-
3
-
-
55649103668
-
Insulin resistance, inflammation, and nonalcoholic fatty liver disease
-
Tilg H, Moschen AR. Insulin resistance, inflammation, and nonalcoholic fatty liver disease. Trends Endocrinol Metab. 2008;19: 371-9.
-
(2008)
Trends Endocrinol Metab
, vol.19
, pp. 371-379
-
-
Tilg, H.1
Moschen, A.R.2
-
4
-
-
34247170807
-
Interleukin-1-receptor antagonist in type 2 diabetes mellitus
-
Larsen CM, Faulenbach M, Vaag A, Volund A, Ehses JA, Seifert B, et al. Interleukin-1-receptor antagonist in type 2 diabetes mellitus. N Engl J Med. 2007;356:1517-26.
-
(2007)
N Engl J Med
, vol.356
, pp. 1517-1526
-
-
Larsen, C.M.1
Faulenbach, M.2
Vaag, A.3
Volund, A.4
Ehses, J.A.5
Seifert, B.6
-
5
-
-
43949097868
-
Fenofibrate reduces fasting and postprandial inflammatory responses among hypertriglyceridemia patients with the metabolic syndrome
-
Rosenson RS, Huskin AL, Wolff DA, Helenowski IB, Rademaker AW. Fenofibrate reduces fasting and postprandial inflammatory responses among hypertriglyceridemia patients with the metabolic syndrome. Atherosclerosis. 2008;198:381-8.
-
(2008)
Atherosclerosis
, vol.198
, pp. 381-388
-
-
Rosenson, R.S.1
Huskin, A.L.2
Wolff, D.A.3
Helenowski, I.B.4
Rademaker, A.W.5
-
6
-
-
0030756346
-
Protection from obesity-induced insulin resistance in mice lacking TNF-alpha function
-
Uysal KT, Wiesbrock SM, Marino MW, Hotamisligil GS. Protection from obesity-induced insulin resistance in mice lacking TNF-alpha function. Nature. 1997;389:610-4.
-
(1997)
Nature
, vol.389
, pp. 610-614
-
-
Uysal, K.T.1
Wiesbrock, S.M.2
Marino, M.W.3
Hotamisligil, G.S.4
-
7
-
-
57349101675
-
A stress signaling pathway in adipose tissue regulates hepatic insulin resistance
-
Sabio G, Das M, Mora A, Zhang Z, Jun JY, Ko HJ, et al. A stress signaling pathway in adipose tissue regulates hepatic insulin resistance. Science. 2008;322:1539-43.
-
(2008)
Science
, vol.322
, pp. 1539-1543
-
-
Sabio, G.1
Das, M.2
Mora, A.3
Zhang, Z.4
Jun, J.Y.5
Ko, H.J.6
-
8
-
-
31044456529
-
CCR2 modulates inflammatory and metabolic effects of high-fat feeding
-
Weisberg SP, Hunter D, Huber R, Lemieux J, Slaymaker S, Vaddi K, et al. CCR2 modulates inflammatory and metabolic effects of high-fat feeding. J Clin Invest. 2006;116:115-24.
-
(2006)
J Clin Invest
, vol.116
, pp. 115-124
-
-
Weisberg, S.P.1
Hunter, D.2
Huber, R.3
Lemieux, J.4
Slaymaker, S.5
Vaddi, K.6
-
9
-
-
65449153256
-
Inflammatory cytokines modulate chemokine production patterns of HepG2 cells toward initially inclined direction
-
Ohashi T, Tanabe J, Ishikawa T, Okumura A, Sato K, Ayada M, et al. Inflammatory cytokines modulate chemokine production patterns of HepG2 cells toward initially inclined direction. Hepatol Res. 2009;39:510-9.
