Macrophage CGI-58 deficiency promotes IL-1β transcription by activating the SOCS3-FOXO1 pathway

Clinical Science

Volumn 128, Issue 8, 2015, Pages 493-506

  Miao, Hongming ^a   Ou, Juanjuan ^a   Zhang, Xuan ^a   Chen, Yujuan ^a   Xue, Bingzhong ^b   Shi, Hang ^b   Gan, Lixia ^a   Yu, Liqing ^c   Liang, Houjie ^a  

^a THIRD MILITARY MEDICAL UNIVERSITY   (China)

^b GEORGIA STATE UNIVERSITY   (United States)

^c UNIVERSITY OF MARYLAND   (United States)

Author keywords

Chronic inflammation; Comparative gene identification 58 (CGI 58); Forkhead box containing protein O subfamily 1 (FOXO1); Insulin resistance; Interleukin 1 (IL 1 ); Obesity

Indexed keywords

CELL PROTEIN; COMPARATIVE GENE IDENTIFICATION 58 PROTEIN; CRYOPYRIN; INFLAMMASOME; INSULIN; INTERLEUKIN 1BETA; LIPOPOLYSACCHARIDE; SATURATED FATTY ACID; SUPPRESSOR OF CYTOKINE SIGNALING 3; TRANSCRIPTION FACTOR FKHR; UNCLASSIFIED DRUG; 1 ACYLGLYCEROPHOSPHATE ACYLTRANSFERASE; ABHD5 PROTEIN, HUMAN; ABHD5 PROTEIN, MOUSE; FATTY ACID; FORKHEAD TRANSCRIPTION FACTOR; FOXO1 PROTEIN, MOUSE; INSULIN RECEPTOR SUBSTRATE; IRS2 PROTEIN, MOUSE; SOCS3 PROTEIN, HUMAN; SOCS3 PROTEIN, MOUSE; SUPPRESSOR OF CYTOKINE SIGNALING;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CHRONIC INFLAMMATION; CONTROLLED STUDY; CYTOKINE RELEASE; GAIN OF FUNCTION MUTATION; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; INSULIN RESISTANCE; LOSS OF FUNCTION MUTATION; MACROPHAGE; MOUSE; NONHUMAN; OBESITY; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN INDUCTION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; ANIMAL; BIOLOGICAL MODEL; BODY MASS; DEFICIENCY; DRUG EFFECTS; GENETICS; LIPID DIET; MALE; METABOLISM; WEIGHT GAIN;

1-ACYLGLYCEROL-3-PHOSPHATE O-ACYLTRANSFERASE; ANIMALS; BODY MASS INDEX; DIET, HIGH-FAT; FATTY ACIDS; FORKHEAD TRANSCRIPTION FACTORS; HUMANS; INFLAMMASOMES; INSULIN RECEPTOR SUBSTRATE PROTEINS; INSULIN RESISTANCE; INTERLEUKIN-1BETA; MACROPHAGES; MALE; MICE; MODELS, BIOLOGICAL; SIGNAL TRANSDUCTION; SUPPRESSOR OF CYTOKINE SIGNALING PROTEINS; TRANSCRIPTION, GENETIC; WEIGHT GAIN;

EID: 84927170282     PISSN: 01435221     EISSN: None     Source Type: Journal    
DOI: 10.1042/CS20140414     Document Type: Article

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