Sulforaphane down-regulates SKP2 to stabilize p27KIP1 for inducing antiproliferation in human colon adenocarcinoma cells

Journal of Bioscience and Bioengineering

Volumn 119, Issue 1, 2015, Pages 35-42

  Chung, Yuan Kai ^a,b   Chi Hung Or, Richard ^a,c   Lu, Chien Hsing ^d,e   Ouyang, Wei Ting ^a   Yang, Shu Yi ^a   Chang, Chia Che ^a  

^a NATIONAL CHUNG HSING UNIVERSITY   (Taiwan)

^b Aqua Fairy Biotechnology CoLtd   (Taiwan)

^c KUANG TIEN GENERAL HOSPITAL   (Taiwan)

^d TAICHUNG VETERANS GENERAL HOSPITAL   (Taiwan)

^e NATIONAL YANG MING UNIVERSITY   (Taiwan)

Author keywords

Antiproliferation; Colon adenocarcinoma; P27KIP1; SKP2; Sulforaphane

Indexed keywords

CELL CULTURE; CELL DEATH; CELL PROLIFERATION; ENZYME INHIBITION;

ANTIPROLIFERATION; COLON ADENOCARCINOMA; P27^KIP1; SKP2; SULFORAPHANE;

STABILIZATION;

BROXURIDINE; CYCLIN DEPENDENT KINASE INHIBITOR 1B; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN KINASE B; S PHASE KINASE ASSOCIATED PROTEIN 2; SULFORAPHANE; ISOTHIOCYANIC ACID DERIVATIVE; S PHASE KINASE ASSOCIATED PROTEIN; SULFORAFAN;

ANTINEOPLASTIC ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; ARTICLE; CLONOGENESIS; COLON ADENOCARCINOMA; CONTROLLED STUDY; DOWN REGULATION; DRUG MECHANISM; DRUG TARGETING; ENZYME ACTIVATION; GENE; GENE EXPRESSION; HUMAN; HUMAN CELL; PROMOTER REGION; PROTEIN STABILITY; SKP2 GENE; UPREGULATION; ADENOCARCINOMA; CELL PROLIFERATION; COLON TUMOR; DRUG EFFECTS; GENETIC TRANSCRIPTION; GENETICS; METABOLISM; PATHOLOGY; TUMOR CELL LINE;

ADENOCARCINOMA; CELL LINE, TUMOR; CELL PROLIFERATION; COLONIC NEOPLASMS; CYCLIN-DEPENDENT KINASE INHIBITOR P27; DOWN-REGULATION; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; HUMANS; ISOTHIOCYANATES; PROTEIN STABILITY; PROTO-ONCOGENE PROTEINS C-AKT; S-PHASE KINASE-ASSOCIATED PROTEINS; TRANSCRIPTION, GENETIC; UP-REGULATION;

EID: 84927176672     PISSN: 13891723     EISSN: 13474421     Source Type: Journal    
DOI: 10.1016/j.jbiosc.2014.06.009     Document Type: Article

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