-
(2009)
Hepatol Res
, vol.39
, pp. 510-519
-
-
Ohashi, T.1
Tanabe, J.2
Ishikawa, T.3
Okumura, A.4
Sato, K.5
Ayada, M.6
-
10
-
-
78049383871
-
Non-genomic action of TCDD to induce inflammatory responses in HepG2 human hepatoma cells and in liver of C57BL/6 J mice
-
Li W, Vogel CF, Wu D, Matsumura F. Non-genomic action of TCDD to induce inflammatory responses in HepG2 human hepatoma cells and in liver of C57BL/6 J mice. Biol Chem. 2010; 391:1205-19.
-
(2010)
Biol Chem.
, vol.391
, pp. 1205-1219
-
-
Li, W.1
Vogel, C.F.2
Wu, D.3
Matsumura, F.4
-
11
-
-
82955235212
-
Berberine inhibits inflammatory response and ameliorates insulin resistance in hepatocytes
-
Lou T, Zhang Z, Xi Z, Liu K, Li L, Liu B, Huang F. Berberine inhibits inflammatory response and ameliorates insulin resistance in hepatocytes. Inflammation. 2010;34:659-67.
-
(2010)
Inflammation
, vol.34
, pp. 659-667
-
-
Lou, T.1
Zhang, Z.2
Xi, Z.3
Liu, K.4
Li, L.5
Liu, B.6
Huang, F.7
-
12
-
-
0033518120
-
Regulation of the forkhead transcription factor FKHR but not the PAX3-FKHR fusion protein, by the serine/threonine kinase Akt
-
del Peso L, Gonzalez VM, Hernandez R, Barr FG, Nunez G. Regulation of the forkhead transcription factor FKHR but not the PAX3-FKHR fusion protein, by the serine/threonine kinase Akt. Oncogene. 1999;18:7328-33.
-
(1999)
Oncogene
, vol.18
, pp. 7328-7333
-
-
Del, P.L.1
Gonzalez, V.M.2
Hernandez, R.3
Barr, F.G.4
Nunez, G.5
-
13
-
-
0033305739
-
FKHR binds the insulin response element in the insulin-like growth factor binding protein-1 promoter
-
Durham SK, Suwanichkul A, Scheimann AO, Yee D, Jackson JG, Barr FG, et al. FKHR binds the insulin response element in the insulin-like growth factor binding protein-1 promoter. Endocrinology. 1999;140:3140-6.
-
(1999)
Endocrinology
, vol.140
, pp. 3140-3146
-
-
Durham, S.K.1
Suwanichkul, A.2
Scheimann, A.O.3
Yee, D.4
Jackson, J.G.5
Barr, F.G.6
-
14
-
-
0033546192
-
Phosphorylation of serine 256 by protein kinase B disrupts transactivation by FKHR and mediates effects of insulin on insulin-like growth factorbinding protein-1 promoter activity through a conserved insulin response sequence
-
Guo S, Rena G, Cichy S, He X, Cohen P, Unterman T. Phosphorylation of serine 256 by protein kinase B disrupts transactivation by FKHR and mediates effects of insulin on insulin-like growth factorbinding protein-1 promoter activity through a conserved insulin response sequence. J Biol Chem. 1999;274:17184-92.
-
(1999)
J Biol Chem.
, vol.274
, pp. 17184-17192
-
-
Guo, S.1
Rena, G.2
Cichy, S.3
He, X.4
Cohen, P.5
Unterman, T.6
-
15
-
-
0035185021
-
The forkhead transcription factor Foxo1 (Fkhr) confers insulin sensitivity onto glucose-6-phosphatase expression
-
Nakae J, Kitamura T, Silver DL, Accili D. The forkhead transcription factor Foxo1 (Fkhr) confers insulin sensitivity onto glucose-6-phosphatase expression. J Clin Invest. 2001;108: 1359-67.
-
(2001)
J Clin Invest
, vol.108
, pp. 1359-1367
-
-
Nakae, J.1
Kitamura, T.2
Silver, D.L.3
Accili, D.4
-
16
-
-
45749133797
-
FoxO1 mediates insulin-dependent regulation of hepatic VLDL production in mice
-
Kamagate A, Qu S, Perdomo G, Su D, Kim DH, Slusher S, et al. FoxO1 mediates insulin-dependent regulation of hepatic VLDL production in mice. J Clin Invest. 2008;118:2347-64.
