Oncogenic Ras blocks transforming growth factor-β-induced cell-cycle arrest by degradation of p27 through a MEK/Erk/SKP2-dependent pathway

Experimental Hematology

Volumn 33, Issue 7, 2005, Pages 747-757

  Schepers, Hein ^a,b   Wierenga, Albertus T J ^a   Eggen, Bart J L ^b   Vellenga, Edo ^a  

^a UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

^b UNIVERSITY OF GRONINGEN   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; 2 [[2 [[2 [(2 AMINO 3 MERCAPTOPROPYL)AMINO] 3 METHYLPENTYL]OXY] 1 OXO 3 PHENYLPROPYL]AMINO] 4 (METHYLSULFONYL)BUTANOIC ACID ISOPROPYL ESTER; BENZYLOXYCARBONYLLEUCYLLEUCYLLEUCINAL; DACTINOMYCIN; ENZYME INHIBITOR; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; PROTEASOME INHIBITOR; PROTEIN FARNESYLTRANSFERASE INHIBITOR; PROTEIN P27; RNA POLYMERASE 2 INHIBITOR; S PHASE KINASE ASSOCIATED PROTEIN 2; THREONINE; TRANSFORMING GROWTH FACTOR BETA; UBIQUITIN PROTEIN LIGASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CANCER CELL CULTURE; CELL CYCLE; CELL CYCLE G0 PHASE; CELL CYCLE G1 PHASE; CELL STRAIN HL 60; CONTROLLED STUDY; GENE MUTATION; GENE OVEREXPRESSION; HEMATOPOIETIC CELL; HUMAN; HUMAN CELL; LEUKEMIA CELL; NONHUMAN; ONCOGENE N RAS; ONCOGENE RAS; PHOSPHORYLATION; PRIORITY JOURNAL; RNA INTERFERENCE; SIGNAL TRANSDUCTION;

ANIMALS; BASE SEQUENCE; CELL CYCLE; CELL CYCLE PROTEINS; CELL LINE, TUMOR; CYCLIN-DEPENDENT KINASE INHIBITOR P27; DNA MUTATIONAL ANALYSIS; ELECTROPORATION; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FLOW CYTOMETRY; GENES, RAS; HL-60 CELLS; HUMANS; MICE; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; RAS PROTEINS; RECOMBINANT PROTEINS; RNA INTERFERENCE; S-PHASE KINASE-ASSOCIATED PROTEINS; SIGNAL TRANSDUCTION; TRANSFECTION; TRANSFORMING GROWTH FACTOR BETA; TUMOR SUPPRESSOR PROTEINS;

EID: 20444481954     PISSN: 0301472X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.exphem.2005.04.006     Document Type: Article

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