appl Physiol 36 (1974) 693-697
    • (1974) J Appl Physiol , vol.36 , pp. 693-697
    • Bergstrom, J.1    Furst, P.2    Noree, L.O.3    Vinnars, E.4
  • 21
    • 14644444464 scopus 로고    scopus 로고
    • Anabolic signaling deficits underlie amino acid resistance of wasting, aging muscle
    • Cuthbertson D., Smith K., Babraj J., Leese G., Waddell T., Atherton P., et al. Anabolic signaling deficits underlie amino acid resistance of wasting, aging muscle. FASEB J 19 (2005) 422-424
    • (2005) FASEB J , vol.19 , pp. 422-424
    • Cuthbertson, D.1    Smith, K.2    Babraj, J.3    Leese, G.4    Waddell, T.5    Atherton, P.6
  • 22
    • 0031831344 scopus 로고    scopus 로고
    • Effects of flooding amino acids on incorporation of labeled amino acids into human muscle protein
    • Smith K., Reynolds N., Downie S., Patel A., and Rennie M.J. Effects of flooding amino acids on incorporation of labeled amino acids into human muscle protein. Am J Physiol 275 (1998) E73-E78
    • (1998) Am J Physiol , vol.275
    • Smith, K.1    Reynolds, N.2    Downie, S.3    Patel, A.4    Rennie, M.J.5
  • 24
    • 37349046013 scopus 로고    scopus 로고
    • Effect of whey protein isolate on strength, body composition and muscle hypertrophy during resistance training
    • Hayes A., and Cribb P.J. Effect of whey protein isolate on strength, body composition and muscle hypertrophy during resistance training. Curr Opin Clin Nutr Metab Care 11 (2008) 40-44
    • (2008) Curr Opin Clin Nutr Metab Care , vol.11 , pp. 40-44
    • Hayes, A.1    Cribb, P.J.2
  • 25
    • 0015388615 scopus 로고
    • Glucagon-stimulating activity of 20 amino acids in dogs
    • Rocha D.M., Faloona G.R., and Unger R.H. Glucagon-stimulating activity of 20 amino acids in dogs. J Clin Invest 51 (1972) 2346-2351
    • (1972) J Clin Invest , vol.51 , pp. 2346-2351
    • Rocha, D.M.1    Faloona, G.R.2    Unger, R.H.3
  • 26
    • 0032080924 scopus 로고    scopus 로고
    • Exogenous amino acids stimulate net muscle protein synthesis in the elderly
    • Volpi E., Ferrando A.A., Yeckel C.W., Tipton K.D., and Wolfe R.R. Exogenous amino acids stimulate net muscle protein synthesis in the elderly. J Clin Invest 101 (1998) 2000-2007
    • (1998) J Clin Invest , vol.101 , pp. 2000-2007
    • Volpi, E.1    Ferrando, A.A.2    Yeckel, C.W.3    Tipton, K.D.4    Wolfe, R.R.5
  • 27
    • 0026561920 scopus 로고
    • Insulin secretion from pancreatic B cells caused by l-arginine-derived nitrogen oxides
    • Schmidt H.H., Warner T.D., Ishii K., Sheng H., and Murad F. Insulin secretion from pancreatic B cells caused by l-arginine-derived nitrogen oxides. Science 255 (1992) 721-723
    • (1992) Science , vol.255 , pp. 721-723
    • Schmidt, H.H.1    Warner, T.D.2    Ishii, K.3    Sheng, H.4    Murad, F.5
  • 28
    • 33644618433 scopus 로고    scopus 로고
    • The biology of incretin hormones
    • Drucker D.J. The biology of incretin hormones. Cell Metab 3 (2006) 153-165
    • (2006) Cell Metab , vol.3 , pp. 153-165
    • Drucker, D.J.1
  • 29
    • 16544362066 scopus 로고    scopus 로고
    • Glycemia and insulinemia in healthy subjects after lactose-equivalent meals of milk and other food proteins: the role of plasma amino acids and incretins