-
(2008)
J Clin Invest
, vol.118
, pp. 2347-2364
-
-
Kamagate, A.1
Qu, S.2
Perdomo, G.3
Su, D.4
Kim, D.H.5
Slusher, S.6
-
17
-
-
45749107163
-
A combination of genomic approaches reveals the role of FOXO1a in regulating an oxidative stress response pathway
-
de Candia P, Blekhman R, Chabot AE, Oshlack A, Gilad Y. A combination of genomic approaches reveals the role of FOXO1a in regulating an oxidative stress response pathway. PLoS One. 2008;3:e1670.
-
(2008)
PLoS One
, vol.3
-
-
De Candia, P.1
Blekhman, R.2
Chabot, A.E.3
Oshlack, A.4
Gilad, Y.5
-
18
-
-
67649213892
-
Down-regulation of FoxOdependent c-FLIP expression mediates TRAIL-induced apoptosis in activated hepatic stellate cells
-
Park SJ, Sohn HY, Yoon J, Park SI. Down-regulation of FoxOdependent c-FLIP expression mediates TRAIL-induced apoptosis in activated hepatic stellate cells. Cell Signal. 2009;21:1495-503.
-
(2009)
Cell Signal
, vol.21
, pp. 1495-1503
-
-
Park, S.J.1
Sohn, H.Y.2
Yoon, J.3
Park, S.I.4
-
19
-
-
70449122132
-
Foxo1 integrates insulin signaling with mitochondrial function in the liver
-
Cheng Z, Guo S, Copps K, Dong X, Kollipara R, Rodgers JT, et al. Foxo1 integrates insulin signaling with mitochondrial function in the liver. Nat Med. 2009;15:1307-11.
-
(2009)
Nat Med.
, vol.15
, pp. 1307-1311
-
-
Cheng, Z.1
Guo, S.2
Copps, K.3
Dong, X.4
Kollipara, R.5
Rodgers, J.T.6
-
20
-
-
45549090182
-
Inactivation of hepatic Foxo1 by insulin signaling is required for adaptive nutrient homeostasis and endocrine growth regulation
-
Dong XC, Copps KD, Guo S, Li Y, Kollipara R, DePinho RA, et al. Inactivation of hepatic Foxo1 by insulin signaling is required for adaptive nutrient homeostasis and endocrine growth regulation. Cell Metab. 2008;8:65-76.
-
(2008)
Cell Metab.
, vol.8
, pp. 65-76
-
-
Dong, X.C.1
Copps, K.D.2
Guo, S.3
Li, Y.4
Kollipara, R.5
Depinho, R.A.6
-
21
-
-
34548349302
-
Impaired regulation of hepatic glucose production in mice lacking the forkhead transcription factor Foxo1 in liver
-
Matsumoto M, Pocai A, Rossetti L, Depinho RA, Accili D. Impaired regulation of hepatic glucose production in mice lacking the forkhead transcription factor Foxo1 in liver. Cell Metab. 2007;6:208-16.
-
(2007)
Cell Metab
, vol.6
, pp. 208-216
-
-
Matsumoto, M.1
Pocai, A.2
Rossetti, L.3
Depinho, R.A.4
Accili, D.5
-
22
-
-
79251557845
-
Targeting forkhead box o1 from the concept to metabolic diseases: Lessons from mouse models
-
Cheng Z, White MF. Targeting forkhead box o1 from the concept to metabolic diseases: lessons from mouse models. Antioxid Redox Signal. 2011;14:649-61.
-
(2011)
Antioxid Redox Signal
, vol.14
, pp. 649-661
-
-
Cheng, Z.1
White, M.F.2
-
23
-
-
15244339047
-
Foxo1 mediates insulin action on apoC-III and triglyceride metabolism
-
Altomonte J, Cong L, Harbaran S, Richter A, Xu J, Meseck M, et al. Foxo1 mediates insulin action on apoC-III and triglyceride metabolism. J Clin Invest. 2004;114:1493-503.
