Sulforaphane induction of p21Cip1 cyclin-dependent kinase inhibitor expression requires p53 and Sp1 transcription factors and Is p53-dependent

Journal of Biological Chemistry

Volumn 287, Issue 20, 2012, Pages 16168-16178

  Chew, Yap Ching ^a   Adhikary, Gautam ^a   Wilson, Gerald M ^a   Xu, Wen ^a   Eckert, Richard L ^a  

^a UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING ELEMENTS; CANCER CELLS; CONCENTRATION-DEPENDENT; CPG ISLANDS; CYCLIN-DEPENDENT KINASE INHIBITORS; KERATINOCYTES; P53 PROTEIN; PREVENTIVE AGENTS; PROMOTER ACTIVITIES; PROMOTER METHYLATION; RESPONSE ELEMENTS; SKIN CANCERS; SULFORAPHANE;

ALKYLATION; BINDING SITES; CELL CULTURE; CELL DEATH; STABILIZATION; TRANSCRIPTION FACTORS;

METHYLATION;

CYCLIN DEPENDENT KINASE INHIBITOR 1; PROTEIN P53; SULFORAPHANE; TRANSCRIPTION FACTOR SP1;

ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL; CELL CYCLE ARREST; CONCENTRATION RESPONSE; CONTROLLED STUDY; CPG ISLAND; DNA METHYLATION; GENE EXPRESSION; HUMAN; HUMAN CELL; KERATINOCYTE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN STABILITY;

ANTICARCINOGENIC AGENTS; APOPTOSIS; CELL LINE, TUMOR; CPG ISLANDS; CYCLIN-DEPENDENT KINASE INHIBITOR P21; DNA METHYLATION; GENE EXPRESSION REGULATION; HUMANS; KERATINOCYTES; PROTEIN STABILITY; RESPONSE ELEMENTS; SP1 TRANSCRIPTION FACTOR; THIOCYANATES; TRANSCRIPTION, GENETIC; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84860871238     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.305292     Document Type: Article

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