    • Nilsson M., Stenberg M., Frid A.H., Holst J.J., and Bjorck I.M. Glycemia and insulinemia in healthy subjects after lactose-equivalent meals of milk and other food proteins: the role of plasma amino acids and incretins. Am J Clin Nutr 80 (2004) 1246-1253
    • (2004) Am J Clin Nutr , vol.80 , pp. 1246-1253
    • Nilsson, M.1    Stenberg, M.2    Frid, A.H.3    Holst, J.J.4    Bjorck, I.M.5
  • 30
    • 34447636241 scopus 로고    scopus 로고
    • Slow versus fast proteins in the stimulation of beta-cell response and the activation of the entero-insular axis in type 2 diabetes
    • Tessari P., Kiwanuka E., Cristini M., Zaramella M., Enslen M., Zurlo C., et al. Slow versus fast proteins in the stimulation of beta-cell response and the activation of the entero-insular axis in type 2 diabetes. Diabetes Metab Res Rev 23 (2006) 378-385
    • (2006) Diabetes Metab Res Rev , vol.23 , pp. 378-385
    • Tessari, P.1    Kiwanuka, E.2    Cristini, M.3    Zaramella, M.4    Enslen, M.5    Zurlo, C.6
  • 31
    • 33749253114 scopus 로고    scopus 로고
    • Effect of insulin on human skeletal muscle protein synthesis is modulated by insulin-induced changes in muscle blood flow and amino acid availability
    • Fujita S., Rasmussen B.B., Cadenas J.G., Grady J.J., and Volpi E. Effect of insulin on human skeletal muscle protein synthesis is modulated by insulin-induced changes in muscle blood flow and amino acid availability. Am J Physiol Endocrinol Metab 291 (2006) E745-E754
    • (2006) Am J Physiol Endocrinol Metab , vol.291
    • Fujita, S.1    Rasmussen, B.B.2    Cadenas, J.G.3    Grady, J.J.4    Volpi, E.5
  • 32
    • 33749249371 scopus 로고    scopus 로고
    • Mechanism of insulin's anabolic effect on muscle: measurements of muscle protein synthesis and breakdown using aminoacyl-tRNA and other surrogate measures
    • Chow L.S., Albright R.C., Bigelow M.L., Toffolo G., Cobelli C., and Nair K.S. Mechanism of insulin's anabolic effect on muscle: measurements of muscle protein synthesis and breakdown using aminoacyl-tRNA and other surrogate measures. Am J Physiol Endocrinol Metab 291 (2006) E729-E736
    • (2006) Am J Physiol Endocrinol Metab , vol.291
    • Chow, L.S.1    Albright, R.C.2    Bigelow, M.L.3    Toffolo, G.4    Cobelli, C.5    Nair, K.S.6
  • 33
    • 0034485454 scopus 로고    scopus 로고
    • The response of muscle protein anabolism to combined hyperaminoacidemia and glucose-induced hyperinsulinemia is impaired in the elderly
    • Volpi E., Mittendorfer B., Rasmussen B.B., and Wolfe R.R. The response of muscle protein anabolism to combined hyperaminoacidemia and glucose-induced hyperinsulinemia is impaired in the elderly. J Clin Endocrinol Metab 85 (2000) 4481-4490
    • (2000) J Clin Endocrinol Metab , vol.85 , pp. 4481-4490
    • Volpi, E.1    Mittendorfer, B.2    Rasmussen, B.B.3    Wolfe, R.R.4
  • 34
    • 10344261406 scopus 로고    scopus 로고
    • Whole body protein breakdown is less inhibited by insulin, but still responsive to amino acid, in nondiabetic elderly subjects
    • Guillet C., Zangarelli A., Gachon P., Morio B., Giraudet C., Rousset P., et al. Whole body protein breakdown is less inhibited by insulin, but still responsive to amino acid, in nondiabetic elderly subjects. J Clin Endocrinol Metab 89 (2004) 6017-6024
    • (2004) J Clin Endocrinol Metab , vol.89 , pp. 6017-6024