-
(2004)
J Clin Invest
, vol.114
, pp. 1493-1503
-
-
Altomonte, J.1
Cong, L.2
Harbaran, S.3
Richter, A.4
Xu, J.5
Meseck, M.6
-
24
-
-
70350539525
-
FoxO1 links insulin resistance to proinflammatory cytokine IL- 1beta production in macrophages
-
Su D, Coudriet GM, Hyun Kim D, Lu Y, Perdomo G, Qu S, et al. FoxO1 links insulin resistance to proinflammatory cytokine IL- 1beta production in macrophages. Diabetes. 2009;58:2624-33.
-
(2009)
Diabetes
, vol.58
, pp. 2624-2633
-
-
Su, D.1
Coudriet, G.M.2
Hyun, K.D.3
Lu, Y.4
Perdomo, G.5
Qu, S.6
-
25
-
-
57049104503
-
Foxo1 increases pro-inflammatory gene expression by inducing C/EBPbeta in TNF-alphatreated adipocytes
-
Ito Y, Daitoku H, Fukamizu A. Foxo1 increases pro-inflammatory gene expression by inducing C/EBPbeta in TNF-alphatreated adipocytes. Biochem Biophys Res Commun. 2009;378: 290-5.
-
(2009)
Biochem Biophys Res Commun
, vol.378
, pp. 290-295
-
-
Ito, Y.1
Daitoku, H.2
Fukamizu, A.3
-
26
-
-
0030936556
-
Does central obesity reflect "Cushing's Disease of the Omentum"?
-
Bujalska IJ, Kumar S, Stewart PM. Does central obesity reflect "Cushing's disease of the omentum"? Lancet. 1997;349:1210-3.
-
(1997)
Lancet
, vol.349
, pp. 1210-1213
-
-
Bujalska, I.J.1
Kumar, S.2
Stewart, P.M.3
-
27
-
-
0035850889
-
MRNA and enzyme activity of hepatic 11beta-hydroxysteroid dehydrogenase type 1 are elevated in C57BL/KsJ-db/db mice
-
Aoki K, Homma M, Hirano T, Oka K, Satoh S, Mukasa K, et al. MRNA and enzyme activity of hepatic 11beta-hydroxysteroid dehydrogenase type 1 are elevated in C57BL/KsJ-db/db mice. Life Sci. 2001;69:2543-9.
-
(2001)
Life Sci.
, vol.69
, pp. 2543-2549
-
-
Aoki, K.1
Homma, M.2
Hirano, T.3
Oka, K.4
Satoh, S.5
Mukasa, K.6
-
28
-
-
15444366462
-
The role of glucocorticoid action in the pathophysiology of the metabolic syndrome
-
Wang M. The role of glucocorticoid action in the pathophysiology of the metabolic syndrome. Nutr Metab (Lond). 2005;2:3.
-
(2005)
Nutr Metab (Lond)
, vol.2
, pp. 3
-
-
Wang, M.1
-
29
-
-
0036324073
-
Tissue-specific changes in peripheral cortisol metabolism in obese women: Increased adipose 11betahydroxysteroid dehydrogenase type 1 activity
-
Rask E, Walker BR, Soderberg S, Livingstone DE, Eliasson M, Johnson O, et al. Tissue-specific changes in peripheral cortisol metabolism in obese women: increased adipose 11betahydroxysteroid dehydrogenase type 1 activity. J Clin Endocrinol Metab. 2002;87:3330-6.
-
(2002)
J Clin Endocrinol Metab
, vol.87
, pp. 3330-3336
-
-
Rask, E.1
Walker, B.R.2
Soderberg, S.3
Livingstone, D.E.4
Eliasson, M.5
Johnson, O.6
-
30
-
-
0029007195
-
Amelioration of high-fat feeding-induced insulin resistance in skeletal muscle with the antiglucocorticoid RU486
-
Kusunoki M, Cooney GJ, Hara T, Storlien LH. Amelioration of high-fat feeding-induced insulin resistance in skeletal muscle with the antiglucocorticoid RU486. Diabetes. 1995;44:718-20.
