A signal transduction pathway from TGF-β1 to SKP2 via Akt1 and c-Myc and its correlation with progression in human melanoma

Journal of Investigative Dermatology

Volumn 134, Issue 1, 2014, Pages 159-167

  Qu, Xuan ^a   Shen, Liangliang ^b   Zheng, Yan ^a   Cui, Yang ^a   Feng, Zhihui ^a   Liu, Feng ^c,d   Liu, Jiankang ^a  

^a XI'AN JIAOTONG UNIVERSITY   (China)

^b FOURTH MILITARY MEDICAL UNIVERSITY   (China)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AKT1 PROTEIN; CYCLIN E; FIBRONECTIN; MESSENGER RNA; MYC PROTEIN; NERVE CELL ADHESION MOLECULE; PROTEIN KINASE B; S PHASE KINASE ASSOCIATED PROTEIN 2; TRANSCRIPTION FACTOR SNAIL; TRANSFORMING GROWTH FACTOR BETA1; UNCLASSIFIED DRUG; UVOMORULIN;

ARTICLE; CANCER GROWTH; CELL STRUCTURE; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; EPITHELIAL MESENCHYMAL TRANSITION; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MELANOMA; MELANOMA CELL; METASTATIC MELANOMA; NEVUS; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; SITE DIRECTED MUTAGENESIS; UPREGULATION;

EID: 84891041882     PISSN: 0022202X     EISSN: 15231747     Source Type: Journal    
DOI: 10.1038/jid.2013.281     Document Type: Article

References (42)