    • Guillet, C.1    Zangarelli, A.2    Gachon, P.3    Morio, B.4    Giraudet, C.5    Rousset, P.6
  • 35
    • 9444290436 scopus 로고    scopus 로고
    • Impaired anabolic response of muscle protein synthesis is associated with S6K1 dysregulation in elderly humans
    • Guillet C., Prod'homme M., Balage M., Gachon P., Giraudet C., Morin L., et al. Impaired anabolic response of muscle protein synthesis is associated with S6K1 dysregulation in elderly humans. FASEB J 18 (2004) 1586-1587
    • (2004) FASEB J , vol.18 , pp. 1586-1587
    • Guillet, C.1    Prod'homme, M.2    Balage, M.3    Gachon, P.4    Giraudet, C.5    Morin, L.6
  • 36
    • 0034947136 scopus 로고    scopus 로고
    • Whole-body nitrogen and splanchnic amino acid metabolism differ in rats fed mixed diets containing casein or its corresponding amino acid mixture
    • Daenzer M., Petzke K.J., Bequette B.J., and Metges C.C. Whole-body nitrogen and splanchnic amino acid metabolism differ in rats fed mixed diets containing casein or its corresponding amino acid mixture. J Nutr 131 (2001) 1965-1972
    • (2001) J Nutr , vol.131 , pp. 1965-1972
    • Daenzer, M.1    Petzke, K.J.2    Bequette, B.J.3    Metges, C.C.4
  • 37
    • 0022636822 scopus 로고
    • Intact protein versus free amino acids in the nutritional support of thermally injured animals
    • Trocki O., Mochizuki H., Dominioni L., and Alexander J.W. Intact protein versus free amino acids in the nutritional support of thermally injured animals. JPEN J Parenter Enteral Nutr 10 (1986) 139-145
    • (1986) JPEN J Parenter Enteral Nutr , vol.10 , pp. 139-145
    • Trocki, O.1    Mochizuki, H.2    Dominioni, L.3    Alexander, J.W.4
  • 38
    • 0038045562 scopus 로고    scopus 로고
    • Functional properties of whey, whey components, and essential amino acids: mechanisms underlying health benefits for active people (review)
    • Ha E., and Zemel M.B. Functional properties of whey, whey components, and essential amino acids: mechanisms underlying health benefits for active people (review). J Nutr Biochem 14 (2003) 251-258
    • (2003) J Nutr Biochem , vol.14 , pp. 251-258
    • Ha, E.1    Zemel, M.B.2
  • 39
    • 40749088092 scopus 로고    scopus 로고
    • Emerging health properties of whey proteins and their clinical implications
    • Krissansen G.W. Emerging health properties of whey proteins and their clinical implications. J Am Coll Nutr 26 (2007) 713S-723S
    • (2007) J Am Coll Nutr , vol.26
    • Krissansen, G.W.1
  • 40
    • 0036653591 scopus 로고    scopus 로고
    • Whey components: millennia of evolution create functionalities for mammalian nutrition: what we know and what we may be overlooking
    • Walzem R.L., Dillard C.J., and German J.B. Whey components: millennia of evolution create functionalities for mammalian nutrition: what we know and what we may be overlooking. Crit Rev Food Sci Nutr 42 (2002) 353-375
    • (2002) Crit Rev Food Sci Nutr , vol.42 , pp. 353-375
    • Walzem, R.L.1    Dillard, C.J.2    German, J.B.3
  • 41
    • 33646515568 scopus 로고    scopus 로고
    • Emerging therapeutic potential of whey proteins and peptides
    • Yalcin A.S. Emerging therapeutic potential of whey proteins and peptides. Curr Pharm Des 12 (2006) 1637-1643
    • (2006) Curr Pharm Des , vol.12 , pp. 1637-1643
    • Yalcin, A.S.1


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