-
(1995)
Diabetes
, vol.44
, pp. 718-720
-
-
Kusunoki, M.1
Cooney, G.J.2
Hara, T.3
Storlien, L.H.4
-
31
-
-
79959423583
-
Vitamin A decreases pre-receptor amplification of glucocorticoids in obesity: Study on the effect of vitamin A on 11beta-hydroxysteroid dehydrogenase type 1 activity in liver and visceral fat of WNIN/Ob obese rats
-
Sakamuri VP, Ananthathmakula P, Veettil GN, Ayyalasomayajula V. Vitamin A decreases pre-receptor amplification of glucocorticoids in obesity: study on the effect of vitamin A on 11beta-hydroxysteroid dehydrogenase type 1 activity in liver and visceral fat of WNIN/Ob obese rats. Nutr J. 2011;10:70.
-
(2011)
Nutr J.
, vol.10
, Issue.70
-
-
Sakamuri, V.P.1
Ananthathmakula, P.2
Veettil, G.N.3
Ayyalasomayajula, V.4
-
32
-
-
33645860825
-
Reactive oxygen species have a causal role in multiple forms of insulin resistance
-
Houstis N, Rosen ED, Lander ES. Reactive oxygen species have a causal role in multiple forms of insulin resistance. Nature. 2006;440:944-8.
-
(2006)
Nature
, vol.440
, pp. 944-948
-
-
Houstis, N.1
Rosen, E.D.2
Lander, E.S.3
-
33
-
-
79959236073
-
Antiinflammatory effect of insulin in the human hepatoma cell line HepG2 involves decreased transcription of IL-6 target genes and nuclear exclusion of FOXO1
-
Wallerstedt E, Sandqvist M, Smith U, Andersson CX. Antiinflammatory effect of insulin in the human hepatoma cell line HepG2 involves decreased transcription of IL-6 target genes and nuclear exclusion of FOXO1. Mol Cell Biochem. 2011;352: 47-55.
-
(2011)
Mol Cell Biochem
, vol.352
, pp. 47-55
-
-
Wallerstedt, E.1
Sandqvist, M.2
Smith, U.3
Andersson, C.X.4
-
34
-
-
14644427890
-
Local and systemic insulin resistance resulting from hepatic activation of IKK-beta and NF-kappaB
-
Cai D, Yuan M, Frantz DF, Melendez PA, Hansen L, Lee J, et al. Local and systemic insulin resistance resulting from hepatic activation of IKK-beta and NF-kappaB. Nat Med. 2005;11: 183-90.
-
(2005)
Nat Med
, vol.11
, pp. 183-190
-
-
Cai, D.1
Yuan, M.2
Frantz, D.F.3
Melendez, P.A.4
Hansen, L.5
Lee, J.6
-
35
-
-
78650266432
-
FoxO1 regulates Tlr4 inflammatory pathway signalling in macrophages
-
Fan W, Morinaga H, Kim JJ, Bae E, Spann NJ, Heinz S, et al. FoxO1 regulates Tlr4 inflammatory pathway signalling in macrophages. EMBO J. 2010;29:4223-36.
-
(2010)
EMBO J.
, vol.29
, pp. 4223-4236
-
-
Fan, W.1
Morinaga, H.2
Kim, J.J.3
Bae, E.4
Spann, N.J.5
Heinz, S.6
-
36
-
-
0034730660
-
Regulation of phosphoenolpyruvate carboxykinase and insulin-like growth factor-binding protein-1 gene expression by insulin, The role of winged helix/forkhead proteins
-
Hall RK, Yamasaki T, Kucera T, Waltner-Law M, O'Brien R, Granner DK. Regulation of phosphoenolpyruvate carboxykinase and insulin-like growth factor-binding protein-1 gene expression by insulin. The role of winged helix/forkhead proteins. J Biol Chem. 2000;275:30169-75.