1. Acloque H, Adams MS, Fishwick K et al. (2009) Epithelial-mesenchymal transitions: the importance of changing cell state in development and disease. J Clin Invest 119: 1438-49
2. Assoian RK, Yung Y (2008) A reciprocal relationship between Rb and Skp2: implications for restriction point control, signal transduction to the cell cycle and cancer. Cell Cycle 7: 24-7
3. Bakin AV, Tomlinson AK, Bhowmick NA et al. (2000) Phosphatidylinositol 3-kinase function is required for transforming growth factor beta-mediated epithelial to mesenchymal transition and cell migration. J Biol Chem 275: 36803-10
4. Bhatt KV, Hu R, Spofford LS et al. (2007) Mutant B-RAF signaling and cyclin D1 regulate Cks1/S-phase kinase-associated protein 2-mediated degradation of p27Kip1 in human melanoma cells. Oncogene 26: 1056-66
5. Bornstein G, Bloom J, Sitry-Shevah D et al. (2003) Role of the SCFSkp2 ubiquitin ligase in the degradation of p21Cip1 in S phase. J Biol Chem 278: 25752-7
6. Bretones G, Acosta JC, Caraballo JM et al. (2011) SKP2 oncogene is a direct MYC target gene and MYC down-regulates p27(KIP1) through SKP2 in human leukemia cells. J Biol Chem 286: 9815-25
7. Cross DA, Alessi DR, Cohen P et al. (1995) Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B. Nature 378: 785-9
8. Dhawan P, Singh AB, Ellis DL et al. (2002) Constitutive activation of Akt/protein kinase B in melanoma leads to up-regulation of nuclear factorkappaB and tumor progression. Cancer Res 62: 7335-42
9. Govindarajan B, Sligh JE, Vincent BJ et al. (2007) Overexpression of Akt converts radial growth melanoma to vertical growth melanoma. J Clin Invest 117: 719-29
10. Grover R, Ross DA, Richman PI et al. (1996) C-myc oncogene expression in human melanoma and its relationship with tumour antigenicity. Eur J Surg Oncol 22: 342-6
11. Houghton AN, Polsky D (2002) Focus on melanoma. Cancer Cell 2: 275-8
12. Huang MJ, Cheng YC, Liu CR et al. (2006) A small-molecule c-Myc inhibitor, 10058-F4, induces cell-cycle arrest, apoptosis, and myeloid differentiation of human acute myeloid leukemia. Exp Hematol 34: 1480-9
13. Inuzuka H, Gao D, Finley LW et al. (2012) Acetylation-dependent regulation of skp2 function. Cell 150: 179-93
14. Irie HY, Pearline RV, Grueneberg D et al. (2005) Distinct roles of Akt1 and Akt2 in regulating cell migration and epithelial-mesenchymal transition. J Cell Biol 171: 1023-34
15. Javelaud D, Alexaki VI, Mauviel A (2008) Transforming growth factor-beta in cutaneous melanoma. Pigment Cell Melanoma Res 21: 123-32
16. Kalluri R,Weinberg RA (2009) The basics of epithelial-mesenchymal transition. J Clin Invest 119: 1420-8
17. Kamura T, Hara T, Kotoshiba S et al. (2003) Degradation of p57Kip2 mediated by SCFSkp2-dependent ubiquitylation. Proc Natl Acad Sci USA 100: 10231-6
18. Katagiri Y, Hozumi Y, Kondo S (2006) Knockdown of Skp2 by siRNA inhibits melanoma cell growth in vitro and in vivo. J Dermatol Sci 42: 215-24
19. Kim SY, Herbst A, Tworkowski KA et al. (2003) Skp2 regulates Myc protein stability and activity. Mol Cell 11: 1177-88
20. Larue L, Bellacosa A (2005) Epithelial-mesenchymal transition in development and cancer: role of phosphatidylinositol 3' kinase/AKT pathways. Oncogene 24: 7443-54
21. Li JQ, Wu F, Masaki T et al. (2004a) Correlation of Skp2 with carcinogenesis, invasion, metastasis, and prognosis in colorectal tumors. Int J Oncol 25: 87-95
22. Li Q, Murphy M, Ross J et al. (2004b) Skp2 and p27kip1 expression in melanocytic nevi and melanoma: an inverse relationship. J Cutan Pathol 31: 633-42
23. Lin CP, Liu JD, Chow JM et al. (2007) Small-molecule c-Myc inhibitor, 10058- F4, inhibits proliferation, downregulates human telomerase reverse transcriptase and enhances chemosensitivity in human hepatocellular carcinoma cells. Anti-Cancer Drugs 18: 161-70
24. Nakayama KI, Nakayama K (2005) Regulation of the cell cycle by SCF-type ubiquitin ligases. Semin Cell Dev Biol 16: 323-33
25. Popov N, Wanzel M, Madiredjo M et al. (2007) The ubiquitin-specific protease USP28 is required for MYC stability. Nat Cell Biol 9: 765-74
26. Qiao D, Meyer K, Friedl A (2012) Glypican-1 stimulates Skp2 autoinduction loop and G1/S transition in endothelial cells. J Biol Chem 287: 5898-909
27. Reichert M, Saur D, Hamacher R et al. (2007) Phosphoinositide-3-kinase signaling controls S-phase kinase-associated protein 2 transcription via E2F1 in pancreatic ductal adenocarcinoma cells. Cancer Res 67: 4149-56
28. Robertson GP (2005) Functional and therapeutic significance of Akt deregulation in malignant melanoma. Cancer Metastasis Rev 24: 273-85
29. Rose AE, Wang G, Hanniford D et al. (2011) Clinical relevance of SKP2 alterations in metastatic melanoma. Pigment Cell Melanoma Res 24: 197-206
30. Sans CL, Satterwhite DJ, Stoltzman CA et al. (2006) MondoA-Mlx heterodimers are candidate sensors of cellular energy status: mitochondrial localization and direct regulation of glycolysis. Mol Cell Biol 26: 4863-71
31. Schlagbauer-Wadl H, Griffioen M, van Elsas A et al. (1999) Influence of increased c-Myc expression on the growth characteristics of human melanoma. J Invest Dermatol 112: 332-6
32. Shen L, Liu X, Hou W et al. (2010) NDRG2 is highly expressed in pancreatic beta cells and involved in protection against lipotoxicity. Cell Mol Life Sci 67: 1371-81
33. Smith AP, Verrecchia A, Faga G et al. (2009) A positive role for Myc in TGF beta-induced Snail transcription and epithelial-to-mesenchymal transition. Oncogene 28: 422-30
34. Stoltzman CA, Peterson CW, Breen KT et al. (2008) Glucose sensing by MondoA:Mlx complexes: a role for hexokinases and direct regulation of thioredoxin-interacting protein expression. Proc Natl Acad Sci USA 105: 6912-7
35. Takahashi K, Tanabe K, Ohnuki M et al. (2007) Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell 131: 861-72
36. Tang Y, Simoneau AR, Liao WX et al. (2009) WIF1, a Wnt pathway inhibitor, regulates SKP2 and c-myc expression leading to G1 arrest and growth inhibition of human invasive urinary bladder cancer cells. Mol Cancer Ther 8: 458-68
37. Totary-Jain H, Sanoudou D, Dautriche CN et al. (2012) Rapamycin resistance is linked to defective regulation of Skp2. Cancer Res 72: 1836-43
38. Tsvetkov LM, Yeh KH, Lee SJ et al. (1999) p27(Kip1) ubiquitination and degradation is regulated by the SCF(Skp2) complex through phosphorylated Thr187 in p27. Curr Biol 9: 661-4
39. Wilkes MC, Mitchell H, Penheiter SG et al. (2005) Transforming growth factorbeta activation of phosphatidylinositol 3-kinase is independent of Smad2 and Smad3 and regulates fibroblast responses via p21-activated kinase-2. Cancer Res 65: 10431-40
40. Yokoi S, Yasui K, Mori M et al. (2004) Amplification and overexpression of SKP2 are associated with metastasis of non-small-cell lung cancers to lymph nodes. Am J Pathol 165: 175-80
41. Zavadil J, Bottinger EP (2005) TGF-beta and epithelial-to-mesenchymal transitions. Oncogene 24: 5764-74
42. Zeisberg M, Neilson EG (2009) Biomarkers for epithelial-mesenchymal transitions. J Clin Invest 119: 1429-37