-
(2000)
J Biol Chem
, vol.275
, pp. 30169-30175
-
-
Hall, R.K.1
Yamasaki, T.2
Kucera, T.3
Waltner-Law, M.4
O'brien, R.5
Granner, D.K.6
-
37
-
-
33845985335
-
SIRT1 regulates adiponectin gene expression through Foxo1-C/enhancer- binding protein alpha transcriptional complex
-
Qiao L, Shao J. SIRT1 regulates adiponectin gene expression through Foxo1-C/enhancer-binding protein alpha transcriptional complex. J Biol Chem. 2006;281:39915-24.
-
(2006)
J Biol Chem
, vol.281
, pp. 39915-39924
-
-
Qiao, L.1
Shao, J.2
-
38
-
-
0037799266
-
Akt modulates STAT3-mediated gene expression through a FKHR (FOXO1a)-dependent mechanism
-
Kortylewski M, Feld F, Kruger KD, Bahrenberg G, Roth RA, Joost HG, et al. Akt modulates STAT3-mediated gene expression through a FKHR (FOXO1a)-dependent mechanism. J Biol Chem. 2003;278:5242-9.
-
(2003)
J Biol Chem
, vol.278
, pp. 5242-5249
-
-
Kortylewski, M.1
Feld, F.2
Kruger, K.D.3
Bahrenberg, G.4
Roth, R.A.5
Joost, H.G.6
-
39
-
-
0038645860
-
Hepatocyte nuclear factor-4 is a novel downstream target of insulin via FKHR as a signal-regulated transcriptional inhibitor
-
Hirota K, Daitoku H, Matsuzaki H, Araya N, Yamagata K, Asada S, et al. Hepatocyte nuclear factor-4 is a novel downstream target of insulin via FKHR as a signal-regulated transcriptional inhibitor. J Biol Chem. 2003;278:13056-60.
-
(2003)
J Biol Chem.
, vol.278
, pp. 13056-13060
-
-
Hirota, K.1
Daitoku, H.2
Matsuzaki, H.3
Araya, N.4
Yamagata, K.5
Asada, S.6
-
40
-
-
33846878069
-
PPAR{alpha} mediates the hypolipidemic action of fibrates by antagonizing FoxO1
-
Qu S, Su D, Altomonte J, Kamagate A, He J, Perdomo G, et al. PPAR{alpha} mediates the hypolipidemic action of fibrates by antagonizing FoxO1. Am J Physiol Endocrinol Metab. 2007;292: E421-34.
-
(2007)
Am J Physiol Endocrinol Metab
, vol.292
-
-
Qu, S.1
Su, D.2
Altomonte, J.3
Kamagate, A.4
He, J.5
Perdomo, G.6
-
41
-
-
0035923514
-
Decreased lipid synthesis in livers of mice with disrupted Site-1 protease gene
-
Yang J, Goldstein JL, Hammer RE, Moon YA, Brown MS, Horton JD. Decreased lipid synthesis in livers of mice with disrupted Site-1 protease gene. Proc Natl Acad Sci USA. 2001;98: 13607-12.
-
(2001)
Proc Natl Acad Sci USA
, vol.98
, pp. 13607-13612
-
-
Yang, J.1
Goldstein, J.L.2
Hammer, R.E.3
Moon, Y.A.4
Brown, M.S.5
Horton, J.D.6
-
42
-
-
16844370417
-
FOXO1 functions as a master switch that regulates gene expression necessary for tumor necrosis factor-induced fibroblast apoptosis
-
Alikhani M, Alikhani Z, Graves DT. FOXO1 functions as a master switch that regulates gene expression necessary for tumor necrosis factor-induced fibroblast apoptosis. J Biol Chem. 2005;280:12096-102.
-
(2005)
J Biol Chem
, vol.280
, pp. 12096-12102
-
-
Alikhani, M.1
Alikhani, Z.2
Graves, D.T